ライフサイエンスコーパス: non-neural

1 1) receptors of neural (cerebral cortex) and non-neural (adipocyte) origin in three different species

2 ing can be mimicked with antibody binding to non-neural agrin, supporting a mechanism of ligand aggre

3 se previous studies is the importance of the non-neural and preplacodal ectoderm, two critical precur

4 sociated with sexual arousal, and in diverse non-neural and reproductive tissues, suggesting a variet

5 to the mechanisms responsible for neural and non-neural aspects of the FXS phenotype.

6 is sufficient to confer this activity to the non-neural bHLH factor MyoD.

7 standing the anatomical semantics encoded in non-neural bioelectrical networks, and of improved bioph

8 Nuclear extracts from neural and non-neural cell lines contained a DNA-binding activity w

9 he association of FMRP with polyribosomes in non-neural cell lines has previously suggested that FMRP

10 KSRP is expressed in both neural and non-neural cell lines, although it is present at higher

11 nce analysis and transcriptional activity in non-neural cell types.

12 dence of critical interactions with glia and non-neural cell types.

13 nct populations of progenitor, neuronal, and non-neural cells across our differentiation time course.

14 However, the p75NTR consistently appears in non-neural cells adjacent to those expressing Trk recept

15 expressed by specific subsets of neural and non-neural cells during embryogenesis and has been shown

16 pecies.Following spinal injury in zebrafish, non-neural cells establish an extracellular matrix to pr

17 ctions in the differentiation of neurons and non-neural cells have important implications not only fo

18 the primary cultures and contamination from non-neural cells have restricted the utility of these cu

19 By adapting optogenetics for use in non-neural cells in embryos, we show that developmentall

20 Reporter assays in central glial (CG-4) and non-neural cells indicated that a 1200-base pair (bp) 5'

21 in start site selection for both neural and non-neural cells indicates that the effect is general.

22 amine transporters (VMATs), one expressed in non-neural cells of the periphery (VMAT1) and the other

23 ever, how the growth cone differs from other non-neural cells remains unclear.

24 In non-neural cells REST is absent from the RE1 of the sile

25 Axonal growth through tubes of non-neural cells seemed to account for this specificity,

26 tion between neurons and between neurons and non-neural cells such as glia and muscle.

27 In this review, we focus on the impact of non-neural cells that participate in the neurogenic nich

28 e long been associated with proliferation in non-neural cells, although they are also expressed in po

29 orters and to trafficking in both neural and non-neural cells, and suggests a relationship between fa

30 In non-neural cells, Rap signaling can antagonize Ras signa

31 In neural progenitor and non-neural cells, REST acts by repression of a subset of

32 results demonstrate that, in both neural and non-neural cells, transcription of the FMR1 gene is init

33 confers little if any transport activity in non-neural cells, we also determined its localization in

34 osis in neurons but suppresses cell death in non-neural cells.

35 onal differences between Notch in neural and non-neural cells.

36 particular form of "forefront" signaling in non-neural cells.

37 nd can then enter the nucleus in neurons and non-neural cells.

38 s without a marked effect on virus growth in non-neural cells.

39 ression occurred in astrocytes, neurons, and non-neural cells.

40 old (+/- 3.7) more active in neurons than in non-neural cells.

41 itical effector of apoptosis in a variety of non-neural cells.

42 metalloprotease released by both neural and non-neural cells.

43 ensively after the expression of subunits in non-neural cells.

44 be expressed in a wide variety of neural and non-neural cells.

45 h may benefit or harm surrounding neural and non-neural cells.

46 Cl(-) currents and taurine release in human non-neural cells.

47 ptor insertion events observed previously in non-neural cells.

48 vercome many of the limitations of viral and non-neural cellular vectors, as well as pharmacologic an

49 of MWS and may underlie some sex-dependent, non-neural characteristics of this human inherited disor

50 les depending on the situations, while other non-neural chemotactic cells usually show uni-directiona

51 arkers in both ventral Xenopus epidermis and non-neural chick epiblast.

52 d smooth muscle contractility via neural and non-neural cholinergic pathways in the colon, the involv

53 were expressed in a previously unidentified non-neural CNS cell type.

54 gion-specific neurodegeneration, but also to non-neural co-morbidities.

55 ral crest neurons in the rostral portion and non-neural crest (nodose) neurons in the more central an

56 emonstrate Rdh10 is specifically required in non-neural crest cells prior to E10.5 for proper choanae

57 Our results elucidate a new function for the non-neural crest core mesoderm and specifically, mesoder

58 formations involved morphological changes to non-neural crest host beak tissues.

59 essed in melanoma cell lines compared with a non-neural crest kidney epithelial cell line (P < 1 x 10

60 The non-neural crest MdPA1 core mesoderm is needed to form m

61 y less than half in such embryos, implying a non-neural crest origin for a subset of them.

62 IBG uptake, of which only 2% (2/100) were of non-neural crest origin.

63 racterized for other neural crest tumors and non-neural crest tumors of childhood.

64 role in modulating growth and development of non-neural crest- derived tissues.

65 s but did so in mixed cultures of crest- and non-neural crest-derived cells; therefore, the endogenou

66 the central nervous system can give rise to non-neural derivatives.

67 Wnt-13 remained expressed in non-neural differentiated NTERA-2 cells, even several we

68 induction, and are refractory to BMP-induced non-neural differentiation.

69 mbryonic stem cells undergoing predominantly non-neural differentiation.

70 mitive embryonic ectoderm into neural versus non-neural domains.

71 or grainyhead-like 2 (GRHL2) is expressed in non-neural ectoderm (NNE) and Grhl2 loss results in full

72 ctors position the border between neural and non-neural ectoderm and are required for the specificati

73 in the lateral neural plate is regulated by non-neural ectoderm and bone morphogenetic proteins.

74 domains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 in the dorsal mesendoderm

75 ntiating cells and allowed discrimination of non-neural ectoderm and otic lineage cells from off-targ

76 Wnt signals from the neural plate, non-neural ectoderm and paraxial mesoderm have all been

77 cesses, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-

78 sensory neurons form at the boundary between non-neural ectoderm and the neural plate.

79 It has been suggested that both neural and non-neural ectoderm can contribute to the neural crest.

80 We report that in response to FGF the non-neural ectoderm can ectopically express several earl

81 These results suggest that the non-neural ectoderm can launch the neural crest program

82 Individual non-neural ectoderm cells on opposing sides of the neura

83 codes arise at the border of the neural- and non-neural ectoderm during anamniote vertebrate developm

84 nitiation signal acting from the extraocular non-neural ectoderm during optic vesicle evagination.

85 demonstrate that Dlx activity is required in non-neural ectoderm for the production of signals needed

86 Neural crest cells require BMP expressing non-neural ectoderm for their induction.

87 e border region between the neural plate and non-neural ectoderm from which multiple cell types, incl

88 we address the molecular mechanisms by which non-neural ectoderm generates neural crest.

89 leading to neural crest development via the non-neural ectoderm in amniotes and present a distinct r

90 neural crest (NC), cranial placode (CP), and non-neural ectoderm in multiple hPSC lines, on different

91 entiation were first recruited to the dorsal non-neural ectoderm in the tunicate-vertebrate ancestor

92 unction homologously to define neural versus non-neural ectoderm in Xenopus.

93 ncoding AP-2 gamma (Tfap2c), is expressed in non-neural ectoderm including transiently in neural cres

94 zed ectoderm, via meso-ectodermal, or neural-non-neural ectoderm interactions.

95 Expression in non-neural ectoderm is a conserved feature in amphioxus

96 We conclude that contact between neural and non-neural ectoderm is capable of inducing RBs, that BMP

97 tive BMP receptor, was transplanted into the non-neural ectoderm of un-manipulated hosts.

98 nteractions at the border between neural and non-neural ectoderm or mesoderm, and defined factors suc

99 Furthermore, the non-neural ectoderm responds to FGF by expressing the pr

100 differentiating cultures first expressed the non-neural ectoderm specific transcriptional factors TFA

101 ling across the interface between neural and non-neural ectoderm that is critical for inducing and pa

102 fusion protein expands the neural plate into non-neural ectoderm tissue whereas ectopic activation of

103 nd spatially restrict mesoderm, endoderm and non-neural ectoderm to their proper locations in the Xen

104 egulation of these neural crest markers, the non-neural ectoderm upregulates both BMP and Wnt molecul

105 ccurs in the inner or sensorial layer of the non-neural ectoderm where a subset of cells are chosen t

106 led an initially synchronous guidance toward non-neural ectoderm, followed by comparatively asynchron

107 epithelia that represent the mouse embryonic non-neural ectoderm, preplacodal ectoderm and otic vesic

108 chronological expression of marker genes of non-neural ectoderm, preplacodal ectoderm, and early oti

109 Signals from the non-neural ectoderm, the neural ectoderm, and the underl

110 influence the differentiation of neural and non-neural ectoderm, we show here that members of the Dl

111 tion that arises at the border of neural and non-neural ectoderm.

112 eries of interactions between the neural and non-neural ectoderm.

113 eural folds at the border between neural and non-neural ectoderm.

114 the expanded neural plate abuts Dlx-positive non-neural ectoderm.

115 n extending throughout the entire neural and non-neural ectoderm.

116 rs is generated within the deep layer of the non-neural ectoderm.

117 al neural tube but are down-regulated in the non-neural ectoderm.

118 evidence, in vertebrates, of compartments in non-neural ectoderm.

119 ted neurosecretory cells in the anteriormost non-neural ectoderm.

120 er between the neural plate and the adjacent non-neural ectoderm.

121 ectopic neurons that extend to the ventral, non-neural, ectoderm, but show no ectopic or enhanced no

122 onverting the lineage from neural/retinal to non-neural ectodermal and endo-mesodermal fates.

123 lx4b act to regulate bmp2b expression at the non-neural ectodermal border.

124 d2 and Smad1 signals to adopt mesodermal and non-neural ectodermal fates even at gastrula stages, aft

125 h as regionalized gene expression and neural/non-neural ectodermal patterning.

126 However, the mechanisms by which these non-neural elements contribute to CNS activity-dependent

127 in the neural ectoderm and E-cadherin in the non-neural (epidermal) ectoderm, and that each cadherin

128 autonomic neural activity rather than other, non-neural factors.

129 e of autonomic neural activity versus other 'non-neural' factors in the origin of BP and R-R variabil

130 on day 2, and the acquisition of neural and non-neural fates is now advanced by inhibition of Fgf si

131 Remarkably, MMP-9 deficiency also corrected non-neural features of Fmr1 deficiency-specifically macr

132 neuronal progenitor fields by downregulating non-neural genes, notably the muscle specifier Macho-1 a

133 neuropeptides, metabolic enzymes, and other non-neural genes.

134 asal transcription both in neural (PC12) and non-neural (HeLa and glial) cell types.

135 Our data demonstrate that non-neural human somatic cells, as well as pluripotent s

136 ived from several types of neural as well as non-neural human tumors.

137 ally in cells that normally express only the non-neural isoform of Neuroglian, we observed the genera

138 rent lesion-related tissue compartments: (a) non-neural lesion core, (b) astrocyte scar border, and (

139 necessary for axons to actively navigate the non-neural lesion site environment.

140 Generation of iN cells from non-neural lineages could have important implications fo

141 nd premutation (54<n<200) cell lines of both non-neural (lymphoblastoid) and neural (primary astrocyt

142 The data add to the growing literature of non-neural manifestations of HD and implicate NO depleti

143 ochlear sensitivity, perhaps both neural and non-neural mechanisms.

144 of tumor cells throughout the brain, whereas non-neural metastases, as well as select lower grade gli

145 cs of learning and information processing in non-neural metazoan somatic cell networks.

146 Elav by Mei-P26, another RBP derepressed in non-neural miRNA pathway clones.

147 onomic arrangements of the Isoptera based on non-neural morphological and DNA sequence analyses.

148 major classes of retinal neurons, as well as non-neural Muller glial cells, are specified in young em

149 that the cell surface-binding LG domains of non-neural (muscle) agrin and perlecan promote AChR clus

150 itive immunohistochemical staining of all 13 non-neural normal human tissues, in contrast to none of

151 and thyroid glands, and no staining of other non-neural normal tissues.

152 ral ectoderm: chordotonal sensory organs and non-neural oenocytes.

153 mesoderm, in the specification of neural and non-neural organ-specific lineages, as well as cell surv

154 ntiation, and during differentiation along a non-neural pathway induced by hexamethylene bisacetamide

155 , ESC aggregates transform sequentially into non-neural, preplacodal and otic-placode-like epithelia.

156 avior, local neural activity, and putatively non-neural processes.

157 ly divide embryonic ectoderm into neural and non-neural regions, followed by the emergence of neural

158 Ectopic ath5 expression in cultures of non-neural retinal pigment epithelial cells elicited tra

159 s are maintained by interactions between the non-neural roof plate and the neural rhombic lip.

160 ibed and post-transcriptionally repressed in non-neural settings.

161 cells, and Schwann cells and Trk-expressing non-neural smooth muscle and dendritic cells.

162 Apoptosis is also described in other non-neural structures such as the notochord, somites, mu

163 did not detect expression in the superficial non-neural structures that express the GABA synthase Gad

164 Repression of Elav in non-neural territories is crucial as misexpression here

165 d axonal processes as they migrate through a non-neural territory.

166 he first demonstration of PS1 abnormality in non-neural tissue and in diseases other than AD and sugg

167 CBP function in the Xenopus embryo abolishes non-neural tissue formation and, strikingly, initiates n

168 Alternatively spliced agrin isoforms in non-neural tissue including muscle lack the z8 insert an

169 PMP22 mRNAs can be detected in a variety of non-neural tissue, including epithelia.

170 in type I diabetes, has unclear function in non-neural tissue, it is important to understand its pat

171 locking the neuronal phenotype in vertebrate non-neural tissue, the invertebrate homolog is absent, r

172 ted neurons by silencing their expression in non-neural tissue.

173 d ASI to suppress innate immune responses in non-neural tissues against Pseudomonas aeruginosa in Cae

174 several other neuronal target genes, in both non-neural tissues and central nervous system neuronal p

175 on of neuron-specific tubulin in a subset of non-neural tissues and embryonic lethality.

176 efficient form of IDE expressed in brain and non-neural tissues and recommend novel regions of the ID

177 mates compared with lipids characteristic of non-neural tissues and show further acceleration of chan

178 e that humans produce a third form of GAD in non-neural tissues and that human islets, although they

179 ns: what are the requirements for Shroom3 in non-neural tissues and what factors control Shroom3 tran

180 SYN1 gene transcription is suppressed in non-neural tissues by the RE1-silencing transcription fa

181 f the nervous system and doublesex specified non-neural tissues culminated with claims that fruitless

182 e Trk receptors are expressed extensively in non-neural tissues during cell differentiation and tissu

183 severalfold higher than in other neural and non-neural tissues examined, consistent with the require

184 ion conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque mon

185 PMP22 protein expression and localization in non-neural tissues have not been studied in detail.

186 for long-term repression of target genes in non-neural tissues in adult zebrafish.

187 r that directs expression to both neural and non-neural tissues in vivo.

188 and humans, but the role of PtdIns(3,5)P2 in non-neural tissues is poorly understood.

189 However, genes with essential roles in non-neural tissues may be missed in traditional loss-of-

190 arly developmental events in both neural and non-neural tissues may be modulated by opioid receptors.

191 Reports of Trk receptor transcripts in non-neural tissues raise the possibility that the sites

192 erentiates into neural tissues and also into non-neural tissues such as the choroid plexus in the bra

193 r (NGF) receptor TrkA is widely expressed in non-neural tissues suggesting pleiotropic functions outs

194 neurotrophin-3 (NT-3) is highly expressed in non-neural tissues that receive peripheral innervation,

195 size of neuronal populations that innervate non-neural tissues to the optimal requirements of these

196 of genes that encode heat shock proteins in non-neural tissues upon exposure to heat.

197 molecular mechanisms that pattern neural and non-neural tissues within the neuroectoderm remain unkno

198 p75NTR with the Trk receptors in developing non-neural tissues would support the hypothesis that the

199 n (PrP(C)) is widely expressed in neural and non-neural tissues, but its function is unknown.

200 Expression of GPIalpha btx in surrounding non-neural tissues, but not in neurons, does not prevent

201 bitors of oxidative death in both neural and non-neural tissues, but their precise mechanism of actio

202 or (p75NTR) has been detected in a number of non-neural tissues, especially during development.

203 wn to affect immune function in vitro and in non-neural tissues, little is known about how the local

204 than the reported 2-3 kb mRNA predominant in non-neural tissues, we identified the major brain isofor

205 known to promote cell survival via Bcl-2 in non-neural tissues, we tested the hypothesis that estrad

206 REST/NRSF is expressed most highly in non-neural tissues, where it is thought to repress gene

207 xpression of the neuronal ankyrin isoform in non-neural tissues.

208 ervous tissue by silencing neuronal genes in non-neural tissues.

209 heir genes are expressed sex-specifically in non-neural tissues.

210 ishing connections with other neurons and/or non-neural tissues.

211 e transgene in brain, as compared with other non-neural tissues.

212 e ovary, luciferase expression was absent in non-neural tissues.

213 o neurons by suppressing their expression in non-neural tissues.

214 the mammalian central nervous system and in non-neural tissues.

215 ntly of the Trk receptors in most developing non-neural tissues.

216 important for the innervation of developing non-neural tissues.

217 cord and electric lobe, and undetectable in non-neural tissues.

218 erg1, which is expressed in both neural and non-neural tissues.

219 the adult rat brain but are not detected in non-neural tissues.

220 o differentiate into a variety of neural and non-neural tissues.

221 anchor composition, exist between neural and non-neural tissues.

222 and also is present at much lower amounts in non-neural tissues.

223 ical region prevents UBE3A-ATS expression in non-neural tissues.

224 hat Su(Hw) is a repressor of neural genes in non-neural tissues.

225 to be broadly distributed in both neural and non-neural tissues.

226 inate the development of adjacent neural and non-neural tissues.

227 regulating the migration and organization of non-neural tissues.

228 pendent on transcellular signaling through a non-neural toll-like receptor, linking neural-specific g

229 exclusively cell associated and were mostly non-neural tropic.

230 These studies were followed by analysis of non-neural tumors such as colorectal carcinomas.

231 pus laevis embryos was transplanted into the non-neural ventral ectoderm of host embryos at the same