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1 1 (ACK1; also known as Tnk2, tyrosine kinase non-receptor 2) as a novel binding partner of SLP-76.
2 monstrated that protein tyrosine phosphatase non-receptor 22 (PTPN22), variants in which are associat
3 ow that inositol hexakisphosphate (IP6) is a non-receptor activator of arrestin-3 and report the stru
9 nce that G proteins can also be activated by non-receptor binding partners, and they can signal from
10 IgE-Fc mutant that is trapped in the closed, non-receptor binding state via an engineered disulfide a
12 , an octamer capped peptide derived from the non-receptor-binding region of urokinase plasminogen act
17 in-tyrosine phosphatases (RPTPs), like their non-receptor counterparts, regulate the level of phospho
21 anism of G-protein activation by a family of non-receptor GEFs containing a Galpha-binding and -activ
23 ing vesicle-associated protein) is the first non-receptor guanine nucleotide exchange factor (GEF) th
25 We have previously demonstrated that the non-receptor guanine nucleotide exchange factor RIC8 act
26 More specifically, we found that GIV is a non-receptor guanine nucleotide exchange factor that act
27 s on members of a newly identified family of non-receptor guanine nucleotide exchange factors (GEFs),
28 i is activated in the Golgi by GIV/Girdin, a non-receptor guanine-nucleotide exchange factor (GEF).
29 out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs)
32 rectly stimulates the activity of a purified non-receptor kinase, Bruton's tyrosine kinase (Btk), whe
39 vation of feedback mechanisms resulting from non-receptor mediated displacement of intraneuronal dopa
45 endovesiculation can be achieved by simple (non-receptor-mediated) mechanical perturbation of the er
46 ors coupled to membrane receptors or through non-receptor pathways by stimuli such as heat shock, UV
50 (interleukin-2 inducible T cell kinase) is a non-receptor protein tyrosine kinase expressed primarily
56 ton's tyrosine kinase (Btk), a hematopoietic non-receptor protein tyrosine kinase that is critical fo
59 CR cross-linking activates three families of non-receptor protein tyrosine kinases (PTKs) and these a
60 addition, the activity of both receptor and non-receptor protein tyrosine kinases along with numerou
62 dermal growth factor receptor (EGFR) and the non-receptor protein tyrosine kinases Src and Pyk2 have
63 ll antigen receptor (TCR) activates a set of non-receptor protein tyrosine kinases that assist in del
64 otein Dab1, Src and Fyn of the Src-family of non-receptor protein tyrosine kinases, and CrkL) are loc
65 osine phosphatase (HePTP) is a 38kDa class I non-receptor protein tyrosine phosphatase (PTP) that is
66 in physically associates with and degrades a non-receptor protein tyrosine phosphatase (PTPN13), and
68 of Corkscrew, the drosophila ortholog of the non-receptor protein tyrosine phosphatase type II (SHP2)
72 rtners and suggest a general role for BCR in non-receptor protein-tyrosine kinase regulation and sign
74 gene encoding a member of the Csk family of non-receptor protein-tyrosine kinases (PTKs) in the earl
75 monstrate here that US28 signals through the non-receptor protein-tyrosine kinases Src and focal adhe
76 sion kinase (FAK) is a member of a family of non-receptor protein-tyrosine kinases that regulates int
79 decrease in the activity of the receptor and non-receptor protein-tyrosine phosphatases that down-reg
81 ted Akt stimulation is regulated by multiple non-receptor PTK families which regulate Akt both proxim
82 ns, whose boundaries are distinct from other non-receptor PTK family members, again indicating a stru
84 le proteins, while the fusion of receptor or non-receptor sequences upstream of 537-673 afforded stab
85 s that a WW domain-mediated process, such as non-receptor signaling, protein degradation or pre-mRNA
86 , we employed pharmacological inhibitors for non-receptor Src homology-2 domain-containing protein ty
92 s in the protein tyrosine phosphatase (PTP), non-receptor type 11 (PTPN11) gene that encodes the SH2
93 per was from a protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) mutated allele encoding Sh
94 : a pathogenic protein tyrosine phosphatase, non-receptor type 11 (PTPN11) variant and variants of un
95 e reported that tyrosine-protein phosphatase non-receptor type 11 (SHP-2) and phosphatidylinositol 3-
97 n expression of tyrosine-protein phosphatase non-receptor type 13 or FAS associated phosphatase 1 (FA
98 locus encoding protein-tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with inf
99 nase FYN (FYN), protein tyrosine phosphatase non-receptor type 2 (PTPN2), and adenylate cyclase-assoc
105 e c-Yes proto-oncogene (pp62c-Yes) encodes a non-receptor-type protein tyrosine kinase (NRPTK) of the
106 t mutations in PTPN11, the gene encoding the non-receptor-type protein tyrosine phosphatase SHP-2 (sr
107 brary screening and identified Fer kinase, a non-receptor-type tyrosine kinase, as a key regulator of
108 ed receptor may initiate the cross-talk with non-receptor-type tyrosine kinases, thereby activating p
109 ion, among those the catalytically inactive, non-receptor-type tyrosine phosphatase PTPN23/HD-PTP.
115 orylated in vitro by representatives of many non-receptor tyrosine kinase (NRTK) sub-families, sugges
119 We have previously shown that the Arg/Abl2 non-receptor tyrosine kinase acts downstream of the EGF
120 nism by which an adaptor protein activates a non-receptor tyrosine kinase by SH2 domain displacement.
124 ronal morphogenesis, we demonstrate that the non-receptor tyrosine kinase c-Abl is an intermediary fo
125 Here, we show that the stress-signaling non-receptor tyrosine kinase c-Abl links parkin to spora
129 pe-selective small molecule inhibitor of the non-receptor tyrosine kinase c-Src (IC(50) = 64 nM).
130 determined that tTG forms a complex with the non-receptor tyrosine kinase c-Src and PI3-kinase, and t
131 e G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras
132 macrophage colony-stimulating factor and the non-receptor tyrosine kinase c-Src play critical roles i
133 ubiquitination of another protooncogene, the non-receptor tyrosine kinase c-Src, as well as of itself
136 reviously showed that targeted expression of non-receptor tyrosine kinase Etk/BMX in mouse prostate i
140 tyrosine kinase (BTK) is a member of the Tec non-receptor tyrosine kinase family that is involved in
142 nase-1 (FRK-1), an ortholog of the mammalian non-receptor tyrosine kinase Fer, is necessary for embry
144 long cytoskeletal filaments and activate the non-receptor tyrosine kinase focal adhesion kinase, whic
145 ignaling protein, the ubiquitously expressed non-receptor tyrosine kinase focal adhesion kinase.
146 Herein, we identified a novel role for the non-receptor tyrosine kinase Fyn in regulating neuroinfl
147 ngest interaction was between MAP-2c and the non-receptor tyrosine kinase Fyn; however, MAP-2b and MA
149 h tyrosine kinase 2 (PYK2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple sign
152 en hMSH5 and c-Abl; the latter is a critical non-receptor tyrosine kinase involved in many critical c
155 ed receptors, results in the activation of a non-receptor tyrosine kinase known as focal adhesion kin
157 blished that BCR is a substrate for c-FES, a non-receptor tyrosine kinase linked to myeloid growth an
159 ase (FAK) potently, we explored whether this non-receptor tyrosine kinase participates in the activat
162 n that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modu
168 d pharmacologic approaches identify that the non-receptor tyrosine kinase Src is required for FN tran
170 in (LRP) was found to be a substrate for the non-receptor tyrosine kinase Src, but the physiological
171 -Cbl also acts as a ubiquitin ligase for the non-receptor tyrosine kinase Src, thereby down-regulatin
173 ted that integrin-mediated activation of the non-receptor tyrosine kinase Syk in hematopoietic cells
174 vated Cdc42-associated kinase-2 (ACK-2) is a non-receptor tyrosine kinase that appears to be a highly
184 uton's tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role
185 target of the enzymatic activity of c-Abl, a non-receptor tyrosine kinase that potently activated in
187 ivated Cdc42-associated kinase-2 (ACK2) is a non-receptor tyrosine kinase that serves as a specific e
191 canonical signaling mechanisms such as Src (non-receptor tyrosine kinase), PI3K, ERK, or MAPK pathwa
195 tudy, we have identified SAM domain-carrying non-receptor tyrosine kinase, activated Cdc42-associated
196 ts with the SH3 domain of Fyn, an Src family non-receptor tyrosine kinase, and is tyrosine-phosphoryl
197 nsistent with genetic studies placing Abl, a non-receptor tyrosine kinase, and the Drosophila ortholo
198 t of the vesicular regulator, dynamin 2, the non-receptor tyrosine kinase, c-Abl, and the NADPH oxida
199 resent study, we examined the role of Fyn, a non-receptor tyrosine kinase, in microglial activation a
200 or TNK2, an ubiquitously expressed oncogenic non-receptor tyrosine kinase, integrates signals from li
204 motes signaling by causing activation of the non-receptor tyrosine kinase, JAK2, which associates wit
206 e reported previously that Janus kinase 3, a non-receptor tyrosine kinase, plays a crucial role in AJ
207 increase in tyrosine phosphorylation of the non-receptor tyrosine kinase, PYK2, in A7r5 cells treate
209 h collagen induced a rapid activation of the non-receptor tyrosine kinase, Syk, as measured by an inc
211 he identification of cellular Src (c-Src), a non-receptor tyrosine kinase, which has since been impli
218 belson family kinases (AFKs; Abl1, Abl2) are non-receptor tyrosine kinases (NRTKs) implicated in canc
220 eelin activates members of the Src family of non-receptor tyrosine kinases (SFKs) and that this activ
221 ein kinase IIdelta2 (CaMKIIdelta2) activates non-receptor tyrosine kinases and EGF receptor, with a S
222 receptor tyrosine kinases, the Src family of non-receptor tyrosine kinases and the Eph receptor tyros
223 members of the Janus kinase (Jak) family of non-receptor tyrosine kinases and the signal transducers
224 d p160(v-Abl) are plasma membrane-associated non-receptor tyrosine kinases and the transforming activ
228 substrate of all the three major classes of non-receptor tyrosine kinases associated with the IL-2R,
229 ough members from three distinct families of non-receptor tyrosine kinases can phosphorylate PLCgamma
232 eptor tyrosine kinases and the Abl family of non-receptor tyrosine kinases have both been implicated
233 inases (SrcFKs), a multi-functional group of non-receptor tyrosine kinases highly expressed in vascul
234 , PF-4618433) reveals a distinct subclass of non-receptor tyrosine kinases identifiable by the gateke
235 lopment and represents an emerging family of non-receptor tyrosine kinases implicated in signal trans
237 stimulation of VGSC, engagement of these two non-receptor tyrosine kinases involves distinct signalin
238 to-oncogenes encode 60 000 and 62 000 Dalton non-receptor tyrosine kinases of the Src family, pp60c-s
239 orylation of cellular proteins including the non-receptor tyrosine kinases p125fak and Src and the ad
242 nsights into the mechanisms by which Abelson non-receptor tyrosine kinases relay information from axo
243 relationship between Notch and either of the non-receptor tyrosine kinases Src42A and Src64B to promo
245 d gene) protein belongs to the Abl family of non-receptor tyrosine kinases that regulate cell motilit
246 s a novel negative regulator of receptor and non-receptor tyrosine kinases through currently undefine
247 eration, we asked whether the recruitment of non-receptor tyrosine kinases to the cytoskeleton might
249 protein Hck is a member of the Src family of non-receptor tyrosine kinases which is preferentially ex
250 kinase Itk is a member of the Tec family of non-receptor tyrosine kinases, and is required for signa
252 Thus, these studies strongly suggest that non-receptor tyrosine kinases, in particular c-Src, may
254 e of signaling nodes Itk and Txk, Tec family non-receptor tyrosine kinases, mice exhibit a significan
256 Btk family kinases represent new members of non-receptor tyrosine kinases, which include Btk/Atk, It
257 main containing proteins, including specific non-receptor tyrosine kinases-Abl via pY251 and C-termin
266 cogenic function via direct interaction with non-receptor tyrosine phosphatase 14 (PTPN14) through th
268 RNA interference (RNAi) screening identified non-receptor tyrosine phosphatases (PTPNs) required for
269 osine kinases (protein-tyrosine kinases) and non-receptor tyrosine phosphatases (PTPs) have been impl
275 osine phosphorylation of GIV by receptor and non-receptor-tyrosine kinases is a key step that is requ
276 SHP-1 antagonizes the action of receptor and non-receptor-tyrosine kinases on GIV and down-regulates
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