ライフサイエンスコーパス: non-specific

1 aptive response is, in fact, stereotyped and non-specific.

2 iogenesis by CpG-ODN is pervasive and tissue non-specific.

3 for DCM, but its delivery is inefficient and non-specific.

4 at anti-SUMO1 immunolabelling at synapses is non-specific.

5 ensation, and pharmacological inhibitors are non-specific.

6 ive Vif 107-115, although recapitulated, are non-specific.

7 immersed into a PBS solution containing the non-specific Ab (anti-HCV for Hepatitis C) antibodies.

8 minimum detection is the result of a reduced non-specific absorption onto the gold nanoparticles (by

9 Local anaesthetics block pain through non-specific actions at all Nav channels, but the discov

10 agulants have some drawbacks including their non-specific actions.

11 variants that display significantly reduced non-specific activities compared with its wild-type coun

12 silent gastric perforations presenting with non-specific acute abdomen.

13 efer to such nanoformulations with decreased non-specific adhesivity and receptor targeting as 'DART'

14 strategies, suitable antibodies, minimizing non-specific adsorption and improving the quality of SPR

15 en 20 coating method is developed to inhibit non-specific adsorption between alpha-Syn and nanopore s

16 blocked sensor surface that exhibits minimal non-specific adsorption for singleplex measurements of e

17 antibodies onto the surface and prevents the non-specific adsorption of analytes and matrix constitue

18 included a PEG-based dithiol, minimised the non-specific adsorption of other proteins and was sensit

19 and illustrate methods employed to minimize non-specific adsorption of undesirables.

20 n on the electrodes' surface and to decrease non-specific adsorption, a Self-Assembled Monolayer (SAM

21 n result in undesirable side effects such as non-specific adsorption, protein denaturation, and steri

22 hich served as the blocking agent to prevent non-specific adsorption.

23 This approach minimized non-specific adsorptions and matrix effects and allowed

24 Ps and ampetoids trigger extensive and rapid non-specific aggregation of intracellular biomacromolecu

25 ocortin receptors in the VMH of rats using a non-specific agonist melanotan II (MTII), compared to ve

26 tosterone and DHT treatment increased tissue non-specific alkaline phosphatase (Alpl) mRNA expression

27 e corresponding exon of the ancestral tissue-non-specific alkaline phosphatase gene (ALPL).

28 were 21 amnestic, 12 non-amnestic, and seven non-specific amyloid-negative Alzheimer's disease cases.

29 While the non-amnestic and non-specific amyloid-negative cases usually showed patte

30 A list of non-specific and false positive interactors is presented

31 e, and because presenting symptoms are often non-specific and fluctuating.

32 Imaging features of neurenteric cyst are non-specific and it should be considered in the differen

33 determining where enrichment analyses report non-specific and non-robust findings, we are able to ass

34 With explicit consideration of non-specific and specific interactions between DPO4 and

35 modeling of protein complexes; prediction of non-specific and transient protein interactions; thermod

36 vic pain shortly after menarche and may show non-specific and variable symptoms with resultant delay

37 In the presence of exosomes, the non-specific and weaker binding between aptamers and the

38 Recent insights suggest that non-specific and/or promiscuous enzymes are common and a

39 dies but have also been suggested to support non-specific antigen diversification of the B-cell reper

40 ly specific and shows negligible response to non-specific antigens.

41 lar training adaptations, but the effects of non-specific antioxidants on exercise training-induced v

42 Two non-specific drugs and one non-specific aptamer, tested as stringent control candid

43 ally mimic rheumatologic conditions owing to non-specific arthralgia and back pain.

44 l dementia or corticobasal degeneration, and non-specific as dementia with Lewy bodies or unknown dia

45 rch for M ulcerans in osteomyelitis cases of non-specific aspect in areas endemic for Buruli ulcer; a

46 ever, this comparison may be contaminated by non-specific attention, alerting, performance, and repor

47 ence of a single-stranded catalyst, and this non-specific background degrades the signal-to-noise rat

48 interference from the large concentration of non-specific binders (proteins, lipids, nucleic acids an

49 region of TALEs is required for the initial non-specific binding and subsequent rapid search along D

50 NA interactions, which are often obscured by non-specific binding at concentrations approaching in vi

51 d to neural cell populations by deleting its non-specific binding domain and replacing it with a C. b

52 onditions, shows optimum specific and little non-specific binding in phosphate buffered saline.

53 ents with magnetic tweezers demonstrate that non-specific binding leads to DNA condensation that is r

54 This increase is achieved while keeping non-specific binding low as established in control tests

55 plain a large increase in off-rate while the non-specific binding model cannot be reconciled with the

56 ion procedure was optimized to eliminate the non-specific binding of antigen on the membrane surface.

57 efficacy, the long circulation half-life and non-specific binding of cytotoxic ADCs can result in sys

58 The non-specific binding of non-target species to functional

59 Non-specific binding of NPs to tumor ECM components was

60 ing from complex food samples as well as the non-specific binding of S-AuNPs.

61 (HSA), suggesting possible resilience to the non-specific binding of serum proteins.

62 mical properties of the PANI/DNNSA layer and non-specific binding prevention were all crucial factors

63 bound to DNA non-specifically, and (ii) that non-specific binding shares common characteristics betwe

64 These sites coincide with non-specific binding sites for multiple transcription fa

65 m albumin (BSA) was used for blocking of the non-specific binding sites.

66 To prevent non-specific binding the gold surface was treated with 3

67 The model is generalizable, using non-specific binding to capture drug-polymer interaction

68 change the equilibrium between specific and non-specific binding to the DNA.

69 cellular uptake via electron microscopy, and non-specific binding to the substrates through a combina

70 ted side effects, either through specific or non-specific binding to unintended membrane protein targ

71 avidity for importin alpha7 while preventing non-specific binding to viral RNA.

72 Non-specific binding was prevented by blocking free spac

73 nds selectively to target molecules, and the non-specific binding where adsorption of BSA protein mol

74 -SPE), followed by (2) blocking the areas of non-specific binding with mercaptosuccinic acid.

75 submicellar and micellar concentrations via non-specific binding with undetectable secondary structu

76 This revealed the importance of minimizing non-specific binding within the relatively adhesive, 'st

77 had high specificity, it was insensitive to non-specific binding, and detected target sequences in t

78 optimal blocking buffer for restraining the non-specific binding.

79 as a benchmark to distinguish specific from non-specific binding.

80 rgeted for cellular uptake with little or no non-specific binding.

81 obtained in buffer indicating the absence of non-specific binding.

82 a high degree of activity and low levels of non-specific binding.

83 y and mismatch DNA sequences, overcoming the non-specific binding.

84 ten encounters large background arising from non-specific bindings, material autofluorescence and lea

85 enous injection of nanoparticles resulted in non-specific biodistribution, with significant accumulat

86 general and for the development of arrays of non-specific biosensors for artificial olfaction applica

87 nhibitors of MMP-14 by modifying the natural non-specific broad MMP inhibitor protein N-TIMP2 to inte

88 activity emerge [7], whereas prior to this, non-specific bursts of activity occur in response to nox

89 y to mediate protective immunity via antigen non-specific bystander killing, a function we show is de

90 terestingly, protein phosphatase 2Cs prevent non-specific Ca(2+)-signaling.

91 chromatin capture (PAtCh-Cap), relies on the non-specific capture of chromatin-bound proteins via the

92 shell is not necessary; there is an optimal non-specific carboxysome shell permeability.

93 % of amnestic versus 94% of non-amnestic and non-specific cases.

94 g and voltage-dependent excitation involving non-specific cation channels.

95 g and voltage-dependent excitation involving non-specific cation channels.

96 promote bacteria attachment while preventing non-specific cell and protein fouling.

97 oped devices are prone to partially focus on non-specific cells or cells associated with the specific

98 models, as DUX4 toxicity could be related to non-specific cellular stress induced by over-expressing

99 se effects did not appear to be explained by non-specific changes in activity, because effects on fea

100 eports of antibody-siRNA complexes relied on non-specific charged interactions and have not been broa

101 677 deaths), symptomatic diagnoses including non-specific chest pain, dyspnoea and syncope (1368 [6%]

102 lenging as most of the patients present with non-specific chronic leg pain.

103 re with a separable DNA-binding domain and a non-specific cleavage domain).

104 as possible, however a greater proportion of non-specific cleavage variants were observed relative to

105 A quantitative estimation of these non-specific cleavages may enable simulating realistic H

106 based on laboratory examinations because of non-specific clinical features, which usually entails th

107 The non-specific clinical manifestations caused by tick-born

108 Each of these cases had a non-specific clinical presentation.

109 novel co-factors Csx27 and Csx28, as well as non-specific collateral RNA damage.

110 wers transcription factor residence time and non-specific collisions during sampling for DNA targets.

111 ysine and arginine residues rather than by a non-specific, colloidal mechanism.

112 most cases high-resolution structures of the non-specific complexes are unavailable.

113 endent manner, consistent with a substantial non-specific component to binding.

114 between the pair of ARG boxes facilitate the non-specific contacts between ArgR subunits and the resi

115 um Albumin (BSA) was used for the control of non-specific currents.

116 much stronger T cell activation coupled with non-specific cytokine production and T cell proliferatio

117 assays were conducted, and the potential for non-specific cytotoxicity determined.

118 tive at killing bacteria, but can also cause non-specific damage to host tissues and contribute to th

119 enotypes are compensated and that secondary, non-specific defects accumulate over time.

120 ns called lipid rafts, and can be blocked by non-specific depletion of plasma membrane cholesterol.

121 Specific and non-specific desensitization and changes in surface IgE

122 There was little or no non-specific desensitization when lung mast cells were e

123 Rather than being a non-specific diagnosis, disseminated TB is a distinct, l

124 guage, visuospatial or frontal symptoms), or non-specific (diffuse cognitive deficits).

125 The new reporter molecule showed a reduced non-specific displacement by BSA and ribonuclease A.

126 lity of these agents is limited due to their non-specific distribution in the body and toxicity to no

127 c tracer retention in hypoxic sites from its non-specific distribution in tumor.

128 We speculate that the association with non-specific DNA afforded by polymerization may enable r

129 ttenuating ETV6 binding to both specific and non-specific DNA and expand the repertoire of characteri

130 mical shift perturbations, both specific and non-specific DNA are bound via the same canonical ETS do

131 values of the free energies of specific and non-specific DNA binding and protein-protein cooperativi

132 motif in SA1 plays dual roles in modulating non-specific DNA binding and subdiffusive dynamics over

133 nts provide no evidence for the promotion of non-specific DNA binding and/or condensation events by t

134 DNA binding predictions and the addition of non-specific DNA binding domains.

135 ve abundance of specific, near-specific, and non-specific DNA binding modes of LacI in vivo, showing

136 nt harbouring alterations designed to reduce non-specific DNA contacts.

137 ctrochemical measurements accomplished using non-specific DNA fragments mixed with samples, revealed

138 significantly lower in affinity, binding to non-specific DNA is auto-inhibited ~5-fold and is also a

139 Binding of ParB to non-specific DNA is more complex and displays apparent p

140 centromere DNA sequence parS and to adjacent non-specific DNA over multiple kilobases in a phenomenon

141 ossessing three histone-binding domains, one non-specific DNA-binding module, and several motifs for

142 nfolds when ETV6 binds to either specific or non-specific DNA.

143 Two non-specific drugs and one non-specific aptamer, tested

144 structural simulation, a fused pol Sdbh with non-specific dsDNA binding protein Sso7d in the N-termin

145 ness research with inclusion of controls for non-specific effects is needed to define a range of addi

146 The first is a non-specific electrostatic influence on activation media

147 nition motif, apparently as a consequence of non-specific electrostatic interactions, supporting the

148 erwent emergency CT and MRI which revealed a non-specific enhancing focal brain lesion.

149 lts and drive the generation of biologically non-specific enrichment results as well as highly fragil

150 However, this protein is non-specific, equally hindering the degradation of non-t

151 e previously shown that high expression of a non-specific esterase is critical for the low overall es

152 e previously shown that high expression of a non-specific esterase is critical for the low overall es

153 te vasodilatory effects of 17beta-estradiol (non-specific estrogen receptor (ER) agonist), PPT (ERalp

154 Minor non-specific facial dysmorphism was also noted in some i

155 in displacement experiments might influence non-specific factors not directly related to navigation

156 Non-specific feature selection is a dimension reduction

157 All 28 patients developed non-specific febrile manifestations, including fever in

158 ound ribosome complexes, suggesting that the non-specific flipping of A1492/3 has no active role in t

159 and high selectivity when compared to other non-specific glycolytic proteins such as d-glucose-6-pho

160 ate immunity typically refers to a quick but non-specific host defense response against invading path

161 Non-specific hydrogen bonding to viral peptide also acco

162 ated mammalian peroxidases in the context of non-specific immune defense.

163 , including efficient small RNA delivery and non-specific immune responses to dsRNA.

164 n understanding if oral vaccination provides non-specific immunity to other infections so that the co

165 ine adjuvant and is under investigation as a non-specific immunomodulator.

166 while those of resveratrol and curcumin are non-specific in that they stem from strong interference

167 strointestinal tract has shown gastritis and non-specific inflammation whereas laparoscopy shows whit

168 s and platelets during steady state limiting non-specific inflammation, but bacterial infection trigg

169 is finding indicates that EC cells represent non-specific information about location relative to an e

170 interneurons (PVs) amplify SSA by providing non-specific inhibition: optogenetic suppression of PVs

171 pre-adaptive) evolution in which an initial non-specific interaction between the CTD of an ancestral

172 nC-SAC first distinguishes specific from non-specific interaction frequencies, then generates 3D

173 ia the self-assembly; (ii) prevention of the non-specific interaction via the PEGylation; (iii) tumor

174 roteins in the cellular environment prevents non-specific interactions and promotes nucleosome format

175 icted mobility (that is, limited diffusion), non-specific interactions between probes are prevented,

176 software packages either fail to correct for non-specific interactions due to genomic proximity or on

177 cific effects in vivo thereby minimizing any non-specific interactions of the liposomes with non-canc

178 evidence that it additionally displays soft, non-specific interactions with the ribozyme.

179 still encounters unfavorable host responses, non-specific interactions, and heterogeneity in targeted

180 However, charged mutations can mediate non-specific interactions, and it is unclear to what ext

181 basic histone proteins, shielding them from non-specific interactions, facilitating their deposition

182 To avoid non-specific interactions, the unpaired cysteine-34 of H

183 tion for distinguishing between specific and non-specific interactions.

184 l amine polyethylene glycol chain to prevent non-specific interactions.

185 with a different species of Bacillus to test non-specific interference using a portable surface plasm

186 ease (kappaw=0.73 [0.68-0.78]); moderate for non-specific interstitial pneumonia (NSIP; kappaw=0.42 [

187 idiopathic pulmonary fibrosis or idiopathic non-specific interstitial pneumonia diagnosed within the

188 panel as usual interstitial pneumonia, 23 as non-specific interstitial pneumonia, 16 as hypersensitiv

189 tor; (iii) 50 mm tetraethylammonium (TEA), a non-specific KCa channel blocker; and (iv) 10 mm l-NNA +

190 Non-specific KCa channel inhibition and triple blockade

191 endent potassium channel (KCa ) inhibitor, a non-specific KCa channel inhibitor or triple blockade.

192 To better understand the non-specific lateral association of a membrane protein w

193 with mixed lineage leukemia 1 (MLL1) and the non-specific lethal (NSL) histone-modifying complexes.

194 ol Carrier Protein-2 (SCP-2) is an important non-specific lipid transfer protein in insects and appea

195 Non-specific lipid transfer proteins (LTPs) are a family

196 ucleotides with 2'-F modifications can cause non-specific loss of cellular protein(s).

197 Thus, non-specific loss of proteins from companion cells to si

198 Non-specific low back pain affects people of all ages an

199 Because non-specific low back pain does not have a known pathoan

200 The prevalence of non-specific main chain-mediated interactions demonstrat

201 AZD6765 impaired performance in a non-specific manner.

202 ging and magnetization transfer imaging in a non-specific manner.

203 replication origin specificity by preventing non-specific MCM helicase loading.

204 d headgroup recognition or flat surfaces for non-specific membrane binding and both types of interact

205 ility of LCM formation was investigated as a non-specific method for removal of a water-soluble dye f

206 nation of anthocyanins had been performed by non-specific methods that limit the accuracy and reliabi

207 B topoisomerase, a type IIA topoisomerase, a non-specific mitochondrial DNA binding protein and a typ

208 or an increase in collagenase concentration (non-specific MMP degradation).

209 of protein therapeutics, but often leads to non-specific modification or loss of bioactivity.

210 However, non-specific multi-site fluorescent labeling often resul

211 Control tests using non-specific myoglobin antigen confirmed the specificity

212 The controlled, yet non-specific nature of enhancement broadens the range of

213 t, nutritional deficiency, Down syndrome and Non-specific neurodevelopmental delay with co-morbid sei

214 e perfused with Ringer solution (control), a non-specific NO synthase inhibitor, a non-selective COX

215 (ii) 10 mm N(G) -nitro-l-arginine (l-NNA), a non-specific NOS inhibitor; (iii) 50 mm tetraethylammoni

216 nguish the specific binding targets from the non-specific ones.

217 th the rim of Hfq and increased annealing of non-specific or U-tailed RNA oligomers.

218 n 384-well format and is sensitive to known, non-specific palmitoylation inhibitors.

219 f diseases, belying the notion that they are non-specific partner proteins.

220 r with the protein drug, which can result in non-specific permeation of the intestine as well as enha

221 Here we show that manipulation of the non-specific phospholipase C1, NPC1, alters silicon cont

222 nitial PROPPIN-membrane binding is driven by non-specific PIP interactions.

223 2mg/kg, i.p.), and chelerythrine chloride (a non-specific PKC inhibitor, 10nmol, intrathecal) for 14

224 ng: (a) via genuine neuromodulation, (b) via non-specific placebo effects and (c) by demonstrating, t

225 to environmental stress based on general and non-specific plant species mechanisms.

226 Hence non-specific plasticity may offer a benefit in noisy env

227 that memory retrieval may benefit from this non-specific plasticity when the applied sparse binary i

228 itory neurons is inconsistent with the local non-specific pooling of excitatory inputs and that inhib

229 ese findings challenge the generality of the non-specific pooling principle for inhibitory neurons, s

230 proaches in the mouse have led to the "local non-specific pooling principle" of inhibitory connectivi

231 evidently obscured in physiological salt by non-specific, predominantly electrostatic interactions.

232 First, a non-specific "preparatory" system learns aversive facial

233 ion (LAMP) is limited by the accumulation of non-specific products, but nucleic acid circuitry can be

234 he PEG net-cloth has excellent resistance to non-specific protein adsorption and cell adhesion; 3) th

235 egligible signal changes (5%) in a very high non-specific protein background, while still able to dif

236 ich revealed prominent cross-reactivity with non-specific proteins in human and animal sera.

237 ellulose acetate membrane for the removal of non-specific proteins was used for the sensitive and sel

238 Finally, Dpp1p, Dpp2p and Dpp3p are non-specific pyrophosphatases responsible for farnesol s

239 d51's ATPase activity and does not depend on non-specific Rad51 binding to undamaged double-stranded

240 hree different plants, our results support a non-specific relationship between Micromonospora and leg

241 ting in the cessation of respiration and the non-specific release of pre-folded, fully active endolys

242 Sonographic gray scale features are non-specific requiring confirmation with colour and spec

243 Chronic non-specific respiratory symptoms are difficult to manag

244 to use in clinical practice in patients with non-specific respiratory symptoms to predict response to

245 to inhaled corticosteroids in patients with non-specific respiratory symptoms.

246 opsylla conformis and Xenopsylla ramesis) on non-specific responses of eight species of rodents (Meri

247 circuit elements reduce noise by eliminating non-specific responses to complex visual information.

248 ypes of apoptosis induction than are lineage-non-specific, retinoic-acid-differentiated hPSCs.

249 , we argue that regarding proteins as merely non-specific rigid inclusions is flawed, and each protei

250 NA the ability to withstand competition from non-specific RNA and at least in part may explain the fa

251 We used the measured sets of non-specific RNA backgrounds to build a common backgroun

252 A recent study measured three sets of non-specific RNA backgrounds which are present in severa

253 Our results highlight a role for non-specific RNA binding in the evolution of RNA-binding

254 The CTD tip competes against non-specific RNA binding, facilitates dsRNA release, and

255 o the presence of moderate concentrations of non-specific RNA competitors, which considerably delay t

256 Non-specific RNAs exerted particularly large inhibitory

257 goal was to characterize the details of the non-specific search mode to complement the crystal struc

258 ithin groups and including participants with non-specific self-identification.

259 ensitivity, prolonged stability, and lack of non-specific sensor fouling may enable long-term in situ

260 selectivity towards the target DNA over the non-specific sequences and also it was cost and time-eff

261 ly not disease-specific but rather part of a non-specific, shared response to health and disease.

262 s, even cells whose responses are considered non-specific show tailoring of their transcriptional rep

263 The other four antibodies detect a non-specific signal at ~150 kDa as evidenced by its abun

264 r was established, but it was susceptible to non-specific signals from complex matrixes.

265 etic immuno-probes to bind sTfR and minimize non-specific signals, while enhancing detection on the P

266 -computed-tomography (CT), for which various non-specific signs for IPA have been described.

267 aximizes discrimination between specific and non-specific sites.

268 Thus, non-specific sodium influx via bonafide calcium channels

269 the signaling and phenotypic consequences of non-specific sodium permeation via calcium channels rema

270 simple mechanism for the binding of ssDNA to non-specific SSBs may be at play, which explains the dis

271 itation of low spatial resolution due to the non-specific stimulation characteristics of electrical s

272 a local infection to evaluate the utility of non-specific stress, harming host and pathogen alike, fo

273 In our model, we found that completely non-specific stressors at the local, regional, and syste

274 ilizing the native fold, they are relatively non-specific, suggesting additional mechanisms contribut

275 rt a rare case of a 44-year-old patient with non-specific symptoms and an association between these t

276 e many tick-borne diseases that present with non-specific symptoms in the early stages of the illness

277 Many people are asymptomatic or have non-specific symptoms such as lethargy, itch, or loss of

278 sease is not always suspected because of its non-specific symptoms, and the diagnostic tests routinel

279 ost, should be relatively more vulnerable to non-specific systemic stress than the host and its cells

280 dominantly repress the development of other, non-specific T cell lineages has not been fully elucidat

281 As our parameters and model are non-specific, they could apply to any tissue TIC and do

282 gests that this is achieved via reduction of non-specific tissue binding.

283 , short half-life, bleeding complications or non-specific tissue targeting.

284 onsider the reduction in response time to be non-specific to the Simon task, and cast our interpretat

285 lation for specific (phosphorylated tau) and non-specific (total tau) protein targets.

286 peptides (AMPs) is largely hindered by their non-specific toxicity against mammalian cells, which is

287 find CRISPRi does not exhibit any detectable non-specific toxicity recently observed with CRISPR nucl

288 d challenges in terms of treatment including non-specific toxicity, chemoresistance and relapse.

289 xin B1 (AfB1) and mixture of AfB1 with other non-specific toxins (NSTs), thus leading to erroneous qu

290 ing potential overall immunosuppression from non-specific Tregs.

291 Patients often report non-specific triggers such as stress or sleep deprivatio

292 8/9 had non specific upper gastrointestinal symptoms and 3/9 had

293 In control experiments, only low-level, non-specific uptake of (89)Zr-labeled isotype IgG was ob

294 In contrast, less, more diffuse, and non-specific uptake without localization to these key re

295 ish specific binding to tumour collagen from non-specific uptake.

296 ical signs and symptoms that are notoriously non-specific, variable, and often absent in the early st

297 ted in these lineages and might provide both non-specific viral defence and access to nucleotides.

298 easure the binding potential relative to the non-specific volume, BPND.

299 Clinical and laboratory findings were non-specific, while imaging features with computed tomog

300 TN1A neurons can drive the activity of a sex-non-specific wing motoneuron, hg1, which is also require