ライフサイエンスコーパス: nonactivated

1 hereas apical canaliculi appeared relatively nonactivated.

2 A convenient approach toward nonactivated 1-alkyl-2-(trifluoromethyl)azetidines as a

3 rmed a prospective clinical trial to compare nonactivated 4-factor prothrombin complex concentrate (4

4 f LN DCs prior to their activation generates nonactivated Ag-pulsed DCs that recruit Ag-specific T ce

5 and stereochemical techniques applicable to nonactivated aliphatic systems remain largely elusive du

6 howed that solvent effects were weak for the nonactivated alkoxyamine 1 (diethyl (1-(tert-butyl(1-(py

7 fast, efficient, and selective oxidation of nonactivated alkyl C-H groups employing H(2)O(2) as term

8 dialkylation of complex 2 with activated and nonactivated alkyl halides, including propargyl derivati

9 een reported for cross-coupling reactions of nonactivated alkyl halides.

10 An efficient cyclocarboamination reaction of nonactivated alkynes with aziridines, catalyzed by Lewis

11 The reactivity of these newly synthesized nonactivated alpha-CF3-aziridines was evaluated by apply

12 Furthermore, nonactivated alpha-CF3-aziridines were easily transforme

13 gamma subunit at the catalytic site of both nonactivated and activated forms of PDE6.

14 To probe the quaternary structure of nonactivated and activated forms of the kinase, we used

15 aled differences in the labeling patterns of nonactivated and activated FXIII.

16 pha(M)beta(2) and alpha(X)beta(2), including nonactivated and activated U937 and THP-1 monocytoid cel

17 Nonactivated and deactivated aryl halides were successfu

18 he effect of supernatants isolated from both nonactivated and IFN-gamma-activated HFRPE cells were co

19 The supernatants of both nonactivated and IFN-gamma-activated HFRPE cells were is

20 ts also demonstrate that: 1) splenic and PLN nonactivated and naive T cells use different molecular m

21 both splenic and peripheral lymph node (PLN) nonactivated and naive T cells, and used both S1P and th

22 uce naive MBP-specific T cells responding to nonactivated APCs to differentiate into a unique, toleri

23 TGF-beta1 in response to activated, but not nonactivated, APCs presenting MBP.

24 ective for a wide range of arenes, including nonactivated arenes bearing simple functionalities such

25 ranslation of new methodologies for labeling nonactivated aromatic molecules with (18)F remains a cha

26 In contrast, nonactivated ATG5-knockout BMMs actually restricted C. n

27 bolites were investigated in supernatants of nonactivated (baseline) and lipopolysaccharide-activated

28 )/K(m), and by catalyzing the elimination of nonactivated benzisoxazoles), its impaired stability pre

29 volve the relocation of existing spines from nonactivated boutons or the outgrowth of newly formed sp

30 to result from the insertion of the terminal nonactivated C horizontal lineC double bond into the Au-

31 1r2s2 tetramer both when alone or within the nonactivated C1 complex.

32 rted over 30 years ago revealed that latent, nonactivated C5 binds specifically and reversibly to C6

33 orm oxidative halogenations of activated and nonactivated carbon centers.

34 se recent approaches to amide synthesis from nonactivated carboxylic acids and derivatives as well as

35 We found that median levels of nonactivated caspase 2 and 3 were higher in AML than in

36 CD4(+) T cells are refractory to infection, nonactivated CD4 T cells present in lymphoid and mucosal

37 Nonactivated CD4+CD25+ regulatory T cells constitutively

38 Small numbers of nonactivated CD4+CD45RO+CXCR5+ T cells are also found in

39 IEC-activated CD8+ T cells, but not nonactivated CD8+ T cells, were suppressive in function.

40 dependent areas of human lymphoid organs are nonactivated cells and belong to a separate lineage that

41 In nonactivated cells these preclustered structures and the

42 vity greater than that of Raf-1 derived from nonactivated cells, and aggregation of the FcepsilonRI d

43 of the LYN and FYN kinases were increased in nonactivated cells, suggesting the involvement of a LYN-

44 No DNA fragmentation was induced in nonactivated cells.

45 a similar conformational change in Syk from nonactivated cells.

46 found to be three times higher than that of nonactivated cells.

47 g the platelet thrombus, reducing effects on nonactivated circulating platelets.

48 onally, TNF-alpha expression is increased in nonactivated, circulating C/EBPepsilon-deficient neutrop

49 ation that requires the cleavage of multiple nonactivated CO bonds.

50 s in suppressing HOXC6 gene expression under nonactivated conditions.

51 owever, we have previously reported that the nonactivated conformation of alpha2beta1 integrin can al

52 Likewise, EMT could be distinguished from nonactivated control fibroblasts, suggesting that EMT do

53 ivated wild-type p21ras, compared with their nonactivated counterparts.

54 fic thermal [2 + 2]-cycloaddition across the nonactivated cumulene double bond, forming distal cycloa

55 M. tuberculosis grew equally well within nonactivated DCs and M phi.

56 DEC205 into mice, Ag presentation occurs by nonactivated DCs, which leads to induction of regulatory

57 was detected in both resting T cells and the nonactivated EL4 T cell line, and was up-regulated in bo

58 T lymphocytes react minimally with nonactivated endothelial cells (ECs).

59 LPG treatment of nonactivated endothelial cells also suppressed by 55 to

60 drogen atom at the terminal olefin moiety of nonactivated enynes, which was found previously in the b

61 60 nM) is reduced 3-4-fold compared with the nonactivated enzyme; the kinetics of cGMP exchange to ac

62 By analyzing the activated and nonactivated enzymes on SDS-polyacrylamide gel electroph

63 ic activity of approximately 57% that of the nonactivated ferrous form of the enzyme.

64 acrophages fostered Shigella replication and nonactivated fibroblast cells fostered both Shigella rep

65 anisotropic ECM architecture, compared with nonactivated fibroblasts.

66 Nonactivated films display a similar oxidic nature but e

67 In contrast, nickel centers in nonactivated films exist predominantly as Ni(III).

68 strate-directable Heck-Matsuda reaction with nonactivated five-membered olefins.

69 2 with its activator UAF1 deubiquitinate the nonactivated form of Notch in cell culture and in vitro.

70 es (Kd = 1-100 nM) composed of activated and nonactivated forms of p38alpha and a splice variant of M

71 eking tests after prolonged withdrawal, with nonactivated Fos-negative neurons.

72 Whereas nonactivated gammadelta T cells had little effect on the

73 ive (GFP+) neurons compared with surrounding nonactivated GFP-negative (GFP-) neurons 90 min after th

74 lterations within activated GFP-positive and nonactivated GFP-negative mPFC neurons following yohimbi

75 n about conformational changes proceeding in nonactivated HCN2 channels when cAMP binds.

76 Expression of the agonist antigen by nonactivated hematopoietic cells produced mostly CD4(+)C

77 Cross-linking of the nonactivated holoenzyme with N-(gamma-maleimidobutyroxy)

78 l lymphocytes or ZAP-70- CLL cells expressed nonactivated Hsp90.

79 cellularly but only rarely on the surface of nonactivated human eosinophils.

80 of the strength of adhesion of activated and nonactivated human neutrophils to a substratum, which is

81 The interaction of purified nonactivated human NK cells with target cells overnight

82 l amounts of CD62L from detergent lysates of nonactivated human PBL.

83 m of cell-mediated cytotoxicity, utilized by nonactivated human peripheral blood NK cells against a v

84 moniae organisms inhibited activated but not nonactivated human T cell proliferation.

85 In the present study, freshly isolated, nonactivated, human NK cells were shown to express TNF,

86 ng c-type heme-containing peptides that uses nonactivated IMAC resin.

87 Nonactivated IMCs and IDCs function as APCs, but activat

88 cells (IDCs) are potent T cell suppressors, nonactivated IMCs and IDCs promote T cell activation and

89 dy, we show that the interaction between the nonactivated integrin and a ligand resulted in the activ

90 tion of breast cancer cells that express the nonactivated integrin.

91 t has a high affinity for both activated and nonactivated integrin.

92 Altogether these results indicate that the nonactivated integrins can induce cellular signaling, bu

93 ulin in the adhesion complexes formed by the nonactivated integrins.

94 NO binds to sGC to form a six-coordinate, nonactivated, intermediate (k(on) > 1.4 x 10(8) M(-1).s(

95 JNK3 alpha 1 had Vmax 715-fold greater than nonactivated JNK3 alpha 1 and MKK7-activated JNK3 alpha

96 JNK3 alpha 1 had Vmax 250-fold greater than nonactivated JNK3 alpha 1.

97 In nonactivated keratocytes, the expression of alpha3(IV) c

98 lular communication with themselves and with nonactivated keratocytes.

99 alpha 1 had no increase in Vmax compared to nonactivated levels and had no phosphorylation on the ba

100 ut were undetectable in the supernatant from nonactivated lymphocytes.

101 Nonactivated lymphoid cells attach preferentially to pol

102 Adhesion of nonactivated lymphoid cells to polymeric ECM components

103 expression of the SPI2 spiC gene recorded in nonactivated macrophages depends on PhoQ.

104 In this study, we show that nonactivated macrophages express basal levels of mTNF-al

105 ype eradicated intracellular Shigella, while nonactivated macrophages fostered Shigella replication a

106 Lm escaped from vacuoles of nonactivated macrophages within 30 min of infection.

107 ast, the virulent strain caused an influx of nonactivated macrophages, neutrophils, and significant e

108 inked drugs without promoting drug uptake by nonactivated macrophages.

109 tivated neurons that was not observed in the nonactivated majority of neurons.

110 ither PoA or IoC is compared with binding to nonactivated MEK.

111 involves interfering with phosphorylation of nonactivated MEK1 by the upstream kinase, B-RAF.

112 Conversely, the K d from nonactivated MEK1 for four of the compounds varies betwe

113 Nonactivated, membrane-associated PDE (PDE-M, alpha beta

114 to suppress 80% of the basal activity of the nonactivated, membrane-bound PDE6 holoenzyme at concentr

115 ted to the site of inflammation maintained a nonactivated memory phenotype and did not express ex viv

116 iseased brains, as well as isolation of pure nonactivated microglia by FACS.

117 n/Fe- and Fe/Fe-bound states, as well as the nonactivated Mn/Mn-bound state.

118 levels of transferrin receptor expression in nonactivated monocytes and with an inability to up-regul

119 looxygenase PG synthase 2 (PGS(2)/ COX-2) in nonactivated monocytes of humans with insulin-dependent

120 onocytes after 10 min activation compared to nonactivated monocytes.

121 increases cell surface hyaluronan (HA), and nonactivated mononuclear leukocytes bind to virus-induce

122 In infections of nonactivated mouse macrophages, HN878 grew more quickly.

123 press angiogenic activity, whereas normoxic, nonactivated MPMs do not.

124 In contrast to normoxic, nonactivated MPMs, inducible nitric oxide synthase-inhib

125 -1 RNA was detected in both "activated" and "nonactivated" mucosal CD4+ T cells.

126 and glycolytic metabolism were evaluated in nonactivated murine peritoneal macrophages (MPhi0) and m

127 despite clear evidence for TCR signaling in nonactivated naive T cells, these data argue against the

128 umor-infiltrating lymphocytes in humans; (c) nonactivated natural killer (NK) cells in rats; and (d)

129 lpha6, and beta3 subunit genes compared with nonactivated neurons.

130 Activated and control nonactivated NGFXAT mice were subjected to different exp

131 r and the total cytotoxic activity of mature nonactivated NK cells within various tissues.

132 of the mechanisms that enable EBV to infect nonactivated, noncycling B cells provide compelling evid

133 distinguishing mitogen-activated (P(+)) from nonactivated (P(-)) AP-1 complexes.

134 eight tumors examined with wild-type ras and nonactivated p21ras demonstrated these alterations.

135 ctures and a novel assay to measure K(d) for nonactivated p38alpha.

136 ults indicate that in the female Wistar rat, nonactivated PAH showed a stereospecific preference for

137 Addition of MIP-3 beta to nonactivated PBMCs had no effect on cytokine production.

138 The properties of nonactivated PDE can be restored upon addition of gamma

139 t inhibitory gamma subunits bind to form the nonactivated PDE holoenzyme (alphabetagamma(2)).

140 concentrations and high cGMP concentrations, nonactivated PDE undergoes activation of cGMP hydrolysis

141 Furthermore, data suggest that nonactivated PDE5 with "super-high" affinities for silde

142 The effectiveness of E4021 to inhibit nonactivated PDE6 (with bound inhibitory gamma subunits)

143 ages to levels sustained by a phoQ mutant in nonactivated phagocytes, suggesting that most NO-depende

144 markers of activated neutrophils revert to a nonactivated phenotype as activated cells make contact w

145 bovine WC1(+) gammadelta T cells expressed a nonactivated phenotype relative to CD62L, CD45RO, and CD

146 early Ag(+)/adjuvant(-) DC population with a nonactivated phenotype, resulting from the earlier targe

147 immunodeficiency viruses (SHIVs) exhibited a nonactivated phenotype.

148 position of naphthalene and to activated and nonactivated phenyl substrates was compared for the firs

149 Here we report on the role of nonactivated phenylalanine 4-monooxygenase activity in r

150 taining TFPI, prothrombin, calcium ions, and nonactivated platelets or factor V and phospholipids, TF

151 ergoing apoptosis may become proadhesive for nonactivated platelets.

152 xynucleotide to both TNF-alpha-activated and nonactivated PMNs.

153 rs in both activated (CD25+ and HLA-DR+) and nonactivated populations, although it is restricted to C

154 Although nonactivated primary T cells cultured with 10 to 1000 nM

155 ICOShigh Treg induced Tr1 cells in nonactivated RC and Th2 cells in preactivated RC.

156 ands can down-regulate signaling by moving a nonactivated receptor into the endocytic pathway.

157 most dramatic effect on the affinity of the nonactivated recombinant PDE5 for sildenafil, revealing

158 detailed structural analysis of R2lox in the nonactivated, reduced, and oxidized resting Mn/Fe- and F

159 receptor, continues to phosphorylate nearby nonactivated rhodopsin.

160 Further, 7 matched activated/nonactivated samples were sequenced using the Trugene HI

161 surface, platelets retained their spherical nonactivated shape.

162 Specific covalent cross-linking of nonactivated signal transducer and activator of transcri

163 Here we show that nonactivated Smad3, but not Smad2, undergoes proteasome-

164 The treatment involved delivery of 10% w/w nonactivated sodium persulfate (Na2S2O8) solution to the

165 n T cell activation, we used a population of nonactivated spleen cells from mice that expressed a tra

166 Mn(2+)-activated alpha(4)beta(1) and to the nonactivated state of the integrin that exists in 1 mm M

167 h cGMP-independent modulation of PDE5 in the nonactivated state, possibly through protein-protein int

168 y low number of transferrin receptors in the nonactivated state, similar to the typically low level e

169 ifically to keep expression levels below the nonactivated state.

170 PDE5 could be converted from a low-activity (nonactivated) state to a high-activity state upon cGMP b

171 The activated, but not the nonactivated, state supported tumor cell arrest during b

172 and distinctive features of activated versus nonactivated states, the water distribution along the ch

173 nometallic species involved are derived from nonactivated substrates (pyridine and terminal alkynes),

174 ons as high as 10(5), for both activated and nonactivated substrates.

175 pyrimidine nucleoside from a free base and a nonactivated sugar in a plausible prebiotic reaction.

176 f alloantigen, iNOS induction is confined to nonactivated T cells and does not depend on MHC molecule

177 constitutive expression of CCR5 and CXCR4 by nonactivated T cells and macrophages, but significantly

178 Analysis of why nonactivated T cells are more resistant, whereas activat

179 Fifty percent of nonactivated T cells in MCC-expressed PD-1, a marker of

180 led that TCDD treatment of activated but not nonactivated T cells led to down-regulation of cellular

181 ion of c-FLIP using small interfering RNA in nonactivated T cells made them sensitive to TCDD-induced

182 nse of Hsp70 treatment when activated versus nonactivated T cells were used.

183 (IELs) bear properties of both activated and nonactivated T cells, although the significance of that

184 In nonactivated T cells, CD4 molecules are clustered in sma

185 in vitro antileukemic effects in contrast to nonactivated T cells.

186 + and CD8+ T cells and in both activated and nonactivated T cells.

187 very by rescuing mutant virus replication in nonactivated T cells.

188 er levels of apoptosis compared with similar nonactivated T cells.

189 late the following biodistribution data: (a) nonactivated T lymphocytes in rats; (b) interleukin 2-ac

190 hesis, the number of reactions that apply to nonactivated terminal alkenes in a catalytic enantiosele

191 Limiting quantities of nonactivated terminal olefins (1 equiv) and slight exces

192 tern blot analysis, we studied the levels of nonactivated (uncleaved) caspase 2 and 3 in peripheral b

193 aved probe in the presence of high levels of nonactivated, uncleaved probe, a difficult task to attai

194 yl small molecule antagonist, compound A, to nonactivated very late antigen-4 (VLA4) was examined in

195 vide evidence that a substantial fraction of nonactivated visual pigments becomes phosphorylated thro

196 atelets with different receptor antagonists, nonactivated, washed human platelets were allowed to adh

197 Under normal cell cycle conditions, nonactivated XCds1 constitutively associates with a Xeno