ライフサイエンスコーパス: nonapoptotic

1 and cytochrome c loss--whereas others appear nonapoptotic.

2 d with confocal microscopy and determined in nonapoptotic and apoptotic cardiocytes by indirect immun

3 ults in loss of viability, but is apparently nonapoptotic and further differs from cellular death def

4 GP-induced cell death is nonapoptotic and is preceded by downmodulation of cell s

5 staglandin J(2) (15d-PGJ2), induced a novel, nonapoptotic and microtubule-associated protein 1 light

6 This nonapoptotic anti-inflammatory regulation of IL-12 and I

7 equent nuclear fusion by a mechanism that is nonapoptotic, as assessed by multiple criteria.

8 ate that T-oligos stimulate the induction of nonapoptotic autophagic also known as type II programmed

9 Curcumin induced G(2)/M arrest and nonapoptotic autophagic cell death in both cell types.

10 he pathways by which ceramide acts to induce nonapoptotic autophagic cell death in malignant gliomas.

11 as either apoptotic, partially apoptotic, or nonapoptotic based on infected HEp-2 cell morphologies,

12 function that is mediated by IgM binding to nonapoptotic BMDC receptors.

13 opulation that is relatively nondividing and nonapoptotic but chemotherapy resistant and chemotactic.

14 is a critical event in caspase-independent, nonapoptotic (but not caspase-dependent, apoptotic) deat

15 Interestingly, physiological nonapoptotic calcium fluxes were capable of activating m

16 highest in the body cells and lowest in the nonapoptotic cap cells, implying that their expression i

17 Compared with nonapoptotic cardiocytes or apoptotic cardiocytes incuba

18 In permeabilized nonapoptotic cardiocytes, Ro and La were predominantly n

19 y immunoprecipitated from apoptotic, but not nonapoptotic cardiocytes.

20 O(2)(.-) levels in nonapoptotic caspase 3-null SCG neurons were lower than

21 ns caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells.

22 ochondrial-associated molecular link between nonapoptotic caspase function and autophagy regulation i

23 this set, which acts via a nonmembranolytic, nonapoptotic caspase-independent mechanism, is more effe

24 crophage differentiation is mediated through nonapoptotic, caspase-3-dependent mechanisms.

25 D4(+) T cells, two minor pathways leading to nonapoptotic, caspase-independent AICD were identified,

26 Nonapoptotic, caspase-independent cell death pathways ha

27 ted a striking increase in the percentage of nonapoptotic CD11b+ VLA-4-negative macrophages/monocytes

28 by infiltration of the tumor with activated, nonapoptotic CD8+ effector T lymphocytes on day 7 postth

29 alternative response closely correlated with nonapoptotic cell death and characterized by proteolysis

30 malignant glioma cells through induction of nonapoptotic cell death and mitochondria hyperpolarizati

31 le for the RB tumor suppressor in preventing nonapoptotic cell death by limiting the extent of BNIP3

32 s is pharmacologically blocked, SAHA-induced nonapoptotic cell death can also be potentiated by autop

33 Methuosis is a form of nonapoptotic cell death characterized by an accumulation

34 grammed necrosis or necroptosis is a form of nonapoptotic cell death driven by the receptor interacti

35 proteolysis is also linked to apoptotic and nonapoptotic cell death following excessive glutamate ex

36 Ferroptosis is a form of nonapoptotic cell death for which key regulators remain

37 of this class, lanperisone, acts by inducing nonapoptotic cell death in a cell cycle- and translation

38 previously been shown that hyperoxia induces nonapoptotic cell death in cultured lung epithelial cell

39 , we first demonstrate that ceramide induces nonapoptotic cell death in malignant glioma cells.

40 e provide molecular inroads to understanding nonapoptotic cell death in metazoan development and dise

41 he Rb tumor suppressor in protecting against nonapoptotic cell death in the developing mouse fetal li

42 ollowing vaccination and suggests a role for nonapoptotic cell death in the regulation of CD4 T cell

43 To identify additional factors that regulate nonapoptotic cell death in yeast, a collection of gene k

44 and azole-class antifungal drugs can induce nonapoptotic cell death in yeasts that can be blocked by

45 We observed that cells dying a nonapoptotic cell death induced by adenovirus infection

46 r, about the molecular mechanisms underlying nonapoptotic cell death induced by ceramide.

47 in that was not found following apoptotic or nonapoptotic cell death induced by stimuli other than me

48 anism of tumor necrosis factor (TNF)-induced nonapoptotic cell death is largely unknown, although the

49 ia, suggesting a hypoxia-induced increase in nonapoptotic cell death of PKCdelta-ECs.

50 his issue, Overholtzer et al. describe a new nonapoptotic cell death pathway termed "entosis" in mamm

51 otein kinase (RIP) 3-mediated necroptosis, a nonapoptotic cell death pathway, is implicated in a vari

52 However, nonapoptotic cell death predominated during prolonged hy

53 Here we describe a nonapoptotic cell death program in matrix-detached cells

54 aspases) mediate apoptosis, the mediators of nonapoptotic cell death programs are much less well char

55 p53(15)Ant peptide induced rapid, nonapoptotic cell death resembling necrosis in all breas

56 ss responses, such as autophagy, and control nonapoptotic cell death routines, such as regulated necr

57 Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse dise

58 tin triggers a unique iron-dependent form of nonapoptotic cell death that we term ferroptosis.

59 gents that induce ferroptosis (iron-mediated nonapoptotic cell death).

60 On the other hand, nonapoptotic cell death, autophagy, has recently attract

61 anism to mitigate SAHA-induced apoptotic and nonapoptotic cell death, suggesting that targeting autop

62 cellular proliferation and high doses caused nonapoptotic cell death, which was not mediated through

63 etaII spectrin, coinciding with the onset of nonapoptotic cell death.

64 y, which is necessary for both apoptotic and nonapoptotic cell death.

65 in the induction of death receptor-mediated, nonapoptotic cell death.

66 ive JCV infection, which eventually leads to nonapoptotic cell death.

67 yl(OMe)-fluoromethylketone (BAF), a delayed, nonapoptotic cell death.

68 dhesion to ePTFE and Dacron triggers a rapid nonapoptotic cell death.

69 nce EC survival during hypoxia by decreasing nonapoptotic cell death.

70 treatment, followed by caspase-independent, nonapoptotic cell death.

71 ferroptosis, a form of regulated, oxidative, nonapoptotic cell death.

72 PARP1 activity and DNA repair and promoting nonapoptotic cell death.

73 Fas-dependent apoptotic and Fas-independent, nonapoptotic cell death.

74 Moreover, when caspase-3 was added to nonapoptotic cell extract, efficient internal cleavage o

75 optosis, but it is also constitutive on some nonapoptotic cell populations where it plays a role in c

76 This is followed by predominantly nonapoptotic cell-in-cell death of the internalized cell

77 d doxorubicin treatment but not in necrotic (nonapoptotic) cell death.

78 oliferative effects followed by significant, nonapoptotic, cell death within 72 hours occurred in 24

79 Bax is predominantly found in the cytosol of nonapoptotic cells and is commonly thought to translocat

80 ative analysis revealed aggresomes in 60% of nonapoptotic cells but only in 10% of apoptotic cells.

81 by approximately 75%, reduced the density of nonapoptotic cells by approximately 70% in residual tumo

82 were determined separately for apoptotic and nonapoptotic cells by flow cytometry.

83 cells were Fas-high-density cells while the nonapoptotic cells expressed a low density of Fas.

84 and CXCL10, which may normally recruit these nonapoptotic cells from the lymph nodes.

85 s had low Bcl-2 and high Bax levels, whereas nonapoptotic cells had high Bcl-2 and low Bax levels.

86 nstitutively targeted to mitochondria but in nonapoptotic cells is constantly translocated back to th

87 Treatment of surviving nonapoptotic cells with antisense oligonucleotides again

88 bility to discriminate between apoptotic and nonapoptotic cells, an ability restored by exogenous ANX

89 dditional 9-fold reduction of the density of nonapoptotic cells, and an additional 30% increase in th

90 a is found predominantly in the cytoplasm of nonapoptotic cells, and the apoptotic signal that activa

91 When added to nuclei from nonapoptotic cells, cyclophilin C induces 50-kilobase pa

92 ereas apoptotic IL-10(-/-) cells, as well as nonapoptotic cells, favor Th1 induction.

93 lation has been reported to occur at G2-M in nonapoptotic cells, raising the possibility that this an

94 ls of NUC70 expression between apoptotic and nonapoptotic cells, suggesting that activation of NUC70

95 cells induced by photodynamic treatment and nonapoptotic cells, we successfully detected caspase-9 a

96 s of apoptotic cells but not with lysates of nonapoptotic cells.

97 mitochondrial and cytosolic distribution in nonapoptotic cells.

98 lved in Bax-dependent O(2)(.-) production in nonapoptotic cells.

99 ocation and confer new functions to cyt c in nonapoptotic cells.

100 pase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can pro

101 fined two distinct groups: those that induce nonapoptotic (Class I) and apoptotic (Class II) parasite

102 tive thymocytes, suggesting the existence of nonapoptotic clonal deletion mechanisms.

103 d these effects in BAECs at much lower (i.e. nonapoptotic) concentrations of C(2)-cer.

104 ivity is restrained and shut down under such nonapoptotic conditions remains unknown.

105 ity of caspase-8 to promote metastasis under nonapoptotic conditions.

106 al targets for autologous NK cells through a nonapoptotic cytotoxic mechanism.

107 y responses of cells dying an apoptotic or a nonapoptotic death as a result of adenoviral infection.

108 also protected cells from ceramide-induced, nonapoptotic death consistent with the idea that severe

109 oinflammatory stimuli, whereas cells dying a nonapoptotic death from infection with E1B 19K-competent

110 cial step for luteolin-induced apoptotic and nonapoptotic death in lung cancer cells.

111 flammatory reactions, but cells that undergo nonapoptotic death in response to such stimuli lack this

112 Nonapoptotic death induced by H2O2 was not prevented by

113 ion of TORC1, which in turn promoted LMP and nonapoptotic death of stressed cells.

114 under pathological conditions, apoptosis and nonapoptotic death paradigms are often interwined, which

115 A related Fas- and caspase-independent, nonapoptotic death process is revealed in wild-type (WT)

116 data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8(+) and CD8(+) T bl

117 totic, involving activation of caspases, but nonapoptotic death responses also have been described.

118 ggering NF-kappaB activation, apoptosis, and nonapoptotic death signals through separate and competin

119 t protein (Q97) undergo a protracted form of nonapoptotic death that is insensitive to Bax deletion o

120 tic death requires caspases; and (4) delayed nonapoptotic death that occurs in the presence of caspas

121 biquitinated proteins; (2) enhanced baseline nonapoptotic death; (3) marked accumulation of autophagi

122 Viruses d2-3, d3-4, d4-5, d5-6, and d6-7 are nonapoptotic, demonstrating that ICP27 contains a large

123 us, activation of ferroptosis results in the nonapoptotic destruction of certain cancer cells, wherea

124 Here, we demonstrate that the large-scale nonapoptotic developmental PCD in the Drosophila ovary o

125 can readily be distinguished from cells with nonapoptotic DNA damage.

126 PH oxidase-dependent mechanism of cytolytic, nonapoptotic eosinophil death initiates nuclear chromato

127 y, active NF-kappaB localized exclusively to nonapoptotic epithelial cells both in vivo and in the ma

128 onversion of naive T cells was mediated by a nonapoptotic Fas signal, resulting in Akt-driven cellula

129 and may therefore be more likely to initiate nonapoptotic Fas signaling due to less RIP1 in the recep

130 In the absence of Fas, the nonapoptotic, Fas-independent pathway could still induce

131 Dying linker cells display nonapoptotic features, including nuclear crenellation, a

132 Entosis is a nonapoptotic form of cell death initiated by actomyosin-

133 Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-in

134 Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in an

135 s are known killers, being responsible for a nonapoptotic form of cell death with features similar to

136 may limit the inflammatory response to this nonapoptotic form of cell death.

137 osis in infected cells but rather leads to a nonapoptotic form of cell death.

138 vive therapy or a mechanism for initiating a nonapoptotic form of programmed cell death remains contr

139 ls has led to the belief that autophagy is a nonapoptotic form of programmed cell death.

140 ts the signaling of the IFN-gamma-activated, nonapoptotic form of TNF receptor superfamily member 6 (

141 During the past three decades, various nonapoptotic forms of cell death have gained increasing

142 Nonapoptotic forms of cell death may facilitate the sele

143 This study investigated the nonapoptotic function and phenotypic expression of activ

144 This finding sheds new light on the CD95 nonapoptotic function and provides a novel mechanism for

145 Casp8 comprises a nonapoptotic function during liver regeneration by balan

146 utes to cell migration and adhesion, a novel nonapoptotic function of an established apoptotic factor

147 This represents a novel nonapoptotic function of caspase-8 acting at the interse

148 The nonapoptotic function of CD95 in gammaherpesvirus-associ

149 ing that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progr

150 of compensatory proliferation in an apparent nonapoptotic function.

151 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the c

152 The nonapoptotic functions of Fas ligation are incompletely

153 nd absence of Bim to separate apoptotic from nonapoptotic functions of Nur77.

154 from NHEJ deficiency is highly restricted by nonapoptotic functions of p53, such as the G1/S checkpoi

155 d p53-dependent apoptosis but did not impair nonapoptotic functions of p53.

156 it is mainly caspase-8 in its apoptotic and nonapoptotic functions that has been an intense research

157 however, that the protein has numerous other nonapoptotic functions.

158 e of the caspase-8-p85 interaction for these nonapoptotic functions.

159 s, and it inhibits Treg suppression via this nonapoptotic GzmB-mediated mechanism.

160 the mammalian Bcl-2 gene in cis restored the nonapoptotic, immunorepressive cell death activity of vi

161 morphology of cell death changes and becomes nonapoptotic in some cells.

162 sis of both apoptotic (high PS exposure) and nonapoptotic (intermediate PS exposure) activated T cell

163 platelet binding (<5%), which was similar to nonapoptotic iRBCs.

164 Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated necrosis

165 flammatory disorders, histiocytes can engulf nonapoptotic leukocytes and nonsenescent erythrocytes an

166 no nuclear NF-kappaB activity, and LY-ar, a nonapoptotic line with constitutive p50 homodimer activi

167 antitation indicated that there was an early nonapoptotic loss of cortical neurons followed by a prog

168 e to M. avium-infected apoptotic, but not to nonapoptotic M. avium-infected Mphi, suggesting a specif

169 ylated annexin A5 localized in apoptotic and nonapoptotic macrophages.

170 phagy will ultimately induce cell death in a nonapoptotic manner.

171 osis, but the neurons still die in a delayed nonapoptotic manner.

172 growth factors did eventually die through a nonapoptotic mechanism associated with loss of DeltaPsi.

173 ses ras-driven skin carcinogenesis through a nonapoptotic mechanism involving ARF and p53.

174 e beta-cell cytotoxicity primarily through a nonapoptotic mechanism linked to a decline in ATP levels

175 of rat beta-cells occurs predominantly by a nonapoptotic mechanism, including the following: 1) A ra

176 at reducing endothelial cell viability via a nonapoptotic mechanism.

177 G(2)-M phase arrest and ultimately died by a nonapoptotic mechanism.

178 , Disruptin inhibits cancer cell growth by a nonapoptotic mechanism.

179 ls vulnerable to weaver die by apoptotic and nonapoptotic mechanisms and indicate that weaver-induced

180 human carcinoma cells by both apoptotic and nonapoptotic mechanisms and potentiates the effects of c

181 inje cells, highlighting a possible role for nonapoptotic mechanisms in the death of these neurons.

182 is and tumor cells engineered to die through nonapoptotic mechanisms, resulting in secretion of eithe

183 e able to kill tumor cells via apoptotic and nonapoptotic mechanisms.

184 cell body, DIP expression induced excessive nonapoptotic membrane blebbing, a physiological process

185 tructures resemble, and may be identical to, nonapoptotic membrane blebs, a feature of the amoeboid f

186 ervention, and lend support to the idea that nonapoptotic modes of cell death may play a crucial role

187 els, the caspase-deficient neurons exhibit a nonapoptotic morphology in which nuclear changes such as

188 a specific interaction between apoptotic and nonapoptotic Mphi.

189 e percentage of apoptotic myocyte nuclei and nonapoptotic myocardial nuclei.

190 The nonapoptotic nature of this cell death is confirmed by n

191 ed polarized intestinal Caco-2 cells undergo nonapoptotic necrotic cell death triggered by inositol 1

192 ich instead induced dramatic accumulation of nonapoptotic necrotic cells.

193 these domains elicits axon degeneration and nonapoptotic neuronal death even in the absence of injur

194 ss exon 1 of mutant huntingtin, showed dark, nonapoptotic neurons and degenerated mitochondria associ

195 at Bax also lies upstream of ROS produced in nonapoptotic neurons and present evidence that caspases

196 Apoptotic and nonapoptotic neurons from Bax-WT/SOD2-null but not Bax-n

197 partially involved in O(2)(.-) production in nonapoptotic neurons, and that other caspases may also b

198 However, forms of nonapoptotic neutrophil death have also been observed.

199 The results establish that in nonapoptotic neutrophils, G6Pase-beta is essential for n

200 Drosophila ovary is an intriguing example of nonapoptotic, nonautonomous PCD, providing insight on th

201 s in PrP functional activity induce a novel, nonapoptotic, nonautophagic form of neuronal death whose

202 expressing cells had a higher frequency of a nonapoptotic, nonnecrotic type of cell death termed para

203 e also suggests that ASPP2 harbors important nonapoptotic p53-independent functions.

204 asmic reticulum vacuolization that precede a nonapoptotic (paraptotic) cell death.

205 More recently, necroptosis, a parallel, nonapoptotic pathway of cell death, has been described,

206 ay be delayed, and the cells appear to use a nonapoptotic pathway of degeneration.

207 neurons degenerate by a caspase-independent, nonapoptotic pathway that involves autophagy.

208 increase in neural degeneration mediated by nonapoptotic pathways.

209 sociated with apoptosis and also occurred in nonapoptotic patient cells treated with PSC-833.

210 e for NADPH oxidase-derived ROS in mediating nonapoptotic PCD evoked by mAbs in B-cell malignancies.

211 ered Fc regions are type II mAb that trigger nonapoptotic PCD in a range of B-lymphoma cell lines and

212 Here we report that alternative, nonapoptotic pcd induced by the neurokinin-1 receptor (N

213 MEK2, and ERK2 is essential for this form of nonapoptotic pcd, leading to the phosphorylation of the

214 h (pcd) may take the form of apoptosis or of nonapoptotic pcd.

215 ed via arrestin 2, modulates NK(1)R-mediated nonapoptotic pcd.

216 at the rear of the invading cell as well as nonapoptotic plasma membrane (PM) blebbing in this cellu

217 bly overexpressed by fusion to an unrelated, nonapoptotic polypeptide, the N-terminal 37 amino acids

218 tant mice, the accumulation of a sub-G1, but nonapoptotic, population was observed that we believe ma

219 with DNA damage resulting from a variety of nonapoptotic processes (necrosis, in vitro autolysis, pe

220 anding of the roles of IAPs in apoptotic and nonapoptotic processes and explore the notion that the l

221 ction in apoptosis, but are also crucial for nonapoptotic processes such as NMDA receptor-dependent l

222 with resveratrol's ability to kill cells via nonapoptotic processes, cells transfected to express hig

223 e caspase and paracaspase families to enable nonapoptotic processes.

224 osis, caspases are also important in several nonapoptotic processes.

225 that has led to their implication in several nonapoptotic processes.

226 nto the complex relationship between ROS and nonapoptotic programmed cell death.

227 cal inflammation, contributing to subsequent nonapoptotic renal injury.

228 retinoid, and retinoic acid as well as other nonapoptotic retinoids did not inhibit IKK.

229 opathicity and replication of human CMV by a nonapoptotic, reversible process that requires nuclear f

230 Thus, this study supports a nonapoptotic role for active caspase-3 in cells residing

231 that extracellular GzmB plays an unexpected, nonapoptotic role in regulating Treg suppression and sug

232 apoptosis, recently has been implicated in a nonapoptotic role in the regulation of the cell cycle, c

233 cent developments have focused on uncovering nonapoptotic roles of caspases ranging from immune regul

234 at DIAP2 controls drICE in its apoptotic and nonapoptotic roles.

235 tor inhibited O(2)(.-) in both apoptotic and nonapoptotic SCG neurons.

236 Here, we review the nonapoptotic side of Bcl-2 family, specifically the role

237 ptor complex and also mediate RIP1-dependent nonapoptotic signaling events, thus reducing caspase act

238 Surprisingly, CD95-mediated nonapoptotic signaling induced beta interferon (IFN-beta

239 o emerging as a tumor promoter by activating nonapoptotic signaling pathways.

240 the dual roles of Fas in both apoptotic and nonapoptotic signaling, the aim of the present study was

241 apoptosis but is also capable of triggering nonapoptotic signals.

242 gers apoptosis by driving DU145 cells from a nonapoptotic status (c-FLIP(short)(high), CD95(low), CD9

243 on, KSHV is reactivated predominantly in the nonapoptotic subpopulation of PEL cells.

244 Our results identify a role for caspase 3 in nonapoptotic T cells and support that caspase 3-dependen

245 target genes such as BAX and PUMA while the nonapoptotic targets p21 and hMDM2 remain unaffected.

246 mRNA expression was significantly greater in nonapoptotic than in apoptotic T lymphocytes.

247 nges were associated with markedly increased nonapoptotic thyroid cell death, suggesting direct toxic

248 , by interacting directly with CD28 on live (nonapoptotic) tumor plasma cells, bone marrow mDCs downr

249 se activity these neurons undergo a distinct nonapoptotic type of degeneration.

250 (+) cells were classified morphologically as nonapoptotic (Type I) or apoptotic (Type II) to verify t

251 Of the nonapoptotic viruses, d4-5 did not produce gC, indicatin

252 of culture with anti-mu, the remaining live, nonapoptotic xid cells were enlarged, viable, and primed