ライフサイエンスコーパス: nonautoimmune

1 Anti-Sm B cells in nonautoimmune 2-12H-transgenic (Tg) mice are functional,

2 In the nonautoimmune 3H9H/56R BALB/c, most B cells generated do

3 lenic and peritoneal anti-Sm B cells of both nonautoimmune and autoimmune genetic backgrounds indicat

4 sm with lower doses of donor BM cells in old nonautoimmune and autoimmune lupus mice.

5 compare the regulation of anti-Sm B cells in nonautoimmune and autoimmune MRL/Mp-lpr/lpr (MRL/lpr) an

6 crimal tissue, or aqueous tear deficiency in nonautoimmune animals and humans.

7 mice can stimulate autoantibody synthesis in nonautoimmune anti-snRNP Tg mice.

8 backcross mice, inheritance of H2b from the nonautoimmune B10 strain was strongly linked with both a

9 , and NZB/W F(1) mouse strains compared with nonautoimmune B10.BR mice.

10 eleted as efficiently as in Dbl-Tg mice of a nonautoimmune B10.D2 genetic background.

11 n vivo, transgenic mice were outcrossed onto nonautoimmune B6 and SLE-prone MRL backgrounds and expos

12 c modifier of the CD45 E613R mutation on the nonautoimmune B6 background to understand how complex su

13 gent anti-CD45RB induces HSC mobilization in nonautoimmune B6 mice but not in diabetes-prone NOD mice

14 nd anti-single-stranded (ss)DNA B cells in a nonautoimmune background by generating mice carrying imm

15 chain knockin (3H9.KI) transgenic mice on a nonautoimmune background resulted in specific activation

16 Taken together, on the nonautoimmune background, Sle3/5 affected V(H)DJ(H) junc

17 omoter induces nondestructive insulitis on a nonautoimmune background.

18 milar to other CfH-deficient mouse models on nonautoimmune backgrounds, immunofluorescence staining s

19 Fas (Fas(lpr)), on both autoimmune (MRL) and nonautoimmune backgrounds.

20 Immunization of nonautoimmune BALB/c mice with multimeric DWEYSVWLSN, a

21 Anti-dsDNA B cells are actively tolerized in nonautoimmune BALB/c mice, as manifested by their develo

22 een used to track anti-dsDNA B cells in both nonautoimmune BALB/c mice, in which autoreactive B cells

23 mic lupus erythematosus-like syndrome in the nonautoimmune BALB/c mouse strain.

24 99D.7E, an IgG2b monoclonal antibody from a nonautoimmune BALB/c mouse that is cross-reactive with b

25 from the lupus-prone MRL-lpr/lpr mouse and a nonautoimmune BALB/c mouse with the pathogenic anti-DNA

26 In this backcross, contributions from the nonautoimmune BALB/c strain were also apparent.

27 mmune (MRL+/+ and lpr/lpr) mice with that in nonautoimmune (BALB/c) mice.

28 at are not seen in similar preparations from nonautoimmune C3H animals.

29 pr/lpr mice compared with MRL-fas/fas and/or nonautoimmune C3H/Hej and BALB/c mice.

30 In heterozygous mice, on a nonautoimmune C57BL/6 background, the transgene allotype

31 pared with the Th2-type response observed in nonautoimmune C57BL/6 mice.

32 ted to the heavy and light chain loci of the nonautoimmune C57BL/6 mouse strain.

33 requency in the periphery of NOD mice versus nonautoimmune C57BL/6 VH125Tg mice; however, the ontogen

34 iagnosis and a deliberate attempt to exclude nonautoimmune causes of thrombocytopenia and secondary I

35 mice in comparison with age- and sex-matched nonautoimmune CD1 mice.

36 re significantly greater than those found in nonautoimmune CD40L-deficient animals.

37 venting islet allograft destruction in other nonautoimmune combinations often fail in NOD recipients.

38 Ag (BCMA) is a receptor for BAFF that, under nonautoimmune conditions, is important for sustaining en

39 cells have been found in organs affected by nonautoimmune conditions.

40 res of bone marrow derived from B6.NZMc1 and nonautoimmune congenic B6 mice carrying allelic T and B

41 lupus-prone MRL mice are more resistant than nonautoimmune control cells to anergy induction.

42 allele frequencies were compared to those in nonautoimmune controls.

43 treatment are no more lymphopenic than their nonautoimmune counterparts, but they show reduced thymop

44 turity-onset diabetes of the young (MODY) or nonautoimmune diabetes in mid-adult life, and to explore

45 e that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominant

46 Mutations in several genes cause nonautoimmune diabetes, but numerous patients still have

47 ly and genetically heterogeneous subgroup of nonautoimmune diabetes, constituting 1-2% of all diabete

48 three strains of mice that develop type II (nonautoimmune) diabetes.

49 yngeneic mouse islets were transplanted into nonautoimmune diabetic hosts and islet function was anal

50 nduction of mixed chimerism with MHC-matched nonautoimmune donor BM transplants did not prevent T1D i

51 ematopoietic cell transplantation (HCT) from nonautoimmune donors could prevent or reverse type 1 dia

52 nocytes or by transplantation of islets from nonautoimmune donors.

53 ands with unexplained MODY, 95 patients with nonautoimmune early-onset diabetes (diagnosed at <35 yea

54 ansplant (+5% [95% CI, 9%-2%]) per year, and nonautoimmune etiology of liver disease (OR, 1.0 for aut

55 odified 2-way avoidance task and compared to nonautoimmune female NZW mice.

56 -fold greater levels of serum IL-21 than the nonautoimmune group.

57 ed the extent of autoreactivity arising in a nonautoimmune host during the response to a foreign anti

58 rmline mutations have been found in familial nonautoimmune hyperthyroidism and sporadic congenital hy

59 g an intercross between MRL/lpr mice and the nonautoimmune inbred strain BALB/cJ.

60 e-stranded (ds)DNA antibodies (Abs), whereas nonautoimmune individuals have negligible levels of thes

61 unomodulatory effects, the high frequency of nonautoimmune inflammation suggests other mechanisms.

62 r results from both insulin resistance and a nonautoimmune insulin secretory defect.

63 ice deficient for both E2F1 and E2F2 develop nonautoimmune, insulin-dependent diabetes with high pene

64 ulthood, especially in males associated with nonautoimmune insulinopenia and reversed alphabeta cell

65 ith alpha 1-antitrypsin (AAT) in a syngeneic nonautoimmune islet graft model.

66 sulin-dependent diabetes mellitus, caused by nonautoimmune loss of beta cells, and neurological dysfu

67 Sm pre-PCs also occur at a high frequency in nonautoimmune mice and show additional phenotypic charac

68 Because nonautoimmune mice are not affected by raltegravir, we c

69 ke anti-dsDNA reactivity can be generated in nonautoimmune mice by immunization with a peptide antige

70 c graft-vs-host (cGVH) disease is induced in nonautoimmune mice by the transfer of alloreactive T cel

71 It is induced in nonautoimmune mice by the transfer of alloreactive T cel

72 Pristane induces a lupus-like syndrome in nonautoimmune mice characterized by the development of g

73 2 mouse were injected intraperitoneally into nonautoimmune mice for evaluation of pathogenicity of ea

74 bitory T cells may play a role in protecting nonautoimmune mice from developing chronic autoimmunity.

75 emonstrated that anti-snRNP B cell anergy in nonautoimmune mice may be reversed by appropriate T cell

76 Thus, inhibitory T cells in nonautoimmune mice may normally inhibit T-dependent acti

77 Even without immunization, nonautoimmune mice possess T cells that can inhibit auto

78 wk-old female BALB/c mice (and several other nonautoimmune mice strains) with alpha-actinin in adjuva

79 Intraperitoneal exposure of nonautoimmune mice to 2,6,10,14-tetramethylpentadecane (

80 lerance and induce a lupus-like phenotype in nonautoimmune mice transgenic for the heavy chain of a p

81 e representative mAbs to induce nephritis in nonautoimmune mice using established adoptive transfer p

82 , the abortive response can be reproduced in nonautoimmune mice when CD4+CD25+ T regulatory cells are

83 diffuse proliferative glomerulonephritis in nonautoimmune mice whereas another anti-ssDNA with appar

84 Immunization of nonautoimmune mice with DNA-containing amyloid fibrils i

85 ogenic anti-DNA Ab, and that immunization of nonautoimmune mice with this peptide induces autoantibod

86 As conventional transgenics in nonautoimmune mice, anti-DNA B cells have been shown to

87 In nonautoimmune mice, B cells bearing immunoglobulin site-

88 In this study, we show that in nonautoimmune mice, dsDNA-specific autoreactive B cells

89 The breakdown of B cell tolerance in nonautoimmune mice, however, was short-lived: anti-DNA A

90 However, in contrast to nonautoimmune mice, there are few if any peritoneal anti

91 e mechanisms involved in their regulation in nonautoimmune mice, we have used Ig transgenes (tgs).

92 To investigate B cell tolerance to GPI in nonautoimmune mice, we increased the GPI-reactive B cell

93 that sera from autoimmune mice, but not from nonautoimmune mice, were able to induce the proliferatio

94 poptotic thymocytes in MRL/MpJ compared with nonautoimmune mice.

95 A B cells have been shown to be tolerized in nonautoimmune mice.

96 analyzed single B cells from these and from nonautoimmune mice.

97 nal anti-Sm B cells in the spleen similar to nonautoimmune mice.

98 e rearranged V(H) domain of an IgM Ab from a nonautoimmune mouse immunized with a DNA-protein complex

99 x NZW F1 (B/W) hybrid mice was compared with nonautoimmune NZW control mice on 3 anxiety tasks: the e

100 bone marrow from lupus patients but not from nonautoimmune patients undergoing myeloablation, where t

101 Vaccination of nonautoimmune prone mice with syngeneic dendritic cells

102 However, in contrast to the nonautoimmune-prone background, B cells recognizing solu

103 On the nonautoimmune-prone C57BL/6 genetic background, TSAd def

104 induce pathological autoimmunity we exposed nonautoimmune-prone galactose-alpha1-3-galactose-deficie

105 ese autoantibodies are normally regulated in nonautoimmune-prone mice but are induced to secrete Abs

106 NOD- and nonautoimmune-prone mice did not differ in ability to de

107 It has been evident that in nonautoimmune-prone mice, dendritic cells (DCs) present

108 ent to generate classic lupus nephritis in a nonautoimmune-prone strain.

109 e to insulinopenia on alloimmunity using the nonautoimmune, spontaneously diabetic H-2(b)-expressing

110 Costimulation delivered by nonautoimmune strain APCs normalized NOD CD4 T cell divi

111 eptide Ag in lupus-prone MRL/MpJ mice with a nonautoimmune strain using an MHC class II-restricted TC

112 pe 1 diabetes-prone NOD strain relative to a nonautoimmune strain.

113 n of the lupus-susceptibility gene from this nonautoimmune strain.

114 iscent of that of MRL mice can be induced in nonautoimmune strains by pristane, which causes a nonspe

115 B cell tolerance mechanisms in NOD mice with nonautoimmune strains by using the IgHEL and Ig3-83 tran

116 Strikingly, none of 13 nonautoimmune strains tested exhibited this defect.

117 KT cells in young BWF1 mice as compared with nonautoimmune strains, implies a regulatory role of CD1d

118 II major histocompatibility complex-matched nonautoimmune strains, including BALB/c, (BALB/cxNZW)F1

119 When compared with homologous IgL genes from nonautoimmune strains, Vkappa genes from NOD mice are po

120 e lower in young wild-type BWF1 mice than in nonautoimmune strains.

121 reas, we find that NOD mice closely resemble nonautoimmune strains.

122 In contrast, autoreactive T cells of nonautoimmune Tg mice are tolerized by Tg B cells in the

123 individuals (2.1%, P < .001), patients with nonautoimmune thrombosis (0%, P = .017), or patients wit

124 sus without thrombosis, 62 with APS, 21 with nonautoimmune thrombosis, and 145 healthy individuals) w

125 pecific B cells are rare in the periphery of nonautoimmune VH125Tg/C57BL/6 mice and WT/NOD autoimmune

126 e, but not young mice from these strains, or nonautoimmune young and old BALB/c, MRL/MpJ/++, and C3H/