ライフサイエンスコーパス: noncanonical

1 n in the alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta binding site that modulates inte

2 rect visualization of cellular response to a noncanonical acrolein warhead.

3 patterns prompts the question of a possible noncanonical action by norepinephrine.

4 We found that EZH2's noncanonical activation function was reaffirmed by its a

5 gement of MM, can inhibit both canonical and noncanonical activation of NF-kappaB in MM cells.

6 h miR-424 as an oncogenic effector linked to noncanonical activation of STAT3 and as a potential ther

7 The mechanism involved activation of AKT and noncanonical activation of the GLI family transcription

8 These studies highlight the role of noncanonical Ahcy enzymes as determinants of healthy agi

9 The metal-chelating noncanonical amino acid (2,2'-bipyridin-5yl)alanine (Bpy

10 patch clamp fluorometry with a fluorescent, noncanonical amino acid (3-(6-acetylnaphthalen-2-ylamino

11 odimer to be dependent on incorporation of a noncanonical amino acid (ncAA) at residue 72.

12 Herein, we genetically encode a novel noncanonical amino acid (ncAA) that contains an aryl iso

13 We have previously genetically encoded the noncanonical amino acid 5-hydroxytryptophan in both E. c

14 synthesized proteins by incorporation of the noncanonical amino acid azidohomoalanine and visualized

15 e (designated L274GMmMetRS) that charges the noncanonical amino acid azidonorleucine (Anl) to elongat

16 Here we show, through the use of noncanonical amino acid mutagenesis, that replacement of

17 The noncanonical amino acid p-azidophenylalanine (AzF) was i

18 ed biosynthetically as the side chain of the noncanonical amino acid p-biphenylalanine.

19 lies on the translational incorporation of a noncanonical amino acid probe into cellular proteins.

20 mics end-binding protein 1 (EB1) via a novel noncanonical amino acid sequence, and this GAR22beta-EB1

21 Bioorthogonal noncanonical amino acid tagging (BONCAT) can reveal acti

22 colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify act

23 Here, we adapt bioorthogonal noncanonical amino acid tagging (BONCAT) to interrogate

24 tive proteome-labeling method [bioorthogonal noncanonical amino acid tagging (BONCAT)] to identify pr

25 alanine and visualized them with fluorescent noncanonical amino acid tagging (FUNCAT).

26 ctively, these results introduce fluorescent noncanonical amino acid tagging as a strategy to investi

27 Here we describe a technique that couples noncanonical amino acid tagging or puromycylation with t

28 Here, we address these challenges by using noncanonical amino acid tagging to fluorescently label e

29 orometry, and incorporation of a fluorescent noncanonical amino acid, we show that there is a rearran

30 o anti-CD3 Fab using the genetically encoded noncanonical amino acid.

31 s such as expanding protein chemistries with noncanonical amino acids (ncAAs) and genetically isolati

32 xpression of Nisin variants that incorporate noncanonical amino acids (ncAAs) at discrete positions.

33 rt the generation of thiopeptides containing noncanonical amino acids (ncAAs) by introducing orthogon

34 The use of genetically encoded noncanonical amino acids (ncAAs) to construct crosslinks

35 The use of noncanonical amino acids (ncAAs) to control the viabilit

36 ein design together with genetically encoded noncanonical amino acids can be used to drive formation

37 Here we report the genetic encoding of noncanonical amino acids containing long side-chain thio

38 The use of noncanonical amino acids in previous MC1R ligand develop

39 mutagenesis strategy allowed a wide range of noncanonical amino acids to be systematically incorporat

40 nt enzymes in which 10 structurally distinct noncanonical amino acids were substituted at single site

41 ndom beta-lactamase mutants containing these noncanonical amino acids.

42 modified with FITC using genetically encoded noncanonical amino acids.

43 e capable of interchanging between different noncanonical and canonical conformations in a dynamic fa

44 pyroptosis through both caspase-11-dependent noncanonical and caspase-1-dependent canonical inflammas

45 We introduced mutations in noncanonical and in conserved residues of either of the

46 that mapped to 5' untranslated regions were noncanonical and led to N-terminal extension of annotate

47 tivity of PPARD in prostate cancer through a noncanonical and ligand-independent pathway.

48 the molecular basis for shape generation in noncanonical and morphologically complex bacteria.

49 ARF3/ETTIN (ETT) is a conserved noncanonical Arabidopsis thaliana ARF that adopts an alt

50 y, calmodulin is bound tightly to STRA6 in a noncanonical arrangement.

51 asingly modified functional microcircuits in noncanonical association cortices that contrast V1.SIGNI

52 ted (ATM)-interacting protein ATMIN mediates noncanonical ATM signaling in response to oxidative and

53 Both noncanonical autophagic pathways and xenophagy are activ

54 ld-type (WT) L. monocytogenes escaped from a noncanonical autophagic process that targets damaged vac

55 In contrast, the roles of Atg8 homologs in noncanonical autophagic processes are not fully understo

56 on L. monocytogenes-containing vacuoles via noncanonical autophagy had no apparent role in restricti

57 reviously, we and others described a form of noncanonical autophagy known as LC3-associated phagocyto

58 iated genes, ATG16L1 and NOD2, to activate a noncanonical autophagy pathway during protection from co

59 ontrol of liver-stage P. vivax by inducing a noncanonical autophagy pathway resembling that of LC3-as

60 In conclusion, although noncanonical autophagy targets phagosomes, xenophagy was

61 prompts a temporal switch from canonical to noncanonical autophagy that is important in controlling

62 4 (Vps34) plays a role in both canonical and noncanonical autophagy, key processes that control the p

63 ing protein 2 in B cells alone enhanced this noncanonical autophagy, resulting in changes of mitochon

64 nical autophagy transiently while triggering noncanonical autophagy.

65 , BET66, self-assembles via Crick-Watson and noncanonical base pairs to form crystals.

66 The software identifies canonical and noncanonical base pairs, including those with modified n

67 A noncanonical base, uracil, may be also present in small

68 cleotides that specifically disrupt critical noncanonical base-pairing interactions in the crystal la

69 anonical G protein pathways but also through noncanonical beta-arrestin2-dependent pathways.

70 ization of a soluble analogue, 2, revealed a noncanonical binding mode for this class of compounds.

71 crystal structures of the complex revealed a noncanonical binding mode of compounds 1 and 2 in DYRK2,

72 ured the importance of regulatory syntax, as noncanonical binding motifs are typically disregarded by

73 l structure of the ternary complex reveals a noncanonical binding site for the toxin that adopts a no

74 es aim to reprogram the genetic code so that noncanonical biopolymers can be synthesized and evolved,

75 clear trend in ground state structures, from noncanonical bond lengths for WT toward solution values

76 degree of operation of a signaling pathway, noncanonical branches also play important roles.

77 ually be highly operational but may be using noncanonical branches.

78 voltage sensor discovered here constitutes a noncanonical by which membrane proteins may sense voltag

79 migration, thereby underscoring the role of noncanonical Ca(2+) stores in the control of Ca(2+)-depe

80 asomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial

81 th canonical Batf3-dependent CD8(+) cDCs and noncanonical CD8(+) cDCs were expanded and showed specif

82 ic backgrounds to ascertain the functions of noncanonical CDPKs.

83 Therefore, loss of TAK1 elicits noncanonical cell death which is mediated by RIPK1-induc

84 as PAR1) and F2RL1 (also known as PAR3) via noncanonical cleavage.

85 ribonucleotides, which are the most abundant noncanonical component of DNA.

86 photoproduct-associated siRNAs involves the noncanonical, concerted action of RNA POLYMERASE IV, RNA

87 ity was supported by significantly increased noncanonical connections (between sensori-motor cerebral

88 anslation of two inhibitory uORFs encoded by noncanonical CUG and UUG initiation codons in the EPRS m

89 ) transcription following treatment with the noncanonical cyclic dinucleotide 2',3'-cGAMP, suggesting

90 nhibition and evade cytostasis, in part, via noncanonical cyclin D1-CDK2-mediated S-phase entry.

91 and extent of CNS myelination, including the noncanonical cyclin-dependent kinase 5 (Cdk5) whose func

92 s article we review studies of some of these noncanonical defense pathways and how herpesvirus gene p

93 Recent findings suggest that noncanonical Dicer generates small noncoding RNA to medi

94 N6-methyldeoxyadenine (6mA) is a noncanonical DNA base modification present at low levels

95 and the NHE III1 and FUSE elements rely upon noncanonical DNA structures and transcriptionally induce

96 ntial recognition and processing of specific noncanonical DNA structures, although the mechanistic ba

97 in a metal-dependent manner and recognizes a noncanonical DNA-binding site.

98 agement by Ets-1 and involves two suboptimal noncanonical docking interactions instead of a single ca

99 ension in response to down-regulation of two noncanonical Drosophila homologs of the SAH hydrolase Ah

100 rs in the presence of high concentrations of noncanonical dUTP, apolipoprotein B mRNA-editing, enzyme

101 The mammalian and fungal noncanonical DXO/Rai1 decapping enzymes efficiently remo

102 l alanine and threonine (CAT) tail through a noncanonical elongation reaction.

103 nduced by weak stimuli by cleaving PAR1 at a noncanonical extracellular site different from the throm

104 L through the novel mechanism of suppressing noncanonical EZH2 activity.

105 tively, the two structures clearly exhibit a noncanonical F1 head, in which the catalytic (alphabeta)

106 -rich, DDXXD motif places these enzymes in a noncanonical family of terpene synthases.

107 ion membrane, displays one canonical and one noncanonical FFAT motif that cooperatively mediated the

108 re, using knockdown strategies, we show that noncanonical FGF13 binds directly to VGSCs in hippocampa

109 ted protein Rubicon, which is critical for a noncanonical form of autophagy called "Light-chain 3 (LC

110 Reiterative transcription is a noncanonical form of RNA synthesis in which a nucleotide

111 Here we show that cGAMP has a noncanonical function in inflammasome activation in huma

112 Our data reveal a new noncanonical function of DGCR8 in the modulation of the

113 This work unveils a noncanonical function of ErbB2 in modulating autophagy a

114 ression data analysis also suggests that the noncanonical function of EZH2 as a transcriptional activ

115 These results highlight a noncanonical function of GABA as a local synaptogenic el

116 To dissociate canonical versus noncanonical functions of DGCR8, we complemented the mut

117 complex, which is required for execution of noncanonical functions of EPRS beyond protein synthesis.

118 al fibroblasts results in AKT activation and noncanonical GLI2 activation with subsequent TGFalpha se

119 th receptor signaling and chemokine binding; noncanonical H3C sequences are functionally linked, with

120 rringbone basic element and its folding to a noncanonical helix were conducted by NMR and CD spectros

121 Instead of a canonical helix, a noncanonical herringbone helix is formed.

122 ignaling and was instead correlated with the noncanonical Hh pathway, involving TGFbeta/SMAD (transfo

123 Ptch2(-/-) niche cells show hyperactive noncanonical HH signaling, resulting in reduced producti

124 ferative disease, which drives canonical and noncanonical HH-signaling.

125 desensitization have been shown to induce a noncanonical high-affinity agonist binding state in MOPr

126 and of HLA-A02-bound peptides identified new noncanonical HIV peptides of up to 16 aa that could not

127 nes of evidence suggest the usage of several noncanonical homology-directed repair (HDR) pathways in

128 Thus, it is considered that noncanonical homology-directed repair regulates the SNGD

129 This noncanonical hormone-sensing mechanism exhibits strong p

130 Here, we show that the noncanonical IkappaB-related kinase, IKBKE, is a critica

131 e human caspase-4 as a critical regulator of noncanonical inflammasome activation that initiates defe

132 sed potential activation of a human-specific noncanonical inflammasome and found that caspase-4 and c

133 elated to the mechanism of activation of the noncanonical inflammasome and its biological functions.

134 This noncanonical inflammasome relies on sensing the cytosoli

135 cell-culture and mouse models is driven by a noncanonical-inflammasome pathway that activates caspase

136 of transcripts associated with canonical and noncanonical inflammasomes was detected in patients with

137 LK2 free of FKBP12 becomes responsive to the noncanonical inflammatory ligand Activin A.

138 roles that previously unexamined uORFs with noncanonical initiation codons can play in modulating ge

139 ed here for the regulated ribosome bypass of noncanonical initiation codons in the EPRS 5'-leader add

140 In this study, we identify a noncanonical interaction between the ATPase domain of th

141 n may participate in apoptosis blockade by a noncanonical interaction mechanism.

142 y a physical constraint--geometries found in noncanonical interactions have similar calculated bond e

143 Os, land plants encode a loosely constrained noncanonical isoform and a variant containing a long ext

144 platelet reactivity and production, and the noncanonical ITIM-containing receptor TREM-like transcri

145 sets of HIV peptides of canonical and novel noncanonical lengths not predictable by the presence of

146 n, occasional antisense loci, and putatively noncanonical loci.

147 CA-3' termini, LTR_retriever also identifies noncanonical LTR-RTs (non-TGCA), which have been largely

148 The majority of noncanonical LTRs are Copia elements, with which the LTR

149 We identified seven types of noncanonical LTRs from 42 out of 50 plant genomes.

150 Taken together, this work reveals a novel, noncanonical mechanism by which an OTU family deubiquiti

151 Examination of this noncanonical mechanism in Gnb5(-/-) MIN6 cells showed th

152 ignaling adaptor for TLR7, suggesting that a noncanonical mechanism occurs in Y. pestis-infected macr

153 II receptor (TbetaRII) and is mediated by a noncanonical mechanism that involves Smad1/5/8 phosphory

154 s within which HER3 was phosphorylated via a noncanonical mechanism.

155 ncoding extracellular domains are defined by noncanonical mechanisms of base pairing to U1 small nucl

156 Noncanonical mechanistic target of rapamycin (mTOR) path

157 We show how a noncanonical member of the DNAJ-chaperone family, DNAJB6

158 Importantly, the noncanonical methionine at peptide position 5 acts as a

159 Replacement of the noncanonical methionine residue M584 (Walker B sequence

160 involving this canonical motif and a second noncanonical motif of the eIF4E surface.

161 inds to eIF4E through both the canonical and noncanonical motifs, similarly to metazoan eIF4E-eIF4G c

162 The finding that several noncanonical mRNA isoforms are relatively unstable sugge

163 hese results indicate that the generation of noncanonical mRNA isoforms is an important feature of th

164 newborn neurons in the adult spinal cord, a noncanonical neurogenic region.

165 lular signal-regulated kinase (MAPK/ERK) and noncanonical NF-kappaB activation were observed to be in

166 of the role of CD63 in limiting LMP1-induced noncanonical NF-kappaB and ERK activation.

167 We conclude that MACs activate noncanonical NF-kappaB by forming a novel Akt(+)NIK(+) s

168 nflammation and disease, the function of the noncanonical NF-kappaB pathway remains ill-defined.

169 dings reveal that NIK, and thus probably the noncanonical NF-kappaB pathway, is critical to allow DCs

170 sed a rapid activation of both canonical and noncanonical NF-kappaB pathway.

171 in family, which regulates the canonical and noncanonical NF-kappaB signaling cascades.

172 sis of airway epithelial cells and implicate noncanonical NF-kappaB signaling in the pathogenesis of

173 g kinase (NIK) is a central component of the noncanonical NF-kappaB signaling pathway.

174 roblasts in a manner requiring canonical and noncanonical NF-kappaB signaling pathways.

175 ly increased expression of genes involved in noncanonical NF-kappaB signaling, including NIK, and imm

176 tingly, zigzag hair shaft bending depends on noncanonical NF-kappaB signaling, which previously has o

177 se (NIK), which is pivotal in LTbeta-induced noncanonical NF-kappaB signaling.

178 12 downstream of increased expression of the noncanonical NF-kappaB transcription factor RelB.

179 trate that pharmacological activation of the noncanonical NF-kappaB-inducing kinase (NIK) disrupts gl

180 ization and activation of both canonical and noncanonical NF-kappaBeta pathways, resulting in a combi

181 IKKalpha-driven p100 phosphorylation in the noncanonical NF-kB pathway without affecting IKKbeta-dep

182 The role of IKKalpha in the noncanonical NF-kB pathway, and indeed in the canonical

183 mining approach identified components of the noncanonical NFkappaB pathway, including the upstream ki

184 s a pathological mediator after stress, this noncanonical nuclear activity of GRK5 is not induced dur

185 resulting in constitutive activation of the noncanonical nuclear factor (NF)-kappaB pathway.

186 nterestingly, AhR and some components of the noncanonical nuclear factor kappaB pathway were shown to

187 nt protist model Tetrahymena, which features noncanonical nuclear organization and divisions.

188 atin-which shares structural similarity with noncanonical nuclear receptor box in AR-antagonizes AR t

189 ponsible for the catabolism of canonical and noncanonical nucleoside triphosphates (dNTPs) and has be

190 ydrolytic capacity from the canonical to the noncanonical nucleotide binding site results in loss of

191 ed in ATP-binding cassette proteins with one noncanonical nucleotide binding site.

192 ough hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs).

193 routine LC-MS sequencing of RNAs containing noncanonical nucleotides, and we furthermore examine the

194 Toxicity of accumulated noncanonical nucleotides, leading to neuronal apoptosis

195 g pathways independently of gene expression (noncanonical or type 3 TR signaling).

196 This is the first demonstration of such noncanonical organization of these brain areas.

197 However, only the noncanonical p38 pathway regulated SMC apoptosis, a path

198 rmine the preferred conformations of the A-A noncanonical pairs in (CAG)n and (GAC)n trinucleotide re

199 The neutralizing ion distribution around the noncanonical pairs is described.

200 e, we identified increased expression of the noncanonical pathway component p100/p52.

201 family transcription factor activated in the noncanonical pathway downstream of NF-kappaB-inducing ki

202 etion and demonstrate signaling occurs via a noncanonical pathway independent of the mediator of clas

203 l autophagy occurred predominantly through a noncanonical pathway.

204 FKB1-dependent canonical and NFKB2-dependent noncanonical pathways plays distinctive roles in a diver

205 tein expression; activation of canonical and noncanonical pathways was examined in peripheral blood m

206 to prototypic H-2D(b) peptides, Trh4 takes a noncanonical peptide-binding pattern with extensive sulf

207 s of HIV proteins leading to presentation of noncanonical peptides by several cell types with distinc

208 proteins leading to common presentations of noncanonical peptides by several cell types with distinc

209 endogenous mGluR1 activator, could encourage noncanonical pharmacological approaches to pain manageme

210 This points the way for developing noncanonical pharmacological approaches to pain manageme

211 Inhibition of the noncanonical poly(A) polymerase PAP-associated domain-co

212 Here, we show that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)-PR

213 of histone H2A signals recruitment of other noncanonical PRC1 complexes and of PRC2, the latter lead

214 origins, diversity, and growing interest in noncanonical protist gene expression and its relationshi

215 and hypoxanthine nucleoside phosphates and a noncanonical pyrimidine nucleoside (zebularine) phosphat

216 carboxy-terminal phosphorylation-independent noncanonical R-Smad-STAT3 signalling network in TH17 dif

217 ocalized RRKM-ME" and "competitive localized noncanonical" rate models are suggested as steps toward

218 ponent of episodic memory, opening a new and noncanonical research avenue in the physiopathology of c

219 l in vitro map of thousands of canonical and noncanonical rG4 structures.

220 nger mechanism, which may be shared by other noncanonical RhoGAP domains lacking the auxiliary aspara

221 onical trkB signaling pathways, suggesting a noncanonical role for trkB in STN DBS-mediated behaviora

222 Thus, this novel noncanonical role of FH as an immunological brake able t

223 creen of the ATG proteome to reveal numerous noncanonical roles for ATG proteins during viral infecti

224 Recent evidence has revealed noncanonical roles for Galphas in endosomal sorting of r

225 oter and RNA polymerase determinants of this noncanonical rrnB P1 start site using biochemical and ge

226 nical sites (T37, T46, S65, and T70) and the noncanonical S83 site, resulting in a mitosis-specific h

227 three-dimensional structures despite having noncanonical secondary structures with shortened interhe

228 r, AMPKalpha1 is a critical mediator linking noncanonical Shh pathway to Warburg-like glycolysis in s

229 This identifies ZBP1 as a new mediator of noncanonical Shh signaling in axon guidance.SIGNIFICANCE

230 on guidance, identifying a new member of the noncanonical Shh signaling pathway.

231 at the unique shape and functionality of the noncanonical side chain enabled the active site to be re

232 Specifically, 13 different noncanonical side chains were incorporated at 12 differe

233 A formidable source of noncanonical signal transduction concepts is neural stem

234 the underlying mechanisms for this apparent noncanonical signal using mouse genetics.

235 ion involving the interplay of canonical and noncanonical signaling and highlight the ability of the

236 Whereas EphA2 canonical and noncanonical signaling have been viewed as mutually excl

237 MENT Sonic hedgehog (Shh) guides axons via a noncanonical signaling pathway that is distinct from the

238 sulfonamide (GPR39-C3) at both canonical and noncanonical signaling pathways.

239 ctivators and thus raised the possibility of noncanonical signaling pathways.

240 By contrast, the noncanonical signaling Wnt5a did not cause cartilage les

241 phosphorylation, and kinase activity; EphA2 "noncanonical" signaling involves phosphorylation of seri

242 to substrates and transducing this event to noncanonical, signaling interaction to Ire1 and Perk.

243 RP6 restrains vascular smooth muscle lineage noncanonical signals that promote osteochondrogenic diff

244 DCL4(NLS) functions in a noncanonical siRNA pathway, producing a unique set of 21

245 equent cleavage of PAR1 by active MMP-2 at a noncanonical site, exposing a previously undescribed tet

246 onical site, but also one or more separate ("noncanonical") sites.

247 the evolution of an Argonaute subclass with noncanonical specificity for a 5'-hydroxylated guide.

248 This noncanonical stimulation of NFkappaB triggers the up-reg

249 nt synthetic access to enantiomerically pure noncanonical strigolactones by a Stille cross-coupling a

250 Noncanonical strigolactones lack the fused tricyclic ABC

251 vel derivatives interact preferentially with noncanonical structures of TAR and cTAR, stabilize their

252 Here we survey these noncanonical structures, from the 4-protofilament microt

253 sive anatomical evidence for the presence of noncanonical subicular projections to CA1.

254 e of OCT2, leading to the transactivation of noncanonical target genes including HIF1a and FCRL3 Fina

255 Our study uncovers a noncanonical thermogenic mechanism through which beige f

256 vidence of protein translation initiation at noncanonical TISs and argues that further studies are re

257 nonical ones in some cases suggests that the noncanonical TISs can have biological functions.

258 at methionine was incorporated at almost all noncanonical TISs identified in this study.

259 ion across species and a higher abundance of noncanonical TISs than canonical ones in some cases sugg

260 e that many human proteins are translated at noncanonical TISs.

261 These findings provide in vivo evidence that noncanonical TR signaling exerts physiologically importa

262 To test the physiological relevance of noncanonical TR signaling, we generated knockin mice wit

263 oncentration, all of which were regulated by noncanonical TR signaling.

264 ligand-activated RTKs with Galphai, and for noncanonical transactivation of G proteins.

265 ed to favor migration over proliferation via noncanonical transactivation of Galphai proteins by the

266 e ribosomal product generated by cytoplasmic noncanonical translation and demonstrate the participati

267 ot only support many annotated and predicted noncanonical translation events but also uncover small O

268 , although it has been shown that non-AUG or noncanonical translation initiation can also occur.

269 However, the evidence for noncanonical translation initiation sites (TISs) is larg

270 identify a functional structure involved in noncanonical translation initiation.

271 ucidation of functional implications of such noncanonical translation initiation.

272 extensively, here we highlight a process of noncanonical translation, IRES-mediated translation, tha

273 riptome, implying that ascoviruses use other noncanonical translational mechanisms, such as internal

274 How these noncanonical tRNAs compensate for their loss of tertiary

275 activation loop phosphorylation occurs via a noncanonical two-step mechanism in which 1) the cyclin-d

276 s (G4s), DNA secondary structures displaying noncanonical Watson-Crick base pairing, have recently em

277 AF inhibitor treatment and that induction of noncanonical Wnt by BMI1 is required for this resistance

278 report evidence favoring such a role for the noncanonical WNT family member Wnt5a.

279 platform for cross-talk between Akt and the noncanonical Wnt pathway but also reveals the impact of

280 LRP6 and noncanonical Wnt pathways are important potential therap

281 strated that induction of host canonical and noncanonical Wnt pathways by E. chaffeensis TRP effector

282 l that E. chaffeensis exploits canonical and noncanonical Wnt pathways through TRP effectors to facil

283 ken together, these results demonstrate that noncanonical Wnt signaling contributes to obesity-induce

284 nd Rac GTPase network, indicating a role for noncanonical WNT signaling in development of colorectal

285 ct receptors for Wnt5a and are implicated in noncanonical Wnt signaling in organogenesis and cancer m

286 wth and steroidogenesis are now established, noncanonical WNT signaling in the ovary has been largely

287 ple, enhances PI3-K-->Akt signals within the noncanonical Wnt signaling pathway and antagonistically

288 We find that Shank regulates a noncanonical Wnt signaling pathway in the postsynaptic c

289 thogenic variants reside in genes within the noncanonical Wnt signaling pathway including ROR2, WNT5A

290 ults in the repression of both canonical and noncanonical Wnt signaling pathways, which are crucial f

291 adipose tissue dysfunction, and the role of noncanonical Wnt signaling remains largely unexplored.

292 Here, we identify a canonical to noncanonical WNT signaling shift contributing to COPD pa

293 positive feedback loop that further enhances noncanonical Wnt signals by compartmentalizing beta-cate

294 mplexes to cell-cell contact sites, enhances noncanonical Wnt signals, and thereby suppresses colony

295 antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers canc

296 We demonstrate enhanced expression of noncanonical WNT-5A in two experimental models of COPD a

297 Noncanonical Wnt-Fzd6 signaling pathway could thus prese

298 Noncanonical WNTs, including WNT5a and WNT11, are expres

299 assicaceae is also true for, e.g., algal and noncanonical YCF1 homologs.

300 division" to indicate the events leading to noncanonical zygotic cytokinesis, segregating the parent