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1 nduced protein kinase SGK1; the mechanism is noncatalytic.
2 e of the substrate, phenylpyruvate (PPA), is noncatalytic.
3 role of VRK1 in neuronal migration is partly noncatalytic.
4 that A3G, A3F, and, to a lesser extent, the noncatalytic A3GC291S block human immunodeficiency virus
10 formation through two genetically distinct, noncatalytic activities: activation of MamE-dependent pr
11 pecificity depends in part on binding of the noncatalytic ADAMTS13 spacer domain to the C-terminal al
17 ATPase domain of Cdc6 in the absence of the noncatalytic amino terminus is not sufficient for either
18 pression of either catalytic domain with the noncatalytic amino-terminal portion of HUGT1 conferred U
22 e DinB tertiary structure suggests these are noncatalytic, and multiple-sequence alignments indicate
23 fold) in the hemostasis models tested than a noncatalytic antidote that is currently in clinical deve
24 phagosome deliver an array of catalytic and noncatalytic antimicrobial peptides, while activation of
25 coumarin-containing oligonucleotide and the noncatalytic APE1, the dye's absorption spectrum is shif
26 lution, 19 aaRSs expanded by acquiring novel noncatalytic appended domains, which are absent from bac
28 act with the redox polymer thus converts the noncatalytic base layer into a catalyst for the electror
32 ermed "protein kinase C substrate 80K-H" or "noncatalytic beta-subunit of glucosidase II." This prote
33 tion of the APLTs, Dnf1p and Dnf2p, or their noncatalytic beta-subunit, Lem3p, blocked the import of
35 ilico experiments reveal that stoichiometric noncatalytic binding and inhibition can generate a robus
37 alytic sites, Pgamma is known to stimulate a noncatalytic binding of cGMP to the regulatory GAFa-GAFb
38 ependent formation of DMSOR(mod)D represents noncatalytic breakdown of the DMS species by a pathway a
42 t, is increased by interaction with the Nek9 noncatalytic C-terminal domain, suggesting a mechanism i
43 inducing a conformational change involving a noncatalytic C-terminal region spanning residues 414-551
46 ell wall degrading enzymes generally contain noncatalytic carbohydrate binding modules (CBMs) that fu
48 ly regulates the Sid1p kinase by binding the noncatalytic carboxyl-terminal region of the protein.
51 efect of H257N is not due to perturbation of noncatalytic cGMP binding to the PDE6alpha' GAF domains.
54 catalytic chain, Trm61, and a homologous but noncatalytic chain, Trm6, repurposed as a tRNA-binding s
57 proteolytic ClpP proteins and four different noncatalytic ClpR proteins, with each present in one or
59 (ORF15) C-terminal basic domain binds to the noncatalytic cofactor interaction domain unique to TTLL5
61 mprising the C-terminal domains of E2p and a noncatalytic component, E3-binding protein (E3BP), which
63 lectivity observed at low temperatures under noncatalytic conditions roughly predicts the regioselect
64 ntermediates in the catalytic reaction under noncatalytic conditions, suggest that N2 was reduced at
66 an intact polo-box, a conserved motif in the noncatalytic COOH-terminal domain of Cdc5, is required f
71 cue flies that express either wild-type or a noncatalytic cysteine-serine mutant PGRP-SC1a, we find t
72 ased ligand design and covalent targeting of noncatalytic cysteines have been employed to develop pot
74 Here, we show that ADAM11, a transmembrane noncatalytic disintegrin, is the first reported Kv1-inte
75 merization reaction, explain the role of the noncatalytic divalent cation in 6 RdRp, and pinpoint the
76 to form ternary complexes in the presence of noncatalytic divalent cations such as Ca(2+), Co(2+), Ni
77 ret these results to suggest that there is a noncatalytic docking site closely associated with PS1-ga
81 d protein with weak sequence similarity to a noncatalytic domain of class B penicillin-binding protei
82 adhesion kinase or with FRNK, the C-terminal noncatalytic domain of focal adhesion kinase, produced m
86 romoting complex (APC)/cyclosome through the noncatalytic domain of Plo1 and the tetratricopeptide re
87 cytoplasmic domain, a transmembrane helix, a noncatalytic domain of unknown function, and a catalytic
88 ugu AID catalytic domain to the entire human noncatalytic domain restores activity in mammalian cells
89 motif was identified in the Nek2 C-terminal noncatalytic domain that allows both microtubule binding
90 ish the specific structural features of this noncatalytic domain that are essential to DNA conjugatio
91 ally associates with Cdt1 via its N-terminal noncatalytic domain, a region we had previously shown to
92 to membrane affinity: (1) the amino-terminal noncatalytic domain, and (2) a region with sequence simi
93 gesting that AID features mapping within the noncatalytic domain, but outside the NES, influence its
97 of these large protein complexes consists of noncatalytic domains and subunits, and the ULK1 complex
98 r progressive and accretive proliferation of noncatalytic domains as the Tree of Life is ascended.
99 mechanisms involving both the catalytic and noncatalytic domains determine the distinct substrate sp
104 Y(551) phosphorylation, and the role of the noncatalytic domains of Btk in the activation process.
105 Our results suggest a mechanism by which the noncatalytic domains of pollen-specific/enriched RopGEFs
106 f this study was to determine whether other, noncatalytic domains of RGS9-1.Gbeta5L enhance the intri
115 attributed to multiple interactions between noncatalytic dynein subunits and an array of regulatory
116 een subunits, insights into the functions of noncatalytic editosome proteins, and a global understand
119 t DNA polymerase epsilon (Pol epsilon) has a noncatalytic essential role during the early stages of D
120 mutagenesis of ADAMTS-5 identified that the noncatalytic first thrombospondin and spacer domains med
123 lin D1 promotes cell cycle progression and a noncatalytic function has been described to sequester th
124 ulatory subunits of cohesin, implicating its noncatalytic function in inactivating cohesin's ability
125 These data show that FIG4 plays a critical noncatalytic function in maintaining lysosomal membrane
128 The sensitizing mutation also impaired a noncatalytic function of Cdk2 in restricting assembly of
129 increased CDK2 activity associated with the noncatalytic function of CDK4, sequestration of p21(Cip1
130 ganisms, fully effective TLS also requires a noncatalytic function of the Y family polymerase REV1.
131 ere, we report that ERK1/2 also utilizes its noncatalytic function to mediate certain signal transduc
135 e that these "pseudogenes" have alternative, noncatalytic functions that have not yet been uncovered.
136 that the EVH1 domain of Spred1 binds to the noncatalytic (GAPex) portion of the GAP-related domain (
140 dicots carry a pseudoenzyme PDX1.2 that is a noncatalytic homolog of the PDX1 subunit of the vitamin
143 bunit disulfide bonds were identified in the noncatalytic interaction domains; two in the MAM (meprin
144 ach of the related b and b' subunits, down a noncatalytic interface of the F1 domain and interacts in
145 l of mutual solvation of the partners of the noncatalytic "intimate" ion pair should release the nucl
146 unctional kinase, whereas phosphorylation of noncatalytic intracellular domains is required for recog
147 e second Glu was involved in binding a third noncatalytic ion in bacteriophage RB69 DNA polymerase.
148 mes (ISAs), including the catalytic ISA1 and noncatalytic ISA2, are major starch biosynthesis determi
149 For instance, the potato tuber enzyme has a noncatalytic L subunit that complements an S subunit wit
150 sphorylation of Ser(886) and Ser(999) in the noncatalytic linker connecting the synthetase cores.
151 Based on antibody binding experiments, the noncatalytic linker regions between the two enzymatic do
153 t library by targeting imperfectly conserved noncatalytic loop residues and examined the effects on p
154 ug et al. propose a polyubiquitin-dependent, noncatalytic mechanism by which the deubiquitinase A20 i
156 cell wall integrity signaling pathway uses a noncatalytic mechanism to activate the SBF (Swi4/Swi6) t
157 the yeast cell wall integrity pathway uses a noncatalytic mechanism to activate transcription of stre
158 1) and its pseudokinase paralog (Mlp1) use a noncatalytic mechanism to activate transcription of the
159 nts transport activity of MCT1 and MCT4 by a noncatalytic mechanism, while leaving transport activity
161 Rp from bacteriophage varphi6 uses the bound noncatalytic Mn(2+) to facilitate the displacement of th
162 We find that this displacement releases the noncatalytic Mn(2+), which must be replaced for elongati
164 Cel8 (SlCel9C1), with a distinct C-terminal noncatalytic module that represents a previously unchara
165 ing strategy that can identify catalytic and noncatalytic molecules that participate in different pat
166 mounts of sodium hydroxide needed to titrate noncatalytic montmorillonites as compared to the catalyt
175 atalytic nucleotidyltransferase domain and a noncatalytic oligonucleotide/oligosaccharide binding (OB
176 associated with characterizing catalytic and noncatalytic outputs in cells, and describe successes an
177 ain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and t
178 structural elements at the C terminus of the noncatalytic p51 subunit and the nucleic acid duplex in
179 nd the apicoplast of the genus Plasmodium, a noncatalytic paralog of ClpP, termed ClpR, has been iden
180 lization in a multisynthetase complex (MSC), noncatalytic peptide appendages, and ancillary functions
183 etion of PP1-87B or depletion of a conserved noncatalytic PP1 phosphatase subunit Sds22 leads to defe
185 ensional diffusion along protein surfaces, a noncatalytic protein bridge was inserted between GOx and
186 basis for a functional in vitro assay for a noncatalytic protein component of the telomerase complex
190 tribution led us to report the first direct, noncatalytic quantitative observation of hydrogenolysis
191 bstrate, NAD+ and TbSIR2rp1 as follows: 1) a noncatalytic reaction between the deacetylation product
192 igomerization of benzylic compounds) and for noncatalytic reactions (Baeyer-Villiger oxidations, oxid
193 the mechanisms of signal initiation of this noncatalytic receptor, as well as to develop therapeutic
198 to search for proteins with homology to the noncatalytic region of NIMA and identified mixed lineage
199 mic portion of ADAM17 through the C-terminal noncatalytic region of PLK2 containing the Polo box doma
200 mbinant SH3.1 domain of the adaptor molecule noncatalytic region of tyrosine kinase (Nck) can bind to
202 als that the KIM docking site, situated in a noncatalytic region opposite of the kinase catalytic poc
203 of these resemble NIMA within its extensive noncatalytic region, a region critical for NIMA function
204 kinetics led to the identification of three noncatalytic regions in MMP-1 (residues 285-295, 302-316
205 This binding supports the involvement of noncatalytic regions to the tight binding of the MK2:p38
206 s new structure supports the idea that these noncatalytic regions work together as a "conformational
207 ull-length kinase and the functional role of noncatalytic regions, we performed hydrogen-deuterium ex
208 alytic subunits (IKKalpha and IKKbeta) and a noncatalytic regulatory component named NEMO (NF-kappaB
209 Human mutations in KATNB1, which encodes the noncatalytic regulatory p80 subunit of katanin, cause se
211 tion, a post-translational modification on a noncatalytic residue that increases its peroxidase activ
212 Interestingly, viruses with a mutation at a noncatalytic residue, D324A, could not be recovered desp
213 lutionary interactions between catalytic and noncatalytic residues have been difficult to define and
214 ytic metal-binding residues and two adjacent noncatalytic residues in LAGLIDADG homing endonucleases
216 cale to create motifs of mixed catalytic and noncatalytic residues that identify enzyme activity and
217 ary for catalysis and structurally important noncatalytic residues that together maintain the archite
218 protein-DNA interactions is demonstrated by noncatalytic restriction mapping on a 4-kb DNA with thre
223 s support a model in which DBT plays a novel noncatalytic role in recruiting additional kinases that
226 uggest that cyclin A-cdk2 plays an ancillary noncatalytic role in the ubiquitination of p27 by the SC
230 overexpression of the MST1 carboxy-terminal noncatalytic segment or by the NORE segment that binds M
231 and Nek7 (303AA), 76% identical, have little noncatalytic sequence but bind to the carboxyl-terminal
232 ivation of transcription by nitroalkenes via noncatalytic sequestration of these ligands, and their g
233 Here we show that the Anopheles gambiae noncatalytic serine protease CLIPA8, an essential factor
235 is accessible by the optimal expression of a noncatalytic signaling component and that altering the e
236 or the i + 2 template position can bind to a noncatalytic site and increase the rate of RNA synthesis
237 demonstrates that L-serine binds to a second noncatalytic site and produces a conformational change i
238 oA levels, the binding of acyl-CoA with this noncatalytic site facilitates homotropic allosteric acti
240 nds to the active site and a unique proximal noncatalytic site formed by Lys-41, Arg-47, and Asp-48.
242 e positions in which they exist at the three noncatalytic site interfaces in crystal structures.
243 tes the activity of another via binding to a noncatalytic site(s) rather than through binding to an a
244 y with the active site and a unique proximal noncatalytic site, we have recently acquired Compound 2,
246 nucleotides or alters communication between noncatalytic sites and catalytic sites during ATP hydrol
247 duce a global effect that alters affinity of noncatalytic sites for nucleotides or alters communicati
249 e under conditions wherein binding of ATP to noncatalytic sites of the wild-type enzyme promotes rele
251 escued by compensatory mutations at adjacent noncatalytic sites that restore an optimal coevolving ne
252 e high affinity cGMP binding to low affinity noncatalytic sites, and retard cGMP exchange with both n
261 (1668) segment in the same domain and on the noncatalytic spacer domain of ADAMTS13, suggesting that
264 of the proteasomes by interactions with the noncatalytic subunit alpha7 in a way that prevents the e
265 Each complex contains one catalytic and one noncatalytic subunit and exhibits endonuclease activity
268 t-translationally by the availability of the noncatalytic subunit collagen Q, and others have shown t
270 Polycomb group (PcG) repressor that is a key noncatalytic subunit in the ESC-Enhancer of zeste [E(Z)]
271 h synthase III (SSIII), and isa2, encoding a noncatalytic subunit of heteromeric isoamylase-type star
272 activated form of C3) on the function of the noncatalytic subunit of natural surface-bound forms of t
278 re we report the identification of a primase noncatalytic subunit, denoted PriX, from the hyperthermo
280 alytic subunits, IKKalpha and IKKbeta, and a noncatalytic subunit, NF-kappaB essential modifier/IKKga
286 B3GAP1 and RAB3GAP2 encode the catalytic and noncatalytic subunits of the hetrodimeric enzyme RAB3GAP
291 NIMA-like catalytic domain is followed by a noncatalytic tail containing seven repeats homologous to
292 c sequence but bind to the carboxyl-terminal noncatalytic tail of Nercc1/Nek9, a NIMA family protein
294 ogether, our data support the existence of a noncatalytic template-specific NTP binding site in the m
296 ant stability vs metastability, catalytic vs noncatalytic transduction, pre- vs post-transcriptional
297 As, one enzyme homodimer plays a role of the noncatalytic unit that positions CCA ends of two tRNA(Se
298 between the globular domain of LpoB and the noncatalytic UvrB domain 2 homolog domain of PBP1B and m
299 id-solid growth and vertical facet-selective noncatalytic vapor-solid growth and their parallel integ
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