ライフサイエンスコーパス: noncoding

1 We describe new mechanisms of coding and noncoding alteration and identify ten recurrently altere

2 Our detailed single-cancer analysis of noncoding alterations identifies regulatory mutations as

3 nal Clustering Operation) to analyze somatic noncoding alterations in 308 pancreatic ductal adenocarc

4 d among animal mRNAs, IRE-RNA structures are noncoding and bind Fe(2+) to regulate biosynthesis rates

5 the genome that may be transcribed: coding, noncoding, and intergenic regions, as well as repetitive

6 aracterized the unique expression of coding, noncoding, and intergenic RNAs in the mature mouse brain

7 rent transcript types (i.e., protein coding, noncoding, and pseudogenes) was associated with islet ex

8 The close correspondence between extreme noncoding conservation and TADs suggests that these TADs

9 TADs that are associated with high levels of noncoding conservation exhibit distinct properties compa

10 roperties compared to TADs devoid of extreme noncoding conservation.

11 strains was performed, with emphasis on the noncoding control region, the major capsid protein gene

12 SNP, 29% in COSMIC coding, and 13% in COSMIC noncoding datasets across all human chromosomes, higher

13 We validated noncoding DHSs against known enhancers from myo-2, myo-3

14 Noncoding DHSs are highly conserved and enriched in mark

15 n how low-abundance lncRNAs transcribed from noncoding DNA function in organisms.

16 Historically, noncoding DNA has lacked the detailed characterization t

17 Transcription of protein-coding and noncoding DNA occurs pervasively throughout the mammalia

18 Noncoding DNA regions have central roles in human biolog

19 little is known about somatic alterations in noncoding DNA.

20 on of not only protein-coding genes but also noncoding DNA.

21 are more likely to carry multiple coding and noncoding DNMs in different genes, which are enriched fo

22 Previously, our group has shown that noncoding double-stranded RNA (dsRNA) released during wo

23 a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sit

24 s likely contribute, these results highlight noncoding dsRNA as an upstream coordinator of prostaglan

25 r in the regions of low density of conserved noncoding elements (CNEs) and that the chromosomal fissi

26 re surrounded by dense clusters of conserved noncoding elements (CNEs).

27 ism in BCC involving mutations in regulatory noncoding elements and uncovers the tumor-suppressor pro

28 ted a cis-regulatory mechanism via conserved noncoding elements or enhancers.

29 n genomes contain many clusters of conserved noncoding elements.

30 We therefore evaluated coding and noncoding expression dynamics at unprecedented temporal

31 The persistence and recurrence of noncoding gain-of-function mutations in these cases sugg

32 a mechanism by which genetic alterations in noncoding gene regions may result in alpha-1-antitrypsin

33 rate the transcription of protein-coding and noncoding genes.

34 in E-cadherin regulation and the impact of a noncoding genetic variant on its function.

35 as the functional impact of disease-related noncoding genetic variants.

36 ding spatial interactions between the genes, noncoding genome elements, and epigenetic and transcript

37 The noncoding genome is pervasively transcribed.

38 The 3'UTRome is a region of the noncoding genome that perfectly fulfills these criteria

39 ChromHMM helps to annotate the noncoding genome using epigenomic information across one

40 Somatic mutations within noncoding genomic regions that aberrantly activate oncog

41 Most disease variants lie within noncoding genomic regions, making their functional inter

42 ibraries that can be used to edit coding and noncoding genomic regions.

43 ent.Cancer driver mutations can occur within noncoding genomic sequences.

44 ed to prioritize and predict the function of noncoding GWAS SNPs have been developed.

45 RNA and therefore we name it LncHIFCAR (long noncoding HIF-1alpha co-activating RNA); we describe its

46 ore in COSMIC coding, and 553 more in COSMIC noncoding indel dataset in addition to the ones reported

47 ack loop within the NANCI (Nkx2.1-associated noncoding intergenic RNA)-Nkx2.1 gene duplex that is ess

48 tly, increasing evidence has shown that long noncoding (lnc) RNAs are involved in various biological

49 ons in the Il1a gene, we also mutated a long-noncoding (lnc)RNA in the complementary strand which has

50 to systematically discover the functions of noncoding loci and elucidate their diverse roles in gene

51 les, using gene expression, DNA methylation, noncoding microRNA, and copy number variation data avail

52 ons between lncRNA, protein coding genes and noncoding miRNAs.

53 dological advances in predicting deleterious noncoding mutations into a practical resource available

54 Abstract: Addressing deleterious effects of noncoding mutations is an essential step towards the ide

55 We find recurrent noncoding mutations to be enriched in PDA pathways, incl

56 thods for quantifying deleterious effects of noncoding mutations to precompute and compare the delete

57 thods for quantifying the deleteriousness of noncoding mutations using artificial intelligence, deep

58 hat substantially improves the prediction of noncoding nucleotide sites at which mutations are likely

59 Targets of silencing are recognized by small noncoding piRNAs that are processed from long precursor

60 small noncoding RNA (BocaSR), within the 3' noncoding region (nucleotides [nt] 5199 to 5338) of the

61 consensus primer/probe set targeting the 5' noncoding region of HRV.

62 ified a novel HBoV1 gene that lies in the 3' noncoding region of the viral positive-sense genome and

63 However, most loci reside in noncoding regions and have unknown biological functions.

64 e genome-wide significant loci in introns or noncoding regions could affect regulation of genes nearb

65 We find that over 5000 distal noncoding regions exhibit dynamic changes in chromatin a

66 r-type-specific indel hotspots targeting the noncoding regions of highly expressed genes defining cer

67 Interpreting genetic variation in noncoding regions of the genome is an important challeng

68 enome-wide association studies (GWAS) are in noncoding regions of the genome, a common polymorphism i

69 ting sites have unknown functions and are in noncoding regions of the genome.

70 ity of shared disease-associated variants in noncoding regions suggests they contribute to risk of au

71 e that germline mutations in both coding and noncoding regions throughout the BAP1 gene can impair pr

72 ntial to dissect the functional landscape of noncoding regions, but is highly susceptible to false di

73 ains of ENBA1, in addition to aberrations in noncoding regions, especially in BamHI A rightward trans

74 ociated genes, a lot of risk variants lie in noncoding regions.

75 alterations in both protein-coding genes and noncoding regulatory elements.

76 e characterized by rearrangements within the noncoding regulatory region (NCCR) and 1 point mutation,

77 H-strand transcription and encompassing the noncoding regulatory region of mtDNA in human and murine

78 Small noncoding regulatory RNAs (sRNAs) are post-transcription

79 Noncoding regulatory variants play a central role in the

80 behavioral diseases and were associated with noncoding risk variants.

81 onal HBoV1 gene, bocavirus-transcribed small noncoding RNA (BocaSR), within the 3' noncoding region (

82 NA custom-made array we identified CDF5 LONG NONCODING RNA (FLORE), a circadian-regulated lncRNA that

83 Iw1 is a long noncoding RNA (lncRNA) containing an inverted repeat (IR

84 an additional layer of complexity, the long noncoding RNA (lncRNA) Flicr (Foxp3 long intergenic nonc

85 hism (SNP) located in the intron of the long noncoding RNA (lncRNA) LINC00305 by searching the GWAS d

86 r, the Hoxd antisense growth-associated long noncoding RNA (lncRNA) located between Hoxd1 and Hoxd3 I

87 How the protein and long noncoding RNA (lncRNA) regulatory networks act in concer

88 timulates the transcription of DANCR, a long noncoding RNA (lncRNA) that is widely overexpressed in h

89 y was designed to determine the role of long noncoding RNA (lncRNA), metastasis-associated lung adeno

90 A previously uncharacterized long noncoding RNA (lncRNA), SMN-antisense 1 (SMN-AS1), repre

91 dimensions of modulation by miRNAs and long-noncoding RNA (lncRNA).

92 ze from microRNA (20-23 nucleotides) to long noncoding RNA (lncRNA, more than 200 nucleotides).

93 onary disease (COPD) development, while long noncoding RNA (lncRNAs) have been shown to cause COPD.

94 We identify Neat1, a noncoding RNA (ncRNA) constituent of paraspeckles, as a

95 polymerase III, thus generating exclusively noncoding RNA (ncRNA) that must hijack the machinery req

96 lex network comprising a promoter-associated noncoding RNA (paRNA), microRNA and epigenetic regulator

97 We have identified a novel long noncoding RNA (slincR) that is upregulated by strong AHR

98 bilize deleterious secondary DNA structures, noncoding RNA associated DNA/RNA hybrid formation, and p

99 These noncoding RNA classes have been shown to use diverse mol

100 Long noncoding RNA FOXD3-AS1 regulates oxidative stress-induc

101 tion of GR ligands and induction of the long noncoding RNA Gas5, leading to c-Myc inhibition.

102 n region encompassing 3 genes, including the noncoding RNA gene SNORD116.

103 CRS regions are located near coding or long noncoding RNA genes or within enhancers.

104 h-confidence protein-coding genes and 10,156 noncoding RNA genes.

105 se that integrating our current knowledge of noncoding RNA into a quantitative biochemical and theore

106 ression patterns with other genes, including noncoding RNA LINC01124 and uncharacterized RNA AK127400

107 croRNAs (miRNAs) are highly conserved, small noncoding RNA molecules that negatively regulate gene ex

108 MicroRNAs (miRNA) are small, noncoding RNA molecules with a master role in the regula

109 is transcribed by RNA polymerase III into a noncoding RNA of 140 nt.

110 n differentiation, while knockdown of a long noncoding RNA overlapping E1 has no detectable effect on

111 y, we tested the use of functionally related noncoding RNA pairs to enhance the discriminatory power

112 f RNA helicase Mtr4 (and senataxin) with the noncoding RNA processing function of RNA exosome determi

113 rotein involved in this process as well as a noncoding RNA produced by alternative processing of RNA

114 The sequence and expression specificity of noncoding RNA promoters are evolutionarily conserved, im

115 vel transcript identification, microRNA, and noncoding RNA quantification.

116 rget factors in the interactome of Xist, the noncoding RNA responsible for X inactivation.

117 WGS revealed a point mutation in noncoding RNA RNU12 that was associated with early onset

118 expression of TOX2 and a brain-specific long noncoding RNA RP1-269M15.3 in frontal cortex and nucleus

119 We propose that the long noncoding RNA species in the D-loop region are generated

120 r findings reveal BocaSR to be a novel viral noncoding RNA that coordinates the expression of viral p

121 e demonstrate a novel role of Malat1, a long noncoding RNA that has been originally identified as a p

122 oliferation by identifying an oncogenic long noncoding RNA that is widely overexpressed in human canc

123 thelial cells and mice, we identified uc.173 noncoding RNA that regulates growth of the intestinal mu

124 in both sexes from inactivation by XIST, the noncoding RNA that silences the inactive X.

125 uch as BCAR1, F3, LDLR, TBC1D2, and the long noncoding RNA TP53TG1.

126 n studied extensively, but its role in plant noncoding RNA transcription remains obscure.

127 Circular RNA (circRNA) is a class of noncoding RNA whose functions remain mostly unknown.

128 ng RNA (lncRNA) Flicr (Foxp3 long intergenic noncoding RNA) is a negative regulator that tunes Foxp3

129 ted lncRNA which we named PINCR (p53-induced noncoding RNA), is induced 100-fold after DNA damage an

130 the identification of a human-specific long noncoding RNA, Heart Brake LncRNA 1 (HBL1), which regula

131 ion signal in the 1q42.2 locus ( TSNAX-DISC1 noncoding RNA, lead single-nucleotide polymorphism: rs14

132 A long noncoding RNA, LincRNA-Tnfaip3, acts as a coregulator of

133 Here, we identify a long noncoding RNA, named Chronos, whose expression in muscle

134 (NAPs) and at least one nucleoid-associated noncoding RNA, naRNA4.

135 aryotes may have such enzymes for processing noncoding RNA.

136 ys should reveal new biological functions of noncoding RNA.

137 t RNA pathways for processing the host's own noncoding RNA.

138 he oxidative stress response by an oncogenic noncoding RNA.

139 While long intergenic noncoding RNAs (lincRNAs) and mRNAs share similar biogen

140 Long intergenic noncoding RNAs (lincRNAs) are emerging as important regu

141 Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as

142 ng RNAs, a growing number of long intergenic noncoding RNAs (lincRNAs) have been described in multice

143 lation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to play major roles in c

144 Long noncoding RNAs (lncRNAs) affect gene regulation through

145 Long noncoding RNAs (lncRNAs) are emerging as critical regula

146 Long noncoding RNAs (lncRNAs) are emerging as key factors in

147 Long noncoding RNAs (lncRNAs) are increasingly recognized as

148 Long noncoding RNAs (lncRNAs) are involved in diverse biologi

149 Long noncoding RNAs (lncRNAs) are known to be important in re

150 Long noncoding RNAs (lncRNAs) are transcripts longer than 200

151 Many long noncoding RNAs (lncRNAs) are unstable and rapidly degrad

152 ibitor JQ1, or knockdown of overlapping long noncoding RNAs (lncRNAs) blocks AngII-induced genes asso

153 ies have demonstrated the importance of long noncoding RNAs (lncRNAs) during oncogenic transformation

154 Long noncoding RNAs (lncRNAs) have been associated with HCC,

155 Thousands of long noncoding RNAs (lncRNAs) have been discovered, yet the f

156 Long noncoding RNAs (lncRNAs) have been implicated in hypoxia

157 Long noncoding RNAs (lncRNAs) have been reported to play dive

158 Long noncoding RNAs (lncRNAs) have emerged as critical regula

159 Increasing evidence indicates that long noncoding RNAs (lncRNAs) have important roles in various

160 Recent studies described the role of long noncoding RNAs (lncRNAs) in cardiac pathologies.

161 human cells, little is known about how long noncoding RNAs (lncRNAs) interact with target loci in th

162 A subset of long noncoding RNAs (lncRNAs) is spatially correlated with tr

163 ory RNAs such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) play crucial roles in the devel

164 easing evidences have demonstrated that long noncoding RNAs (lncRNAs) play important roles in many hu

165 The function of most human long noncoding RNAs (lncRNAs) remains unclear.

166 Long noncoding RNAs (lncRNAs) reside and function primarily i

167 Recently, long noncoding RNAs (lncRNAs) that are natural antisense tran

168 d co-activation and accumulation of the long noncoding RNAs (lncRNAs) XACT and XIST on active X chrom

169 ntain thousands of loci that transcribe long noncoding RNAs (lncRNAs), some of which are known to car

170 tion and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates wi

171 The human genome produces thousands of long noncoding RNAs (lncRNAs)-transcripts >200 nucleotides lo

172 re remain uncataloged, particularly for long noncoding RNAs (lncRNAs).

173 tulated the existence of multiple viral long noncoding RNAs (lncRNAs).

174 lar dynamics and localization of single long noncoding RNAs (lncRNAs).

175 gulation of enhancer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious seco

176 Noncoding RNAs (ncRNAs) generated from enhancers have be

177 The discovery of thousands of noncoding RNAs (ncRNAs) has expanded our view on mammali

178 Noncoding RNAs (ncRNAs) regulate gene expression in all

179 Noncoding RNAs (ncRNAs) regulating virulence have been i

180 Increasing data support the importance of noncoding RNAs (ncRNAs), including microRNAs (miRNAs) an

181 unneeded, defective, and potentially harmful noncoding RNAs (ncRNAs).

182 ons about nervous system diseases (NSDs) and noncoding RNAs (ncRNAs).

183 Small noncoding RNAs (sncRNAs) are recognized as important act

184 Many herpesviruses express small noncoding RNAs (sncRNAs), including microRNAs (miRNAs),

185 t DNA repeats involves the activity of small noncoding RNAs (sRNAs) associated with the RNA interfere

186 dopsis mRNAs, long noncoding RNAs, and other noncoding RNAs across three tissue types (siliques, seed

187 Covalent nucleotide modifications in noncoding RNAs affect a plethora of biological processes

188 xtended 3' UTRs have characteristics of long noncoding RNAs and likely do not interact with miRNAs.

189 lted in the loss of m(5)C sites on mRNAs and noncoding RNAs and reduced the stability of tRNA(Asp(GTC

190 The question of how noncoding RNAs are involved in Polycomb group (PcG) and

191 whether changes in the serum levels of these noncoding RNAs are observed in patients with asymptomati

192 These noncoding RNAs are responsible for mRNA regulation, cont

193 Small, noncoding RNAs are short untranslated RNA molecules, som

194 of functionally related pairs of circulating noncoding RNAs as biomarkers in cardiovascular disease.

195 pairs to enhance the discriminatory power of noncoding RNAs as circulating biomarkers.

196 ions of RNA bases are not only found in many noncoding RNAs but have also recently been identified in

197 mmalian cells, the formation of a 3' end for noncoding RNAs can be a complex process governed by the

198 As expected, many noncoding RNAs fail to terminate properly.

199 ng anti-apoptotic potential, suggesting that noncoding RNAs have an impact on the pathogenesis of hum

200 tal resource to deepen our knowledge on long noncoding RNAs in C3 cereals, allowing the Brachypodium

201 idence implicates both enhancer elements and noncoding RNAs in controlling this spatiotemporal expres

202 latest promises and challenges of targeting noncoding RNAs in disease.

203 n, the biological significance of pathogenic noncoding RNAs in host-pathogen interactions remains lar

204 rature on the role of miRNAs and other small noncoding RNAs in platelets and in the circulation, and

205 The physiologic function of these noncoding RNAs in postnatal renal tubules still remains

206 plore translational regulation of coding and noncoding RNAs in roots of Arabidopsis thaliana shifted

207 r studies evaluating the function of various noncoding RNAs in the brain, including noncoding RNAs th

208 ese stress-induced 3' UTR extensions as long noncoding RNAs in the regulation of their neighboring ge

209 tional layer of complexity, implicating long-noncoding RNAs in the transcriptional regulation of plan

210 e some work has demonstrated that pathogenic noncoding RNAs interact with host factors for function,

211 MicroRNAs (miRNAs) are small noncoding RNAs involved in post-transcriptional regulati

212 MicroRNAs (miRNAs) are short, noncoding RNAs involved in the regulation of several pro

213 Long noncoding RNAs may play important regulatory roles in so

214 molecule in the information network, whilst noncoding RNAs perform additional diverse functions.

215 Moreover, we found discrete long noncoding RNAs produced by H-strand transcription and en

216 tein-coding transcripts; and (4) twenty long noncoding RNAs specifically responsive to TRV vectors.

217 RESULT: Among all small noncoding RNAs studied, miRNAs displayed the most dynami

218 Abundant noncoding RNAs such as tRNAs, rRNAs, and spliceosomal RN

219 ble tool for functional studies of essential noncoding RNAs that are resistant to RNAi and RNase H-ba

220 Viroids are noncoding RNAs that can cause disease in plants.

221 MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression and organ fo

222 ymerases, Pol IV and Pol V, which synthesize noncoding RNAs that coordinate RNA-directed DNA methylat

223 miRNAs are evolutionarily conserved small noncoding RNAs that display important physiological effe

224 s (circRNAs) represent a class of endogenous noncoding RNAs that have recently been recognized as imp

225 rious noncoding RNAs in the brain, including noncoding RNAs that may play a role in psychiatric disea

226 MicroRNAs (miRNAs) are small, noncoding RNAs that modulate gene expression posttranscr

227 MicroRNAs (miRs) are small noncoding RNAs that play a critical role in gene regulat

228 croRNAs (miRNAs) constitute a class of small noncoding RNAs that plays an important role in the post-

229 MicroRNAs, a group of small, noncoding RNAs that post-transcriptionally regulate gene

230 MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression.

231 MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein translation by bind

232 The identities of muscle-enriched, long noncoding RNAs that regulate this process are unknown.

233 nd ASAR15 are monoallelically expressed long noncoding RNAs that remain associated with the chromosom

234 sengers by delivering signaling proteins and noncoding RNAs to alter target cell function.

235 PAP impacting lowly expressed mRNAs and long-noncoding RNAs to the greatest extent.

236 The presence of 6 additional small noncoding RNAs was also verified by TaqMan qPCR in produ

237 Of note, these noncoding RNAs were strongly up-regulated in the absence

238 ive, allowing the identification of numerous noncoding RNAs with key roles in biological processes.

239 e rich in transcription units encoding "long noncoding RNAs" (lncRNAs).

240 e the designation of more than 87 predicted "noncoding RNAs" to conventional mRNAs coded by protein-c

241 Of these noncoding RNAs, a growing number of long intergenic nonc

242 profiles of mRNAs, primary micro-RNAs, long noncoding RNAs, and enhancer RNAs in a large animal mode

243 altering protein-coding sequences, producing noncoding RNAs, and even supporting evolution of new pro

244 tion and predicts novel ORFs in 5'UTRs, long noncoding RNAs, and introns.

245 usand m(5)C sites in Arabidopsis mRNAs, long noncoding RNAs, and other noncoding RNAs across three ti

246 not only the levels of both mRNAs and small noncoding RNAs, but also their cytoplasmic compartmental

247 hancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2.

248 hape, but it's clear that in both coding and noncoding RNAs, dynamic modifications represent a new la

249 Typically, sRNAs, originating from long noncoding RNAs, guide Argonaute-containing effector comp

250 h has implicated microRNAs, a class of small noncoding RNAs, in diverse autoimmune diseases.

251 coding genes, mutations and misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRN

252 Little has been known about the role of noncoding RNAs, including microRNAs (miRNAs), in predisp

253 There is growing evidence that small noncoding RNAs, including miRNAs, can be targeted by the

254 Among these are genes that encode noncoding RNAs, including the microRNA (miRNA) family.

255 ortant functions in the 3'-end processing of noncoding RNAs, including the uridine-rich small nuclear

256 We review the involvement of noncoding RNAs, lncRNAs in particular, in development of

257 genome is transcribed into a broad array of noncoding RNAs, ranging in size from microRNA (20-23 nuc

258 types of all classes of RNAs, including long noncoding RNAs, several of which were confirmed as highl

259 approaches to advance understanding of long noncoding RNAs, we investigate the function of the telom

260 immune systems and the diverse functions of noncoding RNAs.

261 nonsense suppressor tRNAs and/or regulatory noncoding RNAs.

262 Most of these loci encoded long noncoding RNAs.

263 ranscribes all protein-coding genes and many noncoding RNAs.

264 of genes, gene regulatory regions, and long noncoding RNAs.

265 ding genes, and 567 putative long intergenic noncoding RNAs.

266 e posttranslational modifications, and small noncoding RNAs.

267 ies chromatin accessibility in the conserved noncoding sequence 3 (CNS3)/Accessible region 5 (AR5) re

268 sition syndrome caused by a duplication of a noncoding sequence near the gremlin 1, DAN family BMP an

269 Copy number variations (CNVs) often include noncoding sequences and putative enhancers, but how thes

270 r employed to characterize loss of conserved noncoding sequences associated with retained duplicate g

271 ng families identified germline mutations in noncoding sequences surrounding ACTRT1.

272 possibly involving epistatic interactions or noncoding sequences, have been critical in the ongoing e

273 However, coordination is less frequent for noncoding sequences, suggesting a larger role of splicin

274 ions (OCRs) might highlight disease-relevant noncoding sequences.

275 phospho-Thr4 in transcription termination at noncoding small nucleolar RNA (snoRNA) genes.

276 Noncoding SNPs, which represent the majority of GWAS SNP

277 ng analysis of lung adenocarcinomas revealed noncoding somatic mutational hotspots near VMP1/MIR21 an

278 This adjuvant consists of a 547-nt uncapped noncoding ssRNA containing polyU repeats that is stabili

279 ire sequence of the human genome (coding and noncoding) to fill in the missing heritability of comple

280 erging features that distinguish coding from noncoding transcription and discuss how these difference

281 ene regulation, and reveals a major role for noncoding transcription in animal development.

282 Noncoding transcription is a defining feature of active

283 e expression, including extremely widespread noncoding transcription.

284 lications for the functional consequences of noncoding transcription.

285 erentiation cascade that exhibits coding and noncoding transcriptional alterations, transcription fac

286 oupled to cleavage and polyadenylation while noncoding transcripts are terminated through the Nrd1-Na

287 ogens, including viruses, express pathogenic noncoding transcripts during infection.

288 d transcriptome profiling of coding and long noncoding transcripts in the three cell types during dif

289 Noncoding transcripts originating upstream of the immuno

290 iptional regulation for both coding and long noncoding transcripts.

291 This approach identified a noncoding variant, rs1990620, that differentially recrui

292 scuss several leading methods for annotating noncoding variants and how they can be integrated into r

293 best available methods in identifying human noncoding variants associated with inherited diseases.

294 approaches for functional assessment of most noncoding variants has bottlenecked gene discovery.

295 r disease risk variants, linking hundreds of noncoding variants to putative gene targets.

296 rrant splicing in DONSON due to one of these noncoding variants, showing a causative role for DONSON

297 e region but identified several nonconserved noncoding variants.

298 of these data to better prioritize impactful noncoding variation.

299 ypersensitive sites (DHSs) were annotated as noncoding, with 24% in intergenic, 12% in promoters, and

300 ng that the interplay between the coding and noncoding worlds represents a fundamental principle of S