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1  or displacement loop (D-loop), in the major noncoding region.
2 poliovirus lacking the entire genomic RNA 3' noncoding region.
3 3' end of the capsid gene and part of the 3' noncoding region.
4 e complete genome, including both coding and noncoding regions.
5 he entire genome of HSV-1 in both coding and noncoding regions.
6 riminate and identify functional elements in noncoding regions.
7 es was significantly greater for coding than noncoding regions.
8 limited sequence conservation found in these noncoding regions.
9 itates identification of critical coding and noncoding regions.
10 e utilized to assess polymorphic variants in noncoding regions.
11 enerally similar to those for the other four noncoding regions.
12  with DNA repeats localized in 15 apparently noncoding regions.
13 ociated genes, a lot of risk variants lie in noncoding regions.
14 ssion may be evolving differently from other noncoding regions.
15 nt than synonymous ones and substitutions in noncoding regions.
16 e defined, largely through comparison of the noncoding regions.
17 tein-coding regions and is rare or absent in noncoding regions.
18 atio tests for the detection of selection in noncoding regions.
19 e over time, some sequences are conserved in noncoding regions.
20 he synonymous sites of exons compared to the noncoding regions.
21 nsible for the compositional biases found in noncoding regions.
22  21, combining the information of coding and noncoding regions.
23  expressed chimeric mRNAs containing the HCV noncoding regions.
24  enrichment for coding regions compared with noncoding regions.
25  with a slight difference between coding and noncoding regions.
26 ymous mutation rate is 20-30% higher than in noncoding regions.
27 much less frequent in coding regions than in noncoding regions.
28 elevant editing events, many of which are in noncoding regions.
29 s and 10 to 21 short insertions/deletions in noncoding regions.
30 utionary changes in protein-coding genes and noncoding regions.
31 ent in frame-preserving events and events in noncoding regions.
32 ance, incomplete penetrance, or mutations in noncoding regions.
33 ) specificity and overprediction of genes in noncoding regions.
34 of protein coding genes resides within these noncoding regions.
35 ity levels decrease near exons and conserved noncoding regions.
36 e nif structural genes and in the intergenic noncoding regions.
37 ntified within the partial genomic region E2/noncoding region 2 (NCR2) will enable the simpler identi
38 within the partial E2 open reading frame and noncoding region 2.
39 he majority of these polymorphisms reside in noncoding regions, 241 SNPs and 10 indels alter the prot
40                            The poliovirus 3' noncoding region (3' NCR) is necessary for efficient vir
41                                       The 3' noncoding region (3' NCR) of flaviviruses contains secon
42  at nonstructural protein 5 (NS5) and the 3' noncoding region (3'NC) of DENV.
43 brain-expressed microRNAs (miRNAs) in the 3' noncoding region (3'NCR) of the flavivirus genome (chime
44  by comparing nucleotide sequences of the 3' noncoding region (3'NCR).
45                    There are two significant noncoding regions (377 and 294 bp), which are the best c
46 framework would reduce genotyping effort for noncoding regions 4-fold.
47                  The approximately 1.2-kb 5'-noncoding region (5'-NCR) of mRNA species encoding mouse
48 esses a selective binding element for the 5' noncoding region (5'NCR) of viral late mRNAs (known as t
49 majority of the GWAS signals were located to noncoding regions, a consistent outcome of all GWAS to d
50 V genome included an atypical, presumptively noncoding region absent in previously described hepadnav
51 le some studies show that highly constrained noncoding regions act to enhance transcription, other st
52  a very high level of accuracy in coding and noncoding regions alike.
53                          Moreover, conserved noncoding regions among Brassicaceae species are enriche
54 kbp cDNA contains exonic deletions in its 3' noncoding region and a 627-bp 5' truncation that elimina
55  the C2-V3 region of env of HIV-1 and the 5' noncoding region and a region of E1/E2 of HCV.
56 diated by an AU-rich element (ARE) in the 3' noncoding region and by interacting ARE-binding proteins
57  the combined effects of the viral 5' and 3' noncoding regions and 2a polymerase open reading frame.
58 The TGA triplet was also found more often in noncoding regions and as a stop codon, though the bias w
59 ments that control gene expression reside in noncoding regions and can be identified by mapping the b
60  identification of tissue-specific conserved noncoding regions and can simplify the analysis of ances
61 ranscripts, including rearrangements between noncoding regions and clinically relevant genes such as
62 ns a significant challenge, particularly for noncoding regions and distantly related species.
63 nucleotide sequence similarity in coding and noncoding regions and encode identical apoplastic protei
64  humans, 5'CCR5 was more diverse than 90% of noncoding regions and had an excess of common variants.
65                 However, most loci reside in noncoding regions and have unknown biological functions.
66 ns segregating in natural populations are in noncoding regions and provide no evidence for local tran
67 t that ribosomes frequently enter downstream noncoding regions and that Dom34 carries out the importa
68 panzees, 5'CCR5 was less diverse than 80% of noncoding regions and was characterized by an excess of
69 ortion, 10%, encode 2-8 genes), have minimal noncoding regions, and are differentially amplified to a
70 ldin 4 (PFDN4), coregulated genes, conserved noncoding regions, and associate repetitive elements wit
71 ructure, gene and repeat contents, conserved noncoding regions, and relative rates of sequence evolut
72 ited in long stem-loop structures located in noncoding regions, and thus contrast with previously ide
73 ecific DNA, exons, and conserved (coding and noncoding) regions, and to identify rodent evolutionary
74 ing both intergenic regions and, especially, noncoding regions antisense to known open reading frames
75                                              Noncoding regions are also associated with disease; howe
76                                              Noncoding regions are usually less subject to natural se
77 us RNA segments are located in the 5' and 3' noncoding regions as well as in the terminal regions of
78                    This identity encompasses noncoding regions as well as multiple mobilization seque
79 us RNAs (vRNAs) are located in the 5' and 3' noncoding regions, as well as in the terminal regions, o
80 anzee prolactin gene sequences suggests that noncoding regions associated with regulating expression
81 us analyses investigating the implication of noncoding regions at the EBOV gene borders for gene expr
82 ains three potential regulatory sites within noncoding regions at the gene's 3' end, where alternativ
83 cs approach to identify conserved coding and noncoding regions at these genes and resequenced them in
84                    We studied the pattern in noncoding regions, because they are less affected by nat
85 SV-2 sequences from seven regions, including noncoding regions between UL19 and UL20, UL24 and UL25,
86 ntial to dissect the functional landscape of noncoding regions, but is highly susceptible to false di
87  Since a similar effect is also found in the noncoding regions, but is present for all adjacent nucle
88                   In contrast, expansions in noncoding regions cause RNA-mediated toxicity.
89 utside of the IG loci, predominantly targets noncoding regions causing numerous "passenger" mutations
90  Single nucleotide polymorphisms (SNPs) in a noncoding region close to the CDKN2a/b senescence genes
91  The PhiCD119 attachment site attP lies in a noncoding region close to the putative integrase (int) g
92 ggesting that these evolutionarily conserved noncoding regions (CNCs) are selectively constrained and
93 sequence analyses revealed several conserved noncoding regions (CNRs) upstream of beta4 and alpha5.
94 the introduction of four mutations in the 5' noncoding region compared to the present vaccine.
95 ine loses the attenuating mutation in the 5' noncoding region completely.
96    Sequencing of a 150-bp fragment of the 5' noncoding region confirmed EV-D68 in 16 of 506 respirato
97 is study, we tested the hypothesis that ITS1 noncoding regions contain diagnostically useful alleles.
98 binant mitochondrial genomes showed that the noncoding region, containing origins of replication, gov
99 e genome-wide significant loci in introns or noncoding regions could affect regulation of genes nearb
100                                              Noncoding regions could be further fractionated into pro
101 g (ND1, ND4, ND5, and cytochrome b genes) or noncoding regions (D-loop) of the mitochondrial genome.
102 on-PCR (RT-PCR) assay targeting the viral 5' noncoding region defined by sequences obtained from all
103 uence-based approach to characterize a large noncoding region deleted in patients affected by Van Buc
104  that poliovirus RNA harboring a complete 3' noncoding region deletion mutation is infectious (not me
105 ot provide compensatory functions for the 3' noncoding region deletion mutation replication defect.
106 r analyze the consequences of the genomic 3' noncoding region deletion, we examined viral RNA replica
107 ted by copy number alterations, mutations in noncoding regions, dysregulation of microRNA, epigenetic
108 ng editing in exons, but also the editing in noncoding regions (e.g., Alu-repetitive elements and mic
109  sought to identify evolutionarily conserved noncoding regions (ECRs) and motifs shared among them, w
110  for the validity of the rules in coding and noncoding regions, especially for the CIImono rule.
111 ains of ENBA1, in addition to aberrations in noncoding regions, especially in BamHI A rightward trans
112                We find that over 5000 distal noncoding regions exhibit dynamic changes in chromatin a
113 ns, flanking intronic regions, and conserved noncoding regions for variations in COL1A1, COL1A2, COL2
114 rand RNA synthesis, we deleted the entire 3' noncoding regions from human rhinovirus and poliovirus g
115 isorders, expansion of repeated sequences in noncoding regions gives rise to RNA that produces a toxi
116                         Copy number gains of noncoding regions harboring super-enhancers near KLF5, U
117 tDNA) mutations scattered through coding and noncoding regions have been reported in cancer.
118 romic repeat (CRISPR) mutagenesis screens of noncoding regions have emerged as a novel method for fin
119                             We identified 92 noncoding regions highly conserved (>70%) between human
120  of selection we sequenced the homologous 5' noncoding region in chimpanzees, bonobos, a gorilla, an
121 eam terminal similar95 nucleotides of the 3' noncoding region in flavivirus RNA.
122 d we sequenced the coding exons and flanking noncoding regions in 450 asthmatic cases and 515 nonasth
123 her the remaining families have mutations in noncoding regions in BRCA1, mutations in other, as-yet-u
124 is performance in distinguishing coding from noncoding regions in DNA sequences.
125  and UTRs, emphasizing the importance of the noncoding regions in EBOV gene expression control.
126 clusters, in regulatory regions dispersed in noncoding regions in genomic DNA.
127 xplored the evolutionary pressures acting on noncoding regions in Mononegavirales genomes and observe
128 blem, we identified evolutionarily conserved noncoding regions in primate, mammalian, and more distan
129 published 5'CCR5 data from 112 humans and 50 noncoding regions in the human and chimpanzee genomes.
130 ency), there is extensive transcription from noncoding regions, including both intergenic regions and
131     However, the addition of characters from noncoding regions increased the number of parsimony-info
132 icantly higher F(ST) estimates than those in noncoding regions, indicating adaptive evolution in the
133                             When a site in a noncoding region is evolving neutrally zeta = 1, while z
134 imiting in neuronal cells, the poliovirus 3' noncoding region is involved in positive-strand synthesi
135 expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility.
136  C. difficile chromosome (attB) located in a noncoding region just upstream of gene gltP, which encod
137 bstrate through which genetic differences in noncoding regions may affect cellular function and respo
138                                        These noncoding regions may be involved in directing neuronal
139                 It was found that the HCV 3' noncoding region modulates neither the translation nor t
140  of mutations within the conserved 3' and 5' noncoding regions, most likely due to error-prone BMV RN
141 e subtype determined from analysis of the 5' noncoding region (NC) or the nonstructural protein gene
142 eals retention of three primers in the major noncoding region (NCR) and one at the prominent lagging-
143 e transcripts, a miRNA located within a long noncoding region (NCR) of the genome.
144                                       The 5' noncoding region (NCR) of the viral genome functions as
145                                 The terminal noncoding region (NCR) sequences of the eight gene segme
146 c GBV-B containing an HCV insert from the 5' noncoding region (NCR) that was adapted for efficient re
147 ns included substitution of the entire PV 5' noncoding region (NCR) with the encephalomyocarditis vir
148 nting for approximately two-thirds of the 5' noncoding region (NCR).
149 specific packaging signals that include both noncoding regions (NCRs) and adjacent terminal coding re
150 inds to AU-rich elements, or AREs, in the 3' noncoding regions (NCRs) of mRNAs to affect the stabilit
151 gate the contributions of the long 5' and 3' noncoding regions (NCRs) of the S genomic segment to in
152 onfirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of
153 ls for type 2 diabetes risk are located in a noncoding region near CDKN2A.
154  alterations, including partial deletions of noncoding regions not typically captured or considered p
155 observation, combined with identification of noncoding region nucleotide changes in potential cis-act
156  small noncoding RNA (BocaSR), within the 3' noncoding region (nucleotides [nt] 5199 to 5338) of the
157 xanucleotide (GGGGCC) repeat expansions in a noncoding region of C9ORF72 are the major genetic cause
158      The GGGGCC (G4C2) repeat expansion in a noncoding region of C9orf72 is the most common cause of
159 ave a hexanucleotide repeat expansion in the noncoding region of chromosome 9 open reading frame 72 (
160                                          The noncoding region of exon 2 of the p73 gene has two polym
161            A new mutation within an upstream noncoding region of FOXP3 results in a variant of IPEX s
162  internal ribosome entry site, within the 5' noncoding region of genomic RNAs, were presumed to reduc
163 site-mediated translation directed by the 5' noncoding region of HCV and GRP78 is activated in cells
164  consensus primer/probe set targeting the 5' noncoding region of HRV.
165 cy virus type 2 (HIV-2) is present in the 5' noncoding region of RNA and contains a 10-nucleotide pal
166 gh introduction of a kan-gfp cassette into a noncoding region of the 200-kb B. hermsii linear plasmid
167 omosomal breakpoint is located within the 5' noncoding region of the BCL-6 proto-oncogene where the B
168 s of a hexanucleotide repeat (GGGGCC) in the noncoding region of the C9orf72 gene are the most common
169 exanucleotide GGGGCC repeat expansion in the noncoding region of the C9ORF72 gene is the most common
170  luxAB reporter genes were integrated into a noncoding region of the CDC plague-diagnostic phage phiA
171 ant hexanucleotide (GGGGCC) expansion in the noncoding region of the chromosome 9 open reading frame
172 nt oncogenic transgene (targeted into the 3' noncoding region of the cytoplasmic beta-actin locus) th
173  specific three-dimensional structure in the noncoding region of the ferritin mRNA model that is reco
174              CGG repeat expansions in the 5' noncoding region of the fragile X mental retardation 1 g
175 d by inserting the Puro-EGFP cassette into a noncoding region of the FV3 genome (FV3-Puro/GFP).
176 lmost all risk variants are localized to the noncoding region of the genome; therefore, the role of t
177 ensive base-pairing interactions with the 5' noncoding region of the hepatitis C virus (HCV) RNA geno
178            We studied the DNA diversity of a noncoding region of the homologous genes DD44Y and DD44X
179                 Deletion of most of the long noncoding region of the hPIV1 F gene in rSVhMFjCG in add
180 tructs under the control of the 1.2 kb of 5' noncoding region of the human CD40L gene, we have found
181                                       The 5' noncoding region of the picornaviral genome begins with
182  the gene, designated opdB, in an apparently noncoding region of the T. denticola genome unannotated
183 netic interaction between miR-122 and the 5' noncoding region of the viral genome was revealed by mut
184  designed to specifically target an 18-bp 5' noncoding region of the viral genome.
185 ified a novel HBoV1 gene that lies in the 3' noncoding region of the viral positive-sense genome and
186 cture within a CpG island in the 5'-flanking noncoding region of this gene.
187 the LD analysis, we surveyed both coding and noncoding regions of 66 DNA fragments from 47 accessions
188 scent transcripts associated with coding and noncoding regions of Abd-B in developing embryos.
189                                          The noncoding regions of ATM had diversity values comparable
190  structures were inserted at the modified 3' noncoding regions of BMV RNA3 and RNA2 in either positiv
191                          All eight mapped to noncoding regions of BMV RNAs, and the positions of seve
192 ncing efforts should not ignore the study of noncoding regions of cancer patients.
193 tic switches has been found to reside within noncoding regions of certain bacterial mRNAs.
194          Previous phylogenetic studies using noncoding regions of chloroplast DNA and rDNA internal t
195 t the population level can be detected using noncoding regions of DNA.
196 ll help identify regulatory sequences in the noncoding regions of genes and contribute to our underst
197 otifs in putative enhancers found within the noncoding regions of genes having heart expression.
198       The identification of sequences within noncoding regions of genes that are conserved between se
199  biases (excess of G over C and T over A) in noncoding regions of genes.
200 r-type-specific indel hotspots targeting the noncoding regions of highly expressed genes defining cer
201  overwhelming, making it prudent to focus on noncoding regions of known function, for which the effec
202 ches are complex folded RNA domains found in noncoding regions of mRNA that regulate gene expression
203 tructured domains that usually reside in the noncoding regions of mRNAs, where they bind metabolites
204 karyotic genomes and is especially common in noncoding regions of plants.
205  addition, this study pinpoints thousands of noncoding regions of relevance to both Mendelian and com
206 ed by expansions of repeating nucleotides in noncoding regions of RNA.
207           For a subset of diseases, however, noncoding regions of RNAs assume a primary toxic gain-of
208  1 and type 2 strains in which the entire 5' noncoding regions of Sabin 1 and Sabin 2 were replaced e
209  specific sequences or structures present in noncoding regions of some EBV mRNAs.
210 ressivity of HOS, we screened the coding and noncoding regions of TBX5 and SALL4 for mutations in 55
211 e still unknown, and many possibly reside in noncoding regions of the ABCA4 locus.
212 mic rearrangements or mutations occurring in noncoding regions of the ABCC6 gene.
213 e regions of significant conservation in the noncoding regions of the BAC.
214 prion protein expression by the promoter and noncoding regions of the bovine and murine Prnp genes.
215 a subgroup were up to several times those in noncoding regions of the Drosophila genome.
216                   Variation in the coding or noncoding regions of the gene could potentially affect t
217 genome-wide association studies are found in noncoding regions of the genome and are likely to involv
218 egulatory roles played by noncoding RNAs and noncoding regions of the genome during cancer progressio
219            Interpreting genetic variation in noncoding regions of the genome is an important challeng
220                                The role that noncoding regions of the genome play in the etiology of
221 he associated variants are overwhelmingly in noncoding regions of the genome where we have few guidin
222 in genome-wide association studies reside in noncoding regions of the genome with regulatory roles.
223       Genetic risk factors often localize to noncoding regions of the genome with unknown effects on
224 enome-wide association studies (GWAS) are in noncoding regions of the genome, a common polymorphism i
225 ation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehen
226 nals for type 2 diabetes risk are located in noncoding regions of the genome, hindering translation i
227  widespread transcription in both coding and noncoding regions of the genome, including differential
228 ting sites have unknown functions and are in noncoding regions of the genome.
229 ered in the search and are located mainly in noncoding regions of the genome.
230 e believed to be restricted to the 5' and 3' noncoding regions of the genome.
231 the novel loci; the majority of which are in noncoding regions of the genome.
232 ever, the vast majority of these SNPs lie in noncoding regions of the genome.
233 nts included large deletions and variants in noncoding regions of the genome.
234  on novel regulatory functions of p53 within noncoding regions of the genome.
235   Nucleotide substitutions were found in the noncoding regions of the genomes as well as in all codin
236 ic workflow, we assessed both the coding and noncoding regions of the human genome, including the eva
237  to single-nucleotide polymorphism data from noncoding regions of the human genome.
238 t, we demonstrated that DNA sequences in two noncoding regions of the Kaposi's sarcoma-associated her
239 alignments, we found one or more CNSs in the noncoding regions of the majority of genes studied.
240 ally mutate coding sequences and/or the vast noncoding regions of the mouse genome for large-scale fu
241 Still, more than half of the hotspots lie in noncoding regions of the mouse genome.
242 t natural patterns of molecular variation in noncoding regions of the nuclear genome accurately refle
243 ing regions and faster elongation within the noncoding regions of the operon.
244                  The genetic stability of 5' noncoding regions of these viruses matched that of the t
245 n addition, 6 differences were identified in noncoding regions of transcribed mRNA, and 1 silent codo
246 ith high affinity to sites located in the 5' noncoding regions of two additional cp32 genes.
247                Following the Gag-Pol ORF are noncoding regions of ~0.7 and 2 kb, which, respectively,
248 ith initiation factor eIF4G and the viral 5' noncoding region on viral late mRNAs, known as the tripa
249 SNPs was one SNP per 46 bp across coding and noncoding regions on average.
250       Here we build on a continuing study of noncoding regions on the X chromosome in a panel of 41 g
251 s performed on IGH (~1650 nt) and nine other noncoding regions potentially targeted by AID (combined
252       Of particular interest are MCSs within noncoding regions previously shown to contain GDF6 regul
253           An AU rich element (ARE) in the 3' noncoding region promotes the rapid degradation of mamma
254 quence includes an astonishing collection of noncoding regions, regulatory modules, deadbeat pseudoge
255                  The rate of substitution in noncoding regions relative to the rate of synonymous sub
256          We show that one of these conserved noncoding regions represents a transcriptional enhancer
257 creens to interrogate functional elements in noncoding regions requires generating sgRNA libraries th
258              Data from 10 unlinked autosomal noncoding regions, resequenced in 15 individuals from ea
259 n expanded data set of 50 unlinked autosomal noncoding regions, resequenced in samples of Hausa from
260 identified 30 and 5 insertions in coding and noncoding regions, respectively.
261 aled that deleting the poliovirus genomic 3' noncoding region resulted in a positive-strand RNA synth
262 eys of worldwide DNA variation in four 10-kb noncoding regions revealed many interesting but also som
263  evolution in human or chimp, as compared to noncoding regions showing accelerated evolution in mouse
264                                       Within noncoding regions, SNPs in regulatory elements are more
265 dentified 14 methylation peaks in coding and noncoding regions, splicing junctions and splicing regul
266 region is similar to that for the other long noncoding regions studied to date, providing evidence fo
267 copies due to rapid divergence of coding and noncoding regions such that neither retains the complete
268 ity of shared disease-associated variants in noncoding regions suggests they contribute to risk of au
269 re, we analyzed how diverse gene borders and noncoding regions surrounding the gene borders influence
270 tential, A/T richness, insertion bias toward noncoding regions, terminal inverted repeats (TIRs), tar
271 s from published studies (in both coding and noncoding regions) than the recently proposed CADD score
272 e genetic changes in both protein-coding and noncoding regions that affect brain development and evol
273 and other sources to systematically identify noncoding regions that are recurrently mutated in cancer
274 h the expansion of microsatellite repeats in noncoding regions that result in the synthesis of pathog
275 ination rates are increased around conserved noncoding regions that show accelerated evolution in hum
276 phylogenetic comparison identified conserved noncoding regions that stimulate transcriptional activit
277  contain AU-rich elements (AREs) in their 3' noncoding regions that target them for degradation.
278 o amplify cDNA originating from the viral 5' noncoding region, the amplified product mixture was trea
279 e that germline mutations in both coding and noncoding regions throughout the BAP1 gene can impair pr
280 attern of nucleotide variation at DPS2002, a noncoding region tightly linked to a paracentric inversi
281 tes channel function in vivo, and identify a noncoding region underlying this regulation.
282 ation sites, open reading frames, regulatory noncoding regions, untranslated regions and transcriptio
283 ch occurred in ORF 10, ORF 21, ORF 62, and a noncoding region upstream of ORF 64.
284 eotide polymorphisms that occur in conserved noncoding regions upstream of genes and identifying CpG
285 pressure and detecting positive selection in noncoding regions using multiple aligned DNA sequences.
286              To determine whether editing in noncoding regions was a conserved ADAR function, we appl
287                  Conservation of a number of noncoding regions was observed; one coincides with an el
288                    Combining three autosomal noncoding regions, we estimated the long-term effective
289 ne candidates containing deletions in the 3' noncoding region were prepared by passage in DBS-FRhL-2
290 ns within the open reading frames (ORFs) and noncoding regions were identified and compared with the
291       The polymorphism rates from coding and noncoding regions were significantly different (0.07% an
292                           We show that viral noncoding regions were sufficient to drive gene expressi
293 rase coding region, followed by different 3' noncoding regions, were expressed in the cytoplasm of cu
294 ciphering the functionality of coding versus noncoding regions when interpreting GWAS data.
295                Here we studied another 10-kb noncoding region, which is in 6p22.
296 ative genomic analysis to identify conserved noncoding regions, which were resequenced for single nuc
297 or the encoded protein, whereas most fall in noncoding regions with potential to regulate gene expres
298 ong the entire chromosome in both coding and noncoding regions, with an enrichment at the 5' end of g
299                  We analyzed both coding and noncoding regions, with the former corroborating the lat
300  sequences revealed several highly conserved noncoding regions within 30 kb of the Dlx3-7-coding regi

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