ライフサイエンスコーパス: noncompetitive

1 ner, whereas the interaction of VU0360172 is noncompetitive.

2 5-(11)C-methoxy-donepezil, a noncompetitive acetylcholinesterase ligand, was previous

3 A kinetic model for transport describing the noncompetitive action of ibogaine and the competitive ac

4 es with Nodal and activin and functions as a noncompetitive activin antagonist.

5 vely, and are uncompetitive against NADH and noncompetitive against alpha-Kg and lysine, respectively

6 novel allosteric Syk inhibitor, X1, that is noncompetitive against ATP (K(i) 4 +/- 1 muM) and substr

7 e novo design of a potent and selective C5aR noncompetitive allosteric inhibitor, DF2593A, guided by

8 Reparixin and ladarixin, noncompetitive allosteric inhibitors, were used to pharm

9 cterization showed that the compounds act as noncompetitive allosteric inhibitors.

10 extracellular collar, the binding region for noncompetitive allosteric inhibitors.

11 ows an insurmountable blockade, indicating a noncompetitive allosteric mechanism of action.

12 two compounds (23 and 26) is consistent with noncompetitive allosteric modulation of dopamine signali

13 nce or inhibit one another by competitive or noncompetitive (allosteric) mechanisms.

14 n be used to analyze ATP-competitive and ATP-noncompetitive/allosteric kinase inhibitors.

15 e prevented by treatment with the prototypic noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazol

16 ogy experiments showed mixed competitive and noncompetitive alpha-Ctx action.

17 le member of the 2,3 benzodiazepine class of noncompetitive AMPA glutamate receptor antagonists.

18 here, for the first time, the discovery of a noncompetitive AMPA receptor antagonist that is dependen

19 Their agonistic actions are noncompetitive and allow for simultaneous binding of two

20 s indicate, however, that this inhibition is noncompetitive and caused by the interaction of clotrima

21 the inhibition kinetics are mixed, with both noncompetitive and competitive components, and fluoresce

22 ing this technique, we developed methods for noncompetitive and competitive immunoassays, using thyro

23 nzotriazolyl species makes the leaving group noncompetitive and generates the nucleofuge that has bee

24 nanoparticles is the basis of the developed noncompetitive and homogeneous method for the estimation

25 ization characteristics that appear entirely noncompetitive and potentially beneficial.

26 It is a noncompetitive and reversible inhibitor of 20S proteasom

27 rmacologically targeting the linkers through noncompetitive and subunit-specific modes of action.

28 antagonists are classified as competitive or noncompetitive and surmountable or insurmountable based

29 t QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unco

30 ced by these quinazolin-4-one derivatives is noncompetitive and voltage-independent, suggesting that

31 and efficient identification of competitive, noncompetitive, and covalent inhibitors of MIF in a mann

32 various inhibition mechanisms (competitive, noncompetitive, and mixed), with sub- and low micromolar

33 the substituted quinoline HG-829 as a novel, noncompetitive, and potent P-glycoprotein inhibitor that

34 and 5d were identified as extremely potent, noncompetitive, and reversible FAAH inhibitors endowed w

35 h reduced desensitization (type II PAMs), 4) noncompetitive antagonism (NAMs), and 5) compounds that

36 ted neuroactive steroids, those that exhibit noncompetitive antagonism of GABA(A) receptors, altered

37 or binding to cell surface alpha4beta1 shows noncompetitive antagonism.

38 s (IC50 = 600 microM) and the binding of the noncompetitive antagonist [3H]tetracaine to nAChR-rich m

39 Suramin, which is a noncompetitive antagonist at wild-type P2X2 receptors, h

40 e apparent agonist strength of the otherwise noncompetitive antagonist citral.

41 We describe that MMPIP acts as a noncompetitive antagonist in calcium mobilization assays

42 kine CX516 and modulating the NMDAR with the noncompetitive antagonist memantine.

43 yl)-vinyl]-6-fluoro- 3H-quinazolin-4-one), a noncompetitive antagonist of AMPA-selective glutamate re

44 Picrotoxin (PTX) is a noncompetitive antagonist of many ligand-gated ion chann

45 Derquantel was a noncompetitive antagonist of nicotine, revealing N-type

46 Ketamine is a potent noncompetitive antagonist of the N-methyl-D-aspartate gl

47 er donors to the acceptor, crystal violet, a noncompetitive antagonist of the nAChR.

48 this pattern of fluorescence change, but the noncompetitive antagonist picrotoxin failed to elicit op

49 ent nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist, binds with higher affinity in

50 BP acted as a low potency noncompetitive antagonist, reversibly inhibiting the ACh

51 nt glucagon-like peptide-1 receptor (GLP-1R) noncompetitive antagonist.

52 inistration of phencyclidine (PCP), an NMDAR noncompetitive antagonist.

53 s a nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist.

54 to pH sensor of ASIC1a acting as orthosteric noncompetitive antagonist.

55 centrations, it inhibited the binding of the noncompetitive antagonists [(3)H]tetracaine and [(3)H]ph

56 sition 6, respectively, were the most potent noncompetitive antagonists at the NMDA receptor with IC5

57 This new class of noncompetitive antagonists could provide an opportunity

58 Fourteen noncompetitive antagonists of widely diverse chemotypes

59 We investigated the approach of using noncompetitive antagonists to regulate alpha7 receptor f

60 ostatic stabilization of ions and binding of noncompetitive antagonists within the channel.

61 ntaneously open and highly sensitive to many noncompetitive antagonists(NCAs) and Zn(2+).

62 offer an alternative strategy that combines noncompetitive antibodies to achieve robust degradation

63 Noncompetitive appearing kinetics for such inhibitors is

64 The potency and the selectivity of this noncompetitive aptamer rival those of small molecule inh

65 The noncompetitive assay developed with these chimeras perfo

66 We report here a generic noncompetitive assay for cyanobacterial microcystins (MC

67 for the first time, a new strategy using the noncompetitive assay format via a biomimetic material, n

68 The noncompetitive assay is based on the use of recombinant

69 reptavidin and used them to setup phage-free noncompetitive assays for the herbicide clomazone (MW 24

70 ode of antagonism of ticagrelor also appears noncompetitive, at least functionally.

71 The noncompetitive behavior suggests the existence of sorpti

72 We have used this approach to confirm the noncompetitive binding of alitame and cyclamate to the r

73 ory targeted nonagonist binding sites (i.e., noncompetitive binding sites, negative allosteric bindin

74 the development of pharmacophore models for noncompetitive binding sites.

75 played a concentration-dependent, reversible noncompetitive blockade of AP-sensitive tonic current in

76 TETS is a noncompetitive blocker of the GABA type A receptor (GABA

77 methyl]phenylboronic acid (SX-517), a potent noncompetitive boronic acid CXCR1/2 antagonist.

78 in can simultaneously bind KAP1 and SRY in a noncompetitive but also noncooperative manner.

79 The inhibition was noncompetitive, but not due to open channel block.

80 evaluate the role of MyD88 in T cells under noncompetitive conditions, bone marrow chimeras were gen

81 nism-based, competitive or mixed competitive-noncompetitive CYP3A4 inactivator.

82 sulted in the identification of two bivalent noncompetitive D3R-selective antagonists, 18a and 25a, w

83 phage anti-immunocomplex assays (PHAIA) for noncompetitive detection of small molecules.

84 ; (-)-2-amino-5-phosphonopentanoic acid] and noncompetitive (dizocilpine, or MK-801 [(5S,10R)-(+)-5-m

85 e baseline assessment, 12.6% reported other (noncompetitive) employment activity, and 72.9% reported

86 partially inhibited by rapamycin/FKBP12 in a noncompetitive fashion toward ATP.

87 cyl-CoA-to-CoA ratio), whereby CoA acts as a noncompetitive feedback inhibitor through interaction wi

88 The inhibition was shown to be noncompetitive for both natural enzyme substrates (d-luc

89 the detection of these small molecules in a noncompetitive format (PHAIA) with increased sensitivity

90 ed in an assay for rabbit IgG in a sandwich (noncompetitive) format.

91 e the most potent, selective, and reversible noncompetitive IMAO-B.

92 When the noncompetitive immune complex assay was compared to the

93 A broad-spectrum noncompetitive immunoassay allowing sensitive and simple

94 Noncompetitive immunoassays are advantageous over compet

95 facilitate the development of sandwich-type noncompetitive immunoassays for the detection of small a

96 ensitivity and direct proportional signal of noncompetitive immunoassays to develop a new Phage Anti-

97 used to develop a single-step sandwich-type noncompetitive immunocomplex assay.

98 Serum NT-proBNP was quantified using a noncompetitive immunoluminometric assay.

99 m), whereas a Ubc5BC85A product analog shows noncompetitive inhibition (Ki = 2.2 +/- 0.5 mum), consis

100 exhibited competitive inhibition for ATP and noncompetitive inhibition against ATF2.

101 In contrast, noncompetitive inhibition by a UbcH7C86A product analog

102 We find that transinhibition is due to noncompetitive inhibition by L-methionine, much like a n

103 proteins by differentiating competitive and noncompetitive inhibition demonstrates its ability as a

104 hibition in regard to external [K(+)] versus noncompetitive inhibition in respect to external [Cl(-)]

105 This study demonstrates that noncompetitive inhibition kinetics describe the impact o

106 , the hydroxamic acid, SC81956, demonstrated noncompetitive inhibition kinetics with a Ki of 23 nM.

107 time-dependent inhibitors of PC2, exhibiting noncompetitive inhibition kinetics; the most potent inhi

108 Our results represent a molecular view into noncompetitive inhibition of a sodium-coupled transporte

109 UCPH-101 exhibits noncompetitive inhibition of EAAT1, and its binding site

110 te of the FXIa-LC by S-2366 also resulted in noncompetitive inhibition of FIX activation.

111 tory compound, termed JF5, also demonstrated noncompetitive inhibition of the alpha(2A)-adrenergic re

112 resulting in binding to activated fVIII and noncompetitive inhibition of the intrinsic fXase complex

113 d that copper (I) and (II) cations displayed noncompetitive inhibition of the LC (Ki approximately 1

114 r-Burk plots indicated mixed competitive and noncompetitive inhibition of the protease by BV.

115 l molecule analinopyrimidine, exhibited pure noncompetitive inhibition versus ATF2 and competitive in

116 hibits competitive inhibition versus ATP and noncompetitive inhibition versus cysteine, with an inhib

117 such compound, ALS 1-0635, indicated linear, noncompetitive inhibition, and Dixon plot analysis from

118 Consistent with the observed time-dependent noncompetitive inhibition, the cocrystal X-ray structure

119 by the lack of a structural understanding of noncompetitive inhibition.

120 ve inhibitor anakinra (Kineret) and a potent noncompetitive inhibitor 101.10, for efficacy in blockin

121 This peptide functioned as a noncompetitive inhibitor against ATP.

122 ydrolysis of UDP-2,3-diacylglucosamine, is a noncompetitive inhibitor against both substrates.

123 t the peptide substrate and most likely as a noncompetitive inhibitor against NAD(+).

124 titive inhibitor against R-3-OHC14-ACP and a noncompetitive inhibitor against UDP-3-O-(R-3-OHC14)-Glc

125 Cytochalasin B (CB) is a reversible, noncompetitive inhibitor of 3MG uptake with Ki(app) = 0.

126 theta-Defensin RTD-1 is a noncompetitive inhibitor of anthrax lethal factor (LF) p

127 the viscosity of the medium using PEG-400, a noncompetitive inhibitor of ATPase activity.

128 Additionally, the compound is a noncompetitive inhibitor of daunorubicin (MRP1), calcein

129 e substrate, we demonstrate that E acts as a noncompetitive inhibitor of detergent-solubilized MraY,

130 action surface of SUMO1 with DPP9, acts as a noncompetitive inhibitor of DPP9.

131 f migrating neurons with Dynasore, a soluble noncompetitive inhibitor of Dynamin, rapidly arrests the

132 s substrates demonstrated that I3C acts as a noncompetitive inhibitor of elastase activity with an in

133 ells and characterized as a slow, tight, and noncompetitive inhibitor of factor (F) XIa by a mechanis

134 nt form of vitamin E present in humans, is a noncompetitive inhibitor of glutathione S-transferase pi

135 s more accurately described as a reversible, noncompetitive inhibitor of LPL.

136 bistatin is a small-molecule, high-affinity, noncompetitive inhibitor of myosin II.

137 rons of NAD(+) with FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosylt

138 transport substrate clotrimazole, which is a noncompetitive inhibitor of Pdr5 ATPase activity, has a

139 containing residues 1-14 of GRK2 served as a noncompetitive inhibitor of receptor phosphorylation by

140 coralloides synthesizes corallopyronin A, a noncompetitive inhibitor of RNA polymerase ineffective a

141 e (3MG) uptake with Ki(app) = 6 mum but is a noncompetitive inhibitor of sugar exit.

142 ysis characterized NSC48300 as a reversible, noncompetitive inhibitor of Taspase1 (K(i) = 4.22 mumol/

143 In contrast, PAB was found to be a noncompetitive inhibitor of the activation of the macrom

144 idinyl)-2,4-dichlorobenzamide 5 (BPDBA) is a noncompetitive inhibitor of the betaine/GABA transporter

145 We have previously shown that TriCHQ is a noncompetitive inhibitor of the thiol-disulfide exchange

146 TriCHQ acts as a noncompetitive inhibitor of the thiol-disulfide exchange

147 cated in the channel pore and equates with a noncompetitive inhibitor site found in many pLGICs.

148 line agent to treat hypertension, and by the noncompetitive inhibitor tetrabenazine, presently in use

149 Our results show that the aptamer is a noncompetitive inhibitor that selectively inhibits the G

150 sults show that the aptamer we isolated is a noncompetitive inhibitor that selectively inhibits the o

151 tion of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent on

152 HGA, is a competitive inhibitor vs 4PE and a noncompetitive inhibitor vs alpha-ketoglutarate.

153 The most potent compound behaves as a noncompetitive inhibitor with a Ki of 0.7 microM and sho

154 We found that BDZ-f is a noncompetitive inhibitor with a slight preference for th

155 gh the screen was further characterized as a noncompetitive inhibitor with both ATP and PLK-peptide a

156 o the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to AdoMet, the met

157 ive with respect to pyrophosphate (PP(i)), a noncompetitive inhibitor with respect to ATP, but at >10

158 in part by the cellular concentrations of a noncompetitive inhibitor, nicotinamide, that reacts with

159 Complete inhibition of aromatase with ATD, a noncompetitive inhibitor, significantly and similarly re

160 ependent manner and that azide is a mixed or noncompetitive inhibitor.

161 tion site on the enzyme was identified for a noncompetitive inhibitor.

162 Kinetic studies showed that PDPA is a mixed (noncompetitive) inhibitor versus dUMP.

163 The products behaved as noncompetitive inhibitors according to studies using the

164 oped herein allowed identifying new original noncompetitive inhibitors against cN-II that act in a sy

165 rs from compound library screens because ATP-noncompetitive inhibitors are often weaker and commonly

166 inase 4 (CDK4) and the identification of ATP-noncompetitive inhibitors by high-throughput screening a

167 Lastly, compounds known to act as noncompetitive inhibitors exhibited parallel concentrati

168 designing conformation-specific, more potent noncompetitive inhibitors for the GluR2 AMPA receptor.

169 There are challenges to identifying ATP-noncompetitive inhibitors from compound library screens

170 enation of arachidonic acid (AA) but potent, noncompetitive inhibitors of 2-arachidonoylglycerol (2-A

171 PAR1-wt exodomain and P4 and P3 mutants were noncompetitive inhibitors of alpha-thrombin hydrolyzing

172 e, highly potent, and conformation-selective noncompetitive inhibitors of AMPA receptors.

173 reas both compounds behaved as tight-binding noncompetitive inhibitors of FabI.

174 inhibitor of Klenow fragment and two strong noncompetitive inhibitors of HIV-1 reverse transcriptase

175 ternate amino acids act as rapid equilibrium noncompetitive inhibitors of MtIPMS failing to display b

176 hat these aryl diketoacid derivatives act as noncompetitive inhibitors of PTP1B.

177 Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (A

178 ucleotide exchange on beta-tubulin, and were noncompetitive inhibitors of the binding of radiolabeled

179 cid esters have recently been reported to be noncompetitive inhibitors of the N-acylethanolamine acid

180 analysis indicates that these compounds are noncompetitive inhibitors of the p-hydroxyphenylpyruvate

181 NNRTIs are noncompetitive inhibitors that bind in a hydrophobic poc

182 n growing interest in the development of ATP-noncompetitive inhibitors to overcome these problems.

183 studies that analogues of this chemotype are noncompetitive inhibitors, and by using a crystal struct

184 d P-gp inhibition was due to the presence of noncompetitive inhibitors.

185 as WIN 51,708 and N-desmethylclozapine were noncompetitive inhibitors.

186 effect as compared to other competitive and noncompetitive inhibitors.

187 ner allosterically regulated by agonists and noncompetitive inhibitors.

188 uation that favors the identification of ATP noncompetitive inhibitors.

189 subtype GluA2 receptor in complex with three noncompetitive inhibitors.

190 d the most potent ones were characterized as noncompetitive inhibitors.

191 dates the binding site for a series of novel noncompetitive inhibitors.

192 to native or recombinant nAChRs, supporting noncompetitive inhibitory activity.

193 and cell migration that is consistent with a noncompetitive inhibitory mechanism of Met signal transd

194 ablished second generation GSM, E2012, but a noncompetitive interaction between AZ GSMs and the first

195 The KIE was not attenuated in noncompetitive intermolecular experiments with rat liver

196 was not expressed [e.g., (D)(V/K) = 1.2] in noncompetitive intermolecular experiments.

197 Similar to the WT enzyme, high noncompetitive intermolecular kinetic deuterium isotope

198 exhibited time-dependent FAAH inhibition and noncompetitive irreversible inactivation of the enzyme,

199 Histidine and AMP were determined to be noncompetitive (Ki = 81.1 microM) and competitive (Ki =

200 ng docking and in vitro HTS, competitive and noncompetitive ligands of OCT1 can be predicted.

201 reported that treatment with combinations of noncompetitive mAbs can induce receptor clustering, lead

202 highly potent combinations consisting of two noncompetitive mAbs that target EGFR domain 3 reduce sur

203 Ch competitor dihydro-beta-erythroidine in a noncompetitive manner and that morantel still potentiate

204 s, FliW allosterically antagonizes CsrA in a noncompetitive manner by excluding the 5'UTR from the Cs

205 responding to this region inhibits ATGL in a noncompetitive manner in the nanomolar range.

206 R and inhibits IR kinase activity in a mixed noncompetitive manner to ATP, through which piceatannol

207 st with an IC(50) of 70.1 nmol/L, binds in a noncompetitive manner to the ET(A) receptor.

208 s the FeS cluster scaffold protein IscU in a noncompetitive manner, generating a complex that contain

209 IIalpha ATPase activity in a dose-dependent noncompetitive manner, this was secondary to salicylate-

210 ) flux in alpha3beta4-transfected cells in a noncompetitive manner.

211 11-cis and all-trans retinol in an apparent noncompetitive manner.

212 ereas 5MPEP inhibits CPPHA potentiation in a noncompetitive manner.

213 ding of p65 and p50 subunits to the DNA in a noncompetitive manner.

214 ork of a competitive market, suggesting that noncompetitive market forces may be responsible.

215 for highly competitive markets compared with noncompetitive markets.

216 A noncompetitive mechanism in which TRIP8b inhibits the co

217 s-Menten kinetics studies revealed a classic noncompetitive mechanism of action for 24.

218 Compound 211 has a noncompetitive mechanism of action, and it is extremely

219 ist, glutamate or glycine, consistent with a noncompetitive mechanism of action.

220 CsrA regulation, and represents a widespread noncompetitive mechanism of CsrA control.

221 Michelis-Menten kinetic studies indicated a noncompetitive mechanism of inhibition.

222 We conclude that FliW inhibits CsrA by a noncompetitive mechanism that differs dramatically from

223 oncentration [IC(50)], 15 muM), exhibiting a noncompetitive mechanism with a K(i) of 8 muM.

224 mpounds that inhibited UT-A selectively by a noncompetitive mechanism with IC50 down to approximately

225 tolerated AMPA receptor inhibitors act via a noncompetitive mechanism, but many of them produce adver

226 To test generality of this proposed noncompetitive mechanism, we used C57BL/6 wild type mice

227 e, an essential gene, elevate apoptosis by a noncompetitive mechanism.

228 se interaction and RKIP phosphorylation by a noncompetitive mechanism.

229 Both competitive and noncompetitive mechanisms of receptor binding and activa

230 mpetitive PI3K inhibitor ZSTK474 and the ATP-noncompetitive MEK inhibitor PD0325901 is described.

231 e beta-arrestin-dependent pathway, whereas a noncompetitive mGlu1 receptor antagonist blocked both pa

232 The potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethyn

233 nding at the targeted interface supports the noncompetitive mode of inhibition determined by kinetic

234 ic characterization of coumestans revealed a noncompetitive mode of inhibition with respect to nucleo

235 er inhibition was not observed, indicating a noncompetitive mode of viral resistance to the drug.

236 data have revealed that both competitive and noncompetitive modes of inhibition exist.

237 te that HG-829 is a potent, long-acting, and noncompetitive modulator of P-glycoprotein export functi

238 gp-mediated drug efflux but rather acts as a noncompetitive modulator of P-glycoprotein transport fun

239 The neurobiological basis of action of noncompetitive N-methyl-D-aspartate acid receptor (NMDA-

240 Ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist

241 However, the noncompetitive nAChR antagonist mecamylamine acted as a

242 ible inhibitors either of competitive (8) or noncompetitive nature (30).

243 Mechanistic characterization revealed a noncompetitive nature of these inhibitors with binding c

244 r the competitive NMDA antagonist AP5 or the noncompetitive NMDA antagonist MK-801 does not selective

245 LTD, but not LTP, was also observed when the noncompetitive NMDA channel blocker MK-801 was added to

246 Here, we used DCS and the noncompetitive NMDA receptor antagonist (+)-5-methyl-10,

247 Two experiments examined the effect of the noncompetitive NMDA receptor antagonist, dizocilpine mal

248 ivatives have been identified as allosteric, noncompetitive NMDA receptor inhibitors.

249 (i) = 3.2 +/- 0.85 microM) inhibit AcpA in a noncompetitive, nonreversible fashion.

250 Here we identified competitive and noncompetitive OCT1-interacting ligands in a library of

251 hem have interfering effects (competitive or noncompetitive) on a specific protein-receptor binding r

252 protein activation, whereas CCR2-RA showed a noncompetitive or allosteric mode of inhibition.

253 Secondary alcohols were noncompetitive or linear mixed inhibitors with inhibitio

254 t mechanisms of inhibition (ATP-competitive, noncompetitive, or uncompetitive) in PoA compared to IoC

255 the inhibitor binds to an exosite, displays noncompetitive partial inhibition, and is synergistic wi

256 pect to the first substrate, pyruvate, and a noncompetitive partial inhibitor with respect to ASA, an

257 We present a new application of the noncompetitive phage anti-immunocomplex assay (PHAIA) by

258 king studies support that 2 binds to the ATP-noncompetitive pocket of glycogen synthesis kinase-3beta

259 This disparity is important because noncompetitive primary care incomes discourage medical s

260 isual cortex is the outcome of two distinct, noncompetitive processes, a loss of deprived-eye respons

261 ndence on channel activation but exhibited a noncompetitive profile.

262 strate the feasibility of the development of noncompetitive proteasome inhibitors as additives and/or

263 Herein, we describe the optimization of noncompetitive proteasome inhibitors to yield derivative

264 tive inhibitors of sepiapterin reduction but noncompetitive redox cycling inhibitors.

265 and long-term engraftment in competitive and noncompetitive repopulation assays (<1.5% chimerism of V

266 ) (IC50 = 669 pM), acting as competitive and noncompetitive reversible inhibitors, respectively.

267 an existing competitive assay to a versatile noncompetitive sandwich-type format using immunocomplex

268 BDZ-f binds to the same noncompetitive site as GYKI 52466 does.

269 Both compounds bind to the same noncompetitive site.

270 nal validation, we identified BHPI, a potent noncompetitive small molecule ERalpha biomodulator that

271 tween the amygdala and downstream regions in noncompetitive social behavior.

272 ng competitive sports and 58 occurred during noncompetitive sports.

273 Mathematical simulations reproduce this noncompetitive state using short GR/GRE residency times

274 P, but this activity is inhibited by ATP via noncompetitive substrate inhibition and by GTP via mixed

275 resence of large labile DOC pools that yield noncompetitive substrates such as methanol.

276 These compounds represent a new class of noncompetitive subunit-selective NMDA receptor antagonis

277 e converted the mechanism of inhibition from noncompetitive to competitive, such that the antagonist

278 Trans-anethole demonstrated noncompetitive to mixed type of inhibition of lens aldos

279 etitive fashion versus ATF2 while being pure noncompetitive toward ATP.

280 primarily competitive with the substrate and noncompetitive toward the cofactor.

281 Similar to noncompetitive transport inhibition, the current block w

282 Due to noncompetitive transport, the textile-based Li-O2 cathod

283 for direct detection of small compounds in a noncompetitive two-site immunoassay format that performs

284 y two antibodies impeding their detection by noncompetitive two-site immunoassays, which are superior

285 ng the Streptomyces enzymes are of the mixed noncompetitive type, suggesting that (p)ppGpp binds to a

286 -nanomolar inhibitors of Mtb's Lpd that were noncompetitive versus NADH, NAD(+), and lipoamide and >1

287 e inhibition is uncompetitive versus ATP and noncompetitive versus PRPP.

288 hibition by NADP is competitive vs NADPH and noncompetitive vs alpha-AASA and L-glutamate, suggesting

289 ncompetitive vs saccharopine, L-glutamate is noncompetitive vs both NADP and saccharopine, while L-AA

290 etitive vs AASA, uncompetitive vs NADPH, and noncompetitive vs L-glutamate.

291 Saccharopine is noncompetitive vs NADPH, alpha-AASA, and L-glutamate.

292 both NADP and saccharopine, while L-AASA is noncompetitive vs saccharopine and uncompetitive vs NADP

293 oxidation, NADPH is competitive vs NADP and noncompetitive vs saccharopine, L-glutamate is noncompet

294 , the inhibition mechanism of endometase was noncompetitive with a K(i) value of 240muM.

295 upies a novel allosteric binding site and is noncompetitive with both the peptide substrate and cofac

296 The inhibition is incomplete and noncompetitive with other known NMDA receptor agonists o

297 not bind to the catalytic zinc ion, they are noncompetitive with respect to substrate binding, and th

298 he protein framework, making these processes noncompetitive with substrate oxidation.

299 Inhibition was noncompetitive, with SX-517 unable to compete the bindin

300 potentially bioaccessible compounds acted as noncompetitive XO inhibitors.