ライフサイエンスコーパス: noncompetitive antagonist

1 nt glucagon-like peptide-1 receptor (GLP-1R) noncompetitive antagonist.

2 s a nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist.

3 nnel based on its prevention by proadifen, a noncompetitive antagonist.

4 to pH sensor of ASIC1a acting as orthosteric noncompetitive antagonist.

5 inistration of phencyclidine (PCP), an NMDAR noncompetitive antagonist.

6 rtial agonists), competitive antagonists, or noncompetitive antagonists.

7 ceptor (nAChR), in which barbiturates act as noncompetitive antagonists.

8 effects were observed for the binding of the noncompetitive antagonist [(3)H]ethidium when examined i

9 Based upon the inhibition of binding of the noncompetitive antagonist [(3)H]phencyclidine, azietomid

10 centrations, it inhibited the binding of the noncompetitive antagonists [(3)H]tetracaine and [(3)H]ph

11 more potent inhibitor of the binding of the noncompetitive antagonist [3H]phencyclidine (IC50 = 9 mi

12 s (IC50 = 600 microM) and the binding of the noncompetitive antagonist [3H]tetracaine to nAChR-rich m

13 ce, and a specific component, inhibitable by noncompetitive antagonists and localized to the M2 hydro

14 nct protein preparations, in the presence of noncompetitive antagonists, and over a broad range of io

15 Suramin, which is a noncompetitive antagonist at wild-type P2X2 receptors, h

16 sition 6, respectively, were the most potent noncompetitive antagonists at the NMDA receptor with IC5

17 ent nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist, binds with higher affinity in

18 o- 5H-2,3-benzodiazepine (GYKI 53655) act as noncompetitive antagonists; both drugs act through allos

19 the lipid bilayer can be attenuated by other noncompetitive antagonists, but at concentrations substa

20 e apparent agonist strength of the otherwise noncompetitive antagonist citral.

21 This new class of noncompetitive antagonists could provide an opportunity

22 thio-bis[2-nitrobenzoic acid], DTNB), or the noncompetitive antagonist CP101,606 (CP).

23 Treatment of cells with mecamylamine, a noncompetitive antagonist, did not change receptor level

24 The agonist-noncompetitive antagonist hybrids produce bell-shaped co

25 We describe that MMPIP acts as a noncompetitive antagonist in calcium mobilization assays

26 igh-affinity binding site for aromatic amine noncompetitive antagonists in the Torpedo nicotinic acet

27 kine CX516 and modulating the NMDAR with the noncompetitive antagonist memantine.

28 he rate of blocking of NMDA responses by the noncompetitive antagonist MK-801 at the same synapses.

29 receptors was prevented by inclusion of the noncompetitive antagonists MK-801 (2 microM) and GYKI 53

30 NR1/2A responses were inhibited by the noncompetitive antagonists MK-801 and dextromethorphan a

31 ([(125)I]TID) has been shown to be a potent noncompetitive antagonist (NCA) of the nicotinic acetylc

32 fipronil, and the botanical picrotoxinin are noncompetitive antagonists (NCAs) for the GABA receptor.

33 and [(3)H]tetracaine, an aromatic amine, are noncompetitive antagonists (NCAs) of the Torpedo species

34 ntaneously open and highly sensitive to many noncompetitive antagonists(NCAs) and Zn(2+).

35 yl)-vinyl]-6-fluoro- 3H-quinazolin-4-one), a noncompetitive antagonist of AMPA-selective glutamate re

36 These data suggest that L-168,049 is a noncompetitive antagonist of glucagon action.

37 Picrotoxin (PTX) is a noncompetitive antagonist of many ligand-gated ion chann

38 Derquantel was a noncompetitive antagonist of nicotine, revealing N-type

39 VSMC proliferation is inhibited by Mk-801, a noncompetitive antagonist of the N-methyl-D-aspartate (N

40 The effects of MK-801, a noncompetitive antagonist of the N-methyl-D-aspartate (N

41 Ketamine is a potent noncompetitive antagonist of the N-methyl-D-aspartate gl

42 er donors to the acceptor, crystal violet, a noncompetitive antagonist of the nAChR.

43 n for the fluorophor crystal violet (CrV), a noncompetitive antagonist of the nicotinic acetylcholine

44 The binding sites of ethidium, a noncompetitive antagonist of the nicotinic acetylcholine

45 Quinacrine is a noncompetitive antagonist of the nicotinic acetylcholine

46 tion of L-arginine, the effects of MK-801, a noncompetitive antagonist of the NMDA receptor and of LY

47 y intravenous administration of memantine, a noncompetitive antagonist of the NMDA receptor.

48 [(3)H]Tetracaine is a noncompetitive antagonist of the Torpedo nicotinic acety

49 Local anesthetics (LAs) are noncompetitive antagonists of batrachotoxin (BTX) in vol

50 ) have been shown to be selective and potent noncompetitive antagonists of mGluR5.

51 cluding long chain aliphatic alcohols act as noncompetitive antagonists of the nicotinic acetylcholin

52 dine and its potent congener dizocilpine are noncompetitive antagonists of the NMDA receptor complex,

53 Fourteen noncompetitive antagonists of widely diverse chemotypes

54 this pattern of fluorescence change, but the noncompetitive antagonist picrotoxin failed to elicit op

55 receptor, as assessed by the effects of the noncompetitive antagonist proadifen on conotoxin binding

56 ors, CT32521 and CT32228, two small-molecule noncompetitive antagonists representing two different cl

57 BP acted as a low potency noncompetitive antagonist, reversibly inhibiting the ACh

58 Finally, the noncompetitive antagonist ruthenium red inhibited both t

59 Several compounds were found to bind to the noncompetitive antagonist site of the AChR as demonstrat

60 similar structure bind to the high-affinity noncompetitive antagonist site of the AChR associated wi

61 abeling experiments using well-characterized noncompetitive antagonists such as the phencyclidine ana

62 was reduced in the presence of proadifen, a noncompetitive antagonist that desensitizes the receptor

63 -(phenylethynyl)-pyridine (MPEP) is a potent noncompetitive antagonist that is selective for mGluR5.

64 ate that the steroid promegestone is an AChR noncompetitive antagonist that may alter AChR function b

65 We investigated the approach of using noncompetitive antagonists to regulate alpha7 receptor f

66 Whereas cocaine itself is a general nAChR noncompetitive antagonist, we report here the characteri

67 ostatic stabilization of ions and binding of noncompetitive antagonists within the channel.