ライフサイエンスコーパス: noncompetitive inhibition

1 by the lack of a structural understanding of noncompetitive inhibition.

2 tosterone binding to AR-T877A likely through noncompetitive inhibition.

3 nable to distinguish between competitive and noncompetitive inhibition.

4 s not affected by NorA expression, exhibited noncompetitive inhibition.

5 exhibited competitive inhibition for ATP and noncompetitive inhibition against ATF2.

6 Acetylated (Lys14Ac) H3 peptide displayed noncompetitive inhibition against both H3 peptide and Ac

7 te substrates ATP and CEA, respectively, and noncompetitive inhibition against their noncognate subst

8 such compound, ALS 1-0635, indicated linear, noncompetitive inhibition, and Dixon plot analysis from

9 eptide, and isoleucine 8 is critical for its noncompetitive inhibition at alpha(1B)-ARs.

10 In contrast, noncompetitive inhibition by a UbcH7C86A product analog

11 Noncompetitive inhibition by dGMP and 8-oxo-dGMP indicat

12 hanism of activation and its competitive and noncompetitive inhibition by different compounds.

13 We find that transinhibition is due to noncompetitive inhibition by L-methionine, much like a n

14 Thiol specificity of the reaction and noncompetitive inhibition by the cognate methionine, as

15 arsenate has been examined, and reversible, noncompetitive inhibition by theophylline has been studi

16 proteins by differentiating competitive and noncompetitive inhibition demonstrates its ability as a

17 competitive inhibition for Cdc25 DSPases and noncompetitive inhibition for PTP1B.

18 (ACh), PhTX-343 caused activation-dependent, noncompetitive inhibition (IC50 = 17 microM at -100 mV)

19 hibition in regard to external [K(+)] versus noncompetitive inhibition in respect to external [Cl(-)]

20 This noncompetitive inhibition is consistent with interferenc

21 m), whereas a Ubc5BC85A product analog shows noncompetitive inhibition (Ki = 2.2 +/- 0.5 mum), consis

22 This study demonstrates that noncompetitive inhibition kinetics describe the impact o

23 , the hydroxamic acid, SC81956, demonstrated noncompetitive inhibition kinetics with a Ki of 23 nM.

24 time-dependent inhibitors of PC2, exhibiting noncompetitive inhibition kinetics; the most potent inhi

25 nhibit the C-terminal sEH activity through a noncompetitive inhibition mechanism involving a new bind

26 y competition with substrate, and the linear noncompetitive inhibition observed was consistent with i

27 Our results represent a molecular view into noncompetitive inhibition of a sodium-coupled transporte

28 elective and, with respect to the substrate, noncompetitive inhibition of Abeta(1-42) production was

29 .77 microM at-100 mV), activation-dependent, noncompetitive inhibition of ACh-induced whole-cell curr

30 terol cyclase (OSLC) inhibitor showed potent noncompetitive inhibition of bacterial squalene:hopene c

31 HPP+ showed noncompetitive inhibition of both serotonin and dopamine

32 Insulin produced a noncompetitive inhibition of both the chymotrypsin-like

33 UCPH-101 exhibits noncompetitive inhibition of EAAT1, and its binding site

34 ly inhibition is analogous to competitive or noncompetitive inhibition of enzymes.

35 ith PGIP as well as a possible mechanism for noncompetitive inhibition of EPG-II.

36 peptidyl substrate cleavage but as classical noncompetitive inhibition of factor X activation by acti

37 te of the FXIa-LC by S-2366 also resulted in noncompetitive inhibition of FIX activation.

38 ,3', 5-L-triiodothyronine (L-T3) indicated a noncompetitive inhibition of muscimol-stimulated (36)Cl(

39 tory compound, termed JF5, also demonstrated noncompetitive inhibition of the alpha(2A)-adrenergic re

40 strychnine-insensitive glycine binding site (noncompetitive inhibition of the binding of [3H]TCP, pA2

41 n-substrate-binding site that is involved in noncompetitive inhibition of the enzyme.

42 resulting in binding to activated fVIII and noncompetitive inhibition of the intrinsic fXase complex

43 Photoprobes 1-3 showed mixed noncompetitive inhibition of the Klenow fragment polymer

44 d that copper (I) and (II) cations displayed noncompetitive inhibition of the LC (Ki approximately 1

45 r-Burk plots indicated mixed competitive and noncompetitive inhibition of the protease by BV.

46 show that the synthetic Mag-1 peptides cause noncompetitive inhibition of the receptor channel activi

47 The nucleoside 3'-phosphates caused noncompetitive inhibition of the type I adenylyl cyclase

48 is the most potent inhibitor, effecting pure noncompetitive inhibition of the wild type human AMPD3 r

49 osolic GR without affecting K(m), suggesting noncompetitive inhibition of this thiol-dependent enzyme

50 with only two functional residues exhibited noncompetitive inhibition of thrombin.

51 The noncompetitive inhibition pattern observed for both clea

52 at high neomycin concentrations, indicating noncompetitive inhibition rather than direct competitive

53 onal UV-vis spectroscopy, and competitive vs noncompetitive inhibition reactions could be delineated

54 Consistent with the observed time-dependent noncompetitive inhibition, the cocrystal X-ray structure

55 l molecule analinopyrimidine, exhibited pure noncompetitive inhibition versus ATF2 and competitive in

56 e hydrolyzed peptide product, Pd1, exhibited noncompetitive inhibition versus both ATP and S3 substra

57 hibits competitive inhibition versus ATP and noncompetitive inhibition versus cysteine, with an inhib

58 Glutarate gives S-parabolic noncompetitive inhibition versus NADH, indicating the fo

59 than glucose or fructose concentrations, and noncompetitive inhibition was observed.

60 Both analogs exhibited parabolic noncompetitive inhibition, which means that two molecule

61 both classes of compounds display primarily noncompetitive inhibition with respect to either ATP or

62 ibition pattern with respect to pyruvate and noncompetitive inhibition with respect to GAP/d-glyceral

63 respect to erythrose-4-phosphate and partial noncompetitive inhibition with respect to phosphoenolpyr

64 y of triclosan for the enzyme and results in noncompetitive inhibition, with K(i) and K(i)' values of