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1 tent 2',5'-dd-3'ATP, a post-transition state noncompetitive inhibitor.
2 tion site on the enzyme was identified for a noncompetitive inhibitor.
3 ependent manner and that azide is a mixed or noncompetitive inhibitor.
4 allosterically regulated by an agonist or a noncompetitive inhibitor.
5 dates the binding site for a series of novel noncompetitive inhibitors.
6 d the most potent ones were characterized as noncompetitive inhibitors.
7 r drugs that bind to specific RNA targets as noncompetitive inhibitors.
8 d P-gp inhibition was due to the presence of noncompetitive inhibitors.
9 as WIN 51,708 and N-desmethylclozapine were noncompetitive inhibitors.
10 effect as compared to other competitive and noncompetitive inhibitors.
11 ner allosterically regulated by agonists and noncompetitive inhibitors.
12 uation that favors the identification of ATP noncompetitive inhibitors.
13 subtype GluA2 receptor in complex with three noncompetitive inhibitors.
14 ve inhibitor anakinra (Kineret) and a potent noncompetitive inhibitor 101.10, for efficacy in blockin
20 titive inhibitor against R-3-OHC14-ACP and a noncompetitive inhibitor against UDP-3-O-(R-3-OHC14)-Glc
21 oped herein allowed identifying new original noncompetitive inhibitors against cN-II that act in a sy
22 values associated with the formation of the noncompetitive inhibitor-alpha3beta4-nAChR complexes.
23 studies that analogues of this chemotype are noncompetitive inhibitors, and by using a crystal struct
24 rs from compound library screens because ATP-noncompetitive inhibitors are often weaker and commonly
27 ucleotides known to be either competitive or noncompetitive inhibitors but not by agents known not to
28 inase 4 (CDK4) and the identification of ATP-noncompetitive inhibitors by high-throughput screening a
29 hibition of the muscle-type nAChR (1) by the noncompetitive inhibitors cocaine and MK-801 [(+)-dizoci
30 nique to glutathione reductase suggests that noncompetitive inhibitors could also serve as lead compo
31 ge, MA, USA) is a small-molecule, selective, noncompetitive inhibitor directed against human IMPDH.
35 lalanine and phenylalanylalanine are general noncompetitive inhibitors for E3alpha-catalyzed ubiquiti
36 designing conformation-specific, more potent noncompetitive inhibitors for the GluR2 AMPA receptor.
38 M) consistent with reports that it acts as a noncompetitive inhibitor in the steady state at high con
39 d was found to be a competitive, rather than noncompetitive, inhibitor in both radioligand and functi
40 e present together, coniferyl aldehyde was a noncompetitive inhibitor (K(i) = 0.59 microM) of ferulat
41 e crystal structure of a complex between the noncompetitive inhibitor (Kis = 27 microM, Kii = 48 micr
42 , and adsorption rate constants (ka) for the noncompetitive inhibitors: mecamylamine, ketamine, bupro
44 cement of dizocilpine radioligand binding by noncompetitive inhibitors (NCIs) and conversely dizocilp
46 A large number of drug substances act as noncompetitive inhibitors (NCIs) of the nicotinic acetyl
47 in part by the cellular concentrations of a noncompetitive inhibitor, nicotinamide, that reacts with
53 e of 20 mM azide, consistent with CO being a noncompetitive inhibitor of azide reduction and with azi
56 e substrate, we demonstrate that E acts as a noncompetitive inhibitor of detergent-solubilized MraY,
57 ation of S-adenosyl-L-homocysteine (a potent noncompetitive inhibitor of DNMTs) during the catechol-O
59 f migrating neurons with Dynasore, a soluble noncompetitive inhibitor of Dynamin, rapidly arrests the
61 s substrates demonstrated that I3C acts as a noncompetitive inhibitor of elastase activity with an in
62 ells and characterized as a slow, tight, and noncompetitive inhibitor of factor (F) XIa by a mechanis
64 nt form of vitamin E present in humans, is a noncompetitive inhibitor of glutathione S-transferase pi
65 phosphorylation was inhibited by lithium, a noncompetitive inhibitor of glycogen synthase kinase-3be
69 rons of NAD(+) with FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosylt
70 transport substrate clotrimazole, which is a noncompetitive inhibitor of Pdr5 ATPase activity, has a
71 preincubation, we find that darbufelone is a noncompetitive inhibitor of PGHS-2 (K(i) = 10 +/- 5 micr
73 containing residues 1-14 of GRK2 served as a noncompetitive inhibitor of receptor phosphorylation by
74 coralloides synthesizes corallopyronin A, a noncompetitive inhibitor of RNA polymerase ineffective a
76 ysis characterized NSC48300 as a reversible, noncompetitive inhibitor of Taspase1 (K(i) = 4.22 mumol/
77 re, we found that GMP binds as a reversible, noncompetitive inhibitor of TGase 3 transamidation activ
80 idinyl)-2,4-dichlorobenzamide 5 (BPDBA) is a noncompetitive inhibitor of the betaine/GABA transporter
82 vered in the screen, GW4869, functioned as a noncompetitive inhibitor of the enzyme in vitro with an
86 ucture of psi-conotoxin Piiie (psi-Piiie), a noncompetitive inhibitor of the nicotinic acetylcholine
87 as a competitive inhibitor and cyanide was a noncompetitive inhibitor of the nitrate reductase activi
89 We have previously shown that TriCHQ is a noncompetitive inhibitor of the thiol-disulfide exchange
92 psi-conotoxin Piiie, a previously identified noncompetitive inhibitor of Torpedo electroplax nAChR, a
94 enation of arachidonic acid (AA) but potent, noncompetitive inhibitors of 2-arachidonoylglycerol (2-A
95 PAR1-wt exodomain and P4 and P3 mutants were noncompetitive inhibitors of alpha-thrombin hydrolyzing
98 ysis revealed that methoxyestrogens acted as noncompetitive inhibitors of E2 oxidation with K(i) rang
100 port, are consistent with barbiturates being noncompetitive inhibitors of Glc translocation and prefe
101 protease inhibitors (PIs) act as reversible noncompetitive inhibitors of GLUT4 with binding affiniti
102 inhibitor of Klenow fragment and two strong noncompetitive inhibitors of HIV-1 reverse transcriptase
103 trophenols which proved to be very effective noncompetitive inhibitors of mammalian complex II, parti
104 ternate amino acids act as rapid equilibrium noncompetitive inhibitors of MtIPMS failing to display b
106 mbranoids are naturally occurring, uncharged noncompetitive inhibitors of peripheral and neuronal ACh
109 well as 3'-end-truncated tRNA(Val) are mixed noncompetitive inhibitors of the aminoacylation reaction
111 mustine in a dose-dependent fashion and were noncompetitive inhibitors of the binding of estramustine
112 ucleotide exchange on beta-tubulin, and were noncompetitive inhibitors of the binding of radiolabeled
113 cid esters have recently been reported to be noncompetitive inhibitors of the N-acylethanolamine acid
115 analysis indicates that these compounds are noncompetitive inhibitors of the p-hydroxyphenylpyruvate
116 anesthetics which can also act as uncharged noncompetitive inhibitors of the peripheral nicotinic ac
117 idine ([3H]TCP), an analogue of the cationic noncompetitive inhibitor phencyclidine (PCP), was used t
118 bly also overlaps the sites for the cationic noncompetitive inhibitors, procaine and quinacrine.
119 t analog (p'Tide) behaved as competitive and noncompetitive inhibitors, respectively; on varying Tide
120 Complete inhibition of aromatase with ATD, a noncompetitive inhibitor, significantly and similarly re
121 cated in the channel pore and equates with a noncompetitive inhibitor site found in many pLGICs.
122 ion can be exploited to overcome blockade by noncompetitive inhibitors such as beta-amyloid peptide.
123 line agent to treat hypertension, and by the noncompetitive inhibitor tetrabenazine, presently in use
124 netic studies reveal that neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR co
125 ir2 activity is regulated by nicotinamide, a noncompetitive inhibitor that promotes a base-exchange r
127 sults show that the aptamer we isolated is a noncompetitive inhibitor that selectively inhibits the o
128 tion of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent on
131 n growing interest in the development of ATP-noncompetitive inhibitors to overcome these problems.
133 intermediate analog 25-azacycloartanol was a noncompetitive inhibitor versus cycloartenol and an unco
134 s a competitive inhibitor versus urate and a noncompetitive inhibitor versus O2, which suggests that
135 -Acetyltryptamine, a reaction product, was a noncompetitive inhibitor versus tryptamine and uncompeti
138 petitive inhibitors AMP-PCP and Y-27632 were noncompetitive inhibitors versus S6 peptide, and the S6
143 TY720 is therefore an S1P-GPCR-selective and noncompetitive inhibitor with a unique mechanism of acti
144 gh the screen was further characterized as a noncompetitive inhibitor with both ATP and PLK-peptide a
145 )-activated dGTP hydrolysis, 8-oxo-dGMP is a noncompetitive inhibitor with K(I)(sl)(o)(pe) = 49 nM, w
146 o the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to AdoMet, the met
147 wed that a Zn-L-DTT solution functioned as a noncompetitive inhibitor with respect to ATP in the rho
148 ive with respect to pyrophosphate (PP(i)), a noncompetitive inhibitor with respect to ATP, but at >10
149 ated bis(dihydroxyalkylbenzene) 5 was a pure noncompetitive inhibitor with respect to both substrates
152 During turnover, it is found that azide is a noncompetitive inhibitor with respect to O(2), most cons
154 ion kinetic analysis indicates that they are noncompetitive inhibitors with respect to androstenedion
155 059 demonstrates that U0126 and PD098059 are noncompetitive inhibitors with respect to both MEK subst
156 sites: one that equilibrates with the tested noncompetitive inhibitors within approximately 50 ms, an
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