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2 native processing demonstrate a role for the nonconsensus 3' acceptors in Mhc exons 7 and 9 alternati
3 ronic sequence immediately downstream of the nonconsensus 5' donor site that functions as an intronic
6 hc exon 11 reveals that the alternative exon nonconsensus 5'-splice donors are essential for alternat
7 for genotyping: HUM-TH01, a simple STR with nonconsensus alleles, and vWA, a compound STR with nonco
9 ether with kinetic studies indicate that the nonconsensus amino acid Met466 in the Drosophila nonmusc
11 arge and diverse pool of mutants in which 10 nonconsensus amino acids in the DNA recognition helix of
12 This study demonstrates that there is more nonconsensus among experts than consensus regarding most
16 nally, overexpression of c-Rel activated the nonconsensus AP-1 site from the IL-2 promoter (NF-IL-2B)
20 entation, the effects of the orientations of nonconsensus AP-1 sites on the stabilities of Jun-Jun-NF
22 stitution of the consensus base pair for the nonconsensus base pair at position -9 of Pskf produced a
26 haracterized by low predicted free energy of nonconsensus binding have statistically higher experimen
30 tation assays revealed that Elk-1 binds to a nonconsensus binding site in the telokin promoter and El
31 d promoters which contain both consensus and nonconsensus binding sites and have shown that not all E
35 suggested that this feature is due to both a nonconsensus branch point sequence and a suboptimal poly
36 t has suboptimal features characterized by a nonconsensus branch point sequence and a weak polypyrimi
38 quencing (RNA-seq) reveals that introns with nonconsensus branch points are particularly sensitive to
39 and in vivo is, at least in part, due to the nonconsensus branchpoint sequence of the LAT intron.
44 internal site, (pA)p1, is programmed by the nonconsensus core cleavage and polyadenylation specifici
47 priming the IL6 promoter through binding to nonconsensus dioxin response elements located upstream o
50 t (Y(14)), it skips exon 9 in vivo and has a nonconsensus downstream 5' splice site identical to that
51 und that changes in the sequences flanking a nonconsensus ERE can greatly alter ER-ERE affinity, eith
54 nic alternative splice-specificity elements, nonconsensus exon 11 splice donors and, likely, novel ex
55 and SAGA-dominated genes correlate with the nonconsensus free-energy landscape, yet these two groups
57 er activity in erythroid cells, as well as a nonconsensus GATA sequence and several putative c-myb an
61 ast metallothionein gene, CUP1, depends on a nonconsensus heat shock element (HSE), occurs at higher
62 substrate studies show that the RSS with the nonconsensus heptamer, which include the frequently rear
68 ings indicate that binding of Rel p50 to the nonconsensus kappaB site enhances and stabilizes binding
69 in Hep 3B cells and that p50 could bind to a nonconsensus kappaB site overlapping the CCAAT/enhancer
70 demonstrated that recombinant p50 bound to a nonconsensus kappaB site overlapping the proximal C/EBP
71 cell nuclear antigen (PCNA) at lysine 164, a nonconsensus lysine residue that is not modified by the
73 inding also can be seen with a wide range of nonconsensus motifs, which in many cases did not allow S
75 the only input, we further validate that the nonconsensus nucleotide triplet code constitutes a key s
77 me recognizes the BS and alter splicing when nonconsensus nucleotides are present at the -2, -1 and +
78 he IRP3 operator (5'-TTAGGTGAGACGCACCCAT-3' [nonconsensus nucleotides underlined]) overlaps by 2 nucl
79 ivity of POU family members to the candidate nonconsensus octamer sequence of region I that correlate
81 te that the longer transcript results from a nonconsensus polyadenylation recognition sequence, 5'AAC
85 model developed previously, we calculate the nonconsensus protein-DNA binding free energy for the ent
88 esult of this new analysis, we conclude that nonconsensus protein-DNA binding is a widespread phenome
90 erall, the computed free-energy landscape of nonconsensus protein-DNA binding shows strong correlatio
93 e or through nonspecific interactions with a nonconsensus proximal subsite) is a prerequisite for bin
95 owed multiple interruptions of the repeat by nonconsensus repeat units, which differed both in the le
102 certain "composite GREs" GR and AP1 bind to nonconsensus sequences, and GR either activates or repre
104 ntributions of two important mechanisms: the nonconsensus site recognition function conferred by the
107 the Ftz(Q50K) homeodomain fails to recognize nonconsensus sites found in natural enhancer elements.
109 be preferentially restored by converting the nonconsensus sites in natural enhancer elements to conse
112 he gradual DBT-mediated phosphorylation of a nonconsensus SLIMB-binding site establishes a temporal t
117 CIE elements function in combination with a nonconsensus splice donor to direct IFM-specific splicin
119 ree noncoding regions are conserved: (1) the nonconsensus splice junctions at either end of exon 18;
120 ed LRT cDNAs, poly(A)+ or poly(A)-, revealed nonconsensus splice signals at exon/intron and intron/ex
121 a weak promoter-proximal poly(A) site and a nonconsensus splice site in the final secretory-specific
123 ave previously shown that mutagenesis of the nonconsensus src polypyrimidine tract to a 14-nucleotide
125 al that the affinities of both consensus and nonconsensus substrates for the RNase P holoenzyme are e
127 ual core promoter structure that consists of nonconsensus TATA and initiator regions and a novel thir
132 The primary hexanucleotide element must be nonconsensus to allow efficient readthrough of P6-genera
133 an upstream enhancer that contained multiple nonconsensus TREs and augmented ligand action at high re
134 A into chromatin increased TR binding to the nonconsensus TREs, we hypothesize that chromatin disrupt
137 the prototype EBV strain B95-8 contains four nonconsensus variants within a single IR1 repeat unit, i
140 uired AhR binding to the newly characterized nonconsensus xenobiotic response element, in conjunction
141 The present study characterized a novel nonconsensus XRE (NC-XRE) in the promoter of the plasmin
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