ライフサイエンスコーパス: noncytotoxic

1 rs and degradation products were shown to be noncytotoxic.

2 lines tested, whereas 2,7-DAM is relatively noncytotoxic.

3 blocks PEA-induced cell lysis and is itself noncytotoxic.

4 lly, compound 3 inhibits BChE ex vivo and is noncytotoxic.

5 s epidermidis at loadings of silver that are noncytotoxic.

6 uNK cells with angiogenic factors keeps them noncytotoxic.

7 h unique physical properties, are inherently noncytotoxic.

8 0(S)-methylenedioxycamptothecin, but not its noncytotoxic 20(R)-stereoisomer, radiosensitized MCF-7 c

9 s and children can show cytotoxic as well as noncytotoxic activity against viral replication.

10 CD8(+) T cells display a noncytotoxic activity that suppresses transcription of h

11 duced by uNK cells, is responsible for their noncytotoxic activity.

12 ry properties for 1a, 1d, and 6d while being noncytotoxic against human colon cancer cells (HCT-116).

13 their ability to inhibit SerB2 enzyme, were noncytotoxic against mammalian cell lines, and inhibited

14 otoxic against several cancer cell lines and noncytotoxic against normal cells.

15 e recently, were multicenter, or evaluated a noncytotoxic agent.

16 ed commitment to treatment is desirable when noncytotoxic agents are administered.

17 Novel noncytotoxic agents are needed to protect men and women

18 Novel noncytotoxic agents are needed to protect women from sex

19 e been translated into therapeutic trials of noncytotoxic agents for this disorder.

20 has provided a stronger rationale for using noncytotoxic agents that influence the mechanisms involv

21 otoxic agents other than methotrexate (MTX), noncytotoxic agents, and glucocorticoids was compared wi

22 The noncytotoxic analog of AAP, 3-hydroxyacetanilide, neithe

23 Furthermore, SQAs were found to be noncytotoxic and demonstrated efficacy in a mouse model

24 TSA concentrations of 250 nM or less were noncytotoxic and did not alter normal HSF morphology or

25 s secreting catalytically inactive ExoU were noncytotoxic and did not cause acute lung injury or deat

26 nd that (a) the targeted (anti-MG1) HNPs are noncytotoxic and have greater than 20% intratumoral accu

27 he rat version of the peptide, which is both noncytotoxic and nonamyloidogenic, differs from the huma

28 The biocompatible hybrid is noncytotoxic and presents significant potential for appl

29 Both enzymes were noncytotoxic and protected A549 pulmonary epithelial cel

30 ralis and K. denitrificans, were found to be noncytotoxic and to lack the RTX region, as determined b

31 itory KIR for self-HLA class I were commonly noncytotoxic, and anti-HLA-C2 cytotoxicity was nearly ex

32 c agents that are effective against HCC, are noncytotoxic, and are tolerated by the typical patient w

33 vasive abilities upon normally nonhemolytic, noncytotoxic, and noninvasive strains of Escherichia col

34 s NKp44(+) NK cells were mucosae-restricted, noncytotoxic, and produced IL-22 and IL-17.

35 rtially responsible for CD8+ T cell-mediated noncytotoxic anti-HCV activity in PBMCs.

36 This noncytotoxic anti-HCV activity was confirmed in HCV repl

37 HIV infection, CD8+ cells show cytotoxic and noncytotoxic anti-HIV activity.

38 The CD8+ cell noncytotoxic anti-HIV response (CNAR) is associated with

39 The noncytotoxic anti-HIV response, measured by suppression

40 allografts than those with weak-cytotoxic or noncytotoxic antibodies.

41 SM, in which symptoms are usually managed by noncytotoxic antimediator therapy, cytoreduction is usua

42 I and class II loci) regulates CD8(+) T-cell noncytotoxic antiviral activity against infected CD4(+)

43 T cells, which is a property consistent with noncytotoxic antiviral CTLs.

44 This CD8+ cell noncytotoxic antiviral response (CNAR), observed by cocu

45 individuals demonstrate a strong CD8(+) cell noncytotoxic antiviral response (CNAR).

46 tion is suppressed in vitro by a CD8(+) cell noncytotoxic antiviral response (CNAR).

47 (+)VCAM-1(+) cells show enhanced CD8(+) cell noncytotoxic antiviral response activity that could have

48 infected individuals showing the CD8(+) cell noncytotoxic antiviral response unexpectedly revealed mR

49 Its inhibition is regarded as a promising, noncytotoxic approach in cancer therapy by blocking grow

50 row and thymic niches, and provides a novel, noncytotoxic approach to accomplish engraftment after st

51 ix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy.

52 e that MEK inhibitors represent a promising, noncytotoxic approach to the clinical management of colo

53 ity suggest the encouraging possibility of a noncytotoxic approach to the treatment of melanoma.

54 RSV-induced chemokine and MPO release was noncytotoxic as assessed by trypan blue exclusion.

55 new antimalarial lead which was found to be noncytotoxic as compared to the natural product lead tha

56 Many compounds were noncytotoxic at 100 muM, leading to high antiviral selec

57 ance (MDR) reversal agents (C-seco-TRAs) are noncytotoxic at the upper limit of solubility and detect

58 f CPE produces a fragment that appears to be noncytotoxic because it cannot undergo the post-binding

59 BI-9564 (2) is a cell permeable and noncytotoxic BRD9 inhibitor provided to the scientific c

60 A noncytotoxic C-terminal fragment of Clostridium perfring

61 These noncytotoxic cascades are not simply a manifestation of

62 actor consistent with the hallmarks defining noncytotoxic CD8(+) T-cell suppression of HIV-1.

63 Therefore, the observed strong noncytotoxic CD8(+)-cell anti-HIV responses may be an an

64 tions demonstrate the presence of an unusual noncytotoxic CD8+ T cell in patients with the Hu paraneo

65 Given that noncytotoxic cells and natural killer cells can also rel

66 otoxic cells, 3) allospecific TCR alphabeta+ noncytotoxic cells, 4) TCR alphabeta- nonspecific cytoto

67 tumor-infiltrating NK population enriched in noncytotoxic cells.

68 ns into two classes: cytotoxic (class 1) and noncytotoxic (class 2).

69 were used to prepare stable, biocompatible, noncytotoxic CNT dispersions that were then attached to

70 Noncytotoxic compounds with both the ability of disrupti

71 Indeed, exposure to a noncytotoxic concentration of HQ induced both NQO1 and s

72 n (0.1 microM) alone and in combination with noncytotoxic concentration of MSC (10 microM) did not re

73 Similarly, a noncytotoxic concentration of the NO donor S-nitroso-ami

74 ial cell morphology were seen at much lower, noncytotoxic concentrations (0.1 micro M) of ZD6126 and

75 differentiating cells with the NA extract at noncytotoxic concentrations alters expression of various

76 the conclusion that activity against HCMV at noncytotoxic concentrations by benzimidazole ribonucleos

77 C function by chemotherapeutic agents in low noncytotoxic concentrations has not yet been investigate

78 was inhibited by equol, but not daidzein, at noncytotoxic concentrations in a dose-dependent manner.

79 r to taxol as much as 700-fold at relatively noncytotoxic concentrations in vitro; (ii) as a single a

80 The authors found that these compounds at noncytotoxic concentrations induced differentiation and

81 ys broad-spectrum antiviral activity, and at noncytotoxic concentrations it is shown to inhibit the r

82 ell-based phenotypic screening revealed that noncytotoxic concentrations of (Z)-(+/-)-2-(1-benzenesul

83 Noncytotoxic concentrations of all six alpha-defensins (

84 Chronic exposure of ScN2a cells to low noncytotoxic concentrations of branched polyamines for 1

85 shed by synchronization or by treatment with noncytotoxic concentrations of chemotherapy agents that

86 Moreover, noncytotoxic concentrations of IFN-beta significantly in

87 Exposure to noncytotoxic concentrations of ketamine (</=1 mmol/L) in

88 mRNA decay rates following 24-hr exposure to noncytotoxic concentrations of sodium arsenite, and we c

89 Preclinical studies suggest that noncytotoxic concentrations of the DNA methyltransferase

90 ells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic a

91 Noncytotoxic concentrations of these agents acted at an

92 oplastic chemotherapeutic agents used in low noncytotoxic concentrations on the Ag-presenting functio

93 ) macrophages with gedunin (0.01-100 microM, noncytotoxic concentrations) inhibited LPS (50 ng/ml)-in

94 New data demonstrated that in ultralow noncytotoxic concentrations, paclitaxel modulated in imm

95 At noncytotoxic concentrations, protease inhibitors ZnCl2 a

96 At noncytotoxic concentrations, telomestatin suppresses the

97 RS in the human breast cancer MCF-7 cells at noncytotoxic concentrations.

98 selective inhibitors of HCMV replication at noncytotoxic concentrations.

99 nd that PSMs are chemoattractants for DCs at noncytotoxic concentrations.

100 d disrupted capillary-like tube formation at noncytotoxic concentrations.

101 preadipocytes in a dose-dependent manner at noncytotoxic concentrations.

102 e derived ProTides show anti-HIV activity at noncytotoxic concentrations; ester and aryl variation wa

103 tly altered upon isoprene SOA exposure under noncytotoxic conditions (p < 0.05), with the majority (2

104 to the gel indicates that the gel surface is noncytotoxic, conducive to cell adhesion, and allows cel

105 bstrate binding were identified by selecting noncytotoxic CTF mutants followed by in vitro screening.

106 The interaction of noncytotoxic decidual natural killer cells (dNK) and ext

107 n of a dose and schedule of DAC designed for noncytotoxic depletion of DNMT1 suggests a potential rol

108 In addition PMA-activated neutrophils were noncytotoxic, despite the capacity of PMA to generate tw

109 Noncytotoxic DNMT1 depletion was confirmed by serial BM

110 y in a manner that may facilitate accessible noncytotoxic DNMT1-targeted therapy.

111 We demonstrate that when a low, noncytotoxic dose of an optimized 5'triphosphorylated RN

112 Here we demonstrate that in HNSCC cells, a noncytotoxic dose of IB represses mesenchymal-mode migra

113 eous melanoma, we tested effects of ultralow noncytotoxic dose paclitaxel on functions of myeloid-der

114 suggest that the ability of paclitaxel in a noncytotoxic dose to block the immunosuppressive potenti

115 In vitro exposure of the cell models to low, noncytotoxic doses (0.1 and 1 nM) of BaP elicited increa

116 RSV), a plant-derived polyphenol, at low and noncytotoxic doses for immune cells, can efficiently inh

117 Furthermore, prior treatment with noncytotoxic doses of carboplatin sensitized SKOV-3 tumo

118 We investigated the effect of noncytotoxic doses of MTX on latency and lytic KSHV repl

119 that inhibited vaccinia virus replication at noncytotoxic doses.

120 lators for cancer invasion and metastasis at noncytotoxic doses.

121 titumor activity was achieved in mice with a noncytotoxic dosing regimen of ethyl pyruvate shown prev

122 e assessed the impact of circulating HLA and noncytotoxic DSA detected before transplant on developme

123 In this review we discuss the noncytotoxic effector functions of NK cells and how they

124 To explore such noncytotoxic effector mechanisms, we tested whether huma

125 In this study, we demonstrate the noncytotoxic effects of ionizing radiation on MHC class

126 a variety of ways in which NK cells mediate noncytotoxic effects.

127 endothelial cells (BMVEC) using a recyclable noncytotoxic endocytic pathway.

128 Therefore, we used a noncytotoxic ExoU variant, designated ExoU(S142A)-Bla, t

129 Entry of noncytotoxic (exoU) P. aeruginosa into human and rabbit

130 cells but also by controlling the virus in a noncytotoxic fashion that leaves the infected cell funct

131 om 81 to 106 produced a CPE variant that was noncytotoxic for Caco-2 cells and was unable to form CPE

132 acids from the C terminus of CPE produces a noncytotoxic fragment lacking receptor binding activity,

133 Further, a noncytotoxic fragment of anti-APO-1 antibody that blocks

134 Using a CD8(+) T-cell line displaying potent noncytotoxic HIV-1 suppression activity, we have identif

135 = 1 immune response in the form of CD8 cell noncytotoxic HIV-1 suppressive activity, proliferative C

136 We hypothesized that noncytotoxic IgG2 anti-Galalpha1-3Gal was responsible fo

137 Pretreatment of cancer cells with the noncytotoxic imidazoline 1d (10 nM) resulted in a signif

138 The appearance of noncytotoxic immunoregulatory T cell activity after cess

139 Cyclophosphamide was ineffective, but noncytotoxic immunosuppressive agents generally produced

140 Unlike other far-red FPs, E2-Crimson is noncytotoxic in bacterial and mammalian cells.

141 Se2SAP was found to be less photoactive and noncytotoxic in comparison to TMPyP4.

142 The eluates were noncytotoxic in micro-CDC assays.

143 Most were noncytotoxic in their antiviral concentration range.

144 9 and 10 were weakly active against HCMV and noncytotoxic in their antiviral dose range.

145 tive against HCMV (IC50's = 1-10 microM) and noncytotoxic in their antiviral dose ranges.

146 Microspheres were found to be noncytotoxic in vitro, and noninflammatory in vivo.

147 teasomal activity causes formation of large, noncytotoxic inclusions within the cytoplasm of both neu

148 mune responses, WHV establishes a persistent noncytotoxic infection of woodchuck hepatocytes in uPA/R

149 We observed CD8(+)-cell noncytotoxic inhibition of HIV replication in acutely in

150 strate that at 20 muM shornephine A (1) is a noncytotoxic inhibitor of P-glycoprotein-mediated drug e

151 alin-11-one oxime) was found to be a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [int

152 -compound) chemical library, we identified a noncytotoxic inhibitor of this interaction that impaired

153 )-7H-pyrrolo[2,3-d]pyri midine as potent and noncytotoxic inhibitors of HCV RNA replication.

154 This resulted in the identification of noncytotoxic inhibitors that exhibited single digit nano

155 A total of 24 noncytotoxic invasion inhibitors were identified.

156 can be established across MHC barriers by a noncytotoxic, irradiation-free approach using costimulat

157 The lung instillation of a noncytotoxic, isogenic mutant strain (PA103DeltaUT), whi

158 Exposure of 3T3-L1 preadipocytes to noncytotoxic levels of arsenic, including inorganic arse

159 Noncytotoxic levels of oxidative stress downregulate tro

160 that a one-time periadventitial delivery of noncytotoxic levels of PGG inhibits elastin degeneration

161 Fluorescent proteins photoswitchable with noncytotoxic light irradiation and spectrally distinct f

162 We identified a noncytotoxic M. marinum strain with a transposon inserti

163 CSA inhibited, in a dose-dependent and noncytotoxic manner, aggrecanase-mediated proteoglycan c

164 sis and inflammation-associated markers in a noncytotoxic manner.

165 Our data suggest a predominantly noncytotoxic mechanism of action for decitabine, leading

166 reases in HbF and total hemoglobin through a noncytotoxic mechanism of action.

167 rity, consistent with a DNA hypomethylating, noncytotoxic mechanism of action.

168 pecific TCR reduced HCV RNA replication by a noncytotoxic mechanism, the NS3-specific TCR-redirected

169 IV replication in cultured CD4(+) cells by a noncytotoxic mechanism.

170 but not IFN-gamma, elicited IL-4 release by noncytotoxic mechanisms.

171 using challenge with wild-type PAO1 or other noncytotoxic members of the O2/O5 serogroup, there was n

172 , with the ability to discern cytotoxic from noncytotoxic modes of action.

173 Six of the noncytotoxic mutants, however, demonstrated measurable l

174 an increased proportion of more immature and noncytotoxic NK cell subsets in their peripheral blood,

175 ronospora arabidopsidis encodes 10 different noncytotoxic NLPs (HaNLPs) that do not cause necrosis.

176 We discovered that these noncytotoxic NLPs, however, act as potent activators of

177 rimary isolates of HIV by >90% and did so in noncytotoxic/noncytostatic concentrations and in a beta-

178 gardless of their cytokine phenotype, can be noncytotoxic or lyse target cells via either perforin- o

179 17 to inocula of either cytotoxic (exoU+) or noncytotoxic P. aeruginosa resulted in large reductions

180 ic phenotype on some, but not all, otherwise-noncytotoxic P. aeruginosa strains and, for recombinant

181 Seven phenotypically noncytotoxic P. aeruginosa strains were transformed with

182 ertional mutations in the exoU gene confer a noncytotoxic phenotype on mutant strains and decrease vi

183 uction of apoptosis results in a conditional noncytotoxic phenotype, whereas simultaneous inactivatio

184 IFN-gamma and granzyme B, but they exhibit a noncytotoxic phenotype.

185 iphoton excitation is used to focally excite noncytotoxic photosensitizers that promote protein cross

186 lts show that chronic exposure (3 months) to noncytotoxic, physiological relevant concentration (1 mu

187 influenza virus, we developed an efficient, noncytotoxic, plasmid-based virus-like particle (VLP) sy

188 Using an unacylated, noncytotoxic pro-LKT produced by an DeltalktC mutant of

189 The addition of efaproxiral, a noncytotoxic radiation sensitizer, to WBRT may improve r

190 yl)-5'benzimidazolyl] benzimidazole (DMA) as noncytotoxic radioprotector in mammalian cells.

191 E-induced histologic damage, suggesting that noncytotoxic rCPE variants might be useful for protectin

192 treatment of ileal loops with either of the noncytotoxic rCPE variants produced no visible histologi

193 th of which are cytotoxic, with those of the noncytotoxic rCPE variants rCPE D48A and rCPE(168-319).

194 Noncytotoxic regimens of DAC were evaluated for in vitro

195 This anti-HIV response was noncytotoxic; removal of the CD8+ cells from the infecte

196 results suggest that a part of the CD8+ cell noncytotoxic response involves the activity of a proteas

197 The CD8+ noncytotoxic response is mediated by a novel soluble fac

198 tency in vivo in the induced ODC assay using noncytotoxic rotenoid concentrations with cultured MCF-7

199 and (S)-7 have potent in vitro activity, are noncytotoxic, show no adverse effects in vivo following

200 estricted pathway as well as by secretion of noncytotoxic soluble inhibitory factors.

201 Noncytotoxic steatosis in HepG2 cells affected the secre

202 Using transposon mutagenesis, we isolated a noncytotoxic strain of E. tarda.

203 In contrast, the instillation of the noncytotoxic strains (PA01, PA103exsA::omega) did not le

204 e whether introduction of the exoU gene into noncytotoxic strains of P. aeruginosa lacking this gene

205 ical or basolateral surface to cytotoxic and noncytotoxic strains of P. aeruginosa.

206 Apical addition of either noncytotoxic strains or cytotoxic strains failed to affe

207 Both cytotoxic and noncytotoxic strains were identified among corneal and n

208 anges observed after basolateral addition of noncytotoxic strains.

209 nd on APCs, is primarily responsible for the noncytotoxic suppression of HIV replication in CD4+ cell

210 ficant reduction in the level of CD8(+) cell noncytotoxic suppression of HIV replication was observed

211 alizing antibodies, and secretion of soluble noncytotoxic suppressor factors of SIV replication.

212 duction of apoptotic signaling pathways, the noncytotoxic T cell activation showed extended prolifera

213 Matched, noncytotoxic T cells were similarly generated by culturi

214 To study the efficacy of noncytotoxic therapy in this animal model, cohorts of na

215 ch this information might be used to develop noncytotoxic therapy.

216 h regulatory mechanisms may lead to specific noncytotoxic therapy.

217 f 2 and 26 nM, respectively, while remaining noncytotoxic to cells at concentrations exceeding 23 mic

218 Fifteen (65%) of the derivatives were noncytotoxic to host cells (TD(50) > or = 320 microM).

219 Vanilloids were noncytotoxic to the MCs, in contrast to the DRGs.

220 ily infiltrated by CD8(+) T cells, which are noncytotoxic to the renal tissue.

221 otoxic P. aeruginosa strain, and 33 isogenic noncytotoxic transposon mutants for internalization by M

222 on of apoptosis renders serotype Typhimurium noncytotoxic under all conditions tested.

223 Naturally occurring noncytotoxic vacA type s2 strains of Helicobacter pylori

224 ymerase-driven overexpression system, in our noncytotoxic VLP system M1 was not released efficiently

225 ones apoptolidinone A and D were shown to be noncytotoxic when evaluated against human lung cancer ce

226 tent with these data, tempol was found to be noncytotoxic, whereas tempo induced apoptotic cell death

227 l cultures of 0.1 microM and was shown to be noncytotoxic with a CC(50) > 10 microM.