ライフサイエンスコーパス: nondisjunction

1 ormal chromosome segregation during meiosis (nondisjunction).

2 a crossover, which in turn leads to elevated nondisjunction.

3 maternal or paternal age on the frequency of nondisjunction.

4 providing a good model for studying meiotic nondisjunction.

5 uch as that predicted to result from mitotic nondisjunction.

6 pindle attachment, and results in chromosome nondisjunction.

7 t a significant contributor to human meiotic nondisjunction.

8 disrupted centromere clustering and meiotic nondisjunction.

9 at homozygosity occurred through chromosomal nondisjunction.

10 or more on chromosomes that had experienced nondisjunction.

11 mplete Sgo1 redistribution causes chromosome nondisjunction.

12 ly associated with an increased frequency of nondisjunction.

13 fluconazole can be dependent on chromosomal nondisjunction.

14 e a high frequency of 4th chromosome meiotic nondisjunction.

15 e whose activity helps to prevent chromosome nondisjunction.

16 is not due to eggshell defects or chromosome nondisjunction.

17 MI spindle and separate randomly, leading to nondisjunction.

18 s study investigated the basis of meiosis II nondisjunction.

19 e same nucleus for the centromere to undergo nondisjunction.

20 syntely but with some merotely) resulted in nondisjunction.

21 highly transcribed loci can cause chromosome nondisjunction.

22 metic Yen1 mutant increased sister chromatid nondisjunction.

23 inversion heterozygotes as a model of human nondisjunction.

24 ting how oocyte aging contributes to meiotic nondisjunction.

25 ssociated with maternally derived chromosome nondisjunction.

26 daptive mutagenesis can arise by chromosomal nondisjunction, a phenomenon previously associated exclu

27 chromosome number, or aneuploidy, is through nondisjunction--a chromosome distribution error that occ

28 Several situations that yield frequent nondisjunction also produce high levels of chromatin-dep

29 The frequency of nondisjunction among 1784 embryos (3568 meioses) was 15.

30 ts suggest that the greatest risk factor for nondisjunction among younger women is the presence of a

31 better the association of recombination with nondisjunction, an understanding of the pattern of meiot

32 n of sister chromatids, resulting in massive nondisjunction and broken spindles.

33 ne may be a risk factor for maternal meiotic nondisjunction and Down syndrome in young mothers.

34 researchers designing genetic experiments on nondisjunction and improves several methods for the anal

35 ted with very high frequencies of chromosome nondisjunction and loss.

36 e an extreme bobbed visible phenotype and XY nondisjunction and meiotic drive in males.

37 t contain the IGS were found to suppress X-Y nondisjunction and meiotic drive in Xh-/Y males, and to

38 valents were observed, leading to chromosome nondisjunction and semisterility.

39 This analysis demonstrates that, although nondisjunction and sperm lethality are indeed correlated

40 e underlying biochemical changes that induce nondisjunction and the development of chromosomal defect

41 Hence, a combination of nondisjunction and unequal spindle formation at first po

42 o sperm, consistent with a high frequency of nondisjunction and/or chromosome loss.

43 leation, increased chromosome lagging and/or nondisjunction, and abnormal localization of Aurora B at

44 equency of spontaneous mutations, chromosome nondisjunction, and telomere shortening.

45 hromosome 5, which is apparently a result of nondisjunction, appeared with increased frequencies afte

46 onception, maternal risk factors for meiotic nondisjunction are not well established.

47 Because most nondisjunction arises from E(0) tetrads, this observatio

48 t X chromosomes become vulnerable to meiotic nondisjunction as Drosophila oocytes age.

49 r that holds chromosomes together suppresses nondisjunction as long as the tether is near the centrom

50 Y chromosomes during male meiosis by causing nondisjunction at anaphase I.

51 ombine and an associated increase in homolog nondisjunction at meiosis I.

52 D+ protein in mei-S332 mutant males enhances nondisjunction at meiosis II.

53 rvive the pachytene stage display chromosome nondisjunction at the first meiotic division, resulting

54 he B chromosome of maize (Zea mays) involves nondisjunction at the second pollen mitosis, placing two

55 body that is not a consequence of chromosome nondisjunction, but is mimicked by depletion of vesicle

56 vision of chromatids was also found to cause nondisjunction, but it did not increase with maternal ag

57 ivalents going to the same pole and, second, nondisjunction by premature chromatid separation (prediv

58 This process of nondisjunction can be studied by counting experimental p

59 ition, our results suggest that B chromosome nondisjunction can occur during the first microspore div

60 inactive centromere regained the property of nondisjunction causing the translocation chromosome 9 to

61 ere are multiple causes of human age-related nondisjunction, complicating our efforts to understand -

62 esion is under the control of the B-specific nondisjunction control region.

63 e XX <--> Y segregation events as "secondary nondisjunction." Cooper proposed that secondary nondisju

64 enetics of each specific human centromere in nondisjunction disorders and other biological settings.

65 Our findings indicate that nondisjunction does not directly yield aneuploid cells,

66 nd King challenge this view, concluding that nondisjunction does not yield aneuploid cells directly,

67 oocytes are most susceptible to spontaneous nondisjunction during meiosis I.

68 lity that may lead to chromosome breakage or nondisjunction during mitosis.

69 The B chromosomes of maize typically undergo nondisjunction during the second microspore division (ge

70 The Saccharomyces cerevisiae gene NDJ1 (nondisjunction) encodes a protein that accumulates at te

71 In the female germ line, mitotic nondisjunction ensures that the products of meiosis all

72 PWS with UPD in which there was a meiosis I nondisjunction error involving an altered chromosome 15

73 The absence of Mad3 does not induce nondisjunction, even though mad3Delta cells cannot arres

74 combination on chromosome 21, and hence, the nondisjunction event.

75 idence indicate that this contributes to the nondisjunction event.

76 partial isodisomy was caused by a meiosis II nondisjunction event.

77 te-specific dysregulation contributes to the nondisjunction event.

78 nt for distal exchanges among meiosis I (MI) nondisjunction events and for proximal exchanges among m

79 Nondisjunction events were distributed nonrandomly among

80 Nondisjunction events were scored and factors influencin

81 nomaly disorder caused by 3&rcolon;1 meiotic nondisjunction events.

82 ally explained as reflecting two consecutive nondisjunction events.

83 mouse germ cells exhibit prophase I-related nondisjunction events.

84 A (chr7) and PTEN (chr10) as driving initial nondisjunction events.

85 Here, we present findings that X chromosome NonDisjunction factor-1 (XND-1), known for its role in r

86 The frequency of nondisjunction for chromosome 18 was significantly highe

87 The frequency of nondisjunction for chromosome 7 was significantly higher

88 Genetic variation in nondisjunction frequency among X chromosomes from two Dr

89 ckground did not play an appreciable role in nondisjunction frequency.

90 The rate of nondisjunction has traditionally been estimated by assum

91 entify genetic contributors to human meiotic nondisjunction have met with little, if any, success.

92 e hypothesis that some women have a risk for nondisjunction higher than do others of the same age.

93 romosome counts provide evidence against the nondisjunction hypothesis, and probability calculations

94 Deletion of NDJ1 (ndj1Delta) caused nondisjunction, impaired distributive segregation of lin

95 Efforts to recapitulate age-dependent nondisjunction in a mammalian experimental system have s

96 the first molecular correlate of chromosome nondisjunction in both humans and model organisms.

97 c recombination is an important component of nondisjunction in both species.

98 evalence and the deleterious consequences of nondisjunction in D. melanogaster.

99 for both high mean rates of female-specific nondisjunction in Drosophila and humans as well as the s

100 For X chromosome nondisjunction in Drosophila female meiosis, all of the

101 ion of 103 cases of spontaneous X chromosome nondisjunction in Drosophila oocytes strongly parallels

102 both high levels of X and fourth chromosome nondisjunction in FM7/X females and high levels of fourt

103 ation, inducing both X and fourth chromosome nondisjunction in FM7/X females.

104 nsequences of spontaneous mitotic chromosome nondisjunction in human cells are not well understood.

105 believed to increase the risk of chromosome nondisjunction in human oocytes.

106 e configurations that are at higher risk for nondisjunction in humans and other organisms, we examine

107 ite the clinical importance of age-dependent nondisjunction in humans, the underlying mechanisms rema

108 on between altered recombination and meiotic nondisjunction in humans.

109 g on Drosophila, and secondly an overview of nondisjunction in humans.

110 for certain classes of age-dependent meiotic nondisjunction in humans.

111 sister chromatids may contribute to meiotic nondisjunction in humans.

112 ntation disruptor (ord) gene lead to meiotic nondisjunction in males and females because cohesion is

113 or understanding factors influencing meiotic nondisjunction in mammals.

114 ion prior to maternal meiosis I, followed by nondisjunction in maternal meiosis II, resulted in an oo

115 To investigate nondisjunction in mitotic and meiotic germ cells, we per

116 ocess, has implications for the frequency of nondisjunction in our species.

117 Meiosis I nondisjunction in spindle checkpoint mutants could be pr

118 ave reduced map lengths, a high frequency of nondisjunction in the first meiotic division, and essent

119 xplanation for the high incidence of meiotic nondisjunction in the human female.

120 Similarly, mitotic nondisjunction in the male germ line leads to the produc

121 osition complexes, consistent with increased nondisjunction in these double mutant cells.

122 females and high levels of fourth chromosome nondisjunction in X/X females.

123 In addition, virtually all cases of X nondisjunction in XXY females were due to XX <--> Y segr

124 hal alleles in the common region for meiotic nondisjunction, including an allele containing an amino

125 During meiosis in human oocytes, chromosome nondisjunction increases with maternal age, leading to d

126 red and factors influencing the frequency of nondisjunction involving chromosomes 7 and 18 were exami

127 In both, a proportion of nondisjunction is associated with failure to pair and/or

128 accumulation mechanism by demonstrating that nondisjunction is caused by a process that does not depe

129 we show that the direct result of chromosome nondisjunction is gain or loss of a single chromosome, w

130 Meiotic nondisjunction is known to increase in older mothers, an

131 Here we show that chromosome nondisjunction is tightly coupled to regulation of cytok

132 Aberrant recombination is associated with nondisjunction (NDJ) leading to trisomy 21.

133 Chromosomes show different frequencies of nondisjunction (NDJ), reflecting inherent differences in

134 nclusion that chromosome segregation errors (nondisjunction, NDJ) occurred when nonexchange chromosom

135 important clues to the higher frequencies of nondisjunction observed in older women.

136 MII nondisjunction occurred only in oocytes with proximal ex

137 MI nondisjunction occurred primarily in oocytes with non-ex

138 Nondisjunction occurred with high frequency in cells tha

139 In the absence of Smc5-Smc6, chromosome nondisjunction occurs as a consequence of mitotic entry

140 In the absence of Mad2, meiosis I nondisjunction occurs at a high frequency and can be cor

141 It has been assumed that nondisjunction of a chromosome during mitosis will yield

142 First, nondisjunction of bivalent chromosomes resulting in two

143 meiosis I centromere orientation and causing nondisjunction of both homologous and sister chromatids.

144 We found that nondisjunction of Bs is accompanied by centromere activi

145 of age, a significant increase (P < .001) in nondisjunction of full dyads was found in the oocytes wi

146 mation of tripolar or monopolar spindles and nondisjunction of homologous chromosomes at meiosis I.

147 Nondisjunction of homologous chromosomes occurs in mei-3

148 rs in the rec8 mutants were due to meiosis I nondisjunction of homologous chromosomes.

149 aration of sister chromatids, but rather the nondisjunction of homologs.

150 s in the rec10 and rec11 mutants were due to nondisjunction of sister chromatids during meiosis II.

151 mosomes are present during anaphase, causing nondisjunction of some sister chromatids producing aneup

152 e male specific and cause meiosis I-specific nondisjunction of the autosomes.

153 However, the cycle is interrupted by nondisjunction of the B centromere at the second pollen

154 By utilizing the frequent nondisjunction of the B centromere at the second pollen

155 Because of the frequent nondisjunction of the B centromere at the second pollen

156 tic line TB-10L18, our results indicate that nondisjunction of the B centromere occurs at an average

157 ll be driven down to the rate of spontaneous nondisjunction of the X chromosome.

158 dida albicans to fluconazole resulted in the nondisjunction of two specific chromosomes in 17 drug-re

159 Alternative explanations involving nondisjunction or autosomal inheritance are presented an

160 Upon investigation of the rDNA nondisjunction phenomenon, it was found that cdc14 mutan

161 The meiotic nondisjunction phenotype may result from a chromosomal r

162 more, whilst Pa ESP can rescue the chromatid nondisjunction phenotype of Arabidopsis ESP mutants, it

163 The nondisjunction, progression defects and desynapsis can b

164 B centromere to chromosome 7 transferred the nondisjunction property to this chromosome.

165 erimental progeny, but direct measurement of nondisjunction rates is complicated by not all classes o

166 were observed to congress poorly, leading to nondisjunction rates of 25%.

167 pericentromeric X heterochromatin cause X-Y nondisjunction, reduced male fertility and distorted spe

168 Thus, spontaneous MI nondisjunction reflects the failure of the achiasmate se

169 at the region of the chromosome required for nondisjunction resides in the centromeric region.

170 disjunction." Cooper proposed that secondary nondisjunction results from the formation of an X-Y-X tr

171 f cytokinesis in human cell lines, such that nondisjunction results in the formation of tetraploid ra

172 ein Mad2 results in an increase in meiosis I nondisjunction, suggesting that Mad2 has a conserved rol

173 rs are usually used to identify the stage of nondisjunction that leads to UPD and to uncover the asso

174 plicons is the primary reason for chromosome nondisjunction upon CDC14 dysfunction.

175 o statistically significant bias in apparent nondisjunction vs. mitotic recombination among male vs.

176 al polarized light microscope imaging showed nondisjunction was caused by chromosome malorientation.

177 Bridges (1916) observed that X chromosome nondisjunction was much more frequent in XXY females tha

178 However, nondisjunction was not significantly increased in oocyte

179 inversion heterozygotes were pooled, meiotic nondisjunction was slightly but significantly higher in

180 NPCs undergoing nondisjunction were also observed, along with interphase

181 Two mechanisms of nondisjunction were determined.

182 Unbalanced predivision and classical nondisjunction were unaffected by oocyte aging.

183 ericentric heterochromatin exhibit increased nondisjunction when oocytes age.

184 ity associated with an increase in meiosis I nondisjunction, while intergenic recombination is reduce

185 ogenesis, probably as a result of chromosome nondisjunction, with affected animals being mosaics for

186 ng recognized as the primary risk factor for nondisjunction--with altered recombination, although som