ライフサイエンスコーパス: nondividing

1 lacking tryptophan leads to the formation of nondividing, aberrant RB.

2 more than 2 months, hRPE cells were largely nondividing and accumulated autofluorescent granules ide

3 ng-term hRPE culture created cells that were nondividing and accumulated autofluorescent granules.

4 gest that this mechanism can operate in both nondividing and dividing cells.

5 The lentiviral vector transduced both nondividing and dividing cells; the Moloney vector only

6 that the kinetic parameters are distinct for nondividing and dividing NK cell subpopulations.

7 ith those of onco- and lentiviral vectors in nondividing and dividing normal human fibroblasts by sev

8 by differences in the kinetic parameters of nondividing and dividing subsets of NK cells.

9 tumors, are a population that is relatively nondividing and nonapoptotic but chemotherapy resistant

10 odeficiency virus type 1 (HIV-1), can infect nondividing and terminally differentiated cells.

11 ctors are capable of transferring genes into nondividing and terminally differentiated cells.

12 lative contributions of dividing, quiescent (nondividing) and dead cells.

13 se HSAhigh DP and CD4+ stages appeared to be nondividing, and already exhibited the same Vbeta8 bias

14 hether the nuclei of normal, nontransformed, nondividing, and terminally differentiated mammalian cel

15 ) retrotransposition can occur in quiescent, nondividing, and/or terminally differentiated somatic ce

16 Nondividing Arabidopsis pollen vegetative cells, which t

17 ted immunity; the virus is able to transduce nondividing as well as dividing cells; and both wild-typ

18 while newly selected CD4+ and CD8+ cells are nondividing, both subsets subsequently undergo a wave of

19 This system could conceivably kill even the nondividing breast cancer cells, because the levels of 5

20 recurrence is currently thought to be due to nondividing cancer stem/progenitor cells that are resist

21 ears to play an important role in preserving nondividing cardiac myocytes until specific immune respo

22 could be detected in HIV-2 vector-transduced nondividing CD34(+) CD38(-) human hematopoietic progenit

23 ause they achieve efficient integration into nondividing cell genomes and successful long-term expres

24 re efficient than MLV vectors at transducing nondividing cell lines as well as human CD34(+) cells an

25 -long terminal repeat circle accumulation in nondividing cell nuclei was also equivalent to that of L

26 ion of mutant cDNA localized to dividing and nondividing cell nuclei.

27 ses of sensitivity to DNA-damaging agents in nondividing cell populations, such as cochlear hair and

28 ith the cell cycle, typically resulting in a nondividing cell with a unique differentiated morphology

29 vulnerable to h-IAPP-induced apoptosis than nondividing cells (P < 0.05).

30 phase) mutagenesis is a phenomenon by which nondividing cells acquire beneficial mutations as a resp

31 educed, they recovered to original levels in nondividing cells after drug treatment.

32 vectors that express the transduced gene in nondividing cells and (b) increasing the frequency of st

33 a demonstrate essential roles for cohesin in nondividing cells and also introduce a powerful tool by

34 ty of adenoviruses to transduce dividing and nondividing cells and because of their high transduction

35 ribute to the formation of tumors arising in nondividing cells and could also contribute to mutagenes

36 in that is critical for HIV-1 replication in nondividing cells and induces cell cycle arrest and apop

37 eting of the viral preintegration complex in nondividing cells and induces G(2) cell cycle arrest in

38 aries among cell types (e.g. dividing versus nondividing cells and normal versus tumor cells).

39 herefore is linked to higher virus yields in nondividing cells and potentially higher virulence in ex

40 This increased the efficiency of infecting nondividing cells and was sufficient to endow the virus

41 Retroviruses in nondividing cells and yeast retrotransposons must transi

42 The nondividing cells are heterogeneous for naive versus mem

43 andomly into the genome of both dividing and nondividing cells as determined by fluorescence in situ

44 /1107) that prevent efficient replication in nondividing cells but allow replication in dividing canc

45 Lentiviruses likely infect nondividing cells by commandeering host nuclear transpor

46 AMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by dep

47 The efficiency of infection of nondividing cells by the three viruses correlates with t

48 ke the gammaretroviruses, are able to infect nondividing cells by transiting through nuclear pores to

49 s for efficient transduction of dividing and nondividing cells by vector particles based on FIV, a se

50 cells and during transcription initiation in nondividing cells can culminate in genome instability.

51 omal rearrangement frequency during aging of nondividing cells compared with that generated during th

52 The capacity of mutant virions to transduce nondividing cells could help to elucidate incompletely u

53 rocessing and protein synthesis so that even nondividing cells die of protein starvation.

54 as human immunodeficiency virus, that infect nondividing cells generate integration precursors that m

55 Compared with proliferating hRPE cells, the nondividing cells had lower intracellular GSH, GSSG, and

56 r mitotic spindles along the tubule, whereas nondividing cells improperly position their centrosomes.

57 re reduced in their capacity to replicate in nondividing cells in culture and in vivo.

58 Lat1 is also a limiting longevity factor in nondividing cells in that overexpressing Lat1 extends ce

59 ng epithelial cells but not in the nuclei of nondividing cells in the lens fiber compartment.

60 induced by oxidative metabolism, which kills nondividing cells in the nervous system.

61 of 10(9) IU/ml and can efficiently transduce nondividing cells in vitro and in vivo.

62 ts demonstrate the efficient transduction of nondividing cells in vitro by a multiply attenuated FIV

63 that exhibit profound replication defects in nondividing cells in vitro.

64 ectors have recently been shown to transduce nondividing cells in vivo as well as in vitro.

65 to efficiently convert to a circular form in nondividing cells in vivo using transgenic mice.

66 have evolved a number of mechanisms to drive nondividing cells into S phase.

67 rus type 1 (HIV-1) infection of dividing and nondividing cells involves regulatory interactions with

68 human immunodeficiency virus (HIV) to infect nondividing cells is a fundamental property by which HIV

69 act nuclear envelope and productively infect nondividing cells is a salient feature of human immunode

70 Lipofection of nondividing cells is inefficient because much of the tra

71 raries via iterative retroviral infection of nondividing cells led to the identification of a novel v

72 rt models in which UV-induced mutagenesis in nondividing cells occurs during the Pol zeta-dependent f

73 al origin revealed that only differentiated, nondividing cells of the epidermis expressed interferon-

74 rigin of double nonsilent CpG transitions in nondividing cells predicts a significant excess of the h

75 nodeficiency virus type 1 (HIV-1) can infect nondividing cells productively because the nuclear impor

76 HIV-1 is able to infect nondividing cells productively in part because the poste

77 ize that inhibition of retrotransposition in nondividing cells protects somatic tissues from accumula

78 feration could reduce the number of residual nondividing cells remaining after imatinib treatment.

79 virus type 1 (HIV-1) is capable of infecting nondividing cells such as macrophages because the viral

80 gammaretroviruses by their ability to infect nondividing cells such as macrophages, an important vira

81 ce potent and long-lasting HIV inhibition in nondividing cells such as macrophages.

82 critical for efficient virus replication in nondividing cells such as macrophages.

83 iral capsids restrict HIV-1 more potently in nondividing cells than in dividing cells, thus rendering

84 nsgene, we demonstrate that differentiating, nondividing cells that express MEK1 stimulate adjacent t

85 -specific restriction of HIV-1 CA mutants in nondividing cells that is dependent on CypA-CA interacti

86 could deliver the active cellular kinase to nondividing cells that normally do not express it.

87 against viral capsids and the resistance of nondividing cells to retrovirus infection.

88 sification was unclear and nuclear import in nondividing cells was not addressed.

89 diated nuclear translocation of MoMLV DNA in nondividing cells was not sufficient for stable transduc

90 s persistence in myofibers and perhaps other nondividing cells whereby cells that survive infection c

91 re it can identify rAAV integration sites in nondividing cells without cell manipulations.

92 gest that the foamy virus genome persists in nondividing cells without integrating.

93 sistence may be adequate for gene therapy of nondividing cells, a very high MOI or improvements in ba

94 77 impairs viral infectivity in dividing and nondividing cells, although the assembly of these Ser mu

95 DNA, (iii) enabling analysis in individual, nondividing cells, and (iv) uncoupling other potential f

96 n E1A that preclude efficient replication in nondividing cells, and a deletion of the E3 genes which

97 cantly impaired (1,000-fold lower titers) in nondividing cells, and plaque-forming ability was severe

98 or that determines retrovirus infectivity in nondividing cells, and several mutations in HIV type 1 (

99 5-Aza-2'-deoxycytidine-treated and untreated nondividing cells, and their mRNA transcripts were down-

100 t reversibility is not a passive property of nondividing cells, because enforced cell cycle arrest fo

101 t is unclear how repeats are destabilized in nondividing cells, but it cannot involve DNA replication

102 sed lentiviral vectors efficiently transduce nondividing cells, but present complex safety concerns.

103 ncy virus (FIV) is a lentivirus that infects nondividing cells, causes progressive CD4(+) T-cell depl

104 se transcription complex into the nucleus of nondividing cells, cellular differentiation including ce

105 mine whether DNA nanoparticles can transfect nondividing cells, growth-arrested neuroblastoma and hep

106 replicated equivalently to the wild type in nondividing cells, including macrophages.

107 ed transgene integration in several types of nondividing cells, including neurons.

108 Poor nuclear entry, especially into nondividing cells, is a limiting factor in nonviral gene

109 curs on a largely unmethylated genome and in nondividing cells, making it a highly informative model

110 Of all mutations originating de novo in nondividing cells, only those in the transcribed (noncod

111 itially reported to function specifically in nondividing cells, other recently identified sequences a

112 In the remaining nondividing cells, progressive accumulation of a senesce

113 splice variants are expressed highly only in nondividing cells, quiescent cells would be afforded a m

114 n a replication strand-independent manner in nondividing cells, resulting in either fully wild-type o

115 lity to efficiently infect both dividing and nondividing cells, such as activated T cells and macroph

116 unodeficiency virus type 1 is able to infect nondividing cells, such as macrophages, and the viral Vp

117 ormation, especially during the infection of nondividing cells, suggesting that the function of small

118 g mitosis, similar to retroviruses infecting nondividing cells, the cDNA produced must be translocate

119 of these vectors to infect both dividing and nondividing cells, their use as a therapeutic tool for t

120 Because lentiviruses are able to infect nondividing cells, these viruses might be utilized in ge

121 mammalian cell types, including primary and nondividing cells, we are developing lentiviral short ha

122 lation of superoxide-dependent DNA damage in nondividing cells, which induces error-prone DNA repair

123 replicated productively in both dividing and nondividing cells, while viruses with a mutation at IN-V

124 ating vector in directing gene expression in nondividing cells, with the proper choice of an internal

125 d maintenance of phosphoinositide balance in nondividing cells.

126 Rad17, and Chk1 protein expression in these nondividing cells.

127 ficiency virus, by their inability to infect nondividing cells.

128 different half-lives in rapidly dividing or nondividing cells.

129 cript abundance limits retrotransposition in nondividing cells.

130 TDP1), repairs single-stranded DNA breaks in nondividing cells.

131 yeast by measuring the long-term survival of nondividing cells.

132 n of these foci was seen most prominently in nondividing cells.

133 eine also inhibits efficient transduction of nondividing cells.

134 curing of [PSI+] cells in both dividing and nondividing cells.

135 NA-PKcs) that are expressed predominately in nondividing cells.

136 cells are more vulnerable to apoptosis than nondividing cells.

137 on of human immunodeficiency virus type 1 in nondividing cells.

138 ween HIV and MLV in the ability to transduce nondividing cells.

139 uses is their ability to productively infect nondividing cells.

140 protein (CA) in the infectious phenotype in nondividing cells.

141 MLV) loses the ability to efficiently infect nondividing cells.

142 ility to stably integrate into the genome of nondividing cells.

143 stricted infection of this chimeric virus in nondividing cells.

144 rabidopsis culture cells than in stationary, nondividing cells.

145 ave the potential to change the phenotype of nondividing cells.

146 ion, thereby facilitating HIV replication in nondividing cells.

147 lls (HSCs) due to their ability to transduce nondividing cells.

148 cells and their isolated lipids relative to nondividing cells.

149 is defined as the age-dependent viability of nondividing cells.

150 d more sensitive to VEGF(121)/rGel than were nondividing cells.

151 enes that effectively kill both dividing and nondividing cells.

152 required for maintaining a silenced state in nondividing cells.

153 eplicates only in terminally differentiated, nondividing cells.

154 egrating their viral DNA into the genomes of nondividing cells.

155 owed by rapid apoptosis in both dividing and nondividing cells.

156 l for virus replication in both dividing and nondividing cells.

157 ed gene delivery and long-term expression in nondividing cells.

158 st, adenoviruses (Ad) can efficiently infect nondividing cells.

159 is essential for the productive infection of nondividing cells.

160 a gene therapy vector to transfer genes into nondividing cells.

161 virus (SNV), which are capable of infecting nondividing cells.

162 transfer systems for delivery of genes into nondividing cells.

163 ites, which are highly toxic to dividing and nondividing cells.

164 -modified HIV-1 particles are able to infect nondividing cells.

165 t gene delivery to a variety of dividing and nondividing cells.

166 en pathway for generating mutant proteins in nondividing cells.

167 ead to viral- and lipid-free transfection of nondividing cells.

168 1-derived vectors is their ability to infect nondividing cells.

169 essory gene expression in either dividing or nondividing cells.

170 entivirus vectors can transduce dividing and nondividing cells.

171 mited in certain cell types, particularly in nondividing cells.

172 ence of antigenic stimulation and persist as nondividing cells.

173 f high-level gene transfer and expression in nondividing cells.

174 port of the viral genome into the nucleus of nondividing cells.

175 ency virus type 1 (HIV-1) that can transduce nondividing cells.

176 at high titers and infect both dividing and nondividing cells.

177 ly been thought of as metabolically dormant, nondividing cells.

178 gene transfer agents because they can infect nondividing cells.

179 type 1 (HIV-1) vectors to deliver genes into nondividing cells.

180 etrotransposons and retroviruses that infect nondividing cells.

181 resuscitate from starvation, leaving intact nondividing cells.

182 for MMR in helping create new phenotypes in nondividing cells.

183 gesting that R2 is able to retrotranspose in nondividing cells.

184 ds to HIV-1 CA, regulates HIV-1 infection of nondividing cells.

185 mage and genomic instability during aging in nondividing cells.

186 ) CA abrogate the ability of HIV-1 to infect nondividing cells.

187 ich binds to HIV-1 CA, on HIV-1 infection of nondividing cells.

188 es can enter the nuclei of both dividing and nondividing cells.

189 homologous recombination is not essential in nondividing cells.

190 mine effects of growth factor stimulation on nondividing cells.

191 lex across the nuclear pore complex (NPC) of nondividing cellular hosts, the mechanism by which Vpr e

192 o ensure the capacity of HIV to replicate in nondividing cellular hosts.

193 significantly reduced the number of viable, nondividing CFSE bright cells remaining after imatinib e

194 tment further reduced the number of residual nondividing CML CD34(+) cells.

195 timulating factor also significantly reduced nondividing CML CD34(+) cells.

196 genetic control of UV-induced mutagenesis in nondividing cultures of Saccharomyces cerevisiae.

197 become undetectable in confluent cultures of nondividing CV-1 cells and in nonmitotic cells in variou

198 lls that, upon injury, can alternate between nondividing differentiated and dedifferentiated prolifer

199 ells did not produce interferon-beta whereas nondividing differentiated cells expressing keratin 1 di

200 tract and the skin, where it is expressed in nondividing differentiated cells.

201 me from differentiated rat astrocytes into a nondividing differentiated rat neuron resulted in the co

202 ated MAPK kinase 1 (MEK1) in the suprabasal, nondividing, differentiated cell layers (InvEE transgeni

203 an papillomaviruses (HPVs) are restricted to nondividing, differentiated keratinocytes.

204 itro and of a long-term prion infection in a nondividing, differentiated peripheral cell type in cult

205 Transduction of TAT-dnRas into nondividing eosinophils inhibited endogenous Ras activat

206 This study demonstrates that in nondividing Escherichia coli cells, a DNA template base

207 ced at a defined position, indicated that in nondividing Escherichia coli cells, efficient mutagenic

208 entifying factors that affect aging in other nondividing eukaryotic cells.

209 3 weeks to return to steady-state levels in nondividing fibroblasts.

210 The nondividing filamentous cells still exhibited robust cir

211 d to compare gene expression in dividing and nondividing (filamentous) cultures of Escherichia coli.

212 to consolidated populations in dividing and nondividing GEPs, to microorganisms traversing breaches

213 e amplification in both well-differentiated (nondividing) HAE and dividing HEK293 cells.

214 uble-strand breaks within the chromosomes of nondividing haploid cells.

215 ivity of the CA mutants on both dividing and nondividing HeLa cells was relieved by either pharmacolo

216 ep between nuclear import and integration in nondividing HeLa cells.

217 uld have the advantage of allowing access to nondividing hematopoietic cells.

218 We conclude that nondividing hepatocytes can maintain and regenerate live

219 eous tumors in A/J mice and 3-4 weeks in the nondividing hepatocytes of BALB/c mice.

220 Unlike activated CD4(+) T cells, this nondividing HIV-1 target cell type contains a very low l

221 HIV replication in nondividing host cells occurs in the presence of high co

222 The nondividing hRPE cells appeared more susceptible to tBH-

223 However, the nondividing hRPE cells had decreased sensitivity to apop

224 FasL may contribute to the vulnerability of nondividing hRPE cells to oxidant-induced apoptosis.

225 um chelator transduced fully differentiated, nondividing human airway epithelia when applied to the a

226 In addition, infection of nondividing human cells, including unstimulated hematopo

227 en together, our study suggests that in true nondividing human fibroblast cells in culture, micrograv

228 aturally replicates in highly differentiated nondividing human hepatocytes, this system may more accu

229 In nondividing human mesenchymal stem cells, endosomal iron

230 ely selective increase in sensitivity of the nondividing (i.e. terminally differentiated) cell popula

231 ard-rectifying K(+) currents (I(K)), whereas nondividing immature and mature oligodendrocytes display

232 as serially passaged until 80% of cells were nondividing in a 72-hour 5-bromo-2'-deoxyuridine (BrdU)

233 wever, the majority of these cells stay in a nondividing, inactive state.

234 al vectors are able to efficiently transduce nondividing keratinocytes, unlike retroviral vectors, an

235 w that vaccinia can infect both dividing and nondividing limb cells.

236 t Blimp-1 is required for the maintenance of nondividing, long-lived plasma cells in the bone marrow.

237 t cytotoxic effects of 2CdA and CaFdA toward nondividing lymphocytes.

238 the potent cytotoxic effects of 2CdA toward nondividing lymphocytes.

239 otes nuclear entry of viral nucleic acids in nondividing macrophages and also causes a G2 cell-cycle

240 Terminally differentiated/nondividing macrophages, which serve as a key HIV-1 rese

241 dly to inhibit replication of DNA viruses in nondividing macrophages.

242 ukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapo

243 ower law" was explained by a mechanism where nondividing mature T cells inhibit the proliferation of

244 he midgut by attaching to the gut wall, to a nondividing metacyclic promastigote stage that is unable

245 structure and function are disrupted in aged nondividing metazoan cells, although it is unclear wheth

246 Secretion of mitogenic peptides from nondividing NE cells is thought to contribute to a more

247 ver, expression of RTP801 appeared toxic for nondividing neuron-like PC12 cells and increased their s

248 and more broadly SSBR, in the protection of nondividing neuronal cells from the genotoxic consequenc

249 L1s can retrotranspose efficiently in mature nondividing neuronal cells.

250 lso plays critical roles in morphogenesis of nondividing neurons.

251 s in both dividing (e.g., keratinocytes) and nondividing (neurons) cells, the ability of the VZV ORF1

252 ntly influenced by IL-15, the recruitment of nondividing NK cells into the replicating subpopulation

253 omic integrity and to allow transcription in nondividing or slowly dividing cells.

254 ating cells are the precursors of the mostly nondividing or slowly dividing splenic NK cells.

255 aptive mutations are mutations that occur in nondividing or very slowly dividing microbial cells duri

256 This may contribute to the survival of nondividing peripheral memory T cells, enabling them to

257 at although lentivirus vectors can transduce nondividing PHSC, transduction efficiency is severalfold

258 not only in proliferating cells but also in nondividing postmitotic cells.

259 in blood is almost invariably lower than in nondividing (postmitotic) tissues such as skeletal muscl

260 ith clinical features that primarily involve nondividing (postmitotic) tissues.

261 Recent studies have shown that nondividing primary cells, such as hepatocytes, can be e

262 e delivery and stable expression of genes in nondividing primary cells.

263 her choline deprivation induces apoptosis in nondividing primary neuronal cultures of fetal rat corte

264 b preferentially targets dividing cells, and nondividing progenitor cells are resistant to imatinib-m

265 the majority of eukaryotic cells exist in a nondividing, quiescent state.

266 ving morphologically enlarged, aberrant, and nondividing RBs.

267 lacking, cells may enter into a specialized nondividing resting state, known as stationary phase or

268 Saccharomyces cerevisiae cells enter into a nondividing resting state, known as stationary phase.

269 XRCC1 deficiency affected both dividing and nondividing SH-SY5Y cells, with a greater effect on surv

270 -fold and the majority of the parasites were nondividing, short stumpy (SS) forms.

271 her population densities they transform into nondividing, short, stumpy forms.

272 is functionally resemble end-differentiated, nondividing, short-lived effector memory cells that resi

273 Nondividing somatic cell nuclei appeared normal, whereas

274 In Drosophila testes, a group of 12 nondividing somatic cells, called the hub, identifies th

275 cate that L1 retrotransposition can occur in nondividing somatic cells.

276 tions of slow mass increase but formed large nondividing spheroids with noncanonical FtsZ assembly pa

277 a limited number of times before entering a nondividing state called replicative senescence.

278 ber of cell divisions and ultimately enter a nondividing state called replicative senescence.

279 cence was originally described as a terminal nondividing state of normal human cells reached after ma

280 mitochondrial dysfunction and enter a unique nondividing state that shares some properties with malig

281 aintains epidermal stem cells in a quiescent nondividing state, and that Lrig1 down-regulation trigge

282 cally differentiated and transitioned into a nondividing state, characterized by the induction of hep

283 us, as cells transition from a dividing to a nondividing state, there is a propensity for long-lived

284 and to be involved in maintaining cells in a nondividing state.

285 ese mutants do not enter, or exit early, the nondividing stationary-phase state, cooperatively mainta

286 -producing enteroendocrine cells represent a nondividing subpopulation of intestinal epithelial cells

287 sed mice, transduction of dividing basal and nondividing suprabasal keratinocytes could be demonstrat

288 other lentiviruses, is capable of infecting nondividing T cells and macrophages.

289 the transduced ADA gene is not expressed in nondividing T lymphocytes.

290 Therefore, in natural, nondividing targets of HIV-1, IPO7 may be dispensable fo

291 lts oppose the traditional view that DCs are nondividing terminally differentiated cells maintained b

292 l principles that underlie the generation of nondividing terminally differentiated progeny from divid

293 eading to enhancement of viral spread within nondividing tissue macrophages.

294 strate in vitro excretion of ECM by primary (nondividing) tissue cultures of both soft (Xenia elongat

295 e expressed in thymus and spleen, but not in nondividing tissues.

296 induced apoptosis in both proliferating and nondividing tumor cells.

297 n enteroendocrine cells is restricted to the nondividing villus compartment of the intestine, implyin

298 Following the irradiation of nondividing yeast cells with ultraviolet (UV) light, mos

299 We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identifie

300 In nondividing yeast, a eukaryotic model of quiescence, pro