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1 tional) and one tool with flimsy properties (nonfunctional).
2 shing the interaction renders the polymerase nonfunctional.
3 are found in POLE and POLD1 and appear to be nonfunctional.
4 STAT3 gene which renders most of the protein nonfunctional.
5 ion of smbT, which makes the ABC transporter nonfunctional.
6 in five fragmented genes that are presumably nonfunctional.
7 otype" control under which most targeting is nonfunctional.
8 hromosomal deletions and are predicted to be nonfunctional.
9 ds between 81 and 96, rendering the molecule nonfunctional.
10 ulfoxide (MetSO), rendering several proteins nonfunctional.
11 pulation of MC4R at the cell surface becomes nonfunctional.
12 he genome is noncoding and was thought to be nonfunctional.
13 hat NAGNAG splicing is purely stochastic and nonfunctional.
14 nic inflammation, endogenous CD8(+) TCs were nonfunctional.
15 ersity, suggesting that some recently became nonfunctional.
16 ecies to become classical, nonclassical, and nonfunctional.
17 not grow because RNR is disulfide bonded and nonfunctional.
18 the Ste2 receptor of Candida lusitaniae was nonfunctional.
19 ox/m1Bei) mice, in which the m1Bei allele is nonfunctional.
20 ing a truncated protein that is unstable and nonfunctional.
21 h3-1, but CENH3's lacking a tail domain were nonfunctional.
22 ontaining homomeric and heteromeric channels nonfunctional.
23 n infected cells in which the K1 protein was nonfunctional.
24 tivities, and guinea pig OCLN was completely nonfunctional.
25 nant in tumor-derived cells in which ICP0 is nonfunctional.
26 icking likely explains why TLR9(471-1032) is nonfunctional.
27 tems in low- and middle-income countries are nonfunctional.
28 This renders the centrosome nonfunctional.
29 five of which are fragmented and presumably nonfunctional.
30 classification of benign adrenal tumors as "nonfunctional" adequately reflects the continuum of horm
31 Objective: To evaluate the hypothesis that nonfunctional adrenal tumors (NFATs) increase risk for c
38 ense or deletion mutations in Mx1 and thus a nonfunctional allele, whereas wild-derived mouse strains
40 tained one functional allele (A-2) and three nonfunctional alleles (a-3, a-4, and a-5) each containin
41 n, we assessed germination of functional and nonfunctional alleles of these genes and measured their
42 etic analyses in M. tuberculosis showed that nonfunctional alleles were produced either by deletion o
43 pecies I of S. enterica and often present in nonfunctional allelic forms in organisms lacking the ide
45 corresponding chNHE1 residues converted the nonfunctional ALV-J receptor huNHE1 to a functional one.
46 ound that their survival of treatment with a nonfunctional amino acid analog negatively correlates wi
47 hich contained functional NMDA receptors and nonfunctional AMPA receptors only in GFP-positive neuron
48 enerate a population of CD8 T cells that are nonfunctional and apoptotic; thus, our data support a mo
50 L2 double point mutant renders the TM domain nonfunctional and blocks HPV16 infection by preventing e
51 but gB-Tet(-) CD8(+) T cells remain largely nonfunctional and do not provide increased protection fr
53 ochasticity and pathway interconnectivity is nonfunctional and that cellular decisions are likely muc
54 mentation indicated that LARS2 c.1077delT is nonfunctional and that LARS2 p.Thr522Asn is partially fu
55 ion strain verified that the mutant WciG was nonfunctional, and the serology of the mutant could be r
56 cted nuclear localization signals of HMR are nonfunctional, and therefore mature HMR is unable to acc
57 , with p110alpha inactivation giving rise to nonfunctional angiogenesis, which can stunt tumor growth
59 Previously, it was assumed that they were nonfunctional artifacts associated with cellular stress.
60 rica, where handpumps are common, 10-67% are nonfunctional at any one time, and many never get repair
63 ontained two further alleles: a-6, which was nonfunctional because of a large insertion, and a-7, whi
65 re never degraded, the competitive effect of nonfunctional binding sites is completely canceled out b
71 receptor EF-Tu receptor that can be rendered nonfunctional by disruption of single glycosylation site
72 cribe two primate Siglecs that were rendered nonfunctional by single genetic events during hominin ev
74 nal in nature, this evidence might reflect a nonfunctional byproduct rather than having a causal role
75 d predicted the presence of an incomplete or nonfunctional cag pathogenicity island in 18/276 genomes
76 Marijuana is distinguished from hemp by a nonfunctional CBDA synthase that appears to have been po
79 While intercellular competition weeds out nonfunctional cells, it may also select for cells that d
80 ction caused genome-wide misincorporation of nonfunctional CenH3-containing nucleosomes that protect
81 5A), generating variants encoding truncated, nonfunctional channels that are trapped in the endoplasm
85 high light levels are abolished in mice with nonfunctional cones and when horizontal cells are revers
87 People who maternally inherit a deletion or nonfunctional copy of the UBE3A gene develop Angelman sy
88 ions in CREB3L3 that produced hypomorphic or nonfunctional CREB-H protein in humans with extreme hype
90 in two independent lines produced truncated, nonfunctional CRY2 proteins, resulting in the in vivo di
94 al mucus of cystic fibrosis (CF) mice with a nonfunctional cystic fibrosis transmembrane conductance
96 re either partially functional or completely nonfunctional, demonstrating a previously unidentified a
97 ast a few other SC-containing accessions are nonfunctional, despite SCRC encoding a functional full-l
99 populations, even the small cost incurred by nonfunctional DNA because of extra energy and time expen
103 nine (pT)-binding domain, and found it to be nonfunctional due to misfolding in the bacterial peripla
105 litates miRNA-mediated silencing is rendered nonfunctional during cellular stress, including virus in
106 itial infection, many become dysregulated or nonfunctional during the course of chronic infection.
107 fragmented virulence genes that probably are nonfunctional, e.g., F1L, B13R, C10L, K3L, and C3L.
109 ZO-1 prevented maturation of functional into nonfunctional/endocytic channels, rather than ZO-1 inter
111 to the difficulty of separating trimers from nonfunctional Env (uncleaved gp160 and gp41 stumps).
115 on of virions that carry both functional and nonfunctional Envs contributes little to HIV infection o
117 essing either active ns2 or VP3-CTD, but not nonfunctional equivalents, were able to protect ribosoma
119 nae, M. senegalense, and M. peregrinum and a nonfunctional erm gene in M. abscessus subsp. massiliens
120 ions with the same intron polymorphisms, the nonfunctional exon 3-skip P5CS1 splice variant constitut
122 x17b in sortilin mRNA generates a truncated, nonfunctional, extracellularly released protein that bin
127 se diabetic model, which expresses a mutant, nonfunctional form of ins2 in testes and pancreas, was u
128 ons exclusively express either functional or nonfunctional forms of Env has important implications fo
129 bodies interact with HIV-1 primarily through nonfunctional forms of envelope glycoproteins (Env), inc
130 ion of RhCMV-uninfected rhesus macaques with nonfunctional forms of RhCMV vIL-10 greatly restricted p
133 a functional gag or one of the viruses had a nonfunctional gag, providing further support for the tra
134 , ODDD-linked Cx43 N-terminal mutants formed nonfunctional gap junction-like plaques and exhibited do
136 eral types of variation in SM gene clusters: nonfunctional gene polymorphisms; gene gain and loss pol
140 ) shows exacerbated hemichannel activity but nonfunctional GJCs; this also occurs for those Cx26 KID
145 of which are part of structurally intact but nonfunctional hAT transposons (BvhAT), in a B. vulgaris
146 tact arterial program with overproduction of nonfunctional hematopoietic precursors and total absence
149 ti-HIV-1 Ab responses can be directed toward nonfunctional host protein epitopes that do not impair h
150 ce and rhesus monkeys, rendering the cagT4SS nonfunctional; however, these models rarely develop gast
152 RAG-mediated recombination mechanism to edit nonfunctional IgH genes or IgH genes encoding self-react
155 A72P, like the dimer-promoting variants, is nonfunctional in fission, consistent with a model in whi
156 of the red algae Cyanidioschyzon merolae are nonfunctional in isolation, but together form a thermost
158 how that both Mx1 and Mx2 have been rendered nonfunctional in Odontoceti cetaceans (toothed whales, i
159 itical, as the equivalent DshY473F mutant is nonfunctional in PCP signaling and stable membrane assoc
160 se to the NLRP1b activator LT, whereas it is nonfunctional in response to the NLRP3 activator nigeric
161 rase WciG was functional in serotype 35C but nonfunctional in serotype 42 due to a deletion in wciG S
162 is fragmentation did not render mitochondria nonfunctional in terms of ion handling and respiration e
163 However, we also observed that 2-FHisPA was nonfunctional in the ability to mediate cytotoxicity of
165 mic response, and also indicate that phyC is nonfunctional in the absence of other phytochromes.
169 ions may explain the abundance of apparently nonfunctional interactions among proteins observed in hi
171 tion factors drive extensive, low-occupancy, nonfunctional interactions within the accessible portion
176 tion of membrane ion channels involves their nonfunctional isoforms generated by alternative splicing
179 interfering RNA or an adenovirus expressing nonfunctional kinase-dead LKB1 protein, attenuated endot
182 a switch from the functional Kv11.1a to the nonfunctional Kv11.1a-USO isoform in HEK293 cells and HL
185 Conversely, we find that the patient has a nonfunctional lectin pathway, which can be restored by M
186 ing undesired coevolution and propagation of nonfunctional library members, as well as allowing posit
188 effects, disequilibrium among functional and nonfunctional markers, statistical analysis methods, and
189 nterallelic complementation between pairs of nonfunctional mcd1 alleles (mcd1-1 and mcd1-Q266) or smc
190 efore propose that SUMO serves as a mark for nonfunctional mitochondrial proteins, which only sporadi
191 ther functional sites are distinguished from nonfunctional motifs by local primary sequence features
192 e the differences between a functional and a nonfunctional mutant W972A and W972R, respectively.
193 ereas cotransfection with atrogin-1DeltaF (a nonfunctional mutant without the F-box motif) had no eff
195 he membrane-spanning parts of functional and nonfunctional mutants of MS-DesK incorporated in lipid b
204 on of specific domains, and co-expression of nonfunctional NSs with intact NSs will result in the att
207 ains, ultimately preventing the formation of nonfunctional or potentially toxic protein aggregates.
208 xperiments on mouse strains with functional, nonfunctional, or degenerated rods and cones show that D
209 el crack patterns on functional, contact and nonfunctional, or noncontact areas using 3D SS-OCT.
212 ble for misfolded or aggregated proteins and nonfunctional organelle recycling, allowing cells to mai
213 for anticancer drugs that target cells with nonfunctional p53 or impaired reactive oxygen species (R
215 against hypoxia-mediated cell death, whereas nonfunctional Parkinson disease-associated mutants Parki
218 inhibitor of phospholipase C, but not by the nonfunctional phospholipase C inhibitor analog U73343.
219 7 women; age range, 29-82 y) with clinically nonfunctional pituitary adenomas on MRI underwent preope
223 In particular, our results correlate the nonfunctional property of a mutant cytochrome b(5) with
227 substitutions at some positions resulted in nonfunctional proteins, we used in vivo non-canonical am
232 responses of melanocytes with functional vs. nonfunctional receptor to alpha-melanocortin and ultravi
238 h shed RhCMV in saliva, were vaccinated with nonfunctional RhCMV vIL-10, and shedding levels of RhCMV
239 sus macaques were immunized with engineered, nonfunctional rhcmvIL-10 variants, which were constructe
241 local unfolding, allowing the conversion of nonfunctional RNA structure into functional RNA structur
243 es misidentified by TB&S as S. boydii due to nonfunctional S. flexneri O antigen biosynthesis genes.
248 and binding kinetics between wild type and a nonfunctional sequence suggests that the IAV promoter ca
249 rved comparable targeting for functional and nonfunctional sequences, suggesting similar biological p
250 cel Technologies Inc.; n = 29), an identical nonfunctional (sham) device (n = 25), or fixed appliance
251 he alternate sigma factor, sigma(28), from a nonfunctional sigma(28)-FlgM complex, releasing free, fu
253 crete mutations that appear primarily in the nonfunctional, solvent-accessible NNRTI binding pocket.
254 tive immunization with either wild-type or a nonfunctional SpeA mutant, protects mice from nasopharyn
255 brid males, lowered sperm counts rather than nonfunctional sperm, is different from most described ca
258 can be reconstituted even from independent, nonfunctional subunit domains, as shown previously for G
259 stic factors of survival using 326 sporadic, nonfunctional, surgically resected PanNET patients who w
261 ) incidence, number, and expression level of nonfunctional SVs than either NPs (n = 22) or hormone-na
265 of HPC are negated when the A2B receptor is nonfunctional, the hypoxia-->adenosine-->A2B receptor pa
267 ote alternative splicing and production of a nonfunctional transcript lacking exon 3 (exon 3-skip P5C
268 Recent studies suggest that there are many nonfunctional transcription factor binding sites along a
270 sion in temperature transitions by producing nonfunctional transcripts and/or inducing nonsense-media
271 he production of a mixture of functional and nonfunctional transcripts may provide a means to fine-tu
273 r the model to reproduce reported effects of nonfunctional troponin C on myofilament force generation
277 RG2 transcript level and producing a stable, nonfunctional truncated subunit that had a dominant-nega
280 of a short-hairpin RNA (shRNA) that remains nonfunctional until an interrupting reporter cassette is
287 n of our editase and guide RNA can correct a nonfunctional version of enhanced green fluorescent prot
289 repeatedly immunizing infected animals with nonfunctional versions of the rhesus cytomegalovirus-enc
292 allowed us to determine the water volumes in nonfunctional vessels as a function of stress level.
293 aled the presence of both sugars and ions in nonfunctional vessels at elevated levels in comparison w
294 e osmotic potential of liquid collected from nonfunctional vessels increased while its volume decreas
296 A small class of transcripts from apparently nonfunctional Vkappa genes was found, as were occasional
298 been shown that the NaV1.1-L1649Q mutant is nonfunctional when expressed in a human cell line becaus
299 grees )-AurA(AT(0)) heterodimer proved to be nonfunctional, whereas aureothin production was restored
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