ライフサイエンスコーパス: nongenetic

1 erapy of multiple diseases, both genetic and nongenetic.

2 te-matter incoherence with age appears to be nongenetic.

3 the latest inconvenient findings indicating nongenetic and "imprecise" phenotype dynamics of tumors

4 Nongenetic and genetic characteristics were included in

5 mall studies have investigated the effect of nongenetic and genetic factors on the dose response to V

6 For the model with all nongenetic and genetic factors, the respective C statist

7 and present models of the interplay between nongenetic and genetic processes that contribute to the

8 Combining the nongenetic and genetic risk models improved the AUC to 0

9 model was used to partition and account for nongenetic and genetic sources of variation, and quantit

10 Clinical evaluation and investigations (both nongenetic and genetic) can yield an aetiological diagno

11 alleles, and therefore all of the variation (nongenetic and genetic) in methylation patterns within a

12 in their overall survival, thus making this nongenetic and non-in vivo approach a new clinically rel

13 t, for a fictitious disease that is strictly nongenetic and nonenvironmental, lambdaS can be dramatic

14 re addicted to KRAS by illustrating adaptive nongenetic and nontranscriptional mechanisms of resistan

15 to activated KRAS, by illustrating adaptive nongenetic and nontranscriptional mechanisms of resistan

16 entiated cells can give rise to SPEM using a nongenetic approach in mice.

17 allele), and other factors, both genetic and nongenetic, are likely to be important contributors.

18 ylation changes and scedasticity depended on nongenetic as well as genetic factors.

19 with multiorgan involvement and a genetic or nongenetic basis.

20 virus (HCMV) is one of the leading causes of nongenetic birth defects, and development of a prophylac

21 hildren in developed countries are born with nongenetic birth defects.

22 tic risk score was additive to the effect of nongenetic CAD risk factors, and did not change after ad

23 These results suggest that for most nongenetic cardiovascular epidemiology studies, SIR is s

24 alcohol is thought to be the most prevalent nongenetic cause of a wide range of neurodevelopmental d

25 likely to advance the search for genetic and nongenetic causes of ASD.

26 providing mechanistic explanations for some nongenetic causes of CHD.

27 nic role of hepcidin, it is anticipated that nongenetic causes of hepcidin loss (eg, end-stage liver

28 investigate and disentangle the genetic and nongenetic causes of stability and change in lipids and

29 Such stochastic cell fate decisions generate nongenetic cellular diversity, which may be critical for

30 The basis for this nongenetic cellular memory, which records developmental

31 We found that knowing the fitness and nongenetic (cellular) memory associated with specific ge

32 ll cultures represents multistep genetic and nongenetic changes that develop during the neoplastic pr

33 onalized nutrition appears to depend more on nongenetic characteristics (eg, physical activity, abdom

34 osing strategies including genetic-based and nongenetic clinical-based, multiple-dose adjustment prot

35 printing, but it cannot evaluate the role of nongenetic cofactors like exposures.

36 se findings and to establish the genetic and nongenetic contributions to altered callosal morphology

37 n as an important source of both genetic and nongenetic contributions to phenotypic variation and, as

38 Path analysis estimated genetic and nongenetic contributions to variability in systolic bloo

39 The nongenetic conversion of human pancreatic exocrine cells

40 ng the detection of spurious hotspots due to nongenetic correlation induced by uncontrolled environme

41 0.53 for a baseline model that accounted for nongenetic covariates to AUCs of 0.58 (pedigree), 0.62 (

42 After adjusting for nongenetic covariates, the heritability of log-transform

43 Our methods allow adjustment for nongenetic covariates, which may be critical when analyz

44 Second, premating isolation may arise from nongenetic, cultural causes; isolation may be affected p

45 nd mediated by both Lamarckian induction and nongenetic Darwinian selection of drug-tolerant states.

46 data highlight and clarify the importance of nongenetic determinants in spontaneous recovery from HCV

47 Adjustment for the nongenetic determinants of ACR had no significant effect

48 enter, population-based study of genetic and nongenetic determinants of coronary heart disease (CHD),

49 d in our ongoing research on the genetic and nongenetic determinants of major affective disorders.

50 erns of leukocyte subset numbers, as well as nongenetic determinants that affect these patterns, ther

51 Such nongenetic differences are likely heritable between succ

52 , rigorous investigation of both genetic and nongenetic differences is important to identify the vari

53 d is applicable to virtually all genetic and nongenetic disease models of the pancreas.

54 opper metabolism associated with genetic and nongenetic diseases are summarized, including potential

55 , and recognition of the various genetic and nongenetic diseases in which it may develop has led to t

56 and functional cures for diverse genetic and nongenetic diseases.

57 -system atrophy is widely considered to be a nongenetic disorder, we previously identified multiplex

58 his study demonstrates that excess RNS are a nongenetic driving force for Brca2-deficiency-induced pa

59 ounder alleles are treated as random and the nongenetic effects are treated as fixed.

60 deficiency, indicating that the genetic and nongenetic effects converge to common anxiety manifestat

61 thods for dimension reduction to account for nongenetic effects in estimates of expression levels, an

62 ent analysis was used to measure genetic and nongenetic effects on the associations.

63 determined by the magnitudes of genetic and nongenetic effects on the indexing (first) coronary hear

64 om contributions of genetic, epigenetic, and nongenetic (environmental) factors.

65 to estimate the contribution of genetic and nongenetic (environmental) influences to the variation a

66 hood exposures to tobacco smoke suggest that nongenetic, environmental exposures may have long-term i

67 ter insight to deconstruct their genetic and nongenetic etiologies.

68 d effects of genetic susceptibility factors, nongenetic experiences and exposures, and bad luck.

69 To distinguish between simple genetic and nongenetic explanations of sex-specific recombination di

70 Nongenetic explanations such as effects of ASD severity

71 of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these con

72 mmon polymorphisms in the absence of data on nongenetic exposures, and may explain the heterogeneity

73 rtance of each genetic factor (QTL) and each nongenetic factor/covariate included in the function is

74 ence are likely a result of both genetic and nongenetic factors (eg, socioeconomic status, intake of

75 Statistical adjustments for nongenetic factors (gender, ethnicity, age, HIV-1 infect

76 We sought to determine which nongenetic factors affect the dynamics of innate leukocy

77 Thus, other genetic or nongenetic factors also contribute to sex differences in

78 In addition to the candidate QTL, nongenetic factors and covariates, such as age, gender,

79 ariate analysis the relative contribution of nongenetic factors and VKORC1/CYP2C9/CYP4F2 genotypes on

80 Nongenetic factors are still appreciable and account for

81 al explained compared with a model with only nongenetic factors at nearly every significance level.

82 plex etiology influenced both by genetic and nongenetic factors but disentangling these factors is di

83 Together these results indicate that nongenetic factors contribute to the development of SPs

84 Nongenetic factors explained 45.8% and 7.5% of MR-pro-AD

85 While several genetic and nongenetic factors have been linked to HSCR, the underly

86 We analyzed numerous genetic and nongenetic factors impacting short-term and long-term ex

87 Nongenetic factors include smoking, which has been shown

88 pecific areas of the intestine suggests that nongenetic factors may be important for their developmen

89 We hypothesized that nongenetic factors might contribute to disease developme

90 gy of Graves disease is multifactorial, with nongenetic factors playing an important role.

91 ring involvement of nonleukemic elements and nongenetic factors promoting CLL cell growth, identifyin

92 hensive analysis including known genetic and nongenetic factors that determine MPV is still lacking.

93 t, even in well-studied populations in which nongenetic factors that influence adaptively important c

94 ations of sociocultural, economic, and other nongenetic factors that influence family sizes.

95 ations of sociocultural, economic, and other nongenetic factors that influence family sizes.

96 elative contribution of genetic ancestry and nongenetic factors to HbA(1c) values and the effect of g

97 The contribution of host genetic and nongenetic factors to immunological differences in human

98 ne the relative contributions of genetic and nongenetic factors to the association between structural

99 f the contributions of genetic variation and nongenetic factors to the population differences in gene

100 ate the relative contribution of genetic and nongenetic factors to variation in folate, we have evalu

101 few common population-relevant, quantifiable nongenetic factors with strong associations may be the m

102 effects of variants in numerous genes, plus nongenetic factors, determine outcome.

103 al animal model of MS, is also influenced by nongenetic factors, including age and season at immuniza

104 .005 for both), after accounting for several nongenetic factors, including gender, age at estimated d

105 ese genetic associations were independent of nongenetic factors, including number of sex partners, ra

106 Nongenetic factors, including the stage of disease at th

107 Of the nongenetic factors, use of tacrolimus, sirolimus, and ol

108 ultivariate models that included a number of nongenetic factors.

109 etermined by multiple additional genetic and nongenetic factors.

110 lt to measure, and known to be influenced by nongenetic factors.

111 plex trait determined by various genetic and nongenetic factors.

112 action between multiple genetic variants and nongenetic factors.

113 of complex interactions between genetic and nongenetic factors.

114 e in female individuals, indicate a role for nongenetic factors.

115 in older CF patients is caused primarily by nongenetic factors.

116 ndrome in CF patients is caused primarily by nongenetic factors.

117 C level is influenced by several genetic and nongenetic factors.

118 population and are influenced by genetic and nongenetic factors.

119 e/dose and susceptibility due to genetic and nongenetic factors.

120 fected by genes, are determined primarily by nongenetic factors.

121 indicate a contribution of other genetic or nongenetic factors.

122 grating clinical phenotypes with genetic and nongenetic factors.

123 y caused by multiple interacting genetic and nongenetic factors.

124 ment induced by a combination of genetic and nongenetic factors.

125 y to establish patterns mostly determined by nongenetic factors.

126 s are known to be mediated by environmental (nongenetic) factors.

127 ngs support the notion that both genetic and nongenetic fibrogenic factors, particularly TGF-beta1 an

128 inflammatory diseases, including genetic and nongenetic forms of chronic obstructive pulmonary diseas

129 II diabetic GK rats and certain genetic and nongenetic forms of obesity in rats, is associated with

130 the involvement of TRPC6 in the pathology of nongenetic forms of proteinuric disease.

131 Major cellular processes affected by nongenetic functions of the genome include establishment

132 the concept, mechanisms, and implications of nongenetic functions of the genome.

133 >1.6 per allele) and assuming the sum of all nongenetic hazard ratios was <10, bias was usually <10%

134 To address the contribution of nongenetic heritability and cell cycle in cell-to-cell v

135 Multicellular eukaryotes demonstrate nongenetic, heritable phenotypic versatility in their ad

136 from a physiological perspective, and their nongenetic heterogeneity is examined.

137 ment in a discussion of stochastic noise and nongenetic heterogeneity, we explore the hypothesis that

138 ise from complex interactions among genetic, nongenetic host susceptibility, and environmental factor

139 al development) or other factors (genetic or nongenetic) in the parents may contribute to autism.

140 ss, we sought to investigate how genetic and nongenetic influences are balanced to create vascular tr

141 ere is preliminary evidence that genetic and nongenetic influences may modify risks.

142 an animal model for the study of genetic and nongenetic influences on craniofacial variation.

143 o-twins, suggesting a preferential impact of nongenetic influences on long-term memory systems.

144 nd sex effects and to dissociate genetic and nongenetic influences on morphology.

145 We tested for genetic and nongenetic influences on the association among these tra

146 These findings suggest that nongenetic influences play a role in brain volume/cognit

147 c factors and is also cumulatively shaped by nongenetic influences throughout human life; both can in

148 progenitor cells cannot accurately transmit nongenetic information to their progeny; full epigenetic

149 apply this technology to examine the role of nongenetic inheritance in cell heterogeneity of yeast ph

150 pective that includes group organization and nongenetic inheritance.

151 a plastidial response process that involves nongenetic inheritance.

152 The outcomes of both models suggest that nongenetic instability, stress-induced adaptation, selec

153 Genetic and nongenetic instrumental variable approaches (eg, Mendeli

154 ci (QTL) responsible for complex genetic and nongenetic interactions.

155 ever, certain biological questions require a nongenetic labeling approach to purify a distinct cell p

156 les from the selected populations exercise a nongenetic maternal effect on the development time of th

157 iation in host-associated fitness, ruled out nongenetic maternal effects, and discuss the maintenance

158 iPSCs relies on the development of efficient nongenetic means of factor delivery, and although a hand

159 es, the genome affects cellular functions by nongenetic means through its physical and structural pro

160 humans, but these effects can be modified by nongenetic mechanisms [2-4].

161 iency can be transmitted by both genetic and nongenetic mechanisms in a population.

162 We also discuss the implications of nongenetic mechanisms of drug resistance recently report

163 epidemiologic studies are helping to define nongenetic mechanisms of embryopathy.

164 c disruption of NKX3.1 in mice leads to PIN, nongenetic mechanisms reduce NKX3.1 protein levels early

165 in chromatin structure, potentially through nongenetic mechanisms.

166 he development of ASD through genetic and/or nongenetic mechanisms.

167 However, it is unknown whether nongenetic methods of suppressing PTEN have similar effe

168 Likewise, study of the mechanisms of nongenetic models of a common form of human epilepsy, co

169 rrents and membrane potential in genetic and nongenetic models of hypertension.

170 FE-null mouse and HJV-null mouse) and in two nongenetic models of iron overload (cytomegalovirus infe

171 largely followed from the identification of nongenetic modifiable factors.

172 A better understanding of genetic and nongenetic modifiers in ZZ alpha1-antitrypsin deficiency

173 in USH2A, however, suggests that genetic or nongenetic modifiers may be involved in the disease expr

174 nd aggregate effects of putative genetic and nongenetic modifiers of AD risk.

175 ine the relative contribution of genetic and nongenetic modifiers to the development of this major co

176 To discover genetic versus nongenetic molecular pathways important to the pathogene

177 nystagmus most often develops as a result of nongenetic neurologic disease, and it manifests in a var

178 butions of NK cells to HIV-1 immune control, nongenetic NK cell parameters directly associated with s

179 remodeling was more common in patients with nongenetic or nonfamilial DCM than in patients with gene

180 f a major gene in the presence of additional nongenetic or polygenetic familial associations, by rela

181 facilitate genetic analysis in traditionally nongenetic organisms.

182 A nongenetic outcome of the CMAH mutation is human metabol

183 changing profile that implicates genetic and nongenetic patterns of deficits.

184 otoporphyrin accumulation and a reproducible nongenetic porphyria model.

185 reproduction remains a difficult question as nongenetic processes, such as molecular self-organizatio

186 of VHL and will serve as a key reference for nongenetics professionals who encounter patients with VH

187 However, nongenetic risk factors also play an important role and

188 Few data are available on genetic and nongenetic risk factors for CRC among AAs.

189 Our goal was to identify genetic and nongenetic risk factors for osteonecrosis.

190 asis is not yet well understood, but several nongenetic risk factors have been identified as have pos

191 Nongenetic risk factors include age, sex, and other dise

192 iate controls, but it has the advantage that nongenetic risk factors like exposures can be assessed.

193 al for each pairwise combination of SNPs and nongenetic risk factors using age- and cohort-adjusted l

194 The AUC of a risk model based on known nongenetic risk factors was 0.77 (95% CI, 0.76-0.78).

195 One approach is to modify nongenetic risk factors, for instance by lowering elevat

196 btypes and do not appear to be confounded by nongenetic risk factors, suggesting at least some shared

197 l disease influenced by multiple genetic and nongenetic risk factors.

198 Genetic plus nongenetic risk scores provided an area under the receiv

199 cting yet unidentified genetic and, perhaps, nongenetic risks.

200 an of 19 tests and 4 clinical genetics and 4 nongenetics specialist consultations, and 26 (59%) under

201 optosis resistance can also be the result of nongenetic stress adaptation, as seen in the cancer-pron

202 her types of genetic association studies and nongenetic studies.

203 As a result, nongenetic systematic environmental effects can be easil

204 warts such as the fly and mouse, but also to nongenetic systems such as primates.

205 (1) whether PTEN knockdown in adult rats by nongenetic techniques enables CST regeneration, (2) whet

206 significant distinctions between genetic and nongenetic tests justify a different approach to testing

207 logical mechanisms potentially accessible to nongenetic therapies.

208 We propose that an additional genetic or nongenetic "third hit" may be required for rapid develop

209 ein transduction domains (PTDs) are powerful nongenetic tools that allow intracellular delivery of co

210 A nongenetic, transgenerational effect of parental age on

211 logical approaches have found no evidence of nongenetic transmissibility.

212 trains, we serendipitously identified that a nongenetic transmissible factor dramatically increased d

213 type, by a receptor deficit in the mother: a nongenetic transmission of a genetic defect.

214 Together, genetic and nongenetic variability in ectopic expression of peripher

215 The sources and consequences of nongenetic variability in metastatic progression are lar

216 sion and obtain information about sources of nongenetic variability.

217 ransitions that can potentially give rise to nongenetic variability.

218 te analysis adjusted for HLA mismatching and nongenetic variables associated with each clinical end p

219 onmental or behavioral factors (particularly nongenetic variation in obesity) are important determina

220 Nongenetic variation in phenotypes, or bet-hedging, has

221 Nongenetic variation in protein abundances thus leads to

222 In addition to this nongenetic variation, the process underlying RSVIgmyc me

223 n indirect measures was largely explained by nongenetic variation.

224 OMPSON, and SKOLNICK suggested a simplified, nongenetic version of the model involving only 2n + 1 ge