ライフサイエンスコーパス: nonheme iron

1 d further through the intestine than that of nonheme iron.

2 te that the rate of catalysis is enhanced by nonheme iron.

3 multimeric protein containing four atoms of nonheme iron.

4 heme-iron absorption is greater than that of nonheme iron.

5 orbed via a mechanism different from that of nonheme iron.

6 of HO(*) at both the Mn4O5Ca cluster and the nonheme iron.

7 w L1 doses, which partially depleted hepatic nonheme iron.

8 in humans, but the data have been limited to nonheme iron.

9 <21 microg/L (n = 5), adapted to absorb less nonheme iron (3.2% at week 12 compared with 5.0% at week

10 detect any dependence of the NOS reaction on nonheme iron, a cofactor integral to catalysis in every

11 -containing porridge meal leads to decreased nonheme iron absorption and that a 1-h time interval bet

12 se are estimated from predictive algorithms, nonheme iron absorption from meals, and models of iron i

13 of a 1-h time interval of tea consumption on nonheme iron absorption in an iron-containing meal in a

14 Mammalian nonheme iron absorption requires reduction of dietary ir

15 a has been shown to be a potent inhibitor of nonheme iron absorption, but it remains unclear whether

16 he inhibitory effect, resulting in increased nonheme iron absorption.

17 Large variations were observed in mean nonheme-iron absorption (0.7-22.9%) between studies, whi

18 In premenopausal women, the efficiency of nonheme-iron absorption (P = 0.06, two-tailed test), but

19 of fruit, a dietary source of an enhancer of nonheme-iron absorption (vitamin C), promote high iron s

20 No significant relation was observed between nonheme-iron absorption and dietary factors known to inf

21 oux-en-Y gastric bypass (RYGBP) on heme- and nonheme-iron absorption and iron status.

22 domized, placebo-controlled trial, heme- and nonheme-iron absorption by healthy men and women (n = 57

23 We tested whether heme- and nonheme-iron absorption decrease in response to increase

24 Nonheme-iron absorption decreased from 11.1% to 4.7% (P

25 Radioisotopic measurements of nonheme-iron absorption from 25 meals were made in 86 vo

26 al was to examine the effect of vitamin C on nonheme-iron absorption from a complete diet rather than

27 This research indicates 1) 70% lower nonheme-iron absorption from a lactoovovegetarian diet t

28 lcium intake had no significant influence on nonheme-iron absorption from a varied diet.

29 The inhibiting effect of phytate on nonheme-iron absorption from different protein sources w

30 Heme- and nonheme-iron absorption from either high- or low-bioavai

31 even those with low iron stores, had reduced nonheme-iron absorption from food in response to iron su

32 Heme- and nonheme-iron absorption from whole diets were measured i

33 n the mucosal uptake and serosal transfer of nonheme-iron absorption in humans and the effects of cal

34 th serum hepcidin and serum prohepcidin with nonheme-iron absorption in the presence and absence of f

35 Nonheme-iron absorption was less from the lactoovovegeta

36 Nonheme-iron absorption was measured from the whole diet

37 Nonheme-iron absorption was measured in 14 healthy volun

38 Initially, both heme- and nonheme-iron absorption were inversely associated with s

39 om 58 individuals (all from US studies): log[nonheme-iron absorption, %] = -0.73 log[ferritin, mug/L]

40 the individual effects of dietary factors on nonheme-iron absorption, but their combined effect when

41 d total iron without significantly affecting nonheme-iron absorption, regardless of meal bioavailabil

42 etary, and hematologic indexes and heme- and nonheme-iron absorption-using a standardized meal contai

43 reported dietary inhibitor of both heme- and nonheme-iron absorption.

44 sal uptake was the primary control point for nonheme-iron absorption.

45 and ascorbic acid were useful for estimating nonheme-iron absorption.

46 lcium has a strongly inhibitory influence on nonheme-iron absorption.

47 ariations in calcium intake on total dietary nonheme-iron absorption.

48 exes were designed specifically to mimic the nonheme iron active site of superoxide reductase, which

49 hydroxylase (MMOH) that contains a dinuclear nonheme iron active site; a reductase (MMOR) that facili

50 We have identified a conserved group of nonheme iron, alpha-ketoglutarate-dependent oxygenases l

51 ions were associated with greater intakes of nonheme iron and ascorbic acid after control for age, BM

52 ted with greater intakes of foods containing nonheme iron and ascorbic acid.

53 ient mice, sla mouse enterocytes accumulated nonheme iron and ferritin.

54 Treatment with ethanol increased hepatic nonheme iron and hepatic 5-aminolevulinate synthase acti

55 absorption, storage, and cellular export of nonheme iron and in erythroblast uptake and utilization

56 processes in the case of mono- and dinuclear nonheme iron and manganese cofactors has remained largel

57 were applied to determine the 8-h uptake of nonheme iron and the 2-wk retention (absorption) of heme

58 ptake and the subsequent serosal transfer of nonheme iron and to determine the effects of adding calc

59 ailoring enzymes, including both mononuclear nonheme iron and two flavin-dependent halogenases, and a

60 in a model that contained dietary heme iron, nonheme iron, and zinc intakes, dietary heme iron showed

61 n of such a species in the mechanisms of the nonheme iron- and pterin-dependent aryl amino acid hydro

62 nase (HpxE-HpxD enzyme) homologous to Rieske nonheme iron aromatic-ring-hydroxylating systems, such a

63 ed as important intermediates in a number of nonheme iron as well as heme-containing enzymes, yet the

64 Absorption of nonheme iron assessed in the presence (P = 0.038) and ab

65 d as a monomer of M(r) 28,000 that contained nonheme iron at 2.05 +/- 0.34 mol of Fe per FNR monomer.

66 oor man's B(12)), or very small, such as one nonheme iron atom coordinated by protein ligands.

67 de (FMN) the homologs contained six to eight nonheme iron atoms and 1.6 to 1.7 FMN molecules per dime

68 Nonheme iron bioavailability was determined from 2-wk re

69 hown that many dietary factors can influence nonheme-iron bioavailability.

70 ly with the initial uptake and absorption of nonheme iron, but not with the nonheme serosal transfer

71 We measured membrane nonheme iron by its reactivity with ferrozine.

72 The meal contents of nonheme iron, calcium, ascorbic acid, polyphenols, and p

73 d lending credence to proposed mechanisms of nonheme iron catalysis.

74 '',2''''-quinquepyridine) is a highly active nonheme iron catalyst for intra- and intermolecular amin

75 Hydrocarbon oxidations by bio-inspired nonheme iron catalysts and H2O2 have been proposed to in

76 ating Rieske dioxygenases and of bioinspired nonheme iron catalysts for alkane hydroxylation, olefin

77 ske-type [2Fe-2S] center and one mononuclear nonheme iron center in each large oxygenase subunit.

78 roups in the second coordination sphere of a nonheme iron center is reported.

79 s into the active site of RPE65 close to the nonheme iron center.

80 haKG)-dependent dioxygenases use mononuclear nonheme iron centers to effect hydroxylation of their su

81 of secondary coordination sphere effects at nonheme iron centers.

82 The nonheme iron complex, [Fe(NO)(N3PyS)]BF4, is a rare exam

83 y of the family of Rieske oxygenase enzymes, nonheme iron complexes of tetradentate N4 ligands have b

84 is and reactivity of a series of mononuclear nonheme iron complexes that carry out intramolecular aro

85 Methane monooxygenase (MMO) is a nonheme iron-containing enzyme which consists of three p

86 Superoxide reductases (SORs) are nonheme iron-containing enzymes that reduce HO(2) to H(2

87 -His-1-Glu metal center, as found in natural nonheme iron-containing enzymes, was engineered into spe

88 a protein that has significant homology to a nonheme iron-containing ferritin protein from Listeria i

89 iron in other streptococci is that encoding nonheme iron-containing ferritin, dpr, but previous atte

90 both normal and Hfe knock-out mice, duodenal nonheme iron content was found to correlate with liver i

91 Determination of acid-labile sulfur and nonheme iron demonstrated that there is one [2Fe-2S] clu

92 rsenic resistance (ars) operon and encodes a nonheme iron-dependent dioxygenase with C As lyase activ

93 Memo and show it be homologous to class III nonheme iron-dependent dioxygenases, a structural class

94 Many nonheme iron-dependent enzymes activate dioxygen to cata

95 sults appear to connect NOS to the known H4B/nonheme iron-dependent hydroxylases, and suggest a simil

96 terminal olefins using an oxygen-activating, nonheme iron-dependent mechanism.

97 terocyclization reactions catalyzed by other nonheme iron-dependent oxygenase-like enzymes, such as i

98 tochrome P450 monooxygenase, a hydroxylating nonheme-iron-dependent dioxygenase, and an ABM family mo

99 d glomerular renal injury was accompanied by nonheme iron deposition and hypoxia-inducible factor-1al

100 s in serosal transfer indicate that heme and nonheme iron did not enter a common absorptive pool with

101 Prolyl 4-hydroxylase (P4H) is a nonheme iron dioxygenase that catalyzes the posttranslat

102 Because aromatic dioxygenation by nonheme iron dioxygenases is frequently the initial step

103 The lipoxygenases (LOs) are a family of nonheme iron dioxygenases that catalyse the insertion of

104 Our study focused on nonheme iron distribution and the expression of the iron

105 functional models of the active site of the nonheme iron enzyme cysteine dioxygenase (CDO) is report

106 step of the catalytic cycle of the binuclear nonheme iron enzyme Delta(9) desaturase.

107 The nonheme iron enzyme phenylalanine hydroxylase, tyrosine

108 se (PAH) is a tetrahydrobiopterin-dependent, nonheme iron enzyme that catalyzes the hydroxylation of

109 osine hydroxylase (TH) is a pterin-dependent nonheme iron enzyme that catalyzes the hydroxylation of

110 (ACCO), an O2-activating ascorbate-dependent nonheme iron enzyme, catalyzes the last step in ethylene

111 eaving step in the activation of dioxygen by nonheme iron enzymes and in the first step of the Fenton

112 chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in r

113 High-valent intermediates of binuclear nonheme iron enzymes are structurally unknown despite th

114 re relevant to the activation of dioxygen by nonheme iron enzymes have been generated from synthetic

115 XES for identifying intermediate species in nonheme iron enzymes is highlighted.

116 In contrast, engineering mononuclear nonheme iron enzymes is lagging, even though these enzym

117 synthase EgtB represents a unique family of nonheme iron enzymes that catalyze the formation of a C-

118 enases are a catalytically diverse family of nonheme iron enzymes that oxidize their primary substrat

119 a class of substrate activating mononuclear nonheme iron enzymes which catalyze the hydroperoxidatio

120 nsidered in the context of another family of nonheme iron enzymes, the nitrile hydratases, in which p

121 Similar studies can be performed for other nonheme iron enzymes, with the 18O KIEs providing a kine

122 en activation mechanisms of many mononuclear nonheme iron enzymes.

123 on oxidation of substrates proposed for some nonheme iron enzymes.

124 as been made in designing heme and dinuclear nonheme iron enzymes.

125 gh-valent oxo intermediates in the binuclear nonheme iron enzymes.

126 e key intermediates in the catalysis of most nonheme iron enzymes.

127 valent oxoiron(IV) intermediates observed in nonheme iron enzymes.

128 tic strategy established for O(2)-activating nonheme iron enzymes.

129 The structures of nonheme iron-free and di-Fe(2+) forms of BFR showed that

130 We compared the absorption of heme and nonheme iron from minimally or highly fortified test mea

131 bjects in their absorption of either heme or nonheme iron from minimally or highly fortified test mea

132 A member of the nonheme iron group of dietary iron sources, ferritin is

133 halogenase for piperazate) is a mononuclear nonheme iron halogenase that acts on the piperazyl ring

134 ytC3 with the closed conformation of another nonheme iron halogenase, SyrB2, suggests two important c

135 ze the expression of iron-related genes, (2) nonheme iron histochemistry, (3) immunohistochemistry fo

136 acetonitrile to generate a thiolate-ligated, nonheme iron(III)-nitro complex, [Fe(III)(NO2)(N3PyS)](+

137 the 2-wk retention (absorption) of heme and nonheme iron in healthy adults (n = 17) after the consum

138 The increases in nonheme iron in Hfe(-/-) mice were associated with diffu

139 Soybeans are a major source of nonheme iron in many human diets, but information on iro

140 244)Y, which is a bicarbonate ligand for the nonheme iron, induces the propagation of oxidative react

141 er factors, women in the highest quintile of nonheme iron intake had a relative risk of PMS of 0.64 (

142 Bioavailability of nonheme iron is influenced by the concentration of inhib

143 bsorption of heme iron is poorly understood, nonheme iron is transported across the apical membrane o

144 nce in reactivity and chemical properties of nonheme iron(IV)-oxo compared with iron(IV)-tosylimido.

145 X = H (3), and X = CF3 (4)) promoted by the nonheme iron(IV)-oxo complex [(N4Py)Fe(IV) horizontal li

146 ethyl-1-phenylethyl sulfides promoted by the nonheme iron(IV)-oxo complexes [(N4Py)Fe(IV) horizontal

147 iron(IV)-oxo oxidants that include heme and nonheme iron(IV)-oxo oxidants.

148 Mean membrane nonheme iron levels were higher in hemoglobin SS cells t

149 epletion and an increase in serum and kidney nonheme iron levels.

150 Superoxide reductase is a nonheme iron metalloenzyme that detoxifies superoxide an

151 and NdmB are actually two independent Rieske nonheme iron monooxygenases with N(1)- and N(3)-specific

152 ion associated with hemochromatosis absorbed nonheme iron more efficiently than did control subjects

153 Hepatic nonheme iron (NHFe) and hepatocyte iron staining were no

154 c structure determination is the first for a nonheme iron nitroxyl {FeNO}(8) and has allowed to ident

155 Isopenicillin N synthase (IPNS) is a nonheme iron oxidase that catalyzes the central step in

156 for the design of regio- and stereospecific nonheme iron oxidation catalysts but also for providing

157 Myohemerythrin (Mhr) is a nonheme iron oxygen carrier found in the retractor muscl

158 nks to the design of cross-linked artificial nonheme iron oxygenase crystals, we filled this gap by d

159 Rieske nonheme iron oxygenases form a large class of aromatic r

160 D) and methylphosphonate synthase (MPnS) are nonheme iron oxygenases that both catalyze the carbon-ca

161 Nonheme iron oxygenases that carry out four-electron oxi

162 omes encode a family of structurally related nonheme iron oxygenases that modify double bonds of thes

163 phic studies of NDO and other related Rieske nonheme iron oxygenases to develop molecular level insig

164 es are often implicated in the mechanisms of nonheme iron oxygenases, their C-H bond cleaving propert

165 e prepared as models for the active sites of nonheme iron oxygenases.

166 the alpha-ketoglutarate (alpha-KG)-dependent nonheme iron oxygenases.

167 died alpha-ketoglutarate (alphaKG)-dependent nonheme iron oxygenases.

168 ured for two recently discovered mononuclear nonheme iron oxygenases: hydroxyethylphosphonate dioxyge

169 intakes, but not higher intakes of heme and nonheme iron, predicted a lower risk of low hemoglobin a

170 Rubrerythrin is a nonheme iron protein of unknown function isolated from D

171 A five-gene cluster encoding four nonheme iron proteins and a flavoprotein from the thermo

172 and transfer reactions mediated by heme and nonheme iron proteins and the interactions of amphiphili

173 ythrins (Hrs) and myohemerythrins (Mhrs) are nonheme iron proteins that function as O2 carriers in fo

174 site is similar to several other mononuclear nonheme iron proteins, including naphthalene dioxygenase

175 This alternative system consists of the nonheme iron proteins, rubrerythrin (Rbr) and rubredoxin

176 The wide range of nonheme iron receptors matched to the structure of the i

177 f adding calcium to a meal on both heme- and nonheme-iron retention.

178 iron showed a positive association, dietary nonheme iron showed a U-shaped association, and dietary

179 of chemical and biological properties among nonheme iron sources.

180 absorption from supplemental and food-based nonheme-iron sources in iron-replete healthy women.

181 stitutes the first example where a synthetic nonheme iron species responsible for stereospecific and

182 iron-loaded macrophages and elevated hepatic nonheme iron stores.

183 MER was used to introduce the active site of nonheme iron superoxide dismutase (SOD) into the hydroph

184 This first example of a nonheme iron-superoxo intermediate exhibits the highest

185 Two-thirds of the nonheme iron taken up by the mucosa within 8 h was retai

186 forms of chaperone proteins, including, for nonheme iron, the transport protein transferrin and the

187 major regulator of transferrin-independent, nonheme iron uptake.

188 Because absorption of nonheme iron was not substantially greater in pregnant w

189 trend = 0.04); corresponding RRs for dietary nonheme iron were 1.0, 0.93, 0.63, 0.83, and 1.20 (P for

190 The initial uptake and absorption of nonheme iron were 11% and 7%, respectively, and the abso

191 The concentrations of total and nonheme iron were also increased in the lavage fluid of

192 nhancing effect on the absorption of dietary nonheme iron when assessed by feeding single meals to fa

193 n attributed to the local diet consisting of nonheme iron, which has lower absorption than that of he

194 s were found to have severe malabsorption of nonheme iron, which persisted after the development of I

195 to compare the serosal transfer of heme and nonheme iron, which should not differ if the 2 forms hav

196 ptake (8 h) and retention (2 wk) of heme and nonheme iron with and without a calcium supplement (450