ライフサイエンスコーパス: nonhomologous end-joining

1 ithin a population, which typically arise by nonhomologous end joining.

2 imulate DNA double-strand break ligation via nonhomologous end joining.

3 insertions/deletions (indels) via mutagenic nonhomologous end joining.

4 by directly binding and activating DNA-PK in nonhomologous end joining.

5 stant, repairing DNA double-strand breaks by nonhomologous end joining.

6 ogical functions in base excision repair and nonhomologous end joining.

7 n DSBs toward accurate and efficient CSR via nonhomologous end joining.

8 that XRCC1 also participates in alternative nonhomologous end joining.

9 ome circularization is mediated primarily by nonhomologous end joining.

10 air protein that is specifically involved in nonhomologous end joining.

11 t role of Pol zeta in DNA DSB repair through nonhomologous end joining.

12 elomeres are fused by DNA ligase IV-mediated nonhomologous end joining.

13 mage accumulation, with a repair bias toward nonhomologous end joining.

14 ted double-strand-break creation followed by nonhomologous end-joining.

15 rtilization via homologous recombination and nonhomologous end-joining.

16 rom imprecise repair of chromosome breaks by nonhomologous end-joining.

17 d/or extra nucleotide residues, hallmarks of nonhomologous end-joining.

18 d that loss of MSI1 reduces the frequency of nonhomologous end-joining.

19 akpoint of proteins that promote error-prone nonhomologous end-joining.

20 defects that could be reversed by inhibiting nonhomologous end-joining.

21 damage response and classical or alternative nonhomologous end joining (A-NHEJ).

22 uired for its DNA cleavage, DNA-binding, and nonhomologous end joining activities.

23 NA repair, which is accompanied by increased nonhomologous end-joining activity.

24 ated homologous recombination and restrained nonhomologous end joining, affecting cell survival after

25 We now show that knockdown of alt-nonhomologous end joining (alt-NHEJ) components-XRCC1, L

26 ated a poorly defined alternative pathway of nonhomologous end joining (alt-NHEJ) in the generation o

27 l components of the error-prone, alternative nonhomologous end-joining (alt-NHEJ) pathway.

28 ent, various molecular mechanisms, including nonhomologous end joining, Alu-Alu-mediated recombinatio

29 d DNA double-stranded break (DSB) repair via nonhomologous end joining and homologous recombination.

30 SBs) and stimulates DSB repair, through both nonhomologous end joining and homologous recombination.

31 volved in DNA replication and repair by both nonhomologous end joining and homologous repair is misre

32 break produced by Ac excision: footprints by nonhomologous end joining and rearrangements by various

33 atures of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent D

34 d with wild-type cells, indicating that both nonhomologous end-joining and homologous recombination D

35 IgD CSR occurred via both alternative nonhomologous end-joining and homologous recombination p

36 ce between the two major DSB repair pathways-nonhomologous end-joining and homologous recombination r

37 se to DNA damage, which suppresses repair by nonhomologous end-joining and homologous recombination.

38 in the repair of DNA double strand breaks by nonhomologous end-joining and in the signaling of DNA da

39 fore, UbcH7-depleted cells display increased nonhomologous end-joining and reduced homologous recombi

40 mbination, repair of double-strand breaks by nonhomologous end-joining and regulation of cell-cycle c

41 y, which prevents end resection and promotes nonhomologous end-joining and therefore directly compete

42 lar domain, including Tel1 (ATM) activation, nonhomologous end joining, and DNA double-strand break e

43 e involved in homologous recombination (HR), nonhomologous end joining, and translesion synthesis (TL

44 on and DNA-dependent protein kinase-mediated nonhomologous end-joining, and, when combined with olapa

45 t the level of 10-20% of HR when both HR and nonhomologous end joining are available.

46 While gene conversion and classical nonhomologous end-joining are the most physiologically p

47 tropicalis induced mutations consistent with nonhomologous end joining at the target site, resulting

48 s switch recombination, two events requiring nonhomologous end joining, at levels comparable to Atm(-

49 ite of cleavage in the absence of a donor by nonhomologous end joining both in plant cells and in mam

50 ombination (HR) and classical or alternative nonhomologous end joining (C-NHEJ versus A-EJ).

51 Classical nonhomologous end joining (C-NHEJ) is a major mammalian

52 Classical nonhomologous end joining (C-NHEJ) is a major mammalian

53 end-joining (EJ) repair pathways [canonical nonhomologous end joining (C-NHEJ) or alternative end jo

54 double-strand break repair via the canonical nonhomologous end joining (c-NHEJ) pathway.

55 oining of DSBs within S regions by classical nonhomologous end joining (C-NHEJ).

56 most small deletions occur during classical nonhomologous end joining (C-NHEJ).

57 Classical nonhomologous end-joining (C-NHEJ) and alternative end-j

58 The classical nonhomologous end-joining (C-NHEJ) DNA double-strand bre

59 The classic nonhomologous end-joining (c-NHEJ) pathway is largely re

60 many CSR junctions are mediated by classical nonhomologous end-joining (C-NHEJ), which employs the Ku

61 translocations in wild-type versus classical nonhomologous end-joining (C-NHEJ)-deficient NSPCs revea

62 predominantly by classical, DNA-PK-dependent nonhomologous end joining (D-NHEJ).

63 S-S junctions are joined via a nonhomologous end joining DNA repair process.

64 active cell cycle checkpoints and increased nonhomologous end joining DNA repair, suggesting that pe

65 e nuclease domain, and is a component of the nonhomologous end-joining DNA double-strand break repair

66 PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cel

67 DNA-PKcs plays a critical role in the nonhomologous end-joining DNA repair pathway and provide

68 CHO cell lines, which are defective for the nonhomologous end-joining DNA repair pathway, revealed a

69 isruption applications by engaging mutagenic nonhomologous end-joining DNA repair pathways.

70 A damage sites and play a functional role in nonhomologous end-joining DNA repair.

71 uggests that, in addition to its key role in nonhomologous end joining, DNA-PKcs also acts in concert

72 nase catalytic subunit (DNA-PKcs), a classic nonhomologous end joining factor, antagonizes double str

73 and breaks in part through antagonism of the nonhomologous end-joining factor 53BP1.

74 One of the major DSBs repair pathways is nonhomologous end joining for which Ku70/80 is essential

75 es four broken DNA ends that are repaired by nonhomologous end joining forming coding and signal join

76 Yet, how XLF binds XRCC4 and impacts nonhomologous end joining functions has been enigmatic.

77 SPR/SpCas9 system was used to knock out, via nonhomologous end-joining genome repair, the 4'OMT2 in o

78 pair, mismatch repair, base excision repair, nonhomologous end joining, homologous recombination, and

79 ir through both homologous recombination and nonhomologous end-joining, implicating FUS as an upstrea

80 was an indirect effect of the repression of nonhomologous end joining in Sir(-) mutants and that the

81 melphalan sensitivity of the cells, with the nonhomologous end-joining inhibitor SCR7 showing the str

82 Specifically, nonhomologous end joining is the predominant mechanism u

83 Nonhomologous end joining is the primary deoxyribonuclei

84 Finally, we demonstrate that nonhomologous end joining is uniquely required for the d

85 her, these results indicate that HR, but not nonhomologous end-joining, is the major repair or surviv

86 ts of the genome when needed, such as during nonhomologous end-joining, it specifically binds to core

87 In nonhomologous end joining, Ku loads onto broken DNA via

88 me of these rearrangements appear to involve nonhomologous end-joining, many must have involved mecha

89 uence analysis suggested fundamental role of nonhomologous end joining mechanism during eccDNA format

90 Cas9 lesions by homologous recombination or nonhomologous end joining mechanisms can lead to the int

91 nucleus" stage embryos led to high-frequency nonhomologous end-joining-mediated, mutagenic lesions in

92 termined, which supports the conclusion that nonhomologous end joining mediates viral DNA ligation.

93 e Ku heterodimer complex, which functions in nonhomologous end joining, mediates clustering of long t

94 d that, distinct from Ku-dependent classical nonhomologous end joining, MMEJ--even with very limited

95 repair of a single DSB by gene targeting or nonhomologous end-joining, neither of which leads to gro

96 e/phosphatase-like factor (APLF) facilitates nonhomologous end joining (NHEJ) and associates with the

97 We assessed the role of Tdp1 in nonhomologous end joining (NHEJ) and found that linear D

98 Both local mutagenesis through nonhomologous end joining (NHEJ) and gene replacement vi

99 nd breaks are repaired by two main pathways: nonhomologous end joining (NHEJ) and homologous recombin

100 How a cell chooses between nonhomologous end joining (NHEJ) and homologous recombin

101 Cells use two major pathways for DSB repair: nonhomologous end joining (NHEJ) and homologous recombin

102 posure, which is indicative of activation of nonhomologous end joining (NHEJ) and homologous recombin

103 ables the generation of knockout alleles via nonhomologous end joining (NHEJ) and knock-in alleles vi

104 rossovers while alternative pathways such as nonhomologous end joining (NHEJ) are suppressed.

105 Homologous recombination (HR) and nonhomologous end joining (NHEJ) are two distinct DNA do

106 s used to repair DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family

107 Nonhomologous end joining (NHEJ) can effectively resolve

108 We previously showed that the lack of nonhomologous end joining (NHEJ) DNA repair factor ligas

109 between classical (c)- and alternative (alt)-nonhomologous end joining (NHEJ) during DNA double-stran

110 ndings define 53BP1 as a main facilitator of nonhomologous end joining (NHEJ) during the S phase of t

111 ter assay, we found that COH29 could inhibit nonhomologous end joining (NHEJ) efficiency and that no

112 nteraction between the FA gene FANCC and the nonhomologous end joining (NHEJ) factor Ku70.

113 BRCA1, and deletion of Rif1 suppresses toxic nonhomologous end joining (NHEJ) induced by PARP inhibit

114 Nonhomologous end joining (NHEJ) is a recently described

115 Nonhomologous end joining (NHEJ) is essential for effici

116 Nonhomologous end joining (NHEJ) is one of the major DSB

117 by either homology-directed repair (HDR) or nonhomologous end joining (NHEJ) is tightly regulated.

118 examined the role of the MRN/ATM pathway in nonhomologous end joining (NHEJ) of damaged telomeres.

119 Subsequently, nonhomologous end joining (NHEJ) opens, processes, and f

120 Others appear to involve nonhomologous end joining (NHEJ) or aberrant replication

121 double-strand breaks (DSBs) are repaired by nonhomologous end joining (NHEJ) or homologous recombina

122 f tools for Cas9-mediated genome editing via nonhomologous end joining (NHEJ) or homology-directed re

123 Transcriptional up-regulation of major nonhomologous end joining (NHEJ) pathway genes KU80, X-R

124 omyces cerevisiae, the key components of the nonhomologous end joining (NHEJ) pathway that repairs DN

125 DR) mechanisms: the dominant but error-prone nonhomologous end joining (NHEJ) pathway, and the less-f

126 in mre-11(iow1) mutants are repaired by the nonhomologous end joining (NHEJ) pathway, as removing NH

127 A breaks are ultimately resolved through the nonhomologous end joining (NHEJ) pathway.

128 ation repair and antagonizes 53BP1-dependent nonhomologous end joining (NHEJ) pathway.

129 r of double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathway.

130 lso suppress inappropriate activation of the nonhomologous end joining (NHEJ) pathway.

131 SBs) can be repaired by homology independent nonhomologous end joining (NHEJ) pathways involving prot

132 dependent protein kinase (DNA-PK) during the nonhomologous end joining (NHEJ) process.

133 SET-transposase fusion protein that promotes nonhomologous end joining (NHEJ) repair in humans.

134 primase/polymerase (PolDom) is required for nonhomologous end joining (NHEJ) repair of DNA double-st

135 NA-dependent protein kinase (DNA-PK) and the nonhomologous end joining (NHEJ) repair pathway are intr

136 omote KSHV replication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplifi

137 of the DNA-PK enzyme, which are involved in nonhomologous end joining (NHEJ) repair, enhance amplifi

138 Nonhomologous end joining (NHEJ) repairs chromosome brea

139 kinase substrates and stimulates error-prone nonhomologous end joining (NHEJ) selectively in HR-defic

140 ns, including Pseudomonas aeruginosa, have a nonhomologous end joining (NHEJ) system of DNA double st

141 Many bacteria rely on nonhomologous end joining (NHEJ) when only a single copy

142 Nonhomologous end joining (NHEJ), a form of DNA double-s

143 Nonhomologous end joining (NHEJ), a major pathway of DNA

144 he efficiency of these methods is limited by nonhomologous end joining (NHEJ), an alternative DNA rep

145 pair systems: homologous recombination (HR), nonhomologous end joining (NHEJ), and single-strand anne

146 ntify DNA-PKcs complex proteins that mediate nonhomologous end joining (NHEJ), as TRIP13-binding part

147 knockout cells and organisms via error-prone nonhomologous end joining (NHEJ), but the efficiency of

148 on, which is almost exclusively dependent on nonhomologous end joining (NHEJ), CSR can occur in NHEJ-

149 By this assay, two proteins involved in nonhomologous end joining (NHEJ), DNAPKcs and ligase IV,

150 ocalized sequence changes through inaccurate nonhomologous end joining (NHEJ), often leading to gene

151 subunit (DNA-PKcs) is a central component of nonhomologous end joining (NHEJ), repairing DNA double-s

152 nation (HR) but can inhibit normal repair by nonhomologous end joining (NHEJ), the main DSB repair pa

153 aired both homologous recombination (HR) and nonhomologous end joining (NHEJ), the two major DSB repa

154 early phosphorylations promote initiation of nonhomologous end joining (NHEJ), whereas ABCDE phosphor

155 ency and decreased accuracy of DSB repair by nonhomologous end joining (NHEJ), which is required for

156 TRF2--repression of ATM kinase signaling and nonhomologous end joining (NHEJ)--and mice lacking telom

157 Collectively, the data define a nonhomologous end joining (NHEJ)-independent, S-phase-sp

158 outs in the rat and the mouse by introducing nonhomologous end joining (NHEJ)-mediated deletions or i

159 Nonhomologous end joining (NHEJ)-mediated repair of DSBs

160 ct DNA ends from resection and thereby favor nonhomologous end joining (NHEJ).

161 epaired via homologous recombination (HR) or nonhomologous end joining (NHEJ).

162 r, increasing the involvement of error-prone nonhomologous end joining (NHEJ).

163 Bs) and their adequate recombination through nonhomologous end joining (NHEJ).

164 pathways: homology-directed repair (HDR) or nonhomologous end joining (NHEJ).

165 ed in telomere maintenance and DNA repair by nonhomologous end joining (NHEJ).

166 er a novel role for PARylation in regulating nonhomologous end joining (NHEJ).

167 ensitivity is rescued by the inactivation of nonhomologous end joining (NHEJ).

168 capacity for classical, versus alternative, nonhomologous end joining (NHEJ).

169 r: the homologous recombination (HR) and the nonhomologous end joining (NHEJ).

170 B by either homologous recombination (HR) or nonhomologous end joining (NHEJ).

171 at are initiated on free DNA ends: classical nonhomologous end-joining (NHEJ) and ATM-dependent DNA d

172 DNA damage, functioning as part of both the nonhomologous end-joining (NHEJ) and base excision repai

173 lved several DSB repair mechanisms, of which nonhomologous end-joining (NHEJ) and homologous recombin

174 choice between two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombin

175 le is a conserved component of the bacterial nonhomologous end-joining (NHEJ) apparatus that performs

176 esection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologou

177 ing kinases and that it is not suppressed by nonhomologous end-joining (NHEJ) components, arguing tha

178 A double-strand breaks (DSBs) resulting from nonhomologous end-joining (NHEJ) deficiency induce apopt

179 ugh conditional deletion of TRF1 and TRF2 in nonhomologous end-joining (NHEJ) deficient cells.

180 gase 4 (LIG4), NHEJ1, and NBS1 involving the nonhomologous end-joining (NHEJ) DNA repair pathway resu

181 53BP1 gene silencing induces defects in the nonhomologous end-joining (NHEJ) DNA repair pathway.

182 Hypomorphic mutations in the nonhomologous end-joining (NHEJ) DNA repair protein DNA

183 Such mutant alleles result presumably from nonhomologous end-joining (NHEJ) events before the segre

184 Ku70, a known nonhomologous end-joining (NHEJ) factor, also functions

185 Disruption of the nonhomologous end-joining (NHEJ) factor, Ku, promotes DN

186 rearrangements by a process dependent on the nonhomologous end-joining (NHEJ) factors 53BP1 and DNA l

187 t DNA ligation in vitro and assembly of core nonhomologous end-joining (NHEJ) factors on damaged chro

188 In the absence of core nonhomologous end-joining (NHEJ) factors, Ab gene class-

189 Somatic mutations in nonhomologous end-joining (NHEJ) genes (DCLRE1C/ARTEMIS,

190 bination repair, but a role in DSB repair by nonhomologous end-joining (NHEJ) has not been defined.

191 Nonhomologous end-joining (NHEJ) is a key pathway for ef

192 Nonhomologous end-joining (NHEJ) is a major DNA double-s

193 Nonhomologous end-joining (NHEJ) is a major repair pathw

194 Nonhomologous end-joining (NHEJ) is the major DNA double

195 Furthermore, coexpression the nonhomologous end-joining (NHEJ) machinery from the clos

196 A double strand breaks (DSB) are repaired by nonhomologous end-joining (NHEJ) or homologous recombina

197 Subsequent repair of this break via the nonhomologous end-joining (NHEJ) or homology-directed re

198 triggering end resection and inhibiting the nonhomologous end-joining (NHEJ) pathway in G1 phase.

199 are mainly repaired by the DNA-PK-dependent nonhomologous end-joining (NHEJ) pathway in normal mamma

200 i, suggesting that HR is compromised and the nonhomologous end-joining (NHEJ) pathway is elicited to

201 The nonhomologous end-joining (NHEJ) pathway is essential fo

202 The nonhomologous end-joining (NHEJ) pathway is essential fo

203 The nonhomologous end-joining (NHEJ) pathway is the primary

204 y demonstrated that HSCs use the error-prone nonhomologous end-joining (NHEJ) pathway of DNA repair t

205 factor (XLF/Cernunnos) is a component of the nonhomologous end-joining (NHEJ) pathway of double-stran

206 aired DNA ends are joined by proteins of the nonhomologous end-joining (NHEJ) pathway of DSB repair t

207 ge checkpoint and DNA repair mediated by the nonhomologous end-joining (NHEJ) pathway.

208 d mutability, and abnormal regulation of the nonhomologous end-joining (NHEJ) pathway.

209 Nonhomologous end-joining (NHEJ) pathways repair DNA dou

210 ither by homologous recombination (HR) or by nonhomologous end-joining (NHEJ) pathways.

211 tivation of homologous recombination (HR) or nonhomologous end-joining (NHEJ) predisposes to a spectr

212 Cernunnos is involved in the nonhomologous end-joining (NHEJ) process during DNA doub

213 shing that TAs are not covalent conventional nonhomologous end-joining (NHEJ) products.

214 re the first to report a requirement for the nonhomologous end-joining (NHEJ) protein DNA-dependent p

215 The mycobacterial nonhomologous end-joining (NHEJ) protein Ku protects DSB

216 are suppressed by genetically eliminating Ku nonhomologous end-joining (NHEJ) protein, indicating tha

217 Here we show that FBXW7 facilitates nonhomologous end-joining (NHEJ) repair and that FBXW7 d

218 -protein kinase (DNA-PK) phosphorylation and nonhomologous end-joining (NHEJ) repair efficiency and f

219 of mice lacking Lig4, a ligase required for nonhomologous end-joining (NHEJ) repair of DNA double-st

220 lates at DNA double-strand breaks and favors nonhomologous end-joining (NHEJ) repair over ATM-depende

221 e IV (LIG4) is an essential component of the nonhomologous end-joining (NHEJ) repair pathway and play

222 d impaired homologous recombination (HR) and nonhomologous end-joining (NHEJ) repair pathways, with d

223 2609 foci, a surrogate marker for activated nonhomologous end-joining (NHEJ) repair, but also enhanc

224 ic subunit (DNA-PKcs), a protein involved in nonhomologous end-joining (NHEJ) repair.

225 Mycobacteria exploit nonhomologous end-joining (NHEJ) to repair DNA double-st

226 and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recom

227 revealed 47 to 58% of reads as repaired via nonhomologous end-joining (NHEJ) with deletions and/or s

228 However, nonhomologous end-joining (NHEJ), an error-prone repair,

229 DSBs, namely homologous recombination (HR), nonhomologous end-joining (NHEJ), and microhomology-medi

230 ways, homologous recombination repair (HRR), nonhomologous end-joining (NHEJ), and single-strand anne

231 cle-invasive bladder tumors are defective in nonhomologous end-joining (NHEJ), and this phenotype may

232 tein TRF2 by promoting their mobility, their nonhomologous end-joining (NHEJ), and, as we show here,

233 ence of DNA damage checkpoint components and nonhomologous end-joining (NHEJ), but not homologous rec

234 ir by both homologous recombination (HR) and nonhomologous end-joining (NHEJ), causes accumulation of

235 ment in the second major DSB repair pathway, nonhomologous end-joining (NHEJ), remains controversial.

236 nstrict the DNA-binding ring of Ku80 disrupt nonhomologous end-joining (NHEJ), telomeric gene silenci

237 nderstood and has been proposed to occur via nonhomologous end-joining (NHEJ)-mediated double-strand

238 occur in human cancers display hallmarks of nonhomologous end-joining (NHEJ).

239 ase (DNA-PK), a critical enzyme required for nonhomologous end-joining (NHEJ).

240 ted an increased number of DSBs processed by nonhomologous end-joining (NHEJ).

241 NA double-strand break repair pathway termed nonhomologous end-joining (NHEJ).

242 eaks, to recapitulate DSB repair via MMEJ or nonhomologous end-joining (NHEJ).

243 RP-3 and APLF accelerate DNA ligation during nonhomologous end-joining (NHEJ).

244 Imprecise nonhomologous-end-joining (NHEJ) DNA repair following re

245 AD50/NBS1 complex and favors the error-prone nonhomologous-end-joining (NHEJ) DNA-repair pathway inst

246 h as KU70 and LIG4 (both involved in classic nonhomologous end-joining, NHEJ) and SMC6B (involved in

247 he integrity of homology-directed repair and nonhomologous end joining of DNA breaks is impaired in K

248 Several of these genes are also involved in nonhomologous end joining of DNA double-strand break rep

249 ress sensor ATR nor DNA-PK, the initiator of nonhomologous end-joining of DSB, was involved in repair

250 breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination.

251 ble-strand breaks that stimulate error-prone nonhomologous end joining or homology-directed repair at

252 ts must be removed to allow repair by either nonhomologous end joining or homology-directed repair.

253 ecombination but instead form most often via nonhomologous end joining or microhomology-mediated brea

254 smatch, nucleotide excision, Fanconi anemia, nonhomologous end joining, or translesion synthesis repa

255 sis during DNA double strand break repair by nonhomologous end joining, particularly in nonreplicatin

256 mediates inhibition of the DNA-PK-dependent nonhomologous end joining pathway contributing to the ac

257 posed translocation loci that are ligated by nonhomologous end joining pathway for specific transloca

258 genetic disruption strategies relying on the nonhomologous end joining pathway may induce compensator

259 rm of DNA damage, are mainly repaired by the nonhomologous end joining pathway, which relies on DNA-P

260 nsertions or deletions via DNA repair by the nonhomologous end joining pathway.

261 and an increase in repair by the alternative nonhomologous end joining pathway.

262 ologous recombination (HR) and the classical nonhomologous end-joining pathway (cNHEJ).

263 ase and contributes to the repression of the nonhomologous end-joining pathway (NHEJ) at newly replic

264 ir of DNA double-strand breaks (DSBs) by the nonhomologous end-joining pathway (NHEJ) is important no

265 d by the DCLRE1C gene, is a component of the nonhomologous end-joining pathway and participates in ha

266 indels of the kind typically observed in the nonhomologous end-joining pathway of DNA double-strand b

267 XLF/Cernunnos is a core protein of the nonhomologous end-joining pathway of DNA double-strand b

268 ely because they mainly used the error-prone nonhomologous end-joining pathway to repair DSBs.

269 Ku70 is a key component of the nonhomologous end-joining pathway, which is the major pa

270 DNA repair complexes that participate in the nonhomologous end-joining pathway.

271 ich was necessary for DSB repair through the nonhomologous end-joining pathway.

272 pair, single strand break repair, and backup nonhomologous end-joining pathway.

273 ouble-stranded breaks (DSBs) mediated by the nonhomologous end-joining pathway.

274 ion-independent frameshifts generated by the nonhomologous end-joining pathway.

275 ubunit, essential DNA repair proteins in the nonhomologous end-joining pathway.

276 these double-strand breaks by the classical nonhomologous end-joining pathway.

277 mble the nuclear, microhomology-mediated and nonhomologous end joining pathways, in terms of the homo

278 und that intact homologous recombination and nonhomologous end-joining pathways of DSB repair are nee

279 NA double strand breaks that are repaired by nonhomologous end-joining pathways.

280 thways of homologous recombination and other nonhomologous end-joining processes.

281 A-PK(CS), which is involved in DSB repair by nonhomologous end joining rather than homologous recombi

282 ltaAID is impaired in its ability to recruit nonhomologous end joining repair factors, resulting in a

283 n inhibitor of the DNA-PK kinase crucial for nonhomologous end joining repair of DNA DSBs, and BRCA2-

284 Double strand breaks may trigger nonhomologous end joining repair, leading to frameshift

285 s in CML progenitors was mediated by classic nonhomologous end joining repair.

286 re partially disassembled around DSBs during nonhomologous end-joining repair in G1-arrested mammalia

287 can be efficiently ligated by the classical nonhomologous end-joining repair pathway (c-NHEJ), regen

288 nts null for Ku70 or Lig4, components of the nonhomologous end-joining repair pathway.

289 ion and can ultimately become substrates for nonhomologous end-joining repair, leading to large-scale

290 nizing radiation and bleomycin and inhibited nonhomologous end-joining repair.

291 HR)-mediated repair and, to a lesser extent, nonhomologous end-joining repair.

292 irectly to the DNA break and is required for nonhomologous end-joining repair.

293 Nonhomologous end joining repairs DNA double-strand brea

294 ly triggers an activation of the error-prone nonhomologous end joining response.

295 for gap filling by either polymerase during nonhomologous end joining, suggesting that it plays a ma

296 factor (XLF)-XRCC4 complex is essential for nonhomologous end joining, the major repair pathway for

297 also find that MMEJ compensates for loss of nonhomologous end joining to repair rereplication DSBs i

298 s of chromothripsis in TCC-UB is mediated by nonhomologous end-joining using kilobase, rather than me

299 nt protein kinase-mediated (DNA-PK-mediated) nonhomologous end-joining, whereas DNA repair pathways m

300 major pathway for Ku-independent alternative nonhomologous end joining, which contributes to chromoso