ライフサイエンスコーパス: nonhydrolyzable

1 ed phosphodiester backbone with an isosteric nonhydrolyzable 1,2,3-triazole moiety.

2 Clostridium perfringens GH125 enzyme with a nonhydrolyzable 1,6-alpha-thiomannoside substrate mimic

3 In the presence of nonhydrolyzable 5'-adenylyl-beta,gamma-imidodiphosphate,

4 IC(50) approximately 20 mum) as well as by a nonhydrolyzable acyl-CoA thioether analog.

5 ent with high-resolution structural data for nonhydrolyzable acyl-enzyme intermediates from the picro

6 ted by the observation that ATP, but not the nonhydrolyzable adenosine 5'-O-(thiotriphosphate), can i

7 Treatment of mice with the nonhydrolyzable ADP analog, adenosine-5'-0-(2-thiodiphos

8 ture of ADPRase in complex with Mg(2+) and a nonhydrolyzable ADPR analogue, alpha,beta-methylene ADP-

9 Moreover, the maximal capacity of the nonhydrolyzable agonist ADPbetaS to stimulate inositol p

10 In contrast to dADP, both ADP and its nonhydrolyzable alpha, beta-methylphosphonate analog wer

11 present here the synthesis and evaluation of nonhydrolyzable amide isosteres based on this class, lea

12 n function, is also able to detoxify several nonhydrolyzable aminoacyl adenylates but not processed M

13 level of resistance to McC and various toxic nonhydrolyzable aminoacyl adenylates.

14 cture of Aquifex aeolicus ThiL (AaThiL) with nonhydrolyzable AMP-PCP and TMP, and also with the produ

15 Nonhydrolyzable AMP-PNP and adenosine 5'-(beta,gamma-met

16 In contrast, neither nonhydrolyzable (AMP-PNP, AMP-PCP) nor hydrolyzable ATP

17 for microtubules in the presence of the ATP nonhydrolyzable analog 5'-adenylyl-beta, gamma-imidodiph

18 hio)-cAMP (8CPT-cAMP; 30 microM) but not its nonhydrolyzable analog 8-(4-chlorophenylthio)-cAMP, Sp-i

19 The nonhydrolyzable analog 8-bromo-cGMP, when applied to the

20 The nonhydrolyzable analog 8-bromo-cyclic GMP (8-Br-cGMP) po

21 First, in the presence of 1 mm ATP or the nonhydrolyzable analog adenosine 5'-(beta,gamma-imino)tr

22 The nonhydrolyzable analog AMP-PNP and ATP-gamma S also stim

23 ed injuries to spinal cord cultures, and the nonhydrolyzable analog beta-NAAG (250-1000 microM) compl

24 f intracellular cAMP, via application of the nonhydrolyzable analog dibutyryl cAMP (dbcAMP), can bloc

25 GTP, GDP, the nonhydrolyzable analog GMP-PNP, and the slowly hydrolyza

26 gnate dCTP, neither the cognate dTTP nor its nonhydrolyzable analog induced fingers closure, as isomo

27 intermediate can be sequestered by ClpA if a nonhydrolyzable analog is added to displace ATP.

28 the labile properties of 2-AG, 2-AG ether, a nonhydrolyzable analog of 2-AG, was also used.

29 ensitive cell, McC is processed, releasing a nonhydrolyzable analog of aspartyl-adenylate, which inhi

30 of bongkrekic acid (BA), an ANT blocker; the nonhydrolyzable analog of ATP (adenosine 5'-beta,gamma-i

31 l muscle Ca2+ release channel activated by a nonhydrolyzable analog of ATP in the presence of Ca2+.

32 ut can readily dimerize in the presence of a nonhydrolyzable analog of ATP, 5'-adenylyl-beta,gamma-im

33 er of the gamma-phosphate from the generally nonhydrolyzable analog of ATP, adenosine-5'-(beta,gamma-

34 interacted with Hsp90 in the presence of the nonhydrolyzable analog of ATP, AMP-PNP.

35 fect, whereas perfusion of ATP or AMP-PNP, a nonhydrolyzable analog of ATP, significantly inhibited T

36 denosine (3-thiotriphosphate) (ATPgammaS), a nonhydrolyzable analog of ATP, to replication factor C w

37 lication and removal of Mg(2+)-free ATP or a nonhydrolyzable analog of ATP, which binds to the cytopl

38 and no effect was observed with ATPgammaS, a nonhydrolyzable analog of ATP.

39 ) potentiates penile erection by acting as a nonhydrolyzable analog of cGMP and competing with this n

40 Both GDP and the nonhydrolyzable analog of GTP, GMP-PCP, inhibit renatura

41 Based on studies involving a nonhydrolyzable analog of GTP, we conclude that nucleoti

42 of endogenous oocyte PIMT with sinefungin, a nonhydrolyzable analog of S-adenosylhomocysteine, increa

43 Thus, MorphGTP behaves as a nonhydrolyzable analog whose binding induces formation o

44 ct required ATP hydrolysis since ADP and the nonhydrolyzable analog, 5'-adenylyl beta, gamma-imidopho

45 yme can introduce negative supercoils with a nonhydrolyzable analog, adenylyl imidodiphosphate.

46 ulated 2- to 4-fold by binding of ATP or the nonhydrolyzable analog, ATPgammaS (but not ADP), to the

47 ed intermediates, in the presence of the ATP nonhydrolyzable analog, beta,gamma-imidoadenosine-5'-tri

48 ble analog of cGMP, 8-bromo-cGMP, but not by nonhydrolyzable analog, dibutyryl cGMP, suggesting that

49 structures of human DNA polymerase beta with nonhydrolyzable analogs containing all atoms in the acti

50 e been overlooked because of the reliance on nonhydrolyzable analogs for studying a single reaction t

51 equired for protein import into peroxisomes; nonhydrolyzable analogs of ATP could not substitute for

52 The nonhydrolyzable analogs of ATP, adenosine-5'-O-(3-thiotr

53 In the presence of ATP or nonhydrolyzable analogs of ATP, ClpXP had nearly the sam

54 000) that is stabilized by binding of ATP or nonhydrolyzable analogs of ATP.

55 not block activation of peptide cleavage by nonhydrolyzable analogs of ATP.

56 as tested by dialyzing On bipolar cells with nonhydrolyzable analogs of cGMP.

57 Nonhydrolyzable analogs of GTP did not substitute in thi

58 Two nonhydrolyzable analogs of GTP were fully able to activa

59 cay of rod photoresponses in the presence of nonhydrolyzable analogs of GTP.

60 the channel that is required for ATP and its nonhydrolyzable analogs to reduce open probability.

61 Kinetic experiments performed with the nonhydrolyzable analogue ATPgammaS showed overall change

62 maltose-binding protein, and ADP or another nonhydrolyzable analogue does not substitute for ATP.

63 ful for incorporating useful amounts of this nonhydrolyzable analogue for use as an inhibitor of base

64 substrate indole-3-glycerol phosphate or its nonhydrolyzable analogue indole propanol phosphate (IPP)

65 centrations up to 1 mM, suggesting that this nonhydrolyzable analogue may not be a faithful mimic of

66 A nonhydrolyzable analogue of (GlcNAc)(2,) methyl beta-N,

67 Here, we report the synthesis of a nonhydrolyzable analogue of 29-linked polyubiquitin chai

68 f the selective substrate profile of AsbC, a nonhydrolyzable analogue of 3,4-DHB-AMP was synthesized

69 K complex with the addition of substrates; a nonhydrolyzable analogue of adenosine-triphosphate, AMPP

70 e Escherichia coli enzyme, in complex with a nonhydrolyzable analogue of ATP, 5'-adenylimido-diphosph

71 RecA in complex with MgADP and MnAMP-PNP, a nonhydrolyzable analogue of ATP, at resolutions of 1.9 a

72 (-8) M] only in the presence of ATPgammaS, a nonhydrolyzable analogue of ATP, but not other nucleotid

73 32 or replacement of ATP with ATP-gamma-S, a nonhydrolyzable analogue of ATP, suggesting that ATP is

74 ma-methylene]triphosphate (methylene-ATP), a nonhydrolyzable analogue of ATP.

75 cyclic GMP (CPT-cGMP), a membrane-permeable, nonhydrolyzable analogue of cGMP, resulted in an increas

76 Intracellular elevation of either the nonhydrolyzable analogue of GTP, guanosine-5'-O-(3-thiot

77 uanosine 5'(beta-gamma imino)triphosphate, a nonhydrolyzable analogue of GTP, the binding of AdoCbl t

78 beta-D-cellobioside (MUS-CB), a ground-state nonhydrolyzable analogue of the fluorescent cellulase su

79 This work describes a nonhydrolyzable analogue of the tripolyphosphate (PPP(i)

80 nteractions of DNA containing Fapy.dG or the nonhydrolyzable analogue with Fpg and MutY are described

81 rotein was crystallized in the presence of a nonhydrolyzable analogue, AMPPNP, and its structure dete

82 f fluorescence with ADP, no quenching with a nonhydrolyzable analogue, and slow quenching with ATP.

83 OPII vesicle budding is promoted by GTP or a nonhydrolyzable analogue, guanylimide diphosphate (GMP-P

84 re hydrolysis per se and can be induced by a nonhydrolyzable analogue.

85 critical deficiencies, we designed neutral, nonhydrolyzable analogues of the chicoric acids.

86 of bound oligopeptide inhibitors possessing nonhydrolyzable analogues of the scissile peptide bond.

87 p)-8-BDB-TcAMPSMe reacts in the active site, nonhydrolyzable analogues of the substrate cAMP, or the

88 iation of ClpAP complexes in the presence of nonhydrolyzable analogues was >/=30 min.

89 The interaction of DNA containing Fapy.dA or nonhydrolyzable analogues with Fpg and MutY is described

90 ht be different inhibitory tendencies by the nonhydrolyzable analogues, phosphonothioic acids compare

91 and temperature and a requirement for ATP or nonhydrolyzable analogues.

92 ught about by all the nucleotides, including nonhydrolyzable analogues; this effect of vinblastine wa

93 ies of recombinant 6-MSA synthases with both nonhydrolyzable and hydrolyzable substrate mimics have p

94 of Fhit bound to Ado-p-CH2-p-ps-Ado (IB2), a nonhydrolyzable ApppA analog, was refined to 3.1 A, and

95 roteolyzed with release of a toxic warhead-a nonhydrolyzable aspartamidyl-adenylate, which inhibits a

96 " inhibitor microcin C7 (McC7) consists of a nonhydrolyzable aspartyl-adenylate conjugated to a hexap

97 ssed there, and the product of processing, a nonhydrolyzable aspartyl-adenylate, inhibits translation

98 gets processed to release a toxic warhead-a nonhydrolyzable aspartyl-adenylate, which inhibits aspar

99 rved in response to adenosine, AMP, ADP, and nonhydrolyzable ATP (betagammameATP).

100 NHE1 activity is stable with perfusion of nonhydrolyzable ATP [adenosine 5'-(beta,gamma-imido)trip

101 -ray structures of the open state bound to a nonhydrolyzable ATP analog (AMPPCP) and 1,6-anhydroMurNA

102 Moreover, Top2 bound to the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidod

103 singly, ADP, guanosine triphosphate, and the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidod

104 duplexes in the presence and absence of the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidod

105 1 microM) and eliminated by substituting the nonhydrolyzable ATP analog 5-adenylyl-imidodiphosphate o

106 diphosphate and in ternary complex with the nonhydrolyzable ATP analog adenosine 5'-(beta,gamma-imid

107 ral DEAD-box proteins in the presence of the nonhydrolyzable ATP analog ADP-beryllium fluoride.

108 ATP and a nonhydrolyzable ATP analog also influence the stability

109 pA is released upon exchange of ATP with the nonhydrolyzable ATP analog and ATP hydrolysis.

110 is incongruous with the models based on the nonhydrolyzable ATP analog data.

111 The addition of a nonhydrolyzable ATP analog had no effect at early time p

112 Binding of a nonhydrolyzable ATP analog inverts the transporter to an

113 Binding of a nonhydrolyzable ATP analog locks pNS3h in a conformation

114 Second, the binding of a nonhydrolyzable ATP analog to the yeast enzyme appears t

115 ly traps one DNA circle in the presence of a nonhydrolyzable ATP analog under the same conditions tha

116 nthase inhibitor AMP-PNP (gamma-imino ATP, a nonhydrolyzable ATP analog) and Mg(2+)/ADP.

117 Specifically, ATPgammaS (a nonhydrolyzable ATP analog) inhibits secretion of interf

118 s in the presence of magnesium and ATP (or a nonhydrolyzable ATP analog), contains maximal DNA helica

119 One structure, in complex with a nonhydrolyzable ATP analog, adenosine 5'-adenylyl-beta,g

120 ild-type RecF binding in the presence of the nonhydrolyzable ATP analog, adenosine 5'-O-(3-thio)triph

121 er interface mutants, L273A and L108A, and a nonhydrolyzable ATP analog, adenosine 5'-O-(3-thiotripho

122 A nonhydrolyzable ATP analog, ADPCP (beta,gamma-methylene

123 f 46 +/- 1 A in the presence or absence of a nonhydrolyzable ATP analog, AMP-PnP.

124 sence of ATP, 25 microM in the presence of a nonhydrolyzable ATP analog, and 45 microM in the presenc

125 bserved using 5'-adenylylimidodiphosphate, a nonhydrolyzable ATP analog, and was blocked in the prese

126 AMP-PNP, a nonhydrolyzable ATP analog, at a concentration of 1 or 3

127 We demonstrate that the nonhydrolyzable ATP analog, ATP gamma S, supports the fo

128 at the shift in IC50 of inhibitors using the nonhydrolyzable ATP analog, beta, gamma-methyleneadenosi

129 In adenylyl-imidodiphosphate (AMP-PNP), a nonhydrolyzable ATP analog, each kinesin-1 dimer binds t

130 ylyl-beta,gamma-imidodiphosphate (AMPPNP), a nonhydrolyzable ATP analog, promotes stable complex form

131 Hepatocyte treatment with ATPgammaS, a nonhydrolyzable ATP analog, recapitulated early signalin

132 In the presence of a nonhydrolyzable ATP analog, the enzyme is known to promo

133 s open very differently in the presence of a nonhydrolyzable ATP analog, with subconductance openings

134 ease the linking number in the presence of a nonhydrolyzable ATP analog.

135 ranslocation step specifically requires ATP; nonhydrolyzable ATP analogs are ineffective.

136 We have previously shown that nonhydrolyzable ATP analogs block the lytic activity of

137 Nonhydrolyzable ATP analogs did not substitute for ATP t

138 Substitution of nonhydrolyzable ATP analogs for ATP slowed or prevented

139 Effects of two nonhydrolyzable ATP analogs on helicase denaturation wer

140 n, we evaluated the effects of ATP, ADP, and nonhydrolyzable ATP analogs on the lifetime of protein.D

141 ding of ATP, but not ATP hydrolysis, because nonhydrolyzable ATP analogs satisfy the nucleotide requi

142 cence response was observed with MgADP, with nonhydrolyzable ATP analogs, or with MgATP by catalytica

143 mbly system was inhibited by the addition of nonhydrolyzable ATP analogs, suggesting that ATP hydroly

144 TP depletion experiments and inhibition with nonhydrolyzable ATP analogs.

145 rmational changes in the presence of ATP and nonhydrolyzable ATP analogs.

146 of ATP concentration, and by the use of the nonhydrolyzable ATP analogue adenosine 5'-(beta, gamma-i

147 The nonhydrolyzable ATP analogue adenosine 5'-(beta,gamma-im

148 Even though DNA binding is promoted by the nonhydrolyzable ATP analogue adenosine 5'-O-(thiotriphos

149 ctures of MtPPAT in complex with PhP and the nonhydrolyzable ATP analogue adenosine-5'-[(alpha,beta)-

150 nase domain of human Plk1 complexed with the nonhydrolyzable ATP analogue adenylylimidodiphosphate (A

151 proteolysis data indicate that SecB and the nonhydrolyzable ATP analogue AMP-P-C-P induce similar co

152 e, the lysyl-adenylate intermediate, and the nonhydrolyzable ATP analogue AMP-PCP.

153 ransfer was sustained in the presence of the nonhydrolyzable ATP analogue AMP-PNP (adenyl-5'-yl imido

154 The nonhydrolyzable ATP analogue AMP-PNP binds in a unique m

155 The Arp2/3 complex bound to ADP or the nonhydrolyzable ATP analogue AMP-PNP cannot nucleate act

156 In the presence of the nonhydrolyzable ATP analogue AMP-PNP, the drug binding s

157 se from E. coli: one form complexed with the nonhydrolyzable ATP analogue AMPPNP and the second with

158 ct UDP-N-acetylmuramoyl-L-alanine (UMA), the nonhydrolyzable ATP analogue AMPPNP, and Mn(2+) have bee

159 3 degradation in the presence of ATP, or the nonhydrolyzable ATP analogue AMPPNP, indicate a sequenti

160 ase domain in apo form and in complex with a nonhydrolyzable ATP analogue at 2.0 A and 2.5 A resoluti

161 Using the nonhydrolyzable ATP analogue ATP-gamma-S results in form

162 ned with the wild-type protein by use of the nonhydrolyzable ATP analogue ATP-gamma-S.

163 A nonhydrolyzable ATP analogue had the same effects as ATP

164 Simultaneous presence of ADP and a nonhydrolyzable ATP analogue modulates MutSalpha.heterod

165 d GroEL in the presence of ATP, ADP, and the nonhydrolyzable ATP analogue, 5'-adenylyl beta,gamma-imi

166 ted most emphatically in the response to the nonhydrolyzable ATP analogue, 5'-adenylyl-beta,gamma-imi

167 Furthermore, the nonhydrolyzable ATP analogue, 5'-adenylylimidodiphosphat

168 3) Another nonhydrolyzable ATP analogue, adenosine 5'-(beta,gamma-m

169 2) After hexokinase treatment, the nonhydrolyzable ATP analogue, adenyl 5'-(yl iminodiphosp

170 Upon binding the nonhydrolyzable ATP analogue, AMPPNP/Mg(2+), the MutL di

171 imentation rate in the presence of ADP and a nonhydrolyzable ATP analogue, which suggests a change to

172 ce increased upon addition of ATP, ADP, or a nonhydrolyzable ATP analogue.

173 of initial rates obtained in the presence of nonhydrolyzable ATP analogues and the small molecule inh

174 ational/experimental study characterizing 13 nonhydrolyzable ATP analogues as selective human NPP1 in

175 In the presence of DNA and ADP or the nonhydrolyzable ATP analogues ATPgammaS and AMP-PNP, how

176 filter binding assays indicate that ADP and nonhydrolyzable ATP analogues can bind simultaneously to

177 ATP, ADP, and nonhydrolyzable ATP analogues decreased the UIC2 reactiv

178 Nonhydrolyzable ATP analogues partially replicate the ef

179 site for ADP and one high affinity site for nonhydrolyzable ATP analogues per dimer equivalent.

180 e ClpAP complexes requires binding of ATP or nonhydrolyzable ATP analogues to ClpA.

181 s indicate that the nucleotide (ATP, ADP, or nonhydrolyzable ATP analogues) occupancy of the ATPase b

182 l transition was 2 for ATP and ADP but 1 for nonhydrolyzable ATP analogues.

183 the presence of saturating concentrations of nonhydrolyzable ATP analogues.

184 s of wild-type Hsp82 only in the presence of nonhydrolyzable ATP and formed an Hsp82-Cpr6-Cpr7 ternar

185 Nonhydrolyzable ATP, GTP, and guanosine 5'-[gamma-thio]t

186 ATP, but not nonhydrolyzable ATP, is essential for the unwinding acti

187 ATP, but not nonhydrolyzable ATP-gamma S, regulates the SODD binding

188 olution, alone and in the presence of AMP or nonhydrolyzable ATP.

189 Addition of ATP or the nonhydrolyzable ATPgammaS reduces binding of the MSH2-MS

190 Experiments using nonhydrolyzable ATPgammaS show that ATP binding converts

191 , we have demonstrated that a peptide with a nonhydrolyzable beta-amino acid substitution binds DM2 w

192 Nonhydrolyzable branched RNA analogues containing arabin

193 Pretreatment of REF-52 cells with the nonhydrolyzable cAMP analog, 8-(4-chlorophenylthio)-cAMP

194 bited VASP phosphorylation stimulated by the nonhydrolyzable cAMP analog, 8-bromo-cAMP, indicating th

195 by a hydrolyzable cAMP analog, but not by a nonhydrolyzable cAMP analog.

196 /glycosidases and subsequent accumulation of nonhydrolyzable carbohydrate-containing compounds in lys

197 binding of natural glycosides and also of a nonhydrolyzable cellotetraose analogue.

198 purine nucleotides, and membrane-permeable, nonhydrolyzable cyclic nucleotide analogs were all inact

199 he gap (binary complex) and with an incoming nonhydrolyzable dATP analog (ternary complex) were solve

200 mplex structures of polbeta with an incoming nonhydrolyzable dGTP or dCTP analog paired with templati

201 the synthesis of a prodrug that delivers the nonhydrolyzable difluoromethylphosphonate moiety intrace

202 pared to triphosphoric acid is enzymatically nonhydrolyzable due to substitution of two bridging oxyg

203 y at the scissile bond; the other two have a nonhydrolyzable electrophilic group at the P1' position.

204 RNA and K(+) current expression, whereas the nonhydrolyzable Epac activator 8-(4-chlorophenylthio)-2'

205 A nonhydrolyzable ether analog of palmitoyl-carnitine stim

206 , within the nucleus of control L-cells, the nonhydrolyzable fluorescent LCFA-CoA (BODIPY-C16-S-S-CoA

207 Cyclopentyl-adenylylimidodiphosphate, a nonhydrolyzable form of this analog, inhibits the mutant

208 ermore, incubation of Schwann cells with the nonhydrolyzable GDP analog GDP-betaS inhibited TX14(A)-i

209 with 80S complexes formed in the presence of nonhydrolyzable GDPNP, whereas these factors were releas

210 ecause similar results were obtained using a nonhydrolyzable GSL analog.

211 ls, as direct activation of GIRK channels by nonhydrolyzable GTP also potentiated the currents.

212 ermophilus 70S ribosome bound to EF-4 with a nonhydrolyzable GTP analog and A-, P-, and E-site tRNAs.

213 te from ARF1, but only C-1Sec7 displaced the nonhydrolyzable GTP analog bound to mut13F139/L, again i

214 Incubating cells with the nonhydrolyzable GTP analog GTPgammaS (1 microm) or the m

215 of the G protein Gialpha1 complexed with the nonhydrolyzable GTP analog guanosine-5'-(betagamma-imino

216 omponents Sar1p, Sec23/24p, Sec13/31p, and a nonhydrolyzable GTP analog such as GMP-PNP.

217 ard to its internalization, sensitivity to a nonhydrolyzable GTP analog, and anisotropy of a bound fl

218 Ran complexed with the nonhydrolyzable GTP analog, GMPPNP (RanGMPPNP), is used

219 ase binds MeaB 15-fold more tightly when the nonhydrolyzable GTP analog, GMPPNP, is bound versus GDP.

220 The nonhydrolyzable GTP analog, guanosine 5'-(beta, gamma-im

221 The onset of the nonhydrolyzable GTP analog, guanylylimidodiphosphate-med

222 tofilament sheets are assembled in GMPCPP, a nonhydrolyzable GTP analog, or in GTP following chelatio

223 enin is energy dependent and is inhibited by nonhydrolyzable GTP analogs and by a dominant-negative m

224 10 and 25 degrees C using GTP, GDP, and two nonhydrolyzable GTP analogs, guanosine 5'-O-(gamma-thio)

225 In the presence of GTP or nonhydrolyzable GTP analogs, synapsis happens rapidly, w

226 P and derepressed by Snu114p bound to GTP or nonhydrolyzable GTP analogs.

227 any of the proteins even in the presence of nonhydrolyzable GTP analogs.

228 oluble domain was achieved when bound to the nonhydrolyzable GTP analogue guanosine 5'-[beta,gamma-im

229 current activated in cells dialyzed with the nonhydrolyzable GTP analogue guanosine-5'-O-(3-thio)trip

230 ctivated in a Mg2+ complex with GTPgammaS, a nonhydrolyzable GTP analogue that is reported to bind Ga

231 e 70S ribosome with RF3 in the presence of a nonhydrolyzable GTP analogue, guanosine 5'-beta,gamma-me

232 on of guanosine 5'-O-(3-thiotriphosphate), a nonhydrolyzable GTP analogue, or by omission of cytosol.

233 ine 5'-O-(3-thiotriphosphate) (GTPgammaS), a nonhydrolyzable GTP analogue.

234 Given that each of the nonhydrolyzable GTP analogues is able to promote the bin

235 d (signaling-active) state as induced by the nonhydrolyzable GTP analogues, guanosine 5'-(beta,gamma-

236 ndeed, acute desensitization is abolished by nonhydrolyzable GTP analogues.

237 n, driven by the binding of six NTPs (or six nonhydrolyzable GTPgammaS analogues) that are located at

238 quiring acidic phospholipids, Arf1p, and the nonhydrolyzable GTPgammaS.

239 se subunits, one (gp61) primase subunit, and nonhydrolyzable GTPgammaS.

240 e 3 microm and is not supported by Ba(2+) or nonhydrolyzable guanine nucleotides, which do not stimul

241 crystal structures of EF-G complexed with a nonhydrolyzable guanosine 5'-triphosphate (GTP) analog a

242 premutagenic structures were obtained with a nonhydrolyzable incoming nucleotide analog, dAMPCPP, and

243 Other fatty acids, including a nonhydrolyzable inhibitor of both lipooxygenase and cycl

244 it is mimicked by postsynaptic injection of nonhydrolyzable IP(3), and by photolysis of caged IP(3)

245 The fact that nonhydrolyzable L-arginine analogs are not stimulatory i

246 luoromethylene LPA analogues were unique new nonhydrolyzable ligands with surprising enantiospecific

247 ds in rabbit psoas muscle in the presence of nonhydrolyzable ligands.

248 leavage at one site by the introduction of a nonhydrolyzable linkage can lead to the utilization of o

249 A nonhydrolyzable lipoyl-AMP analogue was found to competi

250 xtension was supported by the inability of a nonhydrolyzable malonyl analog to trap products of inter

251 Ub-AMSN (4b) contain a sulfamide group as a nonhydrolyzable mimic of the phosphate group in the cogn

252 to a binary complex composed of Nmt1p and a nonhydrolyzable myristoylCoA analogue (S-(2-oxo)pentadec

253 ion and of a ternary complex of Nmt1p with a nonhydrolyzable myristoylCoA analogue [S-(2-oxo)pentadec

254 ith a bound substrate peptide (GLYASKLA) and nonhydrolyzable myristoylCoA analogue was used as the ba

255 oMet synthetase because of the presence of a nonhydrolyzable NH-link between the beta- and gamma-phos

256 or Pgp is not altered by the presence of the nonhydrolyzable nucleotide 5'-adenylylimididiphosphate a

257 raints due to binding in the presence of the nonhydrolyzable nucleotide adenylylimidodiphosphate.

258 tion activity of Hsp70 can be inhibited by a nonhydrolyzable nucleotide analog and encouraged by phar

259 es, 2-aminopurine nucleotide triphosphate, a nonhydrolyzable nucleotide analogue dAMPCPP, and a rapid

260 Neither phosphatase inhibitors nor nonhydrolyzable nucleotide analogues modified CRAC chann

261 channels were locked open by the addition of nonhydrolyzable nucleotide or when the R334C mutation wa

262 Although the concept of nonhydrolyzable nucleotides has been around for some tim

263 the decrease in UIC2 reactivity produced by nonhydrolyzable nucleotides, but unlike vinblastine, it

264 are reversibly activated (albeit weakly) by nonhydrolyzable nucleotides.

265 alogs-one of the most interesting classes of nonhydrolyzable nucleotides.

266 Nonhydrolyzable or poorly hydrolyzable ATP analogs inhib

267 th adenosine, ATP, and other nucleotides and nonhydrolyzable P2 receptor agonists and antagonists sug

268 rs with methylcarbamyl-PAF (cPAF, 300 nM), a nonhydrolyzable PAF analogue, TNF-alpha (20 ng/mL), and

269 This report examines the effects of the nonhydrolyzable PAF receptor agonist methyl carbamyl PAF

270 ied form was inhibited by S-hexadecyl-CoA, a nonhydrolyzable palmitoyl-CoA analog, demonstrating that

271 turally occurring acyl donor palmitate and a nonhydrolyzable palmitoyl-CoA analog.

272 d novel dipeptides that contain monocharged, nonhydrolyzable phosphate group replacements and bind to

273 Interestingly, the nonhydrolyzable phospholipid dioleoyl ether phosphatidyl

274 Substitution of the phosphate groups with nonhydrolyzable phosphonate groups preserved platelet an

275 nhibited by the cyclic phosphopeptide with a nonhydrolyzable phosphoserine mimetic.

276 tase (PTPase) inhibitors is to incorporate a nonhydrolyzable phosphotyrosine (pTyr) mimic into a pept

277 Results are presented for the binding of a nonhydrolyzable phosphotyrosine analog phosphonodifluoro

278 Using "expressed protein ligation", nonhydrolyzable phosphotyrosine analogs were introduced

279 Protein-tyrosine peptidomimetics containing nonhydrolyzable phosphotyrosine analogues bind to PTPase

280 the greatest stability, ShK-192, contains a nonhydrolyzable phosphotyrosine surrogate, a methionine

281 Nonhydrolyzable phosphotyrosyl (pTyr) mimetics serve as

282 d the potential efficacy of bisphosphonates, nonhydrolyzable PPi analogs, in preventing ectopic miner

283 Free energy profiles demonstrate that the nonhydrolyzable product of the condensation reaction, de

284 T. gondii UPRT bound to uracil and cPRPP, a nonhydrolyzable PRPP analogue, to 2.5-A resolution.

285 report describes the synthesis of three such nonhydrolyzable pTyr mimics that contain alpha-ketoacid,

286 criptase (RT) inhibitors, a new chemotype of nonhydrolyzable purine diphosphate mimic was synthesized

287 We have now synthesized a nonhydrolyzable reactive cAMP analogue, (S(p))-8-[(4-bro

288 We report herein a two-step method to make nonhydrolyzable saccharide-porphyrin conjugates in high

289 ialysis was used to study the binding of two nonhydrolyzable, short chain phospholipid analogues to t

290 d CACNA1H mRNA and Ca(v)3.2 current, whereas nonhydrolyzable Sp-8CPT-cAMP failed to increase either C

291 2+) to the enzyme in the presence of dUDP, a nonhydrolyzable substrate analog, was specific and compe

292 of the YopH PTPase domain in complex with a nonhydrolyzable substrate analogue, the hexapeptide mime

293 ch and identified shortcomings in the use of nonhydrolyzable substrate analogues for conformational a

294 rate specificity, a series of water-soluble, nonhydrolyzable substrate analogues were needed so their

295 , or leucine attached to adenosine through a nonhydrolyzable sulfamoyl bond.

296 s readily displaceable by S-hexadecyl-CoA, a nonhydrolyzable thioether analogue of LCFA-CoAs.

297 synthetic triketide substrates containing a nonhydrolyzable thioether linkage as well as by site-dir

298 from that observed in the presence of ADP or nonhydrolyzable triphosphate alone, and it is unlikely t

299 Usp15, through affinity purification with a nonhydrolyzable ubH2B mimic.

300 A series of nonhydrolyzable ubiquitin dimer analogues has been synth