ライフサイエンスコーパス: nonnative

1 he primary structure formed, both native and nonnative.

2 r reinvasion of sites when treating dominant nonnatives.

3 onnative led to competitive release of other nonnatives.

4 transition state of Protein L is found to be nonnative, a significant result that agrees with our Pro

5 The intrinsic time scales for nonnative aggregate nucleation (tau0(n)) and chain growt

6 vity at the price of protein instability and nonnative aggregation.

7 Results suggest that nonnatives also use a facultative C(4) -like photosynthe

8 etones on the side chain of the incorporated nonnative amino acid and hydroxylamine functionalized mo

9 The ribosomal incorporation of nonnative amino acids into polypeptides in living cells

10 This example illustrates the utility of nonnative amino acids to optimize protein therapeutics i

11 tibodies with site-specifically incorporated nonnative amino acids were produced in stable cell lines

12 m), to determine the solution structure of a nonnative amyloidogenic intermediate at high resolution.

13 the Rosetta energy discriminate between the nonnative and native-like structures significantly bette

14 d infants and tested the discrimination of a nonnative, and hence never-before-experienced, speech so

15 management that assumes negative effects of nonnatives, and emphasize the need to consider context-d

16 genic activities--particularly the spread of nonnative annual grasslands--has led to a breakdown in t

17 concomitant increase in cover and biomass of nonnative annuals, particularly under high levels of exp

18 expanded forms of the capsids, which possess nonnative antigenicity, are now well understood, but hig

19 Interactions among nonnatives are relatively understudied, though the likel

20 se the misfolded state is characterized by a nonnative arrangement of aromatic side chains.

21 hat two key bound intermediates, each with a nonnative arrangement of hydrophobic residues in the MDM

22 Experimental infection with nonnative bacteria reveals that--despite successful colo

23 Structural contacts in the core, including a nonnative base pair, help to stabilize the intermediate

24 le to anticipate positive interactions among nonnatives based upon traits of the co-occurring invader

25 in a protein's dynamics, and we discuss the nonnative, beta-sheet-rich states that play a distinct r

26 , relative abundance decreased with age when nonnative biomass was high and soil moisture was low.

27 wever, the formation of several medium-range nonnative bonds mapping to one of the beta-barrels was o

28 Notably, no long-range nonnative bonds were ever observed, suggesting that a na

29 Yet both these and the short-range nonnative bonds were ultimately "edited" to native, as e

30 Habitat for nonnative brook trout Salvelinus fontinalis and brown tr

31 -terminal beta-hairpin and alpha-helix and a nonnative C-terminal alpha-helix.

32 HIV drugs based on the concept of trapping a nonnative capsid protein conformation.

33 ments in the kcat/Km values for a variety of nonnative carbohydrates.

34 e in amplitude of the mismatch response to a nonnative change of phoneme at the end of the first year

35 The nonnative character partially explains the failure of ac

36 parsely populated, have both native-like and nonnative character; the specificity of the transient lo

37 cluding large-bodied snook, mojarra species, nonnative cichlids, and striped mullet, while having lit

38 d productivity: positive selection effect in nonnative communities and positive complementarity effec

39 ersity-productivity mechanisms in native and nonnative communities differ and are the first to show t

40 did monoculture communities, but native and nonnative communities diverged in root : shoot ratios an

41 of interactions differed between native and nonnative communities.

42 one FkpA contributes to LacZ folding in this nonnative compartment.

43 d a meta-analysis of experiments that tested nonnative competition intensity.

44 atchy, marginal habitats unsuitable to their nonnative competitors.

45 Starting from a nonnative conformation held by an aromatic disulfide bon

46 The resulting nonnative conformation is competent for translocation, w

47 stinct phases in the folding of Top7, that a nonnative conformation is stable at equilibrium, and tha

48 tous metabolite interacts selectively with a nonnative conformation of a protein and facilitates prot

49 t it arrives in the cytosol in a vulnerable, nonnative conformation.

50 increased risk of undergoing transitions to nonnative conformational states or will persist within s

51 ded state and ending either in the native or nonnative conformational states, trajectories are genera

52 Hyperglycosylated GRP94 forms have nonnative conformations and are less active.

53 eld is able to discriminate near-native from nonnative conformations of the six training proteins whe

54 turn interfaces traps the protein in compact nonnative conformations.

55 ee energy gap between sets of nativelike and nonnative conformations.

56 ation of the P3 pseudoknot, and refolding of nonnative conformers, respectively.

57 ticulators impeded their discrimination of a nonnative consonant contrast but only when the relevant

58 he transition state (DeltaF) correlates with nonnative-contact variation (DeltaA), and the simulated

59 contacts, suggesting that for some peptides, nonnative contacts can lead to productive folding events

60 ined in terms of folding of either native or nonnative contacts from a common compact disordered stat

61 g rate depending on the amount of native and nonnative contacts made in those subspaces.

62 ng on the stability of the unbound monomers, nonnative contacts play different roles in the associati

63 d protein alpha3D being a notable exception, nonnative contacts play no significant part in determini

64 nd metal-binding sites, and stabilization of nonnative contacts that leads to a misfolded state.

65 r-shifted sheet, which is composed of solely nonnative contacts, suggesting that for some peptides, n

66 hanisms of protein folding are not biased by nonnative contacts, typically argued to be a consequence

67 cts and partially extended in urea with many nonnative contacts.

68 structure, and an increase in the number of nonnative contacts.

69 after training with a Hindi dental-retroflex nonnative contrast.

70 attachment of a Ru(II) photosensitizer to a nonnative cysteine near the heme (RuIIK97C-FeIIIP450), i

71 scopy has required site-specific labeling of nonnative cysteines, a labor-intensive process occasiona

72 Disrupting the nonnative DBD-DBD interaction or transiently inhibiting

73 f the Trp91/Arg174 packing presumably allows nonnative DBD-DBD interactions that both nucleate aggreg

74 the structures determined thus far are in a nonnative detergent environment.

75 o mimic the formation/dissociation of native/nonnative disulfide bonds).

76 consistent with the formation of interchain, nonnative disulfide bridges and the establishment of mol

77 e to reducing agents due to the formation of nonnative disulfide bridges.

78 iants selectively catalyzed recombination of nonnative DNA sequences > 10,000-fold more effectively t

79 y reglucosylating glycans on slow-folding or nonnative domains to recruit chaperones specifically to

80 relative to native, whereas such a prominent nonnative effect is not observed for H1-H4 packing.

81 ecular recognition, and suggest further that nonnative effects in H1-H2 packing may be largely avoide

82 of the myristoyl with the protein as well as nonnative electrostatic interactions have a pronounced e

83 timates of the funnel size; iii), the native/nonnative energy gap, a major characteristic of the ener

84 th a pseudohelical turn; and 2), less stable nonnative ensembles of conformers characterized by sever

85 on the exterior envelope glycoprotein (Env), nonnative Env protein released from cells, and the glyca

86 omatography (SEC) to isolate NL trimers from nonnative Env species.

87 ould potentially contribute to adaptation to nonnative environments despite the founder population be

88 imers and inconsistent with profiles seen in nonnative Envs.

89 e also predicted that N addition would favor nonnatives, especially annual grasses, leading to higher

90 d CzrA mutants are characterized by distinct nonnative fast internal dynamics "fingerprints" upon Zn

91 The disappearance of nonnative fish from numerous water bodies after cessatio

92 mes and the abundance of multiple native and nonnative fish species over 18 years in a large, dryland

93 gnificant opportunities to favor native over nonnative fishes while rarely, if ever, encroaching on h

94 enefiting native fishes while disadvantaging nonnative fishes.

95 n infrared experiment that could observe the nonnative folding nucleus.

96 l antibodies was used to determine native or nonnative folding of N1922S-fVIII.

97 cterizing misfolding directly by mapping out nonnative folding pathways.

98 entification, missignaling, and unnatural or nonnative folding.

99 ull free energy landscape, including all the nonnative folds.

100 nin GroEL assists protein folding by binding nonnative forms through exposed hydrophobic surfaces in

101 is usually conferred by the acquisition of a nonnative gene encoding a penicillin-binding protein (PB

102 ation of glutamatergic local neurons using a nonnative genetically encoded cation channel.

103 evisiae strains whose growth depended on two nonnative glycolytic pathways: a complete glycolysis fro

104 ubstrates revealed that UGGT can glucosylate nonnative glycoproteins by recognizing subtle folding de

105 ific mannosidase that preferentially targets nonnative glycoproteins trapped in partially structured

106 However, in contrast to the favored nonnative H1-H2 packing in isolation, the native H1-H2 p

107 We manipulated the abundance of the nonnative, habitat-forming seaweed Gracilaria vermiculop

108 Nonnatives had significantly higher Chl, carotene, and a

109 At 330 and 340 K, a nonnative helical segment of residues 15-20 forms, corre

110 experiments and leads us to assign a compact nonnative helical trap as the reason for slower P-jump-i

111 We hypothesize that nonnative helix at helix-turn interfaces traps the prote

112 hetic biology approach to reconstitute, in a nonnative heterologous host, a minimal machinery capable

113 me pocket by the native E7 histidine and two nonnative histidine residues.

114 eplication of human influenza A viruses in a nonnative host drives the evolution of new variants and

115 mics pathway suggests that several transient nonnative hydrogen bonds may facilitate the transition.

116 o native backbone hydrogen bonds assisted by nonnative hydrophobic interactions between the tryptopha

117 ne-binding protein hisactophilin reveal that nonnative hydrophobic interactions of the myristoyl with

118 Despite phytosanitary measures, nonnative insects arrive at United States (U.S.) ports o

119 t invasions, the establishment and spread of nonnative insects in new regions, can have extensive eco

120 Interestingly, the simulation also shows a nonnative interaction between Asp(8) and Glu(48) in the

121 atured state of wild-type, which is due to a nonnative interaction between Asp(8) and Lys(12).

122 traps (>20 k(B)T) that result from multiple nonnative interactions and are sufficient for trapping o

123 We find that specific, attractive nonnative interactions are critical for knot formation.

124 e native-like interactions are developed and nonnative interactions are rearranged.

125 ble of structural intermediates that include nonnative interactions at low Mg(2+) concentration.

126 monomers, thermodynamic states stabilized by nonnative interactions correspond to productive, on-path

127 iased energetics needed to select native vs. nonnative interactions during folding.

128 monomers, in contrast, states stabilized by nonnative interactions generally correspond to traps tha

129 It also illuminates the important role of nonnative interactions in defining folding pathways.

130 hich are sometimes taken to be indicative of nonnative interactions in the transition state.

131 Predicting positive nonnative interactions is an important tool for determin

132 f proteins reveals further that the critical nonnative interactions may originate from evolutionary c

133 and atomistic simulations indicate that the nonnative interactions of the myristoyl group in the fol

134 t extended conformations due to short-range, nonnative interactions rather than generic electrostatic

135 states and discrimination against potential nonnative interactions that favor alternate stable confi

136 and another in the RNA, that weaken specific nonnative interactions that stabilize one of the interme

137 re formed at the transition state, including nonnative interactions, and most of the folding occurs a

138 ntermediate is stabilized by both native and nonnative interactions, friction in the folding transiti

139 ate is profoundly insensitive to omission of nonnative interactions, provided that native contact het

140 inding of charged peptides can be steered by nonnative interactions, which might be a general mechani

141 otein ubiquitin (Ub), which is known to form nonnative intermediate states under a variety of mildly

142 , with the remainder folding in 30-200 s via nonnative intermediates.

143 rtance of monomer geometry, flexibility, and nonnative intermonomeric contacts in the association pro

144 sible this variant leads to the formation of nonnative intra- or intermolecular disulfide bonds.

145 uggesting that they misfold and/or stabilize nonnative intronic structures.

146 thropogenic changes in available habitat and nonnative invasion eliminate the role of evolutionary pr

147 However, nonnative invasion may overwhelm the effect of immigrati

148 esource-use efficiencies in 14 native and 18 nonnative invasive species of common genera found in Eas

149 viruses and virus-like particles (VLPs) bear nonnative "junk" forms of envelope (Env) glycoprotein th

150 dies reported that the removal of a dominant nonnative led to competitive release of other nonnatives

151 from multiple Candida species and identified nonnative ligands that can induce self-mating and biofil

152 proposed for distinguishing native-like from nonnative-like membrane protein structures.

153 ed to replicase proteins, but expressed from nonnative locations, mostly late-transcribed subgenomic

154 By using a set of nonnative low-energy structures found by our extensive s

155 erm AGPase remains unsolved, structures of a nonnative, low-activity form of the potato tuber (Solanu

156 arge data set of GroEL binary complexes with nonnative malate dehydrogenase (MDH), imaged by cryo-ele

157 four residues indicate the presence of some nonnative misfolding interactions.

158 Aggregates in both systems are composed of nonnative monomers with elevated levels of beta-sheet se

159 When introduced to nonnative mosquito hosts, Wolbachia induce resistance to

160 y prior but remained at low densities until nonnative Mysis became established.

161 The TL circles contain nonnative nucleotides resulting from the 3' end created

162 significant conformational changes within a nonnative oligomer, beyond those for monomer unfolding.

163 ssociate with Northern Hemisphere hosts also nonnative, or are some native fungi compatible with nonn

164 Introductions or invasions of nonnative organisms can mediate major changes in the tro

165 a factor in the establishment and spread of nonnative organisms, the colonization of undefended reso

166 n alternative pathway becomes dominant, with nonnative P5abc binding the core and then undergoing an

167 ation is detected in H1-H2 packing in that a nonnative packing orientation is significantly stabilize

168 ibutable to the accidental introduction of a nonnative parasite from Europe, a result of global trade

169 g of the hydrophobic core to accommodate the nonnative peptidyl-prolyl trans-isomer at Pro32.

170 ponse to a change of phoneme at a native and nonnative phonetic boundary in full-term and preterm hum

171 ts show a decline in their discrimination of nonnative phonetic contrasts between 9 and 12 months of

172 Nonnative Phragmites australis (common reed) is one of t

173 t this assumption, estimating the effects of nonnative Phragmites australis on a native amphibian.

174 e created phylogenetically paired native and nonnative plant communities in a glasshouse experiment t

175 as anthropogenic nitrogen (N) deposition and nonnative plant invasion.

176 Until now, nonnative plant species were rarely found at high elevat

177 h N availability also often favors invasive, nonnative plant species, and the loss of woody vegetatio

178 onal fires, erosion, and the introduction of nonnative plant species.

179 ase may play a critical role in invasions by nonnative plants and animals that currently threaten glo

180 and describe the types of interactions among nonnative plants and determine what factors affect inter

181 Our experiment showed, however, that nonnative plants can establish, grow, and flower well ab

182 tegies centered on monocultural plantings of nonnative plants, largely excluding native species from

183 ve, or are some native fungi compatible with nonnative plants?

184 the functional essentiality of all possible nonnative point mutants in the entire hMC4R protein (332

185 can induce conformational changes and expose nonnative polar domains/residues to the lipid environmen

186 ay in E. coli results in accumulation of the nonnative polyamines diaminopropane and sym-norspermidin

187 e physiological order of addition of ATP and nonnative polypeptide, typically to the open trans ring

188 exert an action of forceful unfolding on the nonnative polypeptide.

189 ain movements, followed by slower binding of nonnative polypeptide.

190 TP-dependent ring-shaped complexes that bind nonnative polypeptides and facilitate protein folding in

191 e molecular mechanism for the recognition of nonnative polypeptides by Type I Hsp40s such as yeast Yd

192 Chaperonins are cage-like complexes in which nonnative polypeptides prone to aggregation are thought

193 ies lined with hydrophobic binding sites for nonnative polypeptides.

194 or is traced to the presence of an extensive nonnative polyproline II helical structure, which we loc

195 have greatly diverged between the native and nonnative populations.

196 use sites and the secondary structure of the nonnative portions of the paused complexes are phylogene

197 utants with a single tryptophan residue at a nonnative position 170 (Trp-170) or a native position 7

198 nimal in evolved biological systems although nonnative possibilities are intuitively abundant.

199 ation to the Channel Islands, but native and nonnative prey sources that were important for bald eagl

200 sion of spo0A in the DeltasigK mutant from a nonnative promoter restored solventogenesis and the prod

201 e that is characterized by the appearance of nonnative protein aggregates in various tissues.

202 folding through sequential steps of binding nonnative protein in the central cavity of an open ring,

203 haracterization of structure and dynamics of nonnative protein states is important for understanding

204 The ability of CHIP to recognize nonnative protein structure may aid in selection of slow

205 ample of tunable boron chemistry in a folded nonnative protein, which offers wide implications in des

206 results support a model whereby EDEM1 binds nonnative proteins and uses its mannosidase-like domain

207 Little is known about the topology of nonnative proteins during folding inside the GroEL-GroES

208 We show that EDEM1 specifically binds nonnative proteins in a glycan-independent manner.

209 ce into Hsp70-substrate complexes partitions nonnative proteins toward degradation.

210 ables cells to cope with the accumulation of nonnative proteins under stress and complete development

211 endering the NTD a conformational sensor for nonnative proteins.

212 r chaperones that prevent the aggregation of nonnative proteins.

213 enables it to selectively recognize and bind nonnative proteins.

214 There was no evidence that any of the nonnative rDNA units were transcribed; some showed indic

215 Unfolded proteins may contain a native or nonnative residual structure, which has important implic

216 Introduction of nonnative residues N-terminal to a construct containing

217 ic methodologies provide clear evidence that nonnative RNA can mistakenly map to reference genomes, e

218 of stable virus-like particles encapsidating nonnative RNAs or other cargoes.

219 Here, nonnative rRNA gene [ribosomal DNA (rDNA)] copies were i

220 the inverse sequence of events with the same nonnative salt bridges in the encounter complex.

221 The simulations show that nonnative salt bridges stabilize kinetically the encount

222 ons in which the protein did not fully fold, nonnative salt bridges trapped the protein, which explai

223 * Results show nonnative SAPs are functionally dissimilar to native SAP

224 erences in plant functionality indicate that nonnative SAPs have a competitive advantage over native

225 inguishably from CYT-19 to resolve different nonnative secondary and/or tertiary structures in the Te

226 and alcohol-denatured states with native and nonnative secondary elements supports a hierarchical mec

227 for the stabilization of what appears to be nonnative secondary structure in a marginally stable int

228 entromeric histone protein CENH3, suggesting nonnative sequences can also function as diatom centrome

229 netic, and genomic analyses implied that the nonnative sequences were acquired between 1 and 5 Mya af

230 that was rescued by ORF23 expression from a nonnative site in the VZV genome.

231 onologue either in their native (English) or nonnative (Spanish) language.

232 eness is the phylogenetic distance between a nonnative species and species in the recipient community

233 distribution and abundance, particularly for nonnative species because interactions may influence the

234 w that LCV can immortalize B cells from some nonnative species but that growth transformation is rest

235 eneracy with these properties, as native and nonnative species can overlap.

236 ive phenotypic divergence between native and nonnative species can provide critical insight into the

237 ively understudied, though the likelihood of nonnative species co-occurrence is high.

238 However, native and nonnative species did not differ systematically in leaf

239 Habitat alterations, nonnative species invasion, and water withdrawals during

240 * Nonnative species may change ecosystem functionality at

241 and those of fine roots for 23 native and 25 nonnative species that occur in temperate deciduous fore

242 ed the impact of the invasion of two noxious nonnative species, Polygonum cuspidatum, which produces

243 ny plant communities are invaded by multiple nonnative species, we have limited information on how a

244 excluded from much of its potential range by nonnative species, will lose a further 58% of habitat du

245 s was random or 84% greater if there were no nonnative species.

246 ange, and few ecosystems remain uninvaded by nonnative species.

247 to a greater degree than nonnative, whereas nonnative speech activates motor brain areas to a greate

248 narrowing make it more difficult to process nonnative speech and require them to continue to access

249 mination task and at 6 and 10 mo of age on a nonnative speech and visual language discrimination task

250 shift attention to the eyes when exposed to nonnative speech because increasing native-language expe

251 eyes at 12 mo in response to native but not nonnative speech.

252 sembly at pH 6.4 results in the formation of nonnative spherical oligomers that disrupt synthetic mem

253 The challenge posed by the competition of nonnative stabilization against native-centric forces is

254 Characterization of nonnative states is critical for the understanding of th

255 However, metastability and a web of nonnative states slow the average folding rate.

256 Two of the force fields yield compact nonnative states with misplaced alpha-helix content with

257 hub that can facilitate transitions between nonnative states.

258 stence of a folding intermediate of GB3 with nonnative structural elements.

259 ulation characterized by a higher content of nonnative structure (NNS).

260 ved, reflecting that the population of local nonnative structure can occur even within the cis cavity

261 tifies regions that unfold or rearrange into nonnative structure during the N --> MG transition.

262 based coarse-grained models do not allow for nonnative structure formation.

263 reconstructed the energy landscape governing nonnative structure formation.

264 s suggest a hitherto unforeseen potential of nonnative structure to induce significant compaction of

265 ms that uncleaved gp140 proteins may adopt a nonnative structure with three gp120 moieties "dangling"

266 work at an early stage of folding suppresses nonnative structures and guides the search for the nativ

267 e state generally has lower free energy than nonnative structures but is exceedingly difficult to loc

268 imulation studies, we note the occurrence of nonnative structures intermediates, which may yield a na

269 s significant energy gaps between native and nonnative structures of transmembrane helical interfaces

270 hat this pathway is the least likely to form nonnative structures.

271 rmed conformers, some of which have aberrant nonnative structures.

272 imilarity of functional traits of native and nonnative submersed aquatic plants (SAP) in an aquatic e

273 as much Rubisco activity was recovered when nonnative substrate protein was added after ATP compared

274 lypeptide, enables more efficient capture of nonnative substrate proteins, and thus allows greater re

275 ialize the cytochrome P450 for function on a nonnative substrate.

276 atalytic efficiency, even in the presence of nonnative sugar-1-phosphates.

277 ivation, during discrimination of native and nonnative syllables in infants at two ages that straddle

278 e to speech, and equivalently for native and nonnative syllables.

279 the relative importance of nativelike versus nonnative tertiary contacts for the folding transition.

280 Seedling establishment was 46% lower in nonnative than in native communities and was correlated

281 Our study proves the black francolin was nonnative to the western Mediterranean, and we document

282 We find that nonnative topologies (arrangement of helices) occur freq

283 major determinant of whether the RNA adopts nonnative topology during folding.

284 intermediates as we investigate the role of nonnative topology in dictating the lifetime of the inte

285 merization of Pro32 from its native cis to a nonnative trans conformation is thought to trigger beta2

286 ultiple pathways, facilitated by a number of nonnative transient hydrogen bonds, thus lowering the tr

287 associated with SOD1 aggregation in ALS to a nonnative trimeric SOD1 species.

288 The reason for this paradox is that past nonnative trout invasions and habitat loss have restrict

289 he Upper Colorado River Basin, owing to past nonnative trout invasions and habitat loss.

290 method to map the disulfide bonds present in nonnative uncleaved gp140 proteins and native-like SOSIP

291 To assess the energetic favorability of nonnative versus native interactions, we compute free en

292 Nonnative viral glycoproteins, including Friend murine l

293 erse viral families can be incorporated into nonnative viral particles in a process termed pseudotypi

294 three times more frequent when a neighboring nonnative was a nitrogen fixer and 3.5 times lower when

295 fixer and 3.5 times lower when a neighboring nonnative was an annual.

296 itly includes all misfolded microstates with nonnative Watson-Crick (WC) and non-WC contacts.

297 uditory brain areas to a greater degree than nonnative, whereas nonnative speech activates motor brai

298 invasion and for prioritizing management of nonnatives with a higher likelihood of positive interact

299 osition rates of leaves for 42 native and 36 nonnative woody species, and those of fine roots for 23

300 Therefore, these results suggest why these nonnative zinc ligands in the CH1(1) motif are conserved