ライフサイエンスコーパス: nonobese diabetic mice

1 corticosterone were investigated using male nonobese diabetic mice.

2 ferred 5 x 10(6) splenocytes from 6-week-old nonobese diabetic mice.

3 oimmune diabetes developing spontaneously in nonobese diabetic mice.

4 otocin and during development of diabetes in nonobese diabetic mice.

5 tolerance and the development of diabetes in nonobese diabetic mice.

6 ng grafted and endogenous islets in diabetic nonobese diabetic mice.

7 antigen-specific Tregs from autoimmune-prone nonobese diabetic mice.

8 the onset and severity of type 1 diabetes in nonobese diabetic mice.

9 independent in T cells from autoimmune-prone nonobese diabetic mice.

10 a small population of Ag-specific T cells in nonobese diabetic mice.

11 uction protocol is ineffective in autoimmune nonobese diabetic mice.

12 nize these peptides in type 1 diabetes-prone nonobese diabetic mice.

13 ion protein (LTbetaR-Ig) was administered to nonobese diabetic mice.

14 level of EF-1alpha mRNA was also observed in nonobese diabetic mice.

15 II molecule DQ in humans and to MHC I-Ag7 in nonobese diabetic mice.

16 e sclerosis, and prevents type 1 diabetes in nonobese diabetic mice.

17 tes mellitus by the CD4+ Th1 clone BDC2.5 to nonobese diabetic mice.

18 cell-specific injury or from the pancreas of nonobese diabetic mice.

19 duced a long-term diabetes-free condition in nonobese diabetic mice.

20 In NOD (nonobese diabetic) mice, a model of autoimmune diabetes,

21 -specific expression of TNFalpha in neonatal nonobese diabetic mice accelerated diabetes.

22 tigen-presenting cells, to treat diabetes in nonobese diabetic mice after disease onset.

23 vation and whose adoptive transfer protected nonobese diabetic mice against type 1 diabetes (T1D).

24 Thus, male nonobese diabetic mice allow for translational studies o

25 Nonobese diabetic mice also have salivary gland inflamma

26 on-associated lymphoid neogenesis, including nonobese diabetic mice, also exhibit concomitant express

27 experimental autoimmune encephalomyelitis in nonobese diabetic mice, an experimental model that resem

28 Gastric emptying was measured in nonobese diabetic mice and correlated with levels of HO-

29 cific MHC class II genes, such as I-A(g7) in nonobese diabetic mice and HLA-DQ8 in humans, suggests t

30 work from one laboratory has shown, in both nonobese diabetic mice and humans, an association betwee

31 oth muscle, and neurons were investigated in nonobese diabetic mice and organotypic cultures by immun

32 m-3 pathway blockade accelerated diabetes in nonobese diabetic mice and prevented acquisition of tran

33 completely prevented diabetes development in nonobese diabetic mice and strongly reduced its incidenc

34 Nonobese diabetic mice are a well-known model for human

35 Irradiated SCID/nonobese diabetic mice are injected with a tumor of huma

36 chanisms underlying this observation, female nonobese diabetic mice at 4, 8, and 12 wk of age were gi

37 amounts of insulin (ins) to cure diabetes in nonobese diabetic mice but, unlike transplanted islets,

38 reverses established autoimmune diabetes in nonobese diabetic mice by restoring self-tolerance, and

39 Autoimmune-prone nonobese diabetic mice deficient for B7-2 spontaneously

40 Studies of nonobese diabetic mice demonstrated that disruption of t

41 ogenesis of diabetes, we generated NOD mice (nonobese diabetic mice developing spontaneous autoimmune

42 In adult TCR (BDC2.5) transgenic nonobese diabetic mice, DNA microarray analysis of globa

43 nce of type 1 diabetes (T1D) is decreased in nonobese diabetic mice expressing the complete cassette

44 Macrophage from nonobese diabetic mice failed to provide signals necessa

45 Nonobese diabetic mice fed transformed potato tuber tiss

46 Fas (lpr) or FasL (gld) completely protects nonobese diabetic mice from autoimmune diabetes but also

47 by the beta cell have been shown to protect nonobese diabetic mice from developing diabetes.

48 We show that autoimmune diabetes-prone nonobese diabetic mice have high levels of CD40(+)CD4(+)

49 by the unique class II molecule expressed by nonobese diabetic mice (I-Ag7).

50 In an alternative diabetes model, nonobese diabetic mice, IL15/IL-15Ralpha expression was

51 MM model in severe combined immunodeficient/nonobese diabetic mice in which diffuse MM lesions devel

52 n B13 autoantibodies in young diabetes-prone nonobese diabetic mice is associated with reduced inflam

53 ze that resistance to tolerance induction in nonobese diabetic mice is due to the presence of memory

54 ent population of pathogenic CD8+ T cells in nonobese diabetic mice is islet-specific glucose-6-phosp

55 n a model of passive transfer of diabetes in nonobese diabetic mice, lytic IL-2/Fc, but not nonlytic

56 ia was created by femoral artery ligation in nonobese diabetic mice (NOD mice, n = 20) and in control

57 In an attempt to protect nonobese diabetic mice (NOD) from autoimmune diabetes, w

58 T cells at the earliest stages of disease in nonobese diabetic mice (NOD).

59 nsulin-dependent diabetes mellitus (IDDM) in nonobese diabetic mice (NOD).

60 CD4(+) T cells from JNK2-deficient nonobese diabetic mice produced less IFN-gamma but signi

61 sion of tumor necrosis factor (TNF)-alpha in nonobese diabetic mice promotes diabetes by provoking is

62 tes-inducing CD4 T cell clones isolated from nonobese diabetic mice recognize epitopes formed by cova

63 ocking the SDF-1alpha/CXCR4 axis in IFNgamma-nonobese diabetic mice resulted in diminished proliferat

64 d leukemic cell lines into immunocompromised nonobese diabetic mice resulted in significant elevation

65 enic intermediate lobe tissues into diabetic nonobese diabetic mice resulted in the restoration of ne

66 Nonobese diabetic mice spontaneously develop diabetes th

67 We found that CD4(+) T cells from nonobese diabetic mice spontaneously differentiate into

68 Investigations of humans and nonobese diabetic mice suggest that proinsulin and/or a

69 e 1 or type 2 diabetes, and in the islets of nonobese diabetic mice that have developed insulitis or

70 pe recognized by pathogenic T lymphocytes in nonobese diabetic mice, the animal model for type 1 diab

71 sed Fah(-/-), Rag2(-/-), Il2r(-/-) mice with nonobese diabetic mice to create FRGN mice, whose livers

72 (Treg cells) during diabetes progression in nonobese diabetic mice was investigated to determine whe

73 In spontaneous diabetes in nonobese diabetic mice, we were able to stop the ongoing

74 Transgenic nonobese diabetic mice were created in which insulin exp

75 We used nonobese diabetic mice, which develop autoimmune-mediate

76 ccelerated BDC2.5 T-cell receptor transgenic nonobese diabetic mice, which experience development of

77 Early systemic treatment of nonobese diabetic mice with high doses of recombinant ad

78 xpression of NMI was detected in islets from nonobese diabetic mice with insulitis and in rodent or h

79 Treatment of nonobese diabetic mice with L11 from 1 to 4 or 8 to 12 w

80 oliferation using in vivo teratoma assays in nonobese diabetic mice with severe combined immunodefici

81 In nonobese diabetic mice with uncontrolled type 1 diabetes