ライフサイエンスコーパス: nonresponsive

1 dendritic cells, were able to render T cells nonresponsive.

2 aling, although postnatal cardiomyocytes are nonresponsive.

3 the presence of the drug to which they were nonresponsive.

4 ave left the site of tumor growth and become nonresponsive.

5 phenotype, yet these cells are functionally nonresponsive.

6 esponse to HGF/SF, whereas the NHA cells are nonresponsive.

7 e classified into two groups: responsive and nonresponsive.

8 r response, and FL83B cells were essentially nonresponsive.

9 MCF7 cells that did not express MT1-MMP were nonresponsive.

10 5) and platelets that, when transfected into nonresponsive 1321 cells, confers a specific sensitivity

11 cting directly on the tumor cells, IFN-gamma-nonresponsive 4T1 cells were generated by transfection (

12 ilarly, experimental lung metastasis of E(2)-nonresponsive 4T1 mammary carcinoma cells also leads to

13 ters reserve surgical treatment for patients nonresponsive after 4 weeks of medical treatment.

14 Iron even overcomes the AH-nonresponsive Ahrd allele in the SWR strain but not in D

15 hin 3-4 days, they become activation-induced nonresponsive (AINR) and display a split anergy.

16 the cells rapidly become activation-induced nonresponsive (AINR) and exhibit split anergy.

17 ain restores an anaphylactic response to the nonresponsive alpha-deficient parental mouse line.

18 imals, the mammary carcinomas are hormonally nonresponsive and cannot be prevented by tamoxifen.

19 and 23 (51%) of 45 patients with aGHVD were nonresponsive and in partial remission (PR) after steroi

20 he CR rate in patients who started ECP being nonresponsive and in PR after steroid was 86% and 96%, r

21 In addition, both reproductively nonresponsive and long day-housed mice release less GnRH

22 rived paracrine signals produced by TGF-beta nonresponsive and responsive stromal cells.

23 mplex otitis media (OM; including recurrent, nonresponsive, and chronic OM with effusion) was greater

24 at the D121 lung carcinoma cell line is E(2)-nonresponsive, and following s.c. implantation in OVX ve

25 tive to LPS but were lipoprotein/lipopeptide nonresponsive; and 2) substoichiometric amounts of deacy

26 sary nucleotides into the regions flanking a nonresponsive, ARE-like, GST-Mu promoter sequence produc

27 a indicate that V beta 5+ cells are rendered nonresponsive as a result of in vivo encounter with T. g

28 ses in motor imagery tasks despite remaining nonresponsive behaviorally.

29 umor-specific T cells that had been rendered nonresponsive by the tumor in vivo.

30 sting B cells, from lipopolysaccharide (LPS)-nonresponsive C3H/HeJ mice, proliferated and secreted Ig

31 in macrophages from lipopolysaccharide (LPS)-nonresponsive C3H/HeJ mice.

32 in-6 (IL-6) by macrophages obtained from LPS-nonresponsive C3H/HeJ mice.

33 Lipopolysaccharide-nonresponsive (C3H/HeJ) and TNFalpha null B6x129tnf-/- m

34 ined from LPS-responsive (C3H/HeOuJ) and LPS-nonresponsive (C3H/HeJ) mice.

35 androgen-independent and androgen-responsive/nonresponsive CaP cells and prostaspheres, with a half-m

36 These nonresponsive CD8 T cells were phenotypically similar to

37 Finally, we used pre-existing nonresponsive CD8(low) T cells from male HY TCR transgen

38 First, we used peripheral nonresponsive CD8(low) T cells produced after peripheral

39 mice induced a high frequency of peripheral nonresponsive CD8(low) T cells, yet C2A-D(b) was superio

40 Refractory sprue (nonresponsive celiac disease) appears to be a manifestat

41 hy and severe complications in patients with nonresponsive celiac disease.

42 Transfection of TLR2 into a nonresponsive cell line was sufficient for NF-kappa B ac

43 CHOP expression was not observed in retinoid-nonresponsive cell lines HL60R and NB4-R2.

44 In addition, blocking HDAC activity renders nonresponsive cell types susceptible to the pro-apoptoti

45 Phase I contained cytokine nonresponsive cells that failed to proliferate.

46 , but not WC1-4 SRCR domains from Leptospira-nonresponsive cells, bound to multiple serovars of two L

47 d MTA levels occurred in both responsive and nonresponsive cells, suggesting cell-specific epigenetic

48 tore sensitivity to IFN-lambda in previously nonresponsive cells, thereby enhancing protection agains

49 res the LPA-dependent GROalpha production in nonresponsive cells.

50 ed a slower, smaller increase, especially in nonresponsive cells.

51 CD44(+)) to contain both IL-7-responsive and nonresponsive cells.

52 amma, improves the TZD ligand sensitivity of nonresponsive cells.

53 itaxel-responsive ovarian cells, but not the nonresponsive cells.

54 ity between androgen-responsive and androgen-nonresponsive cells.

55 resence of YVN in the homologous region of a nonresponsive chimera was not sufficient to confer regul

56 lone and the V alpha10 V alpha region from a nonresponsive clone, and 3) responsiveness was transferr

57 ically quiescent state due to their cytokine-nonresponsive (CNR) nature, a characteristic that may pr

58 the chest representation) with >/=1.6 cm of nonresponsive cortex intervening.

59 ter PFS rate than patients with chemotherapy-nonresponsive disease (risk ratio, 3.60; 95% confidence

60 fter HDIT, and 4 patients had progressive or nonresponsive disease.

61 as opposed to only one of the patients with nonresponsive disease.

62 ere capable of inducing T cells from PBMC of nonresponsive donors that recognized the parental peptid

63 androgen-responsive (LNCaP) and two androgen-nonresponsive (DU-145 and PC-3), were examined for the e

64 e periphery are likely to be low avidity and nonresponsive due to peripheral tolerance mechanisms.

65 Removal of both domains results in a nonresponsive, dysregulated enzyme with reduced activity

66 Mice with TGF-beta1-nonresponsive effector T cells had restored antiviral im

67 ted a complete response (FL-NS5A-CR) or were nonresponsive (FL-NS5A-NR) to IFN therapy in HeLa cells

68 ient, who had remained entirely behaviorally nonresponsive for 16 y.

69 -2 also affects expression of multiple auxin-nonresponsive genes.

70 ost inducible CBP peaks occurred near signal-nonresponsive genes.

71 these neurons (21 CRD-responsive and 12 CRD-nonresponsive) had cutaneous receptive fields, of which

72 UV-responsive melanocytes in epidermis to UV nonresponsive, hair growth cycle-coupled melanogenesis i

73 lacement of the P450R-TRE upstream of the T3-nonresponsive heterologous thymidine kinase promoter res

74 umor effect of RT is abolished in type I IFN nonresponsive hosts.

75 x vivo and confers endostatin sensitivity to nonresponsive human endothelial cells in vitro.

76 le rounds of cell division before reaching a nonresponsive (i.e., tolerant) state.

77 First, more areas of crus IIa were nonresponsive in animals lesioned later in development (

78 n wild-type cells in response to MMS but was nonresponsive in cells lacking the TF.

79 ers to normal mice but appeared functionally nonresponsive in vivo.

80 uals either "dietary responsive" or "dietary nonresponsive." In this review, we focus on current know

81 nds mRNAs from both SM-responsive as well as nonresponsive intronless genes and increases the nuclear

82 -responsive IPAH (VR-PAH) versus vasodilator-nonresponsive IPAH (VN-PAH).

83 re growth suppressed by retinoids but not in nonresponsive lines.

84 e of glutamine while the ruthenium acts as a nonresponsive long-lived reference.

85 DT in either apoptosis-responsive (LS513) or nonresponsive (MCF-7) cells.

86 cell death of neurotrophin-3-responsive and nonresponsive medulloblastoma cell lines (Daoy-trkC and

87 leen cells from C3H/HeJ and C57BL/10ScNJ LPS-nonresponsive mice challenged in vitro with Py showed an

88 We demonstrate that nonresponsive mice have inadequate presentation of viral

89 tigators to explore immune responses in IL-2-nonresponsive mice rendered autoimmune-free.

90 eptor 4 (Tlr4)-deficient, lipopolysaccharide-nonresponsive mice were not more resistant to LT.

91 In contrast, in Ahr-nonresponsive mice, adducts 2 and 3 were each < or= 7% o

92 ages and lethal shock in LPS-responsive and -nonresponsive mice.

93 ne production in both LPS-responsive and LPS-nonresponsive mice.

94 lpha and IL-6 in both LPS-responsive and LPS-nonresponsive mice.

95 formed 6-18-fold more adducts than those of nonresponsive mice.

96 hen comparing photoperiod responsive mice to nonresponsive mice.

97 c (AH-responsive) and Ahrd SWR and DBA/2 (AH-nonresponsive) mice, iron overcame the weak hepatic porp

98 Offspring born to nonresponsive mothers had greater susceptibility to lymp

99 Moreover, the LPS-nonresponsive mouse strain C3HHeJ, which has a mutation

100 aques were classified as normalized (n=8) or nonresponsive (n=6) based on their histological improvem

101 curring loss of connections between visually nonresponsive neurons after eye opening.

102 Further analyses revealed that the CI-nonresponsive neurons were narrowly tuned to frequency a

103 d if a SMAC mimetic (JP1201) could sensitize nonresponsive NSCLC cell lines to standard chemotherapy.

104 ot induce DENTT mRNA expression in TGF-beta1 nonresponsive NSCLC cells.

105 mide-responsive hosts but not different from nonresponsive ones.

106 genes; however, genes in the same group were nonresponsive or even suppressed in cells attached to la

107 tional clinical benefit for patients who are nonresponsive or only partially responsive to clozapine

108 multiple copies of pGRE sequence were either nonresponsive or positively responsive (three copies) to

109 Complex (ie, recurrent, nonresponsive, or chronic) otitis media (OM) is frequent

110 We examined 42 responsive and 8 nonresponsive ORFs by conventional Northern blotting, an

111 reporter gene into paclitaxel-responsive and nonresponsive ovarian cancer cells (responsiveness refer

112 A second AP-1-nonresponsive P(-) variant that underexpresses Fra-1 gai

113 Thus, the transformation nonresponsive P- JB6 cells owe their resistance to lack

114 lockers and better survival than vasodilator-nonresponsive PAH (VN-PAH).

115 F1-responsive autocrine phenotype to an SDF1 nonresponsive paracrine state that represses endothelial

116 ds, suggesting a component of corticosteroid nonresponsive pathobiology in adults with SA that may di

117 NS5A protein isolated from a genotype 1b IFN-nonresponsive patient (NS5A-1b) was capable of rescuing

118 The only nonresponsive patient had underlying myelodysplasia.

119 ngle upISDR) isolated from a genotype 1a IFN-nonresponsive patient showed no rescue activity.

120 ed with 33.3 +/- 18 microg/dL in the steroid-nonresponsive patients (p <.0001).

121 In contrast, tumors of nonresponsive patients accumulated mutant p53 and were m

122 discriminate between therapy responsive and nonresponsive patients and predict survival in patients

123 read decreases in absolute metabolism in the nonresponsive patients but not the responsive patients.

124 magnetic resonance imaging that behaviorally nonresponsive patients can use selective auditory attent

125 py-treated patients by Th1 responsivity, Th1-nonresponsive patients demonstrated a worse DFS (median,

126 Approximately 1% (2 of 160) of nonresponsive patients enrolled for treatment had a sust

127 ies, developing BCI systems for behaviorally nonresponsive patients presents substantial technical an

128 nely to detect consciousness in behaviorally nonresponsive patients when all existing clinical techni

129 ived DCs were generated from coccidioidal Ag nonresponsive patients with disseminated coccidioidomyco

130 r/normal tissue ratio between responsive and nonresponsive patients, the ratio decreased for DIABLO a

131 et for restorative therapies in behaviorally nonresponsive patients.

132 s with both levodopa-responsive and levodopa-nonresponsive patients.

133 ions include communication with behaviorally nonresponsive patients.

134 xtracorporeal photopheresis but persisted in nonresponsive patients.

135 ed in androgen-responsive LNCaP and androgen-nonresponsive PC-3 cells.

136 osis in both hormone-responsive (LNCaP) and -nonresponsive (PC3) human prostate cancer cells.

137 unaltered during the early postnatal stress-nonresponsive period, suggesting that deficits at this t

138 plementation, consistent with the pyridoxine-nonresponsive phenotype of the T257M mutation in a homoc

139 Activation of PI 3-kinase and PMA-nonresponsive PKC isoenzymes is shown to be involved dir

140 ec kinase Itk/Emt, and the activation of PMA-nonresponsive PKC isoenzymes.

141 17 pathway in normalized plaques, but not in nonresponsive plaques.

142 sed of both the thermoresponsive polymer and nonresponsive poly(ethylene glycol) (PEG) were then prep

143 specific poly(A) switching onto an otherwise nonresponsive polyadenylation signal in vivo.

144 edged communication systems for behaviorally nonresponsive populations.

145 d only two patients to be consistently donor-nonresponsive posttransplant.

146 IgG4-associated cholangitis and the steroid-nonresponsive primary sclerosing cholangitis.

147 lial cells under the control of a hormonally nonresponsive promoter, neu-related lipocalin (NRL).

148 was blocked by ET-743 with little affect on nonresponsive promoters.

149 ceptor (AR)-positive hormone-responsive and -nonresponsive prostate cancer cells.

150 s modulate distinct biological effects, a NO-nonresponsive Ras mutant (Ras(C118S)) was stably express

151 Four of these donor-nonresponsive recipients were retested 6 to 12 months la

152 sal promoter are only modestly responsive or nonresponsive, respectively, to depolarization.

153 levels following stable transfection in LPA-nonresponsive RH7777 cells.

154 nsive to drug treatment previously and seven nonresponsive schizophrenic patients after a drug-free p

155 leptic challenge in treatment-responsive and nonresponsive schizophrenic patients was measured in ord

156 These findings strongly suggest that the nonresponsive sCPS is not able to communicate occupancy

157 eter of roots of dark-grown (gravitropically nonresponsive) seedlings of the Merit cultivar.

158 ntation was performed in three patients with nonresponsive severe acute rejection.

159 allosteric metal binding sites compared to a nonresponsive site (CadC) and the apo-proteins.

160 estore ETR-3 binding and responsiveness to a nonresponsive splicing reporter in vivo.

161 erity following primary RSV infection of IFN-nonresponsive STAT1(-/-) mice.

162 , are critical to the transition from an EM2 nonresponsive state (during diestrus) to an analgesicall

163 Our published work has shown that this nonresponsive state is specific and not due to clonal de

164 intravenous immunoglobulin (IVIg) induces a nonresponsive state of B cells and to address the simila

165 -2 and appear to result from reversal of the nonresponsive state of the CD8+ T cells.

166 ho survive severe brain injury progress to a nonresponsive state of wakeful unawareness, referred to

167 anti-CD3 mAb are able to induce in T cells a nonresponsive state to subsequent treatment with cytokin

168 specific T cells, followed by a superantigen-nonresponsive state.

169 beta1 to eluted T cells re-established their nonresponsive state.

170 nt of Staphylococcus aureus, a pyrrhocoricin nonresponsive strain.

171 only the mixture of TGF-beta responsive and nonresponsive stromal cells resulted in adenocarcinoma.

172 ted benign prostate growth and 100% TGF-beta nonresponsive stromal cells resulted in precancerous les

173 n which the ratio of TGF-beta responsive and nonresponsive stromal cells was varied.

174 -responsive macrophages develop within a TNF-nonresponsive stromal environment.

175 arate visible burrow system experiments, the nonresponsive subordinates expressed a significantly low

176 nt stressor, leading to their designation as nonresponsive subordinates.

177 entiation of a highly primitive and cytokine nonresponsive subpopulation of human HPC, CD34+cd38- cel

178 immune response is programmed to fail or if nonresponsive T cells can specifically be fixed to elimi

179 N, and J) from the V alpha8 alpha-chain of a nonresponsive T hybrid.

180 ordance, malignant T cells expressing an SEA-nonresponsive T-cell receptor variable region beta chain

181 However, the OT2 T cells were rendered Ag nonresponsive through regulatory action of LPMC non-T ce

182 ly expressed in both estrogen-responsive and nonresponsive tissues, with the highest levels of expres

183 a current major depressive episode that was nonresponsive to a combination of adequate doses of esta

184 A further two children were nonresponsive to a serotype (6B) different than that cau

185 One OCa cell line, OVCA 433, was found to be nonresponsive to androgen stimulation.

186 ion, but engrafted CD4+ cells rapidly became nonresponsive to anti-CD3 Ab stimulation.

187 However, up to 40% of patients are nonresponsive to anti-TNF agents, which makes the identi

188 8 T cells were not deleted but were rendered nonresponsive to antigen-specific stimulation and failed

189 nearly 50% of those afflicted are considered nonresponsive to available treatments.

190 studied IL-4Ralpha-deficient mice, which are nonresponsive to both IL-4 and IL-13.

191 ble to physically interact with CBFbeta were nonresponsive to CBFbeta.

192 dyes and substrate, the array is essentially nonresponsive to changes in humidity.

193 e arthritis, while DQ6alphabeta tg mice were nonresponsive to CII.

194 (PLATO) trial dose of ticagrelor in patients nonresponsive to clopidogrel and after they switch agent

195 with disseminated coccidioidomycosis who are nonresponsive to coccidioidal Ag and healthy nonimmune i

196 is procedure should be reserved for patients nonresponsive to conservative therapy.

197 PFC DA levels were generally nonresponsive to cues after the same training duration.

198 Unexpectedly, GC T cells were virtually nonresponsive to CXCL12, whereas CD57(-)CD4 T cells migr

199 AR-negative prostate cancer cells were nonresponsive to cyclin D1 (a or b) expression, indicati

200 Certain tumor cells are largely nonresponsive to cytokine-mediated induction of the pro-

201 CD4(+)CD45RO(+)CD62L(-) FL TILs were largely nonresponsive to cytokines, in contrast to the correspon

202 subunit, which renders the targeted subunit nonresponsive to diazepam, other benzodiazepines and zol

203 is increasing around the world for patients nonresponsive to dietary modifications.

204 treated with anti-CD154 became specifically nonresponsive to donor cells in mixed lymphocyte reactio

205 ound in the endogenous gene, this element is nonresponsive to ER-beta but confers estrogen-dependent

206 moting more aggressive breast cancer that is nonresponsive to estrogen and the antiestrogenic drug ta

207 to mammary ductal and alveolar cells and is nonresponsive to estrogen manipulations in vitro and in

208 enitors in vitro, generating cells that were nonresponsive to FGF but responsive to other mitogens.

209 mutant 'Ageotropic' cultivar of Zea mays are nonresponsive to gravity.

210 In normal individuals, RF+ B cells remained nonresponsive to help provided by anti-CD3-activated T c

211 t still contains peripheral T cells that are nonresponsive to IL-2 and IL-15.

212 st that Ad-infected DCs induce T cells to be nonresponsive to IL-2 during primary coculture, as the a

213 we report our experience with pediatric PTLD nonresponsive to immunosuppression (IS) withdrawal, mana

214 fective therapy in HCV recurrence and in HCV nonresponsive to interferon and ribavirin.

215 tin in Zucker Diabetic Fatty rats, which are nonresponsive to leptin due to a receptor point mutation

216 receptor (SNARE) genes; double mutants were nonresponsive to mechanical stimulation.

217 respiratory failure and respiratory acidosis nonresponsive to noninvasive ventilation.

218 obsessive-compulsive disorder (OCD) who are nonresponsive to oral clomipramine.

219 ce proliferation of CD34+CD38-cells that are nonresponsive to other early acting cytokines and to imp

220 scular glaucoma, especially in eyes that are nonresponsive to panretinal photocoagulation.

221 All were either ineligible for or nonresponsive to photodynamic therapy, the standard trea

222 The mutant TRbeta(H435A) is nonresponsive to physiological concentrations of T3 but

223 Primary FSGS was once considered an entity nonresponsive to prednisone or immunosuppressive agents,

224 For chronic hepatitis C that is nonresponsive to prior interferon monotherapy, combinati

225 blishment of S-O-PG tolerance, rats remained nonresponsive to S-O-PG but regained full responsiveness

226 cell receptor variable region beta chain are nonresponsive to SEA in monoculture but display strong S

227 in Npn1(Sema-/-) mutants, in which axons are nonresponsive to Sema3A.

228 higher in a subset of IPS patients who were nonresponsive to steroids and anti-tumor necrosis factor

229 e TLR4 locus, causing the mouse strain to be nonresponsive to stimulation by LPS from Escherichia col

230 hibitory markers and were less responsive or nonresponsive to stimulation in vitro.

231 lack of AgR at the cell surface renders them nonresponsive to TCR-directed stimuli.

232 cally infected and ts-4-vaccinated mice were nonresponsive to TCR-induced stimulation (70 to 90% redu

233 f reactivity to self, but made these T cells nonresponsive to the self-ligand and anti-CD3, although

234 on in patients with cancer who are generally nonresponsive to their disease.

235 fied epitopes were either less responsive or nonresponsive to their unmodified counterparts.

236 rast, effector CD8(+) T cells lack CCR4, are nonresponsive to these chemokines and are rarely detecte

237 neurogenesis ended, NC-derived cells became nonresponsive to thimerosal.

238 point mutations in both upstream IRF-Es are nonresponsive to TPA.

239 that began by age 12 years and who had been nonresponsive to typical neuroleptics participated in th

240 72) was reduced in Flcn-deficient hearts and nonresponsive to various stimulations including metformi

241 Wild-type mice could be made nonresponsive to vector by administration of antibodies

242 erant to OVA since endogenous CD8 cells were nonresponsive to VSV-ova infection.

243 cells, which from one donor were initially "nonresponsive" to the wt p53(264-272) peptide.

244 re crossed with strain 129S1/SvIm (AHR(d/d), nonresponsive) to determine the effect of maternal and f

245 til, by the fourth day, rats were completely nonresponsive (tolerant) to S-O-PG-induced hypophagia.

246 Although nonresponsive toward the HPV16 E7 oncoprotein in the CD8

247 were independently associated with having a nonresponsive trajectory, including greater baseline dep

248 or growth and metastasis by analysis of E(2)-nonresponsive tumor cells implanted in ovariectomized (O

249 ar matrix and increased invasion of TGF-beta nonresponsive tumor cells.

250 We have demonstrated that multiple nonresponsive tumor lines are able to undergo synergisti

251 ed DNA damage in the tumors, except that the nonresponsive tumor xenograft had significantly lower le

252 ed to address the need for earlier biopsy in nonresponsive tumors and earlier definitive surgery to r

253 In contrast, these parameters increased in nonresponsive tumors during treatment.

254 cally those compounds that target hormonally nonresponsive tumors.

255 chimeric receptors were introduced into FGF-nonresponsive variant PC12 cells (fnr-PC12 cells), and t

256 dy, we report that over time a population of nonresponsive, virus-specific CD8+ T cells emerged in th

257 also present in secondary analyses excluding nonresponsive voxels or voxels containing chronic blood

258 Block copolymers with PEG as a nonresponsive water-soluble block can self-assemble into

259 First, the SJL strain was shown to be nonresponsive with regard to the development of antisyng

260 ownstream phosphorylation were observed in a nonresponsive xenograft model.

261 as irregularly shaped and marked by internal nonresponsive zones, its topographic organization was gr