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1 ule of the three-subunit (TycABC), 10-module nonribosomal peptide synthetase.
2 d thioester intermediates on a multimodular, nonribosomal peptide synthetase.
3 three-subunit (CepA, CepB, and CepC) modular nonribosomal peptide synthetase.
4 cterization of the termination module of the nonribosomal peptide synthetase.
5 to one of two genes, orbI and orbJ, encoding nonribosomal peptide synthetases.
6 cyl-CoA synthetases, firefly luciferase, and nonribosomal peptide synthetases.
7 bleomycin are assembled by hybrid polyketide/nonribosomal peptide synthetases.
8 , and the adenylation domains of the modular nonribosomal peptide synthetases.
9 zation states between monomers and dimers in nonribosomal peptide synthetases.
10 domains has been less well characterized in nonribosomal peptide synthetases.
11 to the adenylation and thiolation domains of nonribosomal peptide synthetases.
12 sis, functionally similar to the present day nonribosomal peptide synthetases.
13 ion and condensation domain found in certain nonribosomal peptide synthetases.
14 y-guided approach has been unprecedented for nonribosomal peptide synthetases.
15 tide synthases, in contrast to the monomeric nonribosomal peptide synthetases.
16 unds are synthesized on ribosomes and not by nonribosomal peptide synthetases.
17 es that are synthesized wholly or in part by nonribosomal peptide synthetases.
18 ra- and interchain activities within dimeric nonribosomal peptide synthetases.
19 ed to predict the substrate specificities of nonribosomal peptide synthetase adenylation (A) domains
20 s approach, we screened syn-BNPs inspired by nonribosomal peptide synthetases against microbial patho
21 chimeric multimodular polyketide synthase, a nonribosomal peptide synthetase, along with enzymes resp
22 A, DszB, and DszC, with DszC containing both nonribosomal peptide synthetase and polyketide synthase
23 al system for exploring interactions between nonribosomal peptide synthetase and polyketide synthase
26 uperfamily that includes firefly luciferase, nonribosomal peptide synthetases, and acyl- and aryl-CoA
27 s of every known formally classified family, nonribosomal peptide synthetases, and several hybrid clu
28 tension of this methodology to other dimeric nonribosomal peptide synthetases, and to the related fat
31 emodeling, we successfully expressed a 67-kb nonribosomal peptide synthetase biosynthetic gene cluste
32 ally derived modular polyketide synthase and nonribosomal peptide synthetase biosynthetic pathways ar
36 brio cholerae is assembled by a four-subunit nonribosomal peptide synthetase complex, VibE, VibB, Vib
38 ncation of the carboxy terminus carrying the nonribosomal peptide synthetase cores, as well as the si
39 of 16 ORFs, encoding proteins homologous to nonribosomal peptide synthetases, cytochrome P450-relate
42 s of the method are demonstrated on a 37 kDa nonribosomal peptide synthetase domain subject to spectr
43 0 containing genes encoding for a six-module nonribosomal peptide synthetase EcdA, an acyl-AMP ligase
45 the phenylalanine adenylation domain of the nonribosomal peptide synthetase enzyme gramicidin S synt
46 s a natural modification of the product of a nonribosomal peptide synthetase enzyme, whose consequenc
48 important subset of polyketide synthases and nonribosomal peptide synthetases evolve by concerted evo
50 0 genome identified a 59-kb cryptic inactive nonribosomal peptide synthetase gene cluster proposed to
52 sly, we found a widely distributed family of nonribosomal peptide synthetase gene clusters in gut bac
53 ified a cluster of nine genes (including one nonribosomal peptide synthetase gene, ataP) that is requ
55 ies during assembly by polyketide synthases, nonribosomal peptide synthetases, glycosyltransferases a
56 s high molecular weight protein 2 (HMWP2), a nonribosomal peptide synthetase homologue, and YbtE in t
57 tic pathways for both siderophores involve a nonribosomal peptide synthetase independent siderophore
58 biosynthesized using the recently described nonribosomal peptide synthetase independent siderophore
59 this unique acyl carrier protein-dependent, nonribosomal peptide synthetase-independent biosynthetic
60 fslA, encodes a member of the superfamily of nonribosomal peptide synthetase-independent siderophore
61 , we disclose a three-dimensional model of a nonribosomal peptide synthetase-independent siderophore
62 in the synthesis of aminoacyl-thioesters by nonribosomal peptide synthetases is relaxed, whereas the
64 for engineering hybrid PKS-PKS and PKS-NRPS (nonribosomal peptide synthetase) junctions and suggests
65 ubstrates that load carrier domains found in nonribosomal peptide synthetases, large molecule mass sp
69 the AMP-forming family of enzymes, including nonribosomal peptide synthetases, luciferase, and aryl-
70 iron scavenger (siderophore) and product of nonribosomal peptide synthetase machinery, to the C-term
71 ace between its loading module, which uses a nonribosomal peptide synthetase mechanism, and its initi
72 e synthase module (KS-AT-MT(2)-KR-ACP) and a nonribosomal peptide synthetase module (Cy(3)-MT(3)-PCP(
73 inary biochemical analysis of the N-terminal nonribosomal peptide synthetase module from the Thalasso
75 l proteins composed of a loading module, one nonribosomal peptide synthetase module, eight polyketide
77 ll be used in mechanistic studies of the two nonribosomal peptide synthetases NocA and NocB that lie
79 ilis on an enzymatic assembly line with both nonribosomal peptide synthetase (NRPS) and polyketide sy
80 g a PCR approach to clone a thiazole-forming nonribosomal peptide synthetase (NRPS) as a probe, we lo
81 ielding a pentapeptide on the thio-templated nonribosomal peptide synthetase (NRPS) assembly line pro
82 ptide aglycone or intermediates bound to the nonribosomal peptide synthetase (NRPS) assembly line.
83 re any of the canonical epimerase domains of nonribosomal peptide synthetase (NRPS) assembly lines fo
85 the highly dissociated nature of the encoded nonribosomal peptide synthetase (NRPS) domains and modul
86 ly identified fungal anthranilate-activating nonribosomal peptide synthetase (NRPS) domains through b
88 biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) enzymes EpoA-F.
91 genome of Vibrio harveyi BAA-1116 contains a nonribosomal peptide synthetase (NRPS) gene cluster (aeb
92 AS), as the major product of the cryptic has nonribosomal peptide synthetase (NRPS) gene cluster in t
93 ucts produced by a polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) hybrid involving
95 ecture and domain organization of the ncpA-B nonribosomal peptide synthetase (NRPS) is co-linear in a
96 f yersiniabactin (Ybt) synthetase, a 230 kDa nonribosomal peptide synthetase (NRPS) making the N-term
98 h a predicted acyltransferase, a stand-alone nonribosomal peptide synthetase (NRPS) module, and four
100 teins (PacA-V), including highly dissociated nonribosomal peptide synthetase (NRPS) modules and a var
101 e 56-kb gene cluster encodes a series of six nonribosomal peptide synthetase (NRPS) modules distribut
104 the 23 358 bp cymA, which encodes a 7-module nonribosomal peptide synthetase (NRPS) responsible for a
105 enerated by hybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) systems in strept
106 ys where the PKS is fused to a single module nonribosomal peptide synthetase (NRPS) to synthesize pol
108 (TE) domain from the multidomain tyrocidine nonribosomal peptide synthetase (NRPS) was recently show
109 -3, is the nascent product of the LNM hybrid nonribosomal peptide synthetase (NRPS)-acyltransferase (
110 arylamine precursor of chloramphenicol in a nonribosomal peptide synthetase (NRPS)-based pathway to
113 ves assembly of the MBT backbone by a hybrid nonribosomal peptide synthetase (NRPS)/polyketide syntha
115 inone-fused ring systems can be assembled by nonribosomal peptide synthetases (NRPS) using the confor
119 erstanding of domain-domain communication in nonribosomal peptide synthetases (NRPSs) and lay the gro
122 and antifungal properties are synthesized by nonribosomal peptide synthetases (NRPSs) and polyketide
130 he C-terminal thioesterase (TE) domains from nonribosomal peptide synthetases (NRPSs) catalyze the fi
133 intermediates on the carrier domains of the nonribosomal peptide synthetases (NRPSs) or polyketide s
135 In mycobacteria, polyketide synthases and nonribosomal peptide synthetases (NRPSs) produce complex
138 ymes, including polyketide synthases (PKSs), nonribosomal peptide synthetases (NRPSs), and mixed PKS/
139 ynthetic gene cluster predicted that the two nonribosomal peptide synthetases (NRPSs), BlmIV and BlmI
140 terrogation of enzyme-bound intermediates in nonribosomal peptide synthetases (NRPSs), mass spectrome
141 ists of 34 genes encoding fatty acid ligase, nonribosomal peptide synthetases (NRPSs), regulators, tr
142 biosynthesized from amino acid precursors by nonribosomal peptide synthetases (NRPSs), which are orga
144 irs of Esx secreted proteins, a multisubunit nonribosomal peptide synthetase operon, and genes encodi
145 k marks the first direct characterization of nonribosomal peptide synthetase oxidase domain activity
147 the possibility of future engineering within nonribosomal peptide synthetase pathways using oxidase d
148 paS, a hybrid two module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) that generate
149 is a hybrid, two module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) that makes an
150 ins only a single-module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS), although two
151 ructure encodes a hybrid polyketide synthase nonribosomal peptide synthetase (PKS-NRPS), which resemb
152 eosome inhibitors biosynthesized by a hybrid nonribosomal peptide synthetase-polyketide synthase (NRP
153 ey are synthesized by the action of a hybrid nonribosomal peptide synthetase/polyketide synthase in t
154 A) followed by backbone assembly by a hybrid nonribosomal peptide synthetase/polyketide synthase.
155 s-specific biosynthetic loci encoding hybrid nonribosomal peptide synthetase/polyketide synthases con
156 RifR, a type II thioesterase from the hybrid nonribosomal peptide synthetases/polyketide synthase rif
157 st highly induced genes showed homology with nonribosomal peptide synthetases/polyketide synthases.
158 The C-terminal thioesterase domain of the nonribosomal peptide synthetase producing the lipopetide
162 CP2 thiolation domains of PchE and PchF, the nonribosomal peptide synthetases responsible for the bio
164 ion studies revealed the central role of the nonribosomal peptide synthetase Sln9 in constructing and
165 des harboring covalently modified serines in nonribosomal peptide synthetases, streamlined methodolog
167 e is assembled by a four-subunit, ten-domain nonribosomal peptide synthetase system, VibE, VibB, VibH
168 residue is installed into the scaffold by a nonribosomal peptide synthetase that also performs the s
169 denylation (A) domain of the Yersinia pestis nonribosomal peptide synthetase that biosynthesizes the
170 esterase domains of polyketide synthases and nonribosomal peptide synthetases to macrocycles via cova
171 y SgcC1 homologous to adenylation domains of nonribosomal peptide synthetases, was identified as spec
172 s the approximately 450 residue E domains of nonribosomal peptide synthetases were constructed, and t
173 Two biosynthesis gene clusters encoding nonribosomal peptide synthetases were identified, emphas
174 gopeptin and syringomycin are synthesized by nonribosomal peptide synthetases which are encoded by th
175 ntains an unusual hybrid polyketide synthase-nonribosomal peptide synthetase, which resembles iterati
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