ライフサイエンスコーパス: nonself

1 the ability to discriminate between self and nonself.

2 ed on self-peptide-MHCs and primed to detect nonself.

3 al processes to distinguish between self and nonself.

4 s a means of discriminating between self and nonself.

5 h B cells, yet discriminate between self and nonself.

6 ine to methionine substitution at p2 defines nonself.

7 based on the recognition of self rather than nonself.

8 ons by making a distinction between self and nonself.

9 igens to change the specificity from self to nonself.

10 rather than simply to distinguish self from nonself.

11 ) in islet beta cells, some recognize Tag as nonself.

12 s a molecular ruler to distinguish self from nonself.

13 ms of the same species distinguish self from nonself.

14 urites readily discriminate between self and nonself.

15 and readily recognize and reject allogeneic nonself.

16 ity of P. mirabilis to distinguish self from nonself.

17 tem is its ability to discriminate self from nonself.

18 trategies to distinguish self from microbial nonself.

19 hat monocytes mount a response to allogeneic nonself, a function not previously attributed to them, a

20 act on the host immune system of exposure to nonself ABH antigens during early life in human heart ve

21 ific IgM, IgG, and IgA isotype antibodies to nonself ABH subtypes were detected in control participan

22 toimmune diseases, yet little is known about nonself Ag-induced tolerance.

23 e intraocular administration of low doses of nonself Ag.

24 ent mice conserved the ability to respond to nonself Ags and mitogens.

25 T(Reg)) control immune responses to self and nonself Ags.

26 uced, nondeletional tolerance to extrathymic nonself Ags.

27 lesion, in response to unidentified self- or nonself Ags.

28 tor reveals that T cell-mediated immunity to nonself-Ags in the liver is self-limiting.

29 (self-HLA-restricted) and HLA-A*02-negative [nonself (allogeneic) HLA [allo-HLA]-restricted] individu

30 of infectious organisms mediate awareness of nonself and are integral to host defense in plants and a

31 aboratory mice, male tissue is recognized as nonself and destroyed by the female immune system via re

32 e identified a single gene that encodes self-nonself and determines "graft" outcomes in this organism

33 by a foreign DNA, the REase recognizes it as nonself and subjects it to restriction.

34 ights into the peptide universe that defines nonself and the basis of histoincompatibility.

35 delicate balance between the recognition of nonself and the prevention of autoimmunity.

36 nses that are poised to recognize viruses as nonself and to activate antiviral pathways.

37 vely present at the portals between self and nonself, and contain a large and diverse complement of p

38 2-type immune response against an exogenous, nonself antigen, keyhole limpet hemocyanin (KLH), by rel

39 n reject normal grafts that express the same nonself-antigen.

40 which allow discrimination between self and nonself antigens as well as the recognition of potential

41 zonulin up-regulation, the excessive flow of nonself antigens in the intestinal submucosa can cause b

42 We conclude that exogenous, nonself antigens that can induce Th2 responses, can modi

43 tireactive, binding to a variety of self and nonself antigens, including dsDNA (albeit at reduced aff

44 ntracellular discrimination between self and nonself antigens, resulting in the preferential presenta

45 quilibrium between tolerance and immunity to nonself antigens.

46 mental in limiting inflammatory responses to nonself antigens.

47 entation of peptides derived from opsonized, nonself antigens.

48 erally cross-reactive, besides responding to nonself-antigens, they also maintain significant respons

49 ated host immune responses against self- and nonself-antigens; however, the impact of CD4(+) Tregs on

50 the absence of eTh and that persist, whereas nonself are those Ags encountered in the presence of eTh

51 of molecular patterns demarcating infectious nonself, as well as normal and abnormal self.

52 mmune systems in differentiating "self" and "nonself," as well as lay the foundation for resolving th

53 s have any capacity to distinguish self from nonself at the molecular level is an outstanding questio

54 g the particular viral ligands recognized as nonself by cytosolic PRRs, and on defining the nature of

55 cular patterns (PAMPs/MAMPs) are detected as nonself by host pattern recognition receptors (PRRs) and

56 eas microbial pathogens can be recognized as nonself by immune receptors, misfolded protein assemblie

57 ion that RNA genomes are first recognized as nonself by the immune system.

58 role in the distinction between "self" and "nonself" by the cellular immune system.

59 mplement becomes activated on the surface of nonself cells by one of three initiating mechanisms know

60 This led us to suggest that nonself cells may play a role in the disease process.

61 c genes to distinguish self from conspecific nonself cells or tissues.

62 lticellular state and to tell apart self and nonself cells.

63 same TCR has the potential to interact with nonself class I complexed with nonself peptides.

64 Activation of NK cells by nonself class I molecules was not predicted by the missi

65 lleles are present in the population and all nonself combinations of Y and Z alleles are equally func

66 r, we determine the coupling constants for a nonself-complementary 11-mer A-tract DNA duplex from 2D

67 7BL/6 model whether providing the infectious nonself context in a tumor-by injecting CpG-oligodeoxynu

68 immune responses are modified along the self-nonself continuum may offer more effective opportunities

69 clarify how molecular mimicry can drive self/nonself cross-reactivity and illustrate how low peptide-

70 However, the competing demands of nonself discrimination and self-recognition place limita

71 r efforts to understand the "rules" for self-nonself discrimination are constantly evolving.

72 sors raises fundamental questions about self/nonself discrimination because of the abundance of self-

73 largely responsible for reliable self versus nonself discrimination by these receptors.

74 Instead, self-nonself discrimination depends on the intron that progra

75 PRR distribution form a basis of self versus nonself discrimination during the antiviral response.

76 Here we defined the molecular basis of self-nonself discrimination for the murine chromosome 7 encod

77 A link between immunoregulation and self-nonself discrimination has emerged from experiments show

78 understanding the molecular details of self-nonself discrimination in P. mirabilis.

79 As the major site of self-nonself discrimination in the immune system, the thymus,

80 ermediate-avidity T cells to accomplish self-nonself discrimination in the periphery.

81 es and differences between SI and other self/nonself discrimination systems are discussed.

82 ne system evolved several strategies of self/nonself discrimination that are based on the recognition

83 in no way challenges the need to make a self-nonself discrimination, nor, for that matter, does it ch

84 lax that likewise enable genomic self versus nonself discrimination, this time by specifying self seq

85 quence of Hsp60 (Hsp60sp) contribute to self/nonself discrimination.

86 p, which was associated with failure of self/nonself discrimination.

87 ity of peripheral immune regulation and self-nonself discrimination.

88 ne system is often said to function by "self-nonself" discrimination.

89 c protein HET-S causes cell death in a self-/nonself-discrimination process.

90 ellular immunity requires accurate self- vs. nonself-discrimination to protect against infections and

91 s support a role for siglecs in B cell self-/nonself-discrimination, namely suppressing responses to

92 ted from these loci to target complementary "nonself" DNA sequences for destruction, while avoiding b

93 rly phase of IBV infection, the signaling of nonself dsRNA through both MDA5 and TLR3 remains intact

94 ly dynamics to discriminate between self vs. nonself dsRNA.

95 RNAs that are endogenous Dicer products, and nonself dsRNAs such as by-products of viral replication.

96 s of cells must distinguish between self and nonself during the construction of neural circuits.

97 s, the immune system discriminates self from nonself, during adaptive immunity in the periphery, not

98 he potential for T-cell immunity to self and nonself dystrophin epitopes should be considered in desi

99 or editing to accommodate the recognition of nonself-eplets, the driving force of the humoral allores

100 to efficiently distinguish between self and nonself even within three-component mixtures in CDCl3.

101 ferent mating types recognize one another as nonself, form a complex and activate development.

102 the immune system to distinguish infectious nonself from noninfectious self.

103 Discrimination by the host defense system of nonself from self can prevent invasion of pathogens, but

104 s routinely transport antigen (both self and nonself) from the periphery to the thymus, where they po

105 t the basis of TCRs to distinguish self from nonself H13 peptides is their ability to distinguish a s

106 GW and implanted into experimentally induced nonself healing calvarial defects, GW treatment substant

107 In contrast, NK cells expressing self- and nonself-HLA class I-binding inhibitory killer cell Ig-li

108 mammalian transcription-as arbiters of self-nonself identity.

109 C)-mediated antigen presentation in self and nonself immune recognition was derived from immunologica

110 to HSC isolation and its importance in self-nonself immune recognition.

111 l self-tolerance by discriminating self from nonself in humans.

112 that enables them to discriminate self from nonself in the periphery is one of the central issues of

113 T cell regulation to discriminate self from nonself in the periphery to maintain self-tolerance.

114 une system's ability to distinguish self and nonself is essential for both host defense against forei

115 Differentiation of self from nonself is indispensable for maintaining B cell toleranc

116 ther members of the same species (allogeneic nonself) is less clear.

117 the ability to discriminate between self and nonself, is ubiquitous among colonial metazoans and wide

118 to efficiently distinguish between self and nonself-is common in nature but is still relatively rare

119 reactive T cells of activation with a potent nonself ligand, we have generated a TCR transgenic mouse

120 tially autoreactive T cells by high-affinity nonself ligands may be important in breaking self-tolera

121 vaey et al. explore the molecular details of nonself lipid discrimination and self-recognition.

122 e ligand, but does not impact recognition of nonself MHC class II molecules.

123 models suggest that T cell affinity toward a nonself MHC molecule would be lower than that toward a s

124 t limited by a lower affinity of T cells for nonself MHC molecules.

125 T cells recognize determinants expressed on nonself MHC molecules.

126 ts had greater inhibitory neuroactivity than nonself-MHC I molecules, regardless of the nature of the

127 Recognition of nonself molecular patterns such as those seen with viral

128 d by microbial patterns that are detected as nonself molecules.

129 s (PRRs) of the host cell recognize specific nonself-motifs within viral products (known as a pathoge

130 ally synergistic role for it in self- versus nonself-mRNA discernment.

131 elf also had HLA-C2, indicating that neither nonself nor missing-self discrimination was operative.

132 critical in discriminating between self and nonself nucleic acid.

133 mechanisms used to distinguish "self" from "nonself" nucleic acids remain mysterious.

134 g safeguards against aberrantly replicating, nonself or virally infected cells.

135 he ER stress pathway senses influenza HA as "nonself" or misfolded protein and sorts HA to ERAD for d

136 s to and enhances macrophage uptake of other nonself particles, specifically apoptotic polymorphonucl

137 nding of how plants recognize and respond to nonself patterns, a process from which the seemingly cha

138 n is given to the search for viral and tumor nonself peptide epitopes, yet the question remains, "Wha

139 ls requires differentiation between self and nonself peptide-class I major histocompatibility complex

140 T cell activation by nonself peptide-major histocompatibility complex (MHC) a

141 on of peripheral T cells can also respond to nonself peptide-MHC (pMHC) complexes in the context of t

142 t MHC I heavy chains with a defined self- or nonself-peptide presented, on cultured embryonic retinas

143 Mature T cells respond to antigenic nonself peptides bound to self-MHC molecules, but a size

144 eir clonotypic receptor, the TCR, recognizes nonself peptides displayed by MHC class I molecules.

145 ntogeny and with self class I complexed with nonself peptides to initiate Ag-specific responses.

146 interact with nonself class I complexed with nonself peptides.

147 dicted to bind large repertoires of self and nonself peptides.

148 direct or indirect presentation of self and nonself phosphoantigens (pAg).

149 S-RNases interact more with nonself Pi SLFs than with self Pi SLFs, and Pi SLFs also

150 mpatibility, discrimination between self and nonself pollen by the pistil is controlled by the highly

151 Approaching swarms of nonself populations led to increased ids expression and

152 is crucial for elimination of cells bearing "nonself" proteins.

153 What limits this second layer of self- and nonself-reactive Treg production in physiological condit

154 improved strategies to select effective, yet nonself-reactive, TCRs.

155 atibility with het-c) was required for het-c nonself recognition and heterokaryon incompatibility (HI

156 hich may implicate mitochondria in N. crassa nonself recognition and PCD.

157 lly with a transcription factor vib-1 during nonself recognition and programmed cell death (PCD).

158 efficient mechanism to leverage the limited nonself recognition capacity of their innate immune syst

159 Nonself recognition during vegetative growth in filament

160 ns in vib-1 (Deltavib-1) suppress PCD due to nonself recognition events; however, a Deltavib-1 Deltai

161 y in particular-shifted the emphasis of self-nonself recognition from lymphocytes functioning in the

162 similar transmembrane proteins mediate self/nonself recognition in both ciliates, the mechanisms of

163 nonallelic interactions may be important in nonself recognition in filamentous fungi and that protei

164 Nonself recognition in filamentous fungi is conferred by

165 Using epitope-tagged HET-C, we show that nonself recognition is mediated by the presence of a het

166 Our finding is a step towards understanding nonself recognition mechanisms that operate during veget

167 ich, in the prion state, is active in a self/nonself recognition process called heterokaryon incompat

168 atibility (SI) systems are unique among self/nonself recognition systems in being based on the recogn

169 Genetic nonself recognition systems such as vegetative incompati

170 signaling, and may carry out a form of self-nonself recognition that is independent of microbial pat

171 extant animals but nevertheless possess self-nonself recognition that rivals the specificity of the v

172 okaryon and transformation tests showed that nonself recognition was mediated by synergistic nonallel

173 an important factor involved in sponge self/nonself recognition.

174 ion, consistent with the role of het loci in nonself recognition.

175 genetic polymorphism for specificity in self/nonself recognition.

176 PRR-PAMP interactions lead to PRR-dependent nonself-recognition and the downstream induction of type

177 ng the diversity of molecules functioning in nonself-recognition in an invertebrate.

178 ys involved in detecting DNA viruses through nonself-recognition of viral DNA are also being elucidat

179 Exposure to nonself red blood cell (RBC) antigens, either from trans

180 duals, activity in the DMN is reduced during nonself-referential goal-directed tasks, in keeping with

181 ts (49.8%) had obstructive CAD compared with nonself-referral patients (53.5%), with an odds ratio of

182 interact with MDA5, a cytoplasmic sensor of nonself RNA that induces type I IFN.

183 us replication triggered upon recognition of nonself RNAs by the cytoplasmic sensors encoded by retin

184 serve as epigenetic memories of "self" and "nonself" RNAs.

185 ted this hypothesis in the context of native nonself-RNAs.

186 an SCF complex mediating the degradation of nonself S-RNase but not self S-RNase.

187 Pi SLFs, and Pi SLFs also interact more with nonself S-RNases than with self S-RNases.

188 eleterious mutations, and the acquisition of nonself sequences influencing the phylogenetics of viral

189 fter transplantation, T cells may react with nonself structures, contributing to graft-versus-host di

190 Exposure of nonself surfaces such as those of biomaterials or transp

191 cific for a self (MUC.1) and the other for a nonself T cell determinant.

192 es of Abeta(1-11) fused with the promiscuous nonself T cell epitope, PADRE (pan human leukocyte antig

193 protein subunit of Cascade, is required for nonself target recognition and binding.

194 d three base pair motif that is required for nonself target selection.

195 surfaces that determine specificity for the nonself target.

196 ation of an endogenous immunologic signal of nonself that can provoke a sterile inflammatory response

197 ystem uses to distinguish between infectious nonself (that is to be attacked) and noninfectious self

198 Immune systems distinguish "self" from "nonself" to maintain homeostasis and must differentially

199 to recognize "self" from "altered self" or "nonself." To escape the host immune system, some bacteri

200 case proteins that can identify viral RNA as nonself via binding to pathogen associated molecular pat

201 a programmed suicide pathway in uninfected (nonself) yeast.