ライフサイエンスコーパス: nonsense-mediated decay

1 rnative exon that targets the transcript for nonsense mediated decay.

2 from the patient shows it does not result in nonsense mediated decay.

3 spectrum of mutant transcripts that survive nonsense-mediated decay.

4 nd the retained intron product is subject to nonsense-mediated decay.

5 upon UPF1, suggesting that it is related to nonsense-mediated decay.

6 nd the transcript was observed to degrade by nonsense-mediated decay.

7 otein mRNAs are predicted to be sensitive to nonsense-mediated decay.

8 oprotein mRNA translation and sensitivity to nonsense-mediated decay.

9 ytoplasmic decapping and 5'-to-3' decay, and nonsense-mediated decay.

10 either by blocking its membrane targeting or nonsense-mediated decay.

11 he latter presumably due to circumvention of nonsense-mediated decay.

12 equence and degradation of the mutant RNA by nonsense-mediated decay.

13 nto how selenoprotein mRNAs might circumvent nonsense-mediated decay.

14 lower expression because of degradation via nonsense-mediated decay.

15 es that are required for translation and for nonsense-mediated decay.

16 selection for fusion transcripts that evade nonsense-mediated decay.

17 are regulated by selenium and are subject to nonsense-mediated decay.

18 odons (PTCs) that are likely targets of mRNA nonsense-mediated decay.

19 ablements, and thus may be more resistant to nonsense-mediated decay.

20 r nuclear export, efficient translation, and nonsense-mediated decay.

21 plicing, and to downstream events, including nonsense-mediated decay.

22 possibly, serving as a downstream 'mark' for nonsense-mediated decay.

23 ly degraded, presumably by the mechanisms of nonsense-mediated decay.

24 ivo such as mRNA transport, translation, and nonsense-mediated decay.

25 tingly these messages are not substrates for nonsense-mediated decay.

26 ons in the smg genes, which are required for nonsense-mediated decay.

27 edicted effects including protein coding and nonsense-mediated decay.

28 that co-purifies with cytoplasm is immune to nonsense-mediated decay.

29 ent, the mRNA will no longer be sensitive to nonsense-mediated decay.

30 metine, suggesting that the mutation induces nonsense-mediated decay.

31 and demonstrate that SMN6B is a substrate of nonsense-mediated decay.

32 ood and the mutated ASXL2 transcripts escape nonsense-mediated decay.

33 h a premature termination codon that escapes nonsense-mediated decay.

34 ift variant is not a canonical substrate for nonsense-mediated decay.

35 ice-site selection associated with increased nonsense-mediated decay.

36 in domains, or the trigger of or escape from nonsense-mediated decay.

37 n disrupting their translation and promoting nonsense-mediated decay.

38 enomena such as cis-regulatory variation and nonsense-mediated decay.

39 frameshift mutation in RSPRY1 with resulting nonsense-mediated decay.

40 species that are likely rapidly degraded via nonsense-mediated decay.

41 The 1 bp duplication causes a frameshift and nonsense-mediated decay.

42 ficiencies in known roles of SMG1, including nonsense-mediated decay.

43 t the predicted resulting mRNA is subject to nonsense-mediated decay.

44 ng nonfunctional transcripts and/or inducing nonsense-mediated decay.

45 ising from the mutant alleles are subject to nonsense-mediated decay.

46 al sensitivity of the can1-100 transcript to nonsense-mediated decay, a pathway that degrades mRNAs w

47 -gamma is therefore likely to be degraded by nonsense-mediated decay, an important widespread post-tr

48 r the detection of cis-regulatory variation, nonsense mediated decay and imprinting in the personal g

49 or penultimate exons that are not subject to nonsense-mediated decay and are stably translated into m

50 Both mutations predict nonsense-mediated decay and complete loss of function.

51 at truncation variants in this region escape nonsense-mediated decay and continue to be incorporated

52 ects on transcript abundance attributable to nonsense-mediated decay and exonic splicing elements.

53 transcript stability and translation through nonsense-mediated decay and microRNA-mediated gene regul

54 UPF1 is an RNA helicase that orchestrates nonsense-mediated decay and other RNA surveillance pathw

55 HOT RNAs encode components of the nonsense-mediated decay and splicing machinery, as well

56 therapy will sometimes require inhibition of nonsense-mediated decay and translational bypass of the

57 ion of a group II intron in yeast results in nonsense-mediated decay and translational repression of

58 scripts from the mutated allele are prone to nonsense-mediated decay, and expression of ASXL3 is redu

59 the response to oxidative stress, apoptosis, nonsense-mediated decay, and others.

60 for phenomena such as alternative splicing, nonsense-mediated decay, and regulation through untransl

61 rcentage of isoforms targeted, prediction of nonsense-mediated decay, and restriction enzymes for RFL

62 ties of MPZ-truncating proteins that escaped nonsense-mediated decay, and we found that frameshift mu

63 esults regarding the quantitative effects of nonsense-mediated decay, and we show that predicted loss

64 the hierarchy of selenoprotein synthesis and nonsense-mediated decay are discussed.

65 and intron-retaining transcripts that escape nonsense-mediated decay are not actively translated.

66 SMG1 has a well-characterized role in nonsense-mediated decay as well as suggested roles in th

67 sting that alternative splicing coupled with nonsense-mediated decay (AS-NMD) may regulate gene expre

68 selection pressure, and coupling of AS with nonsense-mediated decay (AS-NMD).

69 TEA may be helpful for testing inhibitors of nonsense-mediated decay, as stop codon management therap

70 hypothesis that alternative splicing-coupled nonsense-mediated decay contributes to regulation of ery

71 s were retained in the nucleus, and block of nonsense-mediated decay did not affect their accumulatio

72 As are potential targets for degradation via nonsense-mediated decay due to the presence of in-frame

73 some PRRT2 loss-of-function mutations cause nonsense mediated decay, except when in the last exon, w

74 frameshift mutated allele, probably through nonsense-mediated decay, explaining the more severe phen

75 rate that hDcp1a and hDcp2 interact with the nonsense-mediated decay factor hUpf1, both in the presen

76 Among the findings, UPF1, a key nonsense-mediated decay factor, and PCNA, the polymerase

77 f ZC3H14, double knockdown of ZC3H14 and the nonsense-mediated decay factor, UPF1, rescues ATP5G1 tra

78 ckdown obtained by forced splicing-dependent nonsense-mediated decay (FSD-NMD).

79 microRNA-mediated translation repression and nonsense mediated decay, further supporting the view tha

80 XPC-mRNA, which would have been degraded by nonsense-mediated decay; (ii) increased expression of XP

81 , we also demonstrate the reversible role of nonsense-mediated decay in all four mutations, using sma

82 The mutant transcripts do not undergo nonsense-mediated decay in cells from subjects with GPS.

83 this apparent inconsistency is attributed to nonsense mediated decay independent of exon junction com

84 Nonsense-mediated decay is associated with a number of o

85 Previously, we have shown how nonsense-mediated decay is involved in the degradation o

86 In contrast, nonsense-mediated decay is significantly more associated

87 tiation site, resulting in the prevention of nonsense-mediated decay, leading to a consequent stabili

88 igured to terminate translation and initiate nonsense-mediated decay, limits the production of cellul

89 the targets for degradation by the cellular nonsense-mediated decay machinery if they contain premat

90 ative target of alternative splicing-coupled nonsense-mediated decay mechanism.

91 The EJC core does not recruit the nonsense-mediated decay mediaters UPF2 and UPF3 until th

92 These data suggest that nonsense mediated decay might itself reduce negative sel

93 usually targeted for degradation through the nonsense mediated decay (NMD) pathway.

94 These exons triggered nonsense mediated decay (NMD), as UPF1 and protein synth

95 mpact of PAH mutations on pre-mRNA splicing, nonsense-mediated decay (NMD) and receptor complex inter

96 that the cap-binding protein CBP80 promotes nonsense-mediated decay (NMD) at two steps.

97 Nonsense-mediated decay (NMD) degrades both normal and a

98 Nonsense-mediated decay (NMD) degrades mRNAs containing

99 Nonsense-mediated decay (NMD) eliminates mRNAs that prem

100 Nonsense-mediated decay (NMD) eliminates transcripts wit

101 he EJC proteins Y14, Magoh, and RNPS1 or the nonsense-mediated decay (NMD) factors Upf1, Upf2, and Up

102 ecialized pathway of mRNA degradation termed nonsense-mediated decay (NMD) functions in mRNA quality

103 Nonsense-mediated decay (NMD) is a messenger RNA quality

104 Nonsense-mediated decay (NMD) is a posttranscriptional s

105 Nonsense-mediated decay (NMD) is an important process th

106 Nonsense-mediated decay (NMD) is an RNA surveillance pat

107 radation of UPF1, a central component of the nonsense-mediated decay (NMD) machinery, is associated w

108 mRNA transcript for degradation by the host nonsense-mediated decay (NMD) machinery.

109 Inhibition of the nonsense-mediated decay (NMD) mechanism in cells results

110 ng (P < 0.05) and showed that this triggered nonsense-mediated decay (NMD) of the alternatively splic

111 oan mRNA, including its surveillance via the nonsense-mediated decay (NMD) pathway.

112 genes are dramatically downregulated by the nonsense-mediated decay (NMD) pathway.

113 alized only when the mutant mRNAs escape the nonsense-mediated decay (NMD) pathway.

114 case subfamily as MOV10 and functions in the nonsense-mediated decay (NMD) pathway.

115 Nonsense-mediated decay (NMD) provides quality control o

116 UPF1 is a conserved helicase required for nonsense-mediated decay (NMD) regulating mRNA stability

117 Nonsense-mediated decay (NMD) rids eukaryotic cells of a

118 The nonsense-mediated decay (NMD) RNA surveillance pathway d

119 One is rapid mRNA decay triggered by the nonsense-mediated decay (NMD) RNA surveillance pathway.

120 The nonsense-mediated decay (NMD) surveillance pathway can r

121 e occupancy, with monosomes predominating on nonsense-mediated decay (NMD) targets, upstream open rea

122 eroxidase 1 (GPx1) is subject to cytoplasmic nonsense-mediated decay (NMD) when the UGA selenocystein

123 ure termination codons (PTCs), which trigger nonsense-mediated decay (NMD), a cytoplasmic RNA degrada

124 Importantly, nonsense-mediated decay (NMD), a major checkpoint for tr

125 ether NAS has characteristics in common with nonsense-mediated decay (NMD), a surveillance mechanism

126 rmination codon within the last exon, escape nonsense-mediated decay (NMD), and most likely generate

127 nts, including RNA subcellular localization, nonsense-mediated decay (NMD), and translation.

128 The 3'-extended MAK21 RNA is sensitive to nonsense-mediated decay (NMD), as revealed by its increa

129 ntron-retained mRNAs were not substrates for nonsense-mediated decay (NMD), even though they were det

130 ved mRNA surveillance system, referred to as nonsense-mediated decay (NMD), exists in eukaryotic cell

131 deadenylation-dependent mRNA decay (DDD) and nonsense-mediated decay (NMD), stimulate Ty1 retrotransp

132 chanism allowing UPF1, the central factor in nonsense-mediated decay (NMD), to increasingly attract d

133 nvolved in the mRNA quality control process, nonsense-mediated decay (NMD), were found to genetically

134 In addition, this nonsense mutation induces nonsense-mediated decay (NMD), which degrades the normal

135 lation of fully spliced psiBCH RNA caused by nonsense-mediated decay (NMD), which is an RNA surveilla

136 on 11 skipping produces an RNA substrate for nonsense-mediated decay (NMD).

137 lternative splicing of nPTB mRNA, leading to nonsense-mediated decay (NMD).

138 undant in dendrites, is a natural target for nonsense-mediated decay (NMD).

139 is exon is skipped, PTBP2 mRNA is subject to nonsense-mediated decay (NMD).

140 subjected to accelerated turnover, known as nonsense-mediated decay (NMD).

141 of expression from the mutant allele due to nonsense-mediated decay (NMD).

142 APOBEC1 alone induces nonsense-mediated decay (NMD).

143 t mRNAs with premature termination codons to nonsense-mediated decay (NMD).

144 te the fact that it is a prime candidate for nonsense-mediated decay (NMD).

145 remain in the nucleus and are not subject to nonsense-mediated decay (NMD).

146 1 is required for mRNA discrimination during nonsense-mediated decay (NMD).

147 05 is within the 5' UTR and cannot result in nonsense-mediated decay (NMD).

148 predicted to predispose mRNA transcripts to nonsense-mediated decay (NMD).

149 ture termination events target the mRNAs for Nonsense-Mediated-Decay (NMD).

150 that the encoded mRNA should be subject to "nonsense-mediated decay" (NMD).

151 tems monitor mRNAs for translational errors: nonsense-mediated decay, non-stop decay (NSD) and no-go

152 ses a moderate hearing impairment likely via nonsense-mediated decay of CABP2-mRNA.

153 s from affected individuals, suggesting that nonsense-mediated decay of COL1A1 RNA is a nuclear pheno

154 n abnormal splicing of ERLIN2 transcript and nonsense-mediated decay of ERLIN2 mRNA.

155 ey could also impact gene expression through nonsense-mediated decay of intron-retained transcripts.

156 a group I RNA helicase that functions in the nonsense-mediated decay of mRNA in yeast.

157 d cells, suggesting that the mutation causes nonsense-mediated decay of mRNA.

158 splicing events including nuclear export and nonsense-mediated decay of mRNA.

159 es in export, translation, localization, and nonsense-mediated decay of mRNAs.

160 Compatible with nonsense-mediated decay of mutant transcripts, CAR8 is v

161 ly result in CTCF haploinsufficiency through nonsense-mediated decay of mutant transcripts, or loss-o

162 We propose that nonsense-mediated decay of nonsense-containing Fed-1 mRN

163 oteins functioning in the nuclear export and nonsense-mediated decay of spliced mRNAs.

164 r domain of the protein and possibly causing nonsense-mediated decay of the corresponding mRNA.

165 n within an open reading frame (ORF) induces nonsense-mediated decay of the mRNA in vivo.

166 n present at the 5' end of intron 2 leads to nonsense-mediated decay of the mRNA.

167 and, hence, would not be expected to lead to nonsense-mediated decay of the mRNA; nonetheless, both m

168 asts compared with controls, consistent with nonsense-mediated decay of the mutant transcript and los

169 by the CHADL frameshift mutation results in nonsense-mediated decay of the mutant transcripts.

170 Each mutation triggered nonsense-mediated decay of the respective mRNA transcrip

171 that the c.2737C>T variant does not trigger nonsense-mediated decay of the ZSWIM6 mRNA in affected i

172 nsertion of a retrotransposon causing either nonsense-mediated decay of transcripts or alternative sp

173 splicing that can impact mRNA levels through nonsense-mediated decay or by nuclear mRNA detention.

174 n codon, leading to loss of function through nonsense-mediated decay or truncated protein.

175 ere translation termination occurs too soon (nonsense-mediated decay) or fails to occur (non-stop dec

176 Establishing a link between the nonsense-mediated decay pathway and a gene associated wi

177 ng mutations at the 3' end of MPZ escape the nonsense-mediated decay pathway and cause a mild periphe

178 These transcripts are degraded by the nonsense-mediated decay pathway and have a very short ha

179 y of the OLE1 transcript is resistant to the nonsense-mediated decay pathway and that the essential p

180 iated by the HCV IRES was independent of the nonsense-mediated decay pathway and the cap binding prot

181 genes that up-regulate their RNA signal upon nonsense-mediated decay pathway blockade in chronic lymp

182 nally, we demonstrate that components of the nonsense-mediated decay pathway function in at least one

183 Our manipulation of the nonsense-mediated decay pathway in microsatellite unstab

184 The selective degradation of mRNAs by the nonsense-mediated decay pathway is a quality control pro

185 e it constitutes a rate-limiting step in the nonsense-mediated decay pathway that rids cells of mRNAs

186 d degradation of the rd7 mPNR message by the nonsense-mediated decay pathway, preventing the synthesi

187 els by destabilizing the mutant mRNA via the nonsense-mediated decay pathway.

188 the turnover of selenoprotein mRNAs via the nonsense-mediated decay pathway.

189 strain demonstrated that uAUGs stimulate the nonsense-mediated decay pathway.

190 direct role for DUX4 mRNA in suppression of nonsense-mediated decay pathways has recently been demon

191 icipate in a two-hybrid interaction with the nonsense-mediated decay protein Upf1p.

192 tes that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central rol

193 but rather to decreased mRNA translation by nonsense-mediated decay regulation of translation.

194 letion mutations predicted to result in mRNA nonsense-mediated decay, suggesting haploinsufficiency a

195 Analysis using strains lacking nonsense-mediated decay suggests that as many as half of

196 increase in the retained intron isoform and nonsense mediated decay susceptible isoform and a decrea

197 We determined that while a nonsense-mediated, decay-targeted isoform of MDM4 (MDM4-

198 ould allow selenoprotein mRNAs to circumvent nonsense-mediated decay, thus providing new insights int

199 oding variant at the expense of an mRNA with nonsense-mediated decay-triggering features.

200 y decoded UGA which confer the potential for nonsense-mediated decay when factors required for seleno

201 to the 5' untranslated region does not block nonsense-mediated decay when inserted into exon 6 betwee

202 -induced phenotypic variation and defects in nonsense-mediated decay, which lead to suppression of pr

203 dicts escape of mutant ZIC1 transcripts from nonsense-mediated decay, which was confirmed in a cell l

204 n-dependent splicing of EZH2, which triggers nonsense-mediated decay, which, in turn, results in impa

205 were informational suppressors that affected nonsense-mediated decay, while the remaining 13 were pha

206 tations identified in these subjects lead to nonsense-mediated decay with subsequent reduction of RNA