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1 amount of transcript from the mutant allele (nonsense-mediated mRNA decay).
2 that hERG nonsense mutations are subject to nonsense-mediated mRNA decay.
3 means of an RNA surveillance pathway called nonsense-mediated mRNA decay.
4 or penultimate exon, suggesting escape from nonsense-mediated mRNA decay.
5 odon and, thus, mutant mRNAs were subject to nonsense-mediated mRNA decay.
6 suppressor, and NMD2, which is essential for nonsense-mediated mRNA decay.
7 retention of lipogenic genes, which triggers nonsense-mediated mRNA decay.
8 pt levels, suggesting variable efficiency of nonsense-mediated mRNA decay.
9 All three mutations lead to nonsense-mediated mRNA decay.
10 n mRNA export, cytoplasmic localization, and nonsense-mediated mRNA decay.
11 provides a direct link between splicing and nonsense-mediated mRNA decay.
12 ure stop codon were unstable, as a result of nonsense-mediated mRNA decay.
13 from the mutant allele, as a consequence of nonsense-mediated mRNA decay.
14 delA was also shown to reduce mRNA level via nonsense-mediated mRNA decay.
15 ct and that this interaction is required for nonsense-mediated mRNA decay.
16 mulate translation initiation and to inhibit nonsense-mediated mRNA decay.
17 sidered sterile and innocuous as a result of nonsense-mediated mRNA decay.
18 ode a functional protein but was degraded by nonsense-mediated mRNA decay.
19 TD due to the nonsense mutation, indicating nonsense-mediated mRNA decay.
20 ing to premature translation termination and nonsense-mediated mRNA decay.
21 mily also resulted in protein truncation and nonsense-mediated mRNA decay.
22 timulation, and abrogates the enhancement of nonsense-mediated mRNA decay.
23 ptional events, translational initiation and nonsense-mediated mRNA decay.
24 idly by a proteasomal pathway rather than by nonsense-mediated mRNA decay.
25 te exon derived from 5S rRNA is coupled with nonsense-mediated mRNA decay.
26 B7 mRNAs harboring r.796c>u were degraded by nonsense-mediated mRNA decay.
27 elineated in the initiation factor eIF4G, in Nonsense-mediated mRNA decay 2 protein (NMD2/UPF2), in t
28 tidine-rich region of Upf1p that have normal nonsense-mediated mRNA decay activities but are able to
29 hese results, the role of the Upf complex in nonsense-mediated mRNA decay and nonsense suppression is
30 to the pre-mRNA, which has implications for nonsense-mediated mRNA decay and other mRNA transactions
32 a unifying model in which Dbp2p affects both nonsense-mediated mRNA decay and rRNA processing by alte
33 e implies that the mutant message can escape nonsense-mediated mRNA decay and that a truncated RP1 pr
34 families 3 and 4 are predicted to result in nonsense-mediated mRNA decay and the absence of WNT1.
35 n occur at low or undetectable levels due to nonsense-mediated mRNA decay, and (iii) the levels of th
36 in a downstream premature termination codon, nonsense-mediated mRNA decay, and abrogation of type XVI
37 o the premature termination codon, countered nonsense-mediated mRNA decay, and allowed protein produc
38 e half-life of TAP-1 mRNA is not mediated by nonsense-mediated mRNA decay because deletions of two ad
39 gly, the 151insG mutation does not result in nonsense-mediated mRNA decay due to rescue of the transc
40 epends on translation and recruitment of the nonsense-mediated mRNA decay factor Upf1 to the ARF1 3'-
41 has been completed but is unable to promote nonsense-mediated mRNA decay if it is situated 5' of a t
42 NA decay, suggesting that amlexanox inhibits nonsense-mediated mRNA decay in cells from patients with
44 al-time PCR, we first evaluated AI caused by nonsense-mediated mRNA decay in patients with frameshift
46 from Upf1p and SMG-2, which are required for nonsense-mediated mRNA decay in yeast and Caenorhabditis
49 that the degradation of hERG mutant mRNA by nonsense-mediated mRNA decay is an important mechanism i
50 ination codon-containing mRNA transcripts by nonsense-mediated mRNA decay is increasingly recognized
52 an RNA helicase that plays a central role in nonsense-mediated mRNA decay, is conformationally conver
53 human C(87)G-mutated transcripts bypass the nonsense-mediated mRNA decay machinery, suggesting the A
55 ranscript is unstable, presumably because of nonsense-mediated mRNA decay, neither of the aberrant tr
56 potentially targeted for degradation by the nonsense mediated mRNA decay (NMD) surveillance machiner
58 s a DNA/RNA helicase with essential roles in nonsense-mediated mRNA decay (NMD) and embryonic develop
61 reconstitute Upf1 function in both promoting nonsense-mediated mRNA decay (NMD) and preventing nonsen
62 ion complex core protein Y14 is required for nonsense-mediated mRNA decay (NMD) and promotes translat
63 mRNA is a naturally occurring mRNA target of nonsense-mediated mRNA decay (NMD) and that the binding
65 ed intra-axonal protein synthesis coupled to nonsense-mediated mRNA decay (NMD) controls a switch in
71 ng and RNAi, we showed that depletion of the nonsense-mediated mRNA decay (NMD) factor SMG7 or UPF1 s
72 otypes of prt1-1 cells and those lacking the nonsense-mediated mRNA decay (NMD) factor Upf1p led us t
73 '-to-3' exoribonuclease Xrn1p, and the three nonsense-mediated mRNA decay (NMD) factors, Upf1p, Nmd2p
78 e assessed the role of factors essential for nonsense-mediated mRNA decay (NMD) in nonsense-mediated
79 terplay of splicing repression by hnRNPC and nonsense-mediated mRNA decay (NMD) in the quality contro
100 emature termination codon (PTC) mutations by nonsense-mediated mRNA decay (NMD) is an important mecha
106 ted to the last intron of target loci due to nonsense-mediated mRNA decay (NMD) making them unsuitabl
108 sitide-3 kinase (PI3K) involved in mediating nonsense-mediated mRNA decay (NMD) of transcripts contai
110 s cerevisiae cells lacking components of the nonsense-mediated mRNA decay (NMD) pathway (Upf1,Upf2, o
125 -amino-acid protein that is required for the nonsense-mediated mRNA decay (NMD) pathway, a pathway th
127 productive rearrangements are cleared by the nonsense-mediated mRNA decay (NMD) pathway, the process
139 ytoplasmic localization of the mRNA, and the nonsense-mediated mRNA decay (NMD) surveillance process.
141 on gene location and resulting efficiency of nonsense-mediated mRNA decay (NMD) to eliminate potentia
143 degraded by the surveillance pathway called nonsense-mediated mRNA decay (NMD) when the selenocystei
144 f2, and Upf3 are the principal regulators of nonsense-mediated mRNA decay (NMD), a cytoplasmic survei
145 nds of transcripts, in some cases triggering nonsense-mediated mRNA decay (NMD), a highly conserved R
146 deposited on spliced mRNAs and functions in nonsense-mediated mRNA decay (NMD), a surveillance mecha
147 These transcripts are apparent targets of nonsense-mediated mRNA decay (NMD), a surveillance mecha
149 alternative mRNA isoforms are candidates for nonsense-mediated mRNA decay (NMD), an mRNA surveillance
150 ominantly in the cytoplasm and is subject to nonsense-mediated mRNA decay (NMD), and the mature mRNA
151 s selection in vivo is an indirect result of nonsense-mediated mRNA decay (NMD), as conditions that e
152 fth of cases, one isoform appears subject to nonsense-mediated mRNA decay (NMD), supporting the idea
155 ore likely, trigger mRNA degradation through nonsense-mediated mRNA decay (NMD), thus preventing or r
156 ther RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both
159 ufen 1 (STAU1)-mediated mRNA decay (SMD) and nonsense-mediated mRNA decay (NMD), which we show here a
179 all eukaryotes tested, a phenomenon termed "nonsense-mediated mRNA decay" (NMD) or "mRNA surveillanc
180 wild-type counterparts, a phenomenon termed "nonsense-mediated mRNA decay" (NMD) or "mRNA surveillanc
183 verview of three quality control mechanisms--nonsense-mediated mRNA decay, nonstop mRNA decay, and no
186 frameshift mutations to exon 11 resulted in nonsense-mediated mRNA decay of full-length, but not the
187 anslation and turnover and the dependence of nonsense-mediated mRNA decay on the activity of the UPF1
188 d cells is not related to the suppression of nonsense-mediated mRNA decay or to the inhibition of TNF
189 mutant mRNA was either degraded partially by nonsense-mediated mRNA decay or translated to a stable,
190 significant mRNA destabilization through the nonsense mediated mRNA decay pathway (NMD), and genetic
195 lso been linked to mRNA decay, including the nonsense-mediated mRNA decay pathway, and to nucleocytop
196 ic transport of spliced mRNA, as well as the nonsense-mediated mRNA decay pathway, are discussed.
197 One clear example of this linkage is the nonsense-mediated mRNA decay pathway, in which nonsense
198 In one model, Naxos plakoglobin bypassed the nonsense-mediated mRNA decay pathway, resulting in norma
212 ns cause a decrease in mutant mRNA levels by nonsense-mediated mRNA decay rather than production of t
213 y tune gene expression through coupling with nonsense-mediated mRNA decay, rather than encode differe
214 te of decay of nonsense mutant mRNAs, called nonsense-mediated mRNA decay, requires three proteins, U
215 utations that are expected to be degraded by nonsense-mediated mRNA decay, resulting in haploinsuffic
216 on of UPF-1, an RNA helicase associated with nonsense-mediated mRNA decay, suggesting that amlexanox
217 codon, yet the K8beta mRNA is insensitive to nonsense-mediated mRNA decay, suggesting that the trunca
219 le deletions of UPF1, NMD2, and UPF3 inhibit nonsense-mediated mRNA decay to the same extent; and an
220 In addition, a yeast strain deficient in nonsense-mediated mRNA decay was generated to prevent ra
221 a premature termination codon that triggers nonsense-mediated mRNA decay when included in the transc
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