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1 in enhanced affinity modestly and presumably nonspecifically.
2 of the ring-forming group bind to the motor nonspecifically.
3 ity that Toxoplasma may disrupt all of these nonspecifically.
4 dency to attract fluorescently labeled bases nonspecifically.
5 lly at AT-rich sites; the remainder bind DNA nonspecifically.
6 pansion of polyclonal autoreactive responses nonspecifically.
7 t to the Dnmt3b PWWP domain, which binds DNA nonspecifically.
8 is achieved after DNA binding, which occurs nonspecifically.
9 their ability to bind to double-stranded DNA nonspecifically.
10 e of DES while PC-SPES affects this promoter nonspecifically.
11 e-specific manner and two others that cleave nonspecifically.
12 p" structure that binds to substrate helices nonspecifically.
13 analog and thereby increase binding affinity nonspecifically.
14 f heparin, suggesting that it bound the bait nonspecifically.
15 4 and PSD-95 were disrupted, Kv1.4 localized nonspecifically.
16 ecific antibodies to bind cellular membranes nonspecifically.
17 affinity ( approximately 7.5-50 nM) although nonspecifically.
18 Our results indicate that DGCR8 binds RNA nonspecifically.
19 for an intercalating compound that binds RNA nonspecifically.
20 eption is due to loss of the circadian clock nonspecifically.
21 methylase fusion protein appears to nick DNA nonspecifically.
23 recognize a specific DNA sequence and cleave nonspecifically a short distance away from that sequence
24 gnize a specific DNA sequence and cleave DNA nonspecifically a short distance away from that sequence
25 s shows that HiPIP tends to associate rather nonspecifically about a conserved, relatively hydrophobi
26 t shutoff gene (vhs) encodes a protein which nonspecifically accelerates the degradation of mRNA mole
27 rements indicate that LPS interacts with Skp nonspecifically, accompanied by destabilization of the S
29 tivation, as existing stimulation techniques nonspecifically activate/inhibit all cell types (neurons
32 I:C)-induced protective effect, since siRNAs nonspecifically activated the DCs, inducing the appearan
34 ammaHV68 elicits virus-specific Ab, and also nonspecifically activates B cells to Ab production throu
36 ve, specifically active against bacteria, or nonspecifically active against bacteria and eukaryotic c
37 threshold ratio of DOPE:DOPC = 4:1, and the nonspecifically active AMO requires a drastically lower
40 ogical fluids is challenging as biomolecules nonspecifically adsorb on the electrode surface and adve
41 these results suggest that the nanoparticles nonspecifically adsorb polymerase, thus effectively redu
42 d with a solution of short thiols to release nonspecifically adsorbed DNA before hybridization with c
43 xplanation of this fact is that proteins are nonspecifically adsorbed on DNA, and sliding along DNA p
44 To validate the technique, crude serum was nonspecifically adsorbed on four self-assembled monolaye
45 nd endocytosis of a virus particle initially nonspecifically adsorbed on the host cell membrane are c
48 introduced for binding, and the membrane and nonspecifically adsorbed proteins on the membrane were s
54 demonstrated that only four transcripts were nonspecifically affected by RNAi, whereas approximately
55 een put forward suggesting that Cyt1A rather nonspecifically aggregates on the membrane surface and a
56 sence of negatively charged DNA or RNA could nonspecifically aid in association of these proteins.
57 ds us to propose that MutS: (i) binds to DNA nonspecifically and bends it in search of a mismatch; (i
60 IE62 is capable of associating with DNA both nonspecifically and in a sequence-specific manner via a
61 rs showed that BAF binds double-stranded DNA nonspecifically and is a host component of preintegratio
62 ue indicating that these clusters are formed nonspecifically and that any differences in ion detectio
63 o found that purified UBR1 and CUP9 interact nonspecifically and that specific binding (which involve
64 t the N-terminal domain of SF3b155 binds RNA nonspecifically and that the sites for U2AF65 binding an
65 chanism in which maternal IgG is pinocytosed nonspecifically and then carried to fetal tissues by a p
66 the complex first binds to a dsDNA molecule nonspecifically and then linearly diffuses, or slides, a
67 desmata permit solutes to move between cells nonspecifically and without having to cross a membrane.
68 d short double-stranded DNA oligonucleotides nonspecifically, and a deletion mutant affecting the N-t
69 d by influenza A and B viruses often present nonspecifically, and a rapid, high-throughput laboratory
70 ents, classified numerous compounds that act nonspecifically, and identified compounds that cause cel
71 tivity depends on the ability to bind to DNA nonspecifically, and in its absence, T antigen is unable
72 -dependent public goods that act broadly and nonspecifically, and whose need cannot always be accurat
73 present in the extracellular medium that may nonspecifically associate with virions, we also analyzed
75 t can be specifically primed by trypsin, and nonspecifically associated VP4 that is degraded by tryps
76 l molecule aggregates, which inhibit enzymes nonspecifically at micromolar concentrations in aqueous
78 ing site and were inactive in vivo bound Rev nonspecifically at these concentrations, the real stoich
79 crossbridges from a state in which they are nonspecifically attached to actin to one in which stereo
81 d domains such as p53 TAD bind their targets nonspecifically before folding to a tightly associated c
82 r the two forms, suggesting cationic GrB may nonspecifically bind cytosolic proteins, leading to redu
84 that are ubiquitous in eukaryotic cells and nonspecifically bind to DNA, inducing large-angle DNA be
89 mon resonance analysis show that PKCalpha-C2 nonspecifically binds phosphoinositides, including PtdIn
92 mor, together with fast renal elimination of nonspecifically bound activity, resulted in specific ima
94 degrees C was reduced by the amount that was nonspecifically bound at 4 degrees C to yield the amount
96 ood with enrichment factors (specifically vs nonspecifically bound cells) of up to about 3000 compare
97 assigned as a rapidly exchanging mixture of nonspecifically bound copies (fns) and copies undergoing
100 hat we measure by single-molecule imaging of nonspecifically bound fluorescently labeled LacI in livi
102 blocking effect but minimizing the amount of nonspecifically bound iron cations, supports this conclu
105 e amount of background signal arising due to nonspecifically bound probes and fluorescence that is in
107 a heterogeneous polymer, before exposing the nonspecifically bound protein to immobilized oligomeric
108 when the specificity ratio is low, multiple nonspecifically bound proteins may occupy the region of
111 populated (<1%), transient states involving nonspecifically bound Sox2 in rapid exchange with specif
112 was used to represent tracer in the free and nonspecifically bound state, and equilibrium receptor eq
114 c repressor spends approximately 90% of time nonspecifically bound to and diffusing along DNA with a
116 f the DNA-scanning process in which Egr-1 is nonspecifically bound to DNA and perpetually changes its
117 cribing mRNA and ribosomal RNA (rRNA), RNAPs nonspecifically bound to DNA, free RNAP, and immature RN
118 SEP-7 was used as a carrier to remove FM1-43 nonspecifically bound to the outer leaflet of the plasma
119 en the cyclo[n]pyrroles were intercalated or nonspecifically bound to the quadruplex, or if conformat
120 um between total tissue concentration (free, nonspecifically bound, and specifically bound) and the f
123 fic sites on DNA, via a mechanism in which a nonspecifically-bound protein can switch between two con
125 omplex ubiquitylates free histone substrates nonspecifically but is highly specific for histone H2A l
126 high levels of CD25 and LAG-3 when expanding nonspecifically, but FoxP3 after activation by the autoa
127 DbpA binds group I and group II intron RNAs nonspecifically, but its ATPase activity is activated sp
128 until recently thought to allow IgG movement nonspecifically by constitutive transcytosis in caveolae
133 t, that uses both the targeted reads and the nonspecifically captured off-target reads to infer copy
134 whenever their morphology or composition are nonspecifically changed without any surface treatment.
135 initiation of plus-strand DNA synthesis and nonspecifically cleaves the viral genome to facilitate s
136 This finding indicates that the RNA forms a nonspecifically collapsed intermediate and then searches
137 ith greater sensitivity and specificity than nonspecifically coupled fragments, and can detect extrem
139 polyclonal agents are most widely used; they nonspecifically deplete the T-cell pool and are thus ass
140 -directed therapy (rituximab, two patients), nonspecifically depleted T-cells and was associated with
142 ctrometry revealed that this enzyme pair can nonspecifically digest oligonucleotides and DNA into fra
145 ns are scavenger cells that continuously and nonspecifically endocytose fluid from the pseudocoelom (
149 specifically within the IL-1 family but also nonspecifically for TLR ligands and the innate immune re
150 he trilobite neuron phenotype does not arise nonspecifically from aberrant gastrulation-associated mo
152 e DBMC group, as well as a greater number of nonspecifically high reactors in the controls (P = 0.058
153 ere numerous permissive substitutions, which nonspecifically improved cooperativity and affinity of D
154 er cytosolic material, including organelles, nonspecifically in a process called nonselective macroau
155 om a multicopy plasmid, HetR-GFP accumulated nonspecifically in all cells under nitrogen-replete cond
157 ion of the high affinity binding sites found nonspecifically in conventional microtiter well assays.
160 e other hand, haloduracin beta was localized nonspecifically in the absence of haloduracin alpha, but
163 that the gp3 ring binds double-stranded DNA nonspecifically in vitro via electrostatic interactions
165 strate that both viral and cellular RNAs are nonspecifically incorporated into HCMV, potentially thro
167 lished approach to prevent or treat PVAN but nonspecifically increasing host immune competence also a
168 valent salts, which stabilize the folded RNA nonspecifically, induce states that fold in less than 30
169 tic model revealed that most genetic factors nonspecifically influence risk for either all 11 symptom
171 ignaling, indicating that Stat3beta does not nonspecifically inhibit other signaling pathways or Src
172 ents, suggesting that staurosporine does not nonspecifically inhibit protein transport to the endocyt
173 -responsive gene, with tungstate or vanadate nonspecifically inhibited NaPi-2b mRNA expression and Pi
174 measure, geminivirus proteins reverse TGS by nonspecifically inhibiting cellular transmethylation rea
175 portantly, this effect was not reproduced by nonspecifically inhibiting mPFC neurons in VPA-exposed m
181 selenomethionine, and these are incorporated nonspecifically into proteins in place of cysteine and m
182 traditionally seen as proteins packaging RNA nonspecifically into ribonucleoprotein particles (RNPs),
183 ibute to the early innate immune response by nonspecifically killing pathogens, virus-infected cells,
185 wn on macrophages as "garbage men" that act "nonspecifically." Last fall's Nobel Prizes honored two o
186 e groups: (I) four genes were down-regulated nonspecifically, likely involving both parental ortholog
187 ys showed a trend toward a greater number of nonspecifically low reactors in the DBMC group, as well
188 or in the absence of a wild-type marbox, Fis nonspecifically lowered the activity of the mar promoter
189 ectively, the data indicate the Vsa proteins nonspecifically mediate M. pulmonis surface interactions
192 ches and DNA ligase to reseal incorrectly or nonspecifically nicked sites was previously developed in
193 hat K(+) ions bind transiently (</=5 ns) and nonspecifically (nine different positions) to the two tr
194 ipid compositions tested, SNARE-mediated and nonspecifically nucleated pores had similar openness, su
196 ubstantial quantities of VP22 and UL11 bound nonspecifically onto or were precipitated with gE and gD
197 , autophagy can degrade cytoplasmic contents nonspecifically or can target the degradation of specifi
198 ile favoring growth arrest and apoptosis for nonspecifically or inappropriately activated B cells.
199 hown to significantly decrease the amount of nonspecifically or noncovalently bound probe, creating b
200 th submillimolar affinity to BSA, but either nonspecifically or with considerably lower affinity to m
201 observation that retroviral particles adhere nonspecifically, or 'hitchhike,' to the surface of T cel
202 obtained after 12 days of incubation, killed nonspecifically pig, human, and mouse normal and maligna
203 nto homomultimers, binds single-stranded RNA nonspecifically, possesses a Mg2+-dependent nucleoside t
204 cule, other ions bind to the protein surface nonspecifically, presumably because the electrostatic at
206 ce, in combination with CD8 T cells that can nonspecifically produce IFN-gamma, leads to transient co
207 nce of TCR ligation, the pathogen is able to nonspecifically promote Th1 responses against nonparasit
209 eociliary ankle links or pillar cells, which nonspecifically react with two antisera raised against T
210 ng various potential interfering substances, nonspecifically reacting substances (including mRNA from
213 er cell cultures with DNase I to degrade DNA nonspecifically reduced metastatic characters associated
215 ensitivity to vancomycin and SDS but did not nonspecifically release periplasmic proteins or VirE2 tr
217 e possibility that the Hsp70.1/70.3 mice are nonspecifically sensitized to all protein misfolding dis
218 nd transcriptome sequencing (RNA-Seq), which nonspecifically sequences all RNA, including host and ba
219 half of S phase, to ask whether all origins nonspecifically show decreased firing (as expected for d
220 ssible inorganic arsenic associated with (1) nonspecifically sorbed phases, (2) specifically sorbed p
221 us, certain fluorophore-containing compounds nonspecifically stain degenerating neuronal tissue in hi
223 egulated in allogeneic T cells compared with nonspecifically stimulated T cells were validated in vit
224 hanism by which an HIV-specific response can nonspecifically suppress both HIV-specific and unrelated
225 cult because existing stimulation techniques nonspecifically target all cell types near the stimulate
226 , which targets the human telomeric sequence nonspecifically, the platinum-intercalator technology ha
227 heir target sequence by first binding to DNA nonspecifically, then by linearly diffusing or hopping a
228 egulate synaptic weights homeostatically and nonspecifically, thereby improving the signal:noise rati
229 the acyl chains of lipid antigens relatively nonspecifically, thereby positioning the hydrophilic com
230 ntly in the on-state; when these bind to DNA nonspecifically, they form clusters that grow indefinite
231 nuclei (MITN) were long believed to project "nonspecifically," they are now known from rat studies to
233 that mast cells influence T-cell activation nonspecifically through the release of inflammatory medi
234 es not activate arrestin, but acts, probably nonspecifically, through some other part of the transduc
235 othesis that magnesium ions bind loosely and nonspecifically to actin filaments, and thus show a beha
237 xpress HA-specific Abs, but it does not bind nonspecifically to B cells, and this mutation has no eff
239 projections from midbrain DA neurons target nonspecifically to both the dorsolateral striatum and th
240 ior through sex-specific transcripts and sex-nonspecifically to control the development of imaginal d
241 monoclonal antibodies of the IgM class bind nonspecifically to CSA-selected iRBC, an important consi
243 py suppressor for dnaJ mutations and to bind nonspecifically to DNA and preferentially to curved DNA.
244 e DNA-ACTD interaction; ACTD initially binds nonspecifically to DNA but exerts its activity by dissoc
246 phase in a sigma(S)-dependent fashion, bind nonspecifically to DNA, and form a crystalline structure
248 , both with and without thioredoxin, binding nonspecifically to double-stranded DNA and diffusing alo
250 minal protein fragment (residues 1-70) binds nonspecifically to DRE in a Ca(2+)-independent manner, w
251 ed that Escherichia coli HU(alphabeta) binds nonspecifically to duplex DNA in three different binding
253 a primer-template configuration rather than nonspecifically to either ssDNA or dsDNA, and (ii) UL42
255 ostulates that anesthetics and alcohols bind nonspecifically to interfacial areas of proteins and rev
257 tribute to RNA-chaperone activity by binding nonspecifically to large RNA substrates and flexibly tet
261 , UL11, and VP16 are highly prone to binding nonspecifically to other proteins, and this did not repr
262 show that if ParB complexes bind weakly and nonspecifically to ParA filaments, then they can closely
264 rs have shown that basic residues in NC bind nonspecifically to RNA, which in turn scaffolds or nucle
265 gp120s from CXCR4-using HIV-1 strains bound nonspecifically to several cell lines lacking human CXCR
269 g inverted repeat sequences (i.e., IR-1) and nonspecifically to single-stranded DNA, and related gene
271 remarkable ability to adhere tenaciously and nonspecifically to solid surfaces such as glass, plastic
273 ion of IN in which viral DNA initially binds nonspecifically to the C-terminal portion of IN but the
274 Interference from matrix components adhering nonspecifically to the column was minimized by the inser
276 serum components, that otherwise would bind nonspecifically to the HPIAC column, but allowed the flu
279 ns ruled out variables that might contribute nonspecifically to this result such as differences in ac
280 ductase DsbA, a soluble periplasmic protein, nonspecifically transfers a disulfide to a substrate pro
281 ally, irregularly shaped sickle cells become nonspecifically trapped, resulting in vaso-occlusion.
282 dicate that yRad6 has an in vitro ability to nonspecifically ubiquitylate all core histones in the ab
283 mer bridges and compacts double-stranded DNA nonspecifically via two symmetry-related DNA binding sit
285 e C1a domain, most notably Arg(77), interact nonspecifically with anionic phospholipids prior to the
286 anding how gene regulatory proteins interact nonspecifically with DNA in terms of both structure and
287 y in which the chaperone initially interacts nonspecifically with hydrophobic regions of the partiall
289 binding domain of the LacI protein interacts nonspecifically with nonoperator DNA adjacent to the ope
295 e membrane which had been covalently labeled nonspecifically with the hapten p-diazoniumphenyl-beta-D
296 on the tentacles themselves likely interact nonspecifically with the substrate's transmembrane helic
298 ly (with high affinity) to A2RE sequences or nonspecifically (with lower affinity) to other RNA seque
299 that the cytoplasm interacts favorably, but nonspecifically, with CI2, and these interactions overco
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