ライフサイエンスコーパス: nonstructural

1 n vitro autoprocessing of an N-terminal SHFV nonstructural 1a polypeptide fragment showed that each o

2 Here, we identified the RSV-encoded nonstructural 2 (NS2) protein as a viral genetic determi

3 rotective efficacy of an attenuated WNV, the nonstructural 4B-P38G mutant, which was previously shown

4 The viruses contain an exceptionally long nonstructural 5A (NS5A) gene, approximately half of whic

5 the function of the hepatitis C virus (HCV) nonstructural 5A (NS5A) protein have been identified by

6 The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is highly phosphorylated

7 s a lipid kinase that interacts with the HCV nonstructural 5A protein (NS5A) and enriches the HCV rep

8 The viral nonstructural 5A protein (NS5A) is the target for new an

9 HCV nonstructural 5B (NS5B) amplicons (n = 94) were generate

10 or BMS-986094, an HCV nucleotide polymerase (nonstructural 5B) inhibitor.

11 PB1-F2 is a nonstructural accessory protein of Influenza A virus des

12 Previously, an HBoV1 nonstructural and capsid protein-expressing plasmid, pHB

13 erated HCV-specific T cell responses against nonstructural and structural HCV sequences 6-10 weeks af

14 synthesis (A), stomatal conductance (gs) and nonstructural carbohydrate (NSC) content were analyzed t

15 as measured, and leaf nitrogen (N) and total nonstructural carbohydrate (TNC) concentrations were det

16 , specific leaf weight (SLW), and leaf total nonstructural carbohydrate concentration (TNC) were decr

17 with xylem water tension and positively with nonstructural carbohydrate concentrations.

18 tic architecture of rice (Oryza sativa) stem nonstructural carbohydrates (NSC) at two critical develo

19 verage leaf mass per unit area (LMA), water, nonstructural carbohydrates (NSCs) and polyphenols with

20 raulic conductivity (PLC) and the content of nonstructural carbohydrates (NSCs) of distal branches in

21 hlorophyll, and carbon allocation (including nonstructural carbohydrates) are most strongly correlate

22 reater quantities of more labile components: nonstructural carbohydrates, cellulose and soluble pheno

23 While trees store substantial amounts of nonstructural carbon (NSC) for later use, storage regula

24 We know surprisingly little about whole-tree nonstructural carbon (NSC; primarily sugars and starch)

25 The nonstructural compartment of the ECM houses a variety of

26 CW3) strains to identify a domain within the nonstructural gene NS1/2 that is necessary and sufficien

27 d to EV-A in capsid genes and to EV-B in the nonstructural gene region.

28 yprotein highlighted recombinant hotspots in nonstructural genes and at gene boundaries.

29 ipah, chikungunya, and influenza viruses and nonstructural genes from Semliki Forest virus.

30 egion and that recombination hotspots map to nonstructural genes with in-frame duplications at gene b

31 creening each of the six VHSV structural and nonstructural genes, we identified matrix protein (M) as

32 nome, present within both the structural and nonstructural genes.

33 uctural protein 1 (NS1) is a unique secreted nonstructural glycoprotein.

34 nuclear antigen, HBV-encoded X antigen, and nonstructural HCV protein 5A are all involved in the reg

35 We demonstrate that individual nonstructural HRV16 proteins, when expressed in HeLa cel

36 Influenza virus NS1 protein is a nonstructural, multifunctional protein that counteracts

37 functionally distinct domains: a disordered nonstructural N-terminal domain (amino acids [aa] 1 to 1

38 West Nile virus (WNV) nonstructural (NS) 4B-P38G mutant has several features f

39 Recent work showed that an attenuated WNV, a nonstructural (NS) 4B-P38G mutant, induced no lethality

40 ed West Nile virus (WNV) vaccine strain, the nonstructural (NS) 4B-P38G mutant.

41 the efficacy and safety of therapy with the nonstructural (NS) 5A inhibitor, ledipasvir, combined wi

42 The nonstructural (NS) gene of influenza A virus encodes an

43 The nonstructural (NS) gene of influenza virus encodes both

44 T cell receptors (TCRs) recognizing the HCV nonstructural (NS) NS3 or NS5 viral peptide target were

45 eading frame 2 (ORF2) and a second duplicate nonstructural (NS) polyprotein from ORF1.

46 RC) formation, where it interacts with viral nonstructural (NS) proteins and inhibits viral RNA repli

47 ral vectors encoding hepatitis C virus (HCV) nonstructural (NS) proteins induce multispecific, high-m

48 ng a role in facilitating the integration of nonstructural (NS) proteins into viral membrane-associat

49 tease activity is required to generate viral nonstructural (NS) proteins involved in RNA replication.

50 y, whereas broad responses to structural and nonstructural (NS) proteins were observed after monovale

51 posed donors were mostly CD8(+) and targeted nonstructural (NS) proteins, whereas IFN-gamma responses

52 dual horses with a simultaneous emergence of nonstructural (NS)3-specific Abs and transient elevation

53 ribavirin, with or without inhibition of the nonstructural (NS)3/4A protease, on intrahepatic immunit

54 tivirals (DAAs) targeted epitopes in the E2, nonstructural (NS)5a, and NS5b proteins.

55 2.0 Assay (Innogenetics, Ghent, Belgium) and nonstructural (NS)5B sequencing.

56 Alere, including the SD Bioline Dengue Duo (nonstructural [NS] 1 Ag and IgG/IgM), the Panbio Dengue

57 hat TDV elicits CD8(+) T cells targeting the nonstructural NS1, NS3, and NS5 proteins of TDV-2.

58 were focused predominantly on the capsid and nonstructural NS3 and NS5 antigens.

59 The nonstructural NS5 proteins of several flaviviruses antag

60 The hepatitis C virus nonstructural NS5A protein has roles in genome replicati

61 These findings identify a novel function of nonstructural NSs in SFTSV-infected cells where it is a

62 ene (green fluorescent protein) or the viral nonstructural NSs protein.

63 of the assembly-activating protein (AAP), a nonstructural, nucleolar-localizing AAV protein essentia

64 genome encodes a partly conserved 40-residue nonstructural polypeptide, called the delta peptide, tha

65 ion of simian hemorrhagic fever virus (SHFV) nonstructural polyprotein 1a is predicted to encode thre

66 Proteolytic processing of the viral nonstructural polyprotein is required for norovirus repl

67 These findings provide a link between nonstructural polyprotein processing and the virulence o

68 (S4 subsite residue of nsP2 protease) in the nonstructural polyprotein.

69 Rac1 inhibitor and is regulated by a dynamic nonstructural pool of F-actin.

70 cross-reactive Abs, which can recognize DENV nonstructural protein (NS) 1, have been found in dengue

71 in cell culture identified a mutation in HCV nonstructural protein (NS) 4B conferring partial resista

72 were stratified by their cirrhosis and past nonstructural protein (NS) 5A inhibitor exposure.

73 Here, we show that the HCV protein, nonstructural protein (NS) 5B, directly binds to the tum

74 ing plasmid, pHBoV1NSCap, that harbors HBoV1 nonstructural protein (NS) and capsid protein (Cap) gene

75 y and safety of a combination regimen of the nonstructural protein (NS)5A inhibitor ledipasvir (LDV),

76 CypA binds to HCV's nonstructural protein (NS)5A to promote replication of v

77 Nonstructural protein (NS)5B inhibitors sofosbuvir, meri

78 nor sites, namely, A1' and D1', in the large nonstructural protein (NS1)-encoding region of the HBoV1

79 hipathic peptide resembling a segment of the nonstructural protein (NS5A) of the hepatitis C virus.

80 genic, involving at least one gene from both nonstructural protein (nsP) and structural protein (sP)

81 by a replicase-transcriptase composed of 16 nonstructural protein (nsp) subunits.

82 iruses, it has been well documented that the nonstructural protein (NSs) enables the virus to counter

83 V (rHB29NSsKO) that cannot express the viral nonstructural protein (NSs) upon infection of cells in c

84 Of note, unlike the large nonstructural protein (Rep78/68 or NS1) of other parvovi

85 e of an RDT that detects dengue virus (DENV) nonstructural protein 1 (NS1) and anti-DENV IgM during s

86 y spliced to express two viral proteins, the nonstructural protein 1 (NS1) and the nuclear export pro

87 rbent assays (ELISAs), for detection of DENV nonstructural protein 1 (NS1) antigen and anti-DENV IgM.

88 ctivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to Z

89 The flavivirus nonstructural protein 1 (NS1) functions in genome replic

90 DENV nonstructural protein 1 (NS1) has long been considered a

91 Antibodies directed against the flavivirus nonstructural protein 1 (NS1) have been proposed as sero

92 The Flavivirus nonstructural protein 1 (NS1) is a conserved, membrane-a

93 Flavivirus nonstructural protein 1 (NS1) is a unique secreted nonst

94 Influenza A virus (IAV) nonstructural protein 1 (NS1) is a virulence factor esse

95 The viral nonstructural protein 1 (NS1) is essential in this proce

96 The multifunctional nonstructural protein 1 (NS1) is the main viral factor c

97 Interestingly, nonstructural protein 1 (NS1) of RSV promoted proteasome

98 In this study, we demonstrated that the nonstructural protein 1 (NS1) of WNV antagonizes IFN-bet

99 This study demonstrated that the nonstructural protein 1 (NS1) of WNV antagonizes the ind

100 ZIKV nonstructural protein 1 (NS1) plays an essential role in

101 Nonstructural protein 1 (NS1) proteins from avian influe

102 notransferase (AST) level, positivity in the nonstructural protein 1 (NS1) rapid test, and viremia ma

103 rbent assays (ELISAs) based on ZIKV and DENV nonstructural protein 1 (NS1) were established to test a

104 Antibodies to nonstructural protein 1 (NS1) were largely ZIKV-specific

105 of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1) which are cross-reactive w

106 2), PB1, PB1-F2, Polymerase Acidic-X (PA-X), Nonstructural Protein 1 (NS1), and Nuclear Export Protei

107 uenza virus encodes both the multifunctional nonstructural protein 1 (NS1), essential for innate immu

108 We previously generated a ZIKV nonstructural protein 1 (NS1)-specific human monoclonal

109 tudy, we applied a previously developed anti-nonstructural protein 1 (NS1)-specific MAC-ELISA (NS1-MA

110 antibodies for rapid detection of the dengue nonstructural protein 1 (NS1).

111 ied M segment and the open reading frames of nonstructural protein 1 (NS1)/nuclear export protein (NE

112 toantibodies elicited by dengue virus (DENV) nonstructural protein 1 (NS1; anti-NS1 Igs) induce plasm

113 viously, we reported that replacement of the nonstructural protein 1 (nsP1) gene of the mouse-virulen

114 The nonstructural protein 1 (nsp1) of CoVs is one such prote

115 Similar to the nonstructural protein 1 (nsp1) of SARS-CoV that inhibits

116 oV genome: the papain-like protease (PLPro), nonstructural protein 1 (nsp1), ORF6, and ORF7a.

117 (SARS-CoV), establish host shutoff via their nonstructural protein 1 (nsp1).

118 c 5' untranslated region and 186 nt from the nonstructural protein 1 [nsp1]-coding region) not found

119 during different stages of infection (viral nonstructural protein 1 and immunoglobulin M) has greatl

120 odes were determined to be VCD by means of a nonstructural protein 1 antigen immunoassay and reverse-

121 virus autoregulation by targeting the virus nonstructural protein 1 gene.

122 Moreover, rotavirus NSP1 (nonstructural protein 1) employs a pLxIS motif to target

123 dance proteins like the matrix protein 2 and nonstructural protein 1, with a similar impurity level o

124 CoV nonstructural protein 14 (nsp14) encodes 3'-to-5' exorib

125 The coronavirus (CoV) nonstructural protein 14 (nsp14) is a multifunctional pr

126 in encoding a 3'-->5' exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is required f

127 CoVs encode a proofreading exonuclease in nonstructural protein 14 (nsp14-ExoN), which confers a g

128 Here we report that coronavirus nonstructural protein 15 (nsp15), an endoribonuclease, i

129 ctive and respiratory syndrome virus (PRRSV) nonstructural protein 1beta (nsp1beta) is a multifunctio

130 ne coronavirus (mouse hepatitis virus [MHV]) nonstructural protein 2 (ns2) is a 2',5'-phosphodiestera

131 The RSV nonstructural protein 2 (NS2) is a multifunctional prote

132 in of murine hepatitis virus as fusions with nonstructural protein 2 or 3 and whether such reporters

133 t protein and firefly luciferase with either nonstructural protein 2 or 3 is tolerated and that these

134 Flavivirus nonstructural protein 2B (NS2B) is a transmembrane prote

135 n an interaction between capsid proteins and nonstructural protein 2C(ATPase) In particular, residue

136 of capsid proteins with the multifunctional nonstructural protein 2C(ATPase) In this study, we have

137 fficient expression of a transframe protein [nonstructural protein 2TF (nsp2TF)] of porcine reproduct

138 ify groups of coevolving residues within HCV nonstructural protein 3 (NS3) by analyzing diverse seque

139 turally occurring polymorphism, Q80K, in the nonstructural protein 3 (NS3) gene encoding the viral pr

140 The viral nonstructural protein 3 (NS3) plays a key role in mediat

141 The capsid protein followed by nonstructural protein 3 (NS3), NS2A, and NS5 were the mo

142 licase contained in the C-terminal domain of nonstructural protein 3 (NS3).

143 V replication complex is a helicase known as nonstructural protein 3 (NS3).

144 was subsequently shown to recognize the HCV nonstructural protein 3 (NS3):1406-1415 epitope with hig

145 sion of the reporter protein in frame within nonstructural protein 3 (nsP3) or insertion of the repor

146 One determinant of alphavirus virulence is nonstructural protein 3 (nsP3) that contains a highly co

147 his phenotypic difference is associated with nonstructural protein 3 (nsP3).

148 ase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3).

149 ssential for viral replication and assembly (nonstructural protein 3 [NS3]).

150 Based upon nonstructural protein 3 sequence analysis, no compartmen

151 nent of the replicase-transcriptase complex, nonstructural protein 3, at a critical early stage of in

152 to strengthen interaction between RCHY1 and nonstructural protein 3, leading to a further increase i

153 ithin the Ubl domain, residues 785 to 787 of nonstructural protein 3, which negatively affect proteas

154 -like protease is encoded next to SUD within nonstructural protein 3.

155 5A inhibitor velpatasvir with or without the nonstructural protein 3/4A protease inhibitor voxilaprev

156 an inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A protease; MK-5172 is taken on

157 Nonstructural protein 3A of foot-and-mouth disease virus

158 Rotavirus (RV) nonstructural protein 4 (NSP4) is a virulence factor tha

159 Rotavirus nonstructural protein 4 (NSP4) is an endoplasmic reticul

160 PgV-2 E2 glycoprotein or bacterium-expressed nonstructural protein 4AB (NS4AB) in detecting past or p

161 Dengue virus nonstructural protein 4B (NS4B) is a membrane protein co

162 n of proline at amino acid 219 (P219) of the nonstructural protein 4B (NS4B) with serine, threonine o

163 cation via direct interaction with the viral nonstructural protein 4B (NS4B).

164 The large flavivirus nonstructural protein 5 (NS5) (105 kDa) has RNA methyltr

165 Nonstructural protein 5 (NS5) contains a methyltransfera

166 One RRV construct expressed nonstructural protein 5 (NS5), while a second recombinan

167 Further study showed that nonstructural protein 5 (nsp5) of PRRSV induced the STAT

168 unds inhibiting the interaction between DENV nonstructural protein 5 and host nuclear transport prote

169 Nonstructural protein 5 is essential for capping and rep

170 riments showed that ZIKV RNA replication and nonstructural protein 5 translation were reduced below t

171 etween PI(4,5)P2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the viral

172 Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and its interaction with

173 ary structure and long-range interactions in nonstructural protein 5A (NS5A) from hepatitis C virus (

174 tudy to assess whether adding daclatasvir, a nonstructural protein 5A (NS5A) inhibitor that is active

175 een treated with an HCV regimen containing a nonstructural protein 5A (NS5A) inhibitor; and * genotyp

176 s recommend that patients who have failed on nonstructural protein 5A (NS5A) inhibitors should be ret

177 Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a phosphoprotein that

178 Nonstructural protein 5A (NS5A) of hepatitis C virus (HC

179 Direct-acting antivirals that target nonstructural protein 5A (NS5A), such as daclatasvir, ha

180 All-oral therapy with daclatasvir (nonstructural protein 5A [NS5A] inhibitor), asunaprevir

181 ral protein 5B inhibitor sofosbuvir plus the nonstructural protein 5A inhibitor velpatasvir with or w

182 ombination of daclatasvir (DCV; pangenotypic nonstructural protein 5A inhibitor) and sofosbuvir (SOF;

183 containing regimens, particularly those with nonstructural protein 5A inhibitors, are limited and rem

184 rug that targets the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase and inhibits

185 gimens that included the nucleotide analogue nonstructural protein 5B inhibitor sofosbuvir plus the n

186 A inhibitor) and sofosbuvir (SOF; nucleotide nonstructural protein 5B inhibitor) for 12 weeks previou

187 all HCV DAAs and, in particular, not all HCV nonstructural protein 5B inhibitors may exhibit this car

188 vir, an oral nucleotide inhibitor of the HCV nonstructural protein 5B RNA-dependent RNA polymerase en

189 tis C viral genome is catalyzed by the NS5B (nonstructural protein 5B) RNA-dependent RNA polymerase,

190 Nonstructural protein 9 (Nsp9) is the RNA-dependent RNA

191 ssociated substitutions (RASs) in HCV genes (nonstructural protein [NS]3, NS5A, NS5B) targeted by DAA

192 ek regimen of daclatasvir (DCV; pangenotypic nonstructural protein [NS]5A inhibitor) plus sofosbuvir

193 First, we expressed each individual nonstructural protein and examined their cellular locali

194 y important TM dimer interface within an HCV nonstructural protein and reveal a fundamental role of t

195 Using monoclonal antibody fragments against nonstructural protein dengue NS1, an early biomarker for

196 ell populations specific for variants of the nonstructural protein epitope NS3133 that characterize t

197 ovides a unique example of how a small viral nonstructural protein facilitates the multifaceted regul

198 the genetic background of codon-deoptimized nonstructural protein genes and a deleted small hydropho

199 Among them, we proved that one nonstructural protein is critical to the replication of

200 The MRV nonstructural protein muNS comprises the structural matr

201 researchers have focused on visualizing the nonstructural protein muNS, which forms the VF matrix.

202 viruses as well as viruses with only p7 and nonstructural protein mutations.

203 Further analysis identified that the small nonstructural protein NP1 is required for HBoV1 DNA repl

204 In this study, we demonstrated that the nonstructural protein NP1 is required for the expression

205 The large viral nonstructural protein NS1 is sufficient to induce the DD

206 HCV nonstructural protein NS3/4A interacts with CHK2 and dow

207 In this study, we show that the BTV nonstructural protein NS4 favors viral replication in sh

208 this piperazinone chemotype targets the HCV nonstructural protein NS4B.

209 Here, we report that the nonstructural protein NS5 of ZIKV and other flaviviruses

210 otent viral inhibitor of this pathway is the nonstructural protein NS5.

211 ntified a novel cellular target of the viral nonstructural protein NS5A and demonstrated its role in

212 show here that phosphorylation of the viral nonstructural protein NS5A at serine residues is importa

213 es to elucidate host factors involved in HCV nonstructural protein NS5A function and found that MOBKL

214 helical (AH) domain of the hepatitis C virus nonstructural protein NS5A, anchored at the cytoplasmic

215 host response to HCV infection is the viral nonstructural protein NS5A, which, in addition to its ro

216 The nonstructural protein NSP4 of rotavirus is a multifuncti

217 We generated viruses lacking the nonstructural protein NSs and show that UUKV NSs is a we

218 ments through interactions between the viral nonstructural protein NSs and the host general transcrip

219 The nonstructural protein NSs is a major virulence factor kn

220 In this study, we report that the nonstructural protein NSs of the newly described severe

221 ed two recombinant viruses, one in which the nonstructural protein NSs open reading frame was deleted

222 Viral nonstructural protein NSs was inhibitory to the inductio

223 resulting from deletions or mutations in the nonstructural protein NSs.

224 In this study, we show that a nonstructural protein of BTV (NS4) is critical to counte

225 fers nuclear trafficking capabilities to the nonstructural protein of the virus and that lysine resid

226 t the Ebola virus delta peptide, a conserved nonstructural protein produced in large quantities by in

227 may be facilitated by association of the MRV nonstructural protein sigmaNS with the major SG effector

228 SH3-binding protein 1 (G3BP1), with the MRV nonstructural protein sigmaNS, which localizes to VFs vi

229 eproducibly detected low levels of the viral nonstructural protein, NS3.

230 l structural glycoproteins, Gn and Gc, and a nonstructural protein, NSm.

231 A virus-encoded nonstructural protein, termed NSs, is a major virulence

232 Here, we report that flavivirus nonstructural protein-1 (NS1), which is abundantly secre

233 Here we show that the point mutations in the nonstructural protein-coding region (P2, P3) that accumu

234 addition to NP1, MVC encodes five additional nonstructural proteins (NS) that share an initiation cod

235 However, we found that the other four nonstructural proteins (NS1 to -4) are not required for

236 NP1 and other viral nonstructural proteins (NS1 to NS4) colocalized within t

237 d complex networks of interactions involving nonstructural proteins (NSPs) 2, 5, and 6 and structural

238 y complex networks of interactions involving nonstructural proteins (NSPs) and structural proteins (V

239 Three viral nonstructural proteins (nsps), nsp3, nsp4, and nsp6, are

240 Coronaviruses encode 16 nonstructural proteins (nsps), three of which, nsp3, nsp

241 that is unusually complex and composed of 16 nonstructural proteins (nsps).

242 Our data are consistent with RSV nonstructural proteins 1 and/or 2 perturbing the Jak-STA

243 First, we confirmed the presence of HCV nonstructural proteins 3, 4b, and 5a besides HCV core an

244 rsal of the Golgi structure, and these three nonstructural proteins also inhibited protein secretion.

245 In HCV-infected cells, various HCV nonstructural proteins also interact or colocalize with

246 Viral nonstructural proteins are often important for virus rep

247 HCV nonstructural proteins are shown to colocalize with DDX3

248 proteomics led to the identification of HCV nonstructural proteins as well as proteins involved in m

249 Our data indicate that both structural and nonstructural proteins contribute to MHV liver pathogene

250 in of murine hepatitis virus as fusions with nonstructural proteins could define the expression and t

251 y of immunodominance among structural versus nonstructural proteins differs as a function of the infe

252 h genetic vaccines encoding the HCV NS3-NS5b nonstructural proteins during DAA treatment resulted in

253 studies have suggested that multifunctional nonstructural proteins encoded by flaviviruses antagoniz

254 e, little information is available about the nonstructural proteins essential for viral replication,

255 (HCV) using T-cell-based vaccines targeting nonstructural proteins has not resulted in the same leve

256 eus and is essential for expression of viral nonstructural proteins independent of RNA-activated prot

257 Many of the nonstructural proteins involved in replication possess m

258 Viral tegument, envelope, and some nonstructural proteins localize to the cVAC, and cytoske

259 mbined the codon deoptimization of genes for nonstructural proteins NS1 and NS2 (dNS), deletion of th

260 SR regulates the expression of HBoV1-encoded nonstructural proteins NS1, NS2, NS3, and NP1 but not NS

261 B (GBV-B) chimeric virus carrying the major nonstructural proteins NS2 to NS4A (HCV NS2 to -4A chime

262 glycoproteins Gn and Gc, as well as putative nonstructural proteins NSs and NSm.

263 In this report, we identified three new nonstructural proteins of human bocavirus 1 that are exp

264 virus-based vector system that combines the nonstructural proteins of Semliki Forest virus with the

265 ne is expressed from a replicon encoding the nonstructural proteins of Semliki Forest virus.

266 nsgenes, placed either immediately after the nonstructural proteins or at the 3' end of the viral cod

267 ning the three structural proteins and seven nonstructural proteins present in ZIKV, we found that tw

268 ve attenuated vaccines based on deletions of nonstructural proteins since single mutations in the vir

269 ons between distantly related structural and nonstructural proteins that are essential for virion pro

270 RNA genome, which encodes 3 structural and 7 nonstructural proteins that are expressed as a single po

271 al 20-kDa 3C-like protease (Pro, NS6) into 6 nonstructural proteins that are necessary for viral repl

272 lyprotein is required to generate the mature nonstructural proteins that form the viral replicase.

273 Like RSV, PVM also encodes two nonstructural proteins that have been implicated to supp

274 n is restricted by the inability of the EILV nonstructural proteins to form functional replicative co

275 ral replication by generating structural and nonstructural proteins via the cleavage of the viral pol

276 FMDV structural and nonstructural proteins were localized to follicle-associ

277 Furthermore, these drugs target HCV nonstructural proteins, and with selective pressure, the

278 ectural network consisting of structural and nonstructural proteins, creating strength and plasticity

279 e compared to the African lineage, mainly in nonstructural proteins, especially protein NS4B.

280 sid proteins (53.7% coverage), but none from nonstructural proteins, indicating capsids are packaged

281 We also detected interactions involving nonstructural proteins, such as the DNA-binding protein

282 In addition to many viral nonstructural proteins, the presence of cell nuclear pro

283 share common structures in their capsid and nonstructural proteins, there is often low homology at t

284 to the immunodominance hierarchy of the DENV nonstructural proteins, with NS3, NS5, and NS1 being dom

285 ied as a novel inducer of apoptosis, as were nonstructural proteins.

286 ural DENV infection and were more focused on nonstructural proteins.

287 o be inhibited through interference of viral nonstructural proteins.

288 with live virus to expression of individual nonstructural proteins.

289 s abundantly present in virions and shorter, nonstructural proteins.

290 a, virus shedding or antibodies against FMDV nonstructural proteins.

291 1b region and provide alternative sources of nonstructural proteins.

292 DENV T cell epitopes are found primarily in nonstructural proteins.IMPORTANCE The issue of potential

293 an be replicated by expression of individual nonstructural proteins; however the situation with diffe

294 morphisms in JHM.WU structural protein M and nonstructural replicase proteins nsp1 and nsp13 are esse

295 isition of multiple point mutations in their nonstructural replicase proteins.

296 combination of the structural protein M and nonstructural replicase-associated proteins nsp1 and nsp

297 ins G(n) and G(c), nucleoprotein (NP), and a nonstructural S segment (NSs) protein.

298 ssion of the GP gene results in synthesis of nonstructural secreted glycoprotein sGP.

299 esponse directed against both structural and nonstructural viral proteins during acute infection in b

300 g the role for the NS3 protein, one of seven nonstructural viral proteins, which remains to be elucid