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1 on binding to monoamine oxidase A or to the norepinephrine transporter.
2 small-molecule inhibitor of Rho kinase and a norepinephrine transporter.
3 aining a small (34 amino acid) region of the norepinephrine transporter.
4 ized single amino acid variants of the human norepinephrine transporter.
5 echolamines (uptake 1) via the cell membrane norepinephrine transporter.
6 cy most closely resembling that of mammalian norepinephrine transporters.
7 highest affinity for both the serotonin and norepinephrine transporters.
8 nsporter (DAT) relative to the serotonin and norepinephrine transporters.
9 and almost 1000 times more potent at 5-HT vs norepinephrine transporters.
10 ve for the DAT compared to the serotonin and norepinephrine transporters.
11 , increased neu mRNA levels and lack of both norepinephrine transporter activity and nerve growth fac
12 en validated as a highly specific marker for norepinephrine transporter activity of the sympathetic n
13 DHD), which blocks dopamine transporters and norepinephrine transporters, ameliorated the behavioral
14 enzylguanidine (MIBG) scan for uptake by the norepinephrine transporter and [(18)F]fluorodeoxyglucose
15 0- and 28,000-fold selectivity for SERT over norepinephrine transporter and dopamine transporter, res
16 es of 1.19 and 16.5 nM for the serotonin and norepinephrine transporter and is thus a nonselective mo
17 h those of other SLC6 members, including the norepinephrine transporter and other GATs, to identify l
19 mpathetic nerve varicosities by the neuronal norepinephrine transporter and taken up into storage ves
20 rotonin transporter, [3H]nisoxetine from the norepinephrine transporter, and [3H]pirenzepine from mus
21 ing affinities at the serotonin transporter, norepinephrine transporter, and muscarinic receptors wer
22 bind to the dopamine transporter (DAT), the norepinephrine transporter, and the serotonin transporte
23 transporters such as serotonin, dopamine, or norepinephrine transporters, and because of the resoluti
24 malian catecholamine transporters, including norepinephrine transporter- and DAT-selective antagonist
27 fering binding profiles at the serotonin and norepinephrine transporters as well as at muscarinic rec
29 affinities for the dopamine, serotonin, and norepinephrine transporter binding sites were determined
30 termined by alpha2-adrenoreceptors (ARs) and norepinephrine transporter binding sites; and (3) sprout
31 techolamine levels and neural gain using the norepinephrine transporter blocker atomoxetine and demon
32 ctions of yohimbine were not mimicked by the norepinephrine transporter blocker reboxetine, they were
33 at SERT stimulation is shared with the human norepinephrine transporter but not the human dopamine tr
34 ical differences may reflect blockade of the norepinephrine transporter by cocaine but not by GBR-129
35 iscovery that a coding mutation in the human norepinephrine transporter contributes to orthostatic in
36 hypothesis that impaired functioning of the norepinephrine transporter contributes to the pathophysi
38 )-cis analogues exhibit dopamine transporter/norepinephrine transporter (DAT/NET) selectivity as was
40 the behavior of the dopamine, serotonin, and norepinephrine transporters (DAT, SERT, NET) in the pres
41 ade of the dopamine transporter, but not the norepinephrine transporter, during P22-41 also increases
42 revealed increased glucose transporter-1 and norepinephrine transporter expression in BAT cell membra
43 of a single METH injection on serotonin and norepinephrine transporter function and effects of direc
44 e permits quantitative assessment of cardiac norepinephrine transporter function in active chronic co
46 f the present study was to determine whether norepinephrine transporter gene (NET) and serotonin tran
47 e transcription initiation site of the human norepinephrine transporter gene [solute carrier family 6
48 Eleven new mutations were found in the human norepinephrine transporter gene, although none were dire
49 pillover and clearance, and we sequenced the norepinephrine-transporter gene and evaluated its functi
51 lates expression of tyrosine hydroxylase and norepinephrine transporter genes in brain neurons; howev
52 transporters (i.e., serotonin, dopamine, and norepinephrine transporters) have been implicated as pla
54 s this limitation, we have evaluated a human norepinephrine transporter (hNET) permitting imaging of
55 cocaine- and antidepressant-sensitive human norepinephrine transporter (hNET) was assessed in stably
56 ries of compounds potently blocked the human norepinephrine transporter (hNET) while exhibiting selec
57 th retroviral vectors encoding for the human norepinephrine transporter (hNET), human sodium-iodide s
59 amined whether paroxetine inhibits the human norepinephrine transporter in addition to the human sero
60 onic stimulation of tyrosine hydroxylase and norepinephrine transporter in brain neurons by angiotens
61 n binding to dopamine, serotonin (5-HT), and norepinephrine transporters in membranes from rat striat
62 nergic proteins (e.g., tyrosine hydroxylase, norepinephrine transporters) in the locus coeruleus has
63 (LNAA-) IP to lower brain tyrosine, and the norepinephrine transporter inhibitor desipramine (DMI) 1
64 In pharmacological blocking studies with the norepinephrine transporter inhibitor desipramine (DMI),
66 thalmic solution, a rho-kinase inhibitor and norepinephrine transporter inhibitor, in patients with o
67 tiomers as a dual inhibitor of serotonin and norepinephrine transporters is in the low nanomolar rang
68 also has good affinity for the serotonin and norepinephrine transporters (K(i) = 21 and 6.5 nM, respe
69 tion of a DAT-like substrate selectivity and norepinephrine transporter-like inhibitor pharmacology w
70 unoreactivity and radioligand binding to the norepinephrine transporter, monoamine oxidase A, and alp
74 transported into sympathetic neurons by the norepinephrine transporter (NET) and stored in vesicles.
75 ttenuation of the Ang II-induced increase in norepinephrine transporter (NET) and tyrosine hydroxylas
78 The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent ne
79 nic stress is associated with a reduction in norepinephrine transporter (NET) availability in the loc
83 pothesis that in the absence of the DAT, the norepinephrine transporter (NET) could provide an altern
84 ine self-administration on the regulation of norepinephrine transporter (NET) distribution and functi
85 -hydroxydopamine (6-OHDA)-lesioned striatum, norepinephrine transporter (NET) expression increases an
87 raft-mediated internalization of the native norepinephrine transporter (NET) following protein kinas
89 at the SERT, dopamine transporter (DAT) and norepinephrine transporter (NET) in native rodent tissue
90 ter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) in the brain by measuri
91 ter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) in the brain by measuri
92 ter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) in the brain by measuri
93 t the DAT, serotonin transporter (SERT), and norepinephrine transporter (NET) in the brain by measuri
100 on and sympathetic nerve conduction, and the norepinephrine transporter (NET) is crucial in limiting
103 ity and selectivity over the closely related norepinephrine transporter (NET) is not well understood.
107 e indoline ring enhanced selectivity for the norepinephrine transporter (NET) over the serotonin tran
109 we demonstrated a role for p38 MAPK-mediated norepinephrine transporter (NET) Thr(30) phosphorylation
111 human SERT, dopamine transporter (DAT), and norepinephrine transporter (NET) using [(3)H]citalopram,
112 human SERT, dopamine transporter (DAT), and norepinephrine transporter (NET) using [(3)H]citalopram,
113 antly in the apical plasma membrane, whereas norepinephrine transporter (NET) was found in the basola
114 trated that 1-4 have a high affinity for the norepinephrine transporter (NET) with K(i)'s = 1.02, 3.1
115 tudies in cells transfected with human SERT, norepinephrine transporter (NET), and dopamine transport
116 inities to the monoamine transporters (SERT, norepinephrine transporter (NET), and dopamine transport
117 bitors of the dopamine transporter (DAT) and norepinephrine transporter (NET), and low Na(+) produced
118 sporter (DAT), serotonin transporter (SERT), norepinephrine transporter (NET), and muscarinic (M(1))
119 rs of the dopamine transporter (DAT) and the norepinephrine transporter (NET), but they were less pot
121 iated osteoblasts, like neurons, express the norepinephrine transporter (NET), exhibit specific NE up
122 dopamine beta-hydroxylase (DbetaH), and the norepinephrine transporter (NET), in part, by influencin
125 2), which packages NE into vesicles, and the norepinephrine transporter (NET), which removes NE from
138 over serotonin transporter (SERT/DAT = 94), norepinephrine transporter (NET/DAT = 63), and sigma(1)
139 osing changes of the mRNA expression for the norepinephrine transporter (NET; decreased) and the dopa
140 essing SERT, dopamine transporters (DAT), or norepinephrine transporters (NET) showed excellent bindi
141 ver serotonin transporters (SERT; 989-fold), norepinephrine transporters (NET; 261-fold) and muscarin
142 CAs), such as desipramine (DMI), which block norepinephrine transporters (NETs), also produce mild an
144 for indices of function of the cell membrane norepinephrine transporter, norepinephrine synthesis, an
145 differences were found in GAD+ somata, or in norepinephrine transporter or serotonin transporter immu
146 h are potent and selective inhibitors of the norepinephrine transporter over both the serotonin and d
149 l mice, but responded similarly to SERT- and norepinephrine transporter-selective antidepressants.
150 (DAT) affinity relative to the serotonin and norepinephrine transporters (SERT and NET, respectively)
151 inding to the human serotonin, dopamine, and norepinephrine transporters (SERT, DAT, and NET, respect
152 ne oxidases A and B and at the serotonin and norepinephrine transporters) showed antidepressant-like
153 e five putatively functional variants of the norepinephrine transporter (SLC6A2, NET) and serotonin t
154 carriers and is functional in the homologous norepinephrine transporter, suggesting that this region
156 ing affinity at the dopamine, serotonin, and norepinephrine transporter systems in the brain by compe
158 d that is a potent inhibitor of dopamine and norepinephrine transporters that achieves stable plasma
159 dinium) has micromolar potency for the human norepinephrine transporter, that ASP(+) accumulation is
160 ding studies at the dopamine, serotonin, and norepinephrine transporters using [(125)I]RTI-55 in clon
161 mouse dopamine transporter (V152M) or human norepinephrine transporter (V148M) result in transporter
162 upling protein-1, glucose transporter-1, and norepinephrine transporter was evaluated with immunohist
163 mpound to the human serotonin, dopamine, and norepinephrine transporters was determined using transfe
164 Binding selectivity for dopamine versus norepinephrine transporters was greater for (+)-2 than f
165 ntrast, none of the analogues recognized the norepinephrine transporter with an affinity of <1.3 micr
166 abuse, bind to dopamine (DA), serotonin, and norepinephrine transporters with high affinity and block
167 ded selective inhibitors of the dopamine and norepinephrine transporters with little effect upon sero
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