ライフサイエンスコーパス: normal

1 ith 89.8% delayed relative to 90(th) %ile of normal, 85.75 minutes), recent vomiting, and gastropares

2 osition is associated with premature loss of normal Abeta42 day/night patterns in older adults, sugge

3 ation is already evident in individuals with normal Abeta42 in the CSF and normal amyloid PET who sub

4 I activity was classified into 3 categories: normal (activity >50%), mild deficiency (activity = 30%-

5 l elderly without amyloid-beta accumulation (normal ageing, n = 13), and neurologically normal elderl

6 -basal ganglia circuits that are affected by normal ageing.

7 poiesis-driver mutations (CHDMs) occurs with normal aging and these mutations have been detected in m

8 ective mitophagy is thought to contribute to normal aging and to various neurodegenerative and cardio

9 We observe noise reduction during normal aging of a cell, followed by a short catastrophe

10 People develop presbyopia as part of the normal aging process.

11 Changes in sleep pattern are typical for the normal aging process.

12 wn of brain networks during progression from normal aging to Alzheimer disease dementia (AD) has also

13 sthma and reversible airflow obstruction and normal airway structure.

14 Among those with high-normal aldosterone (>/=9 ng/dL, n = 202), we found no si

15 > 25 kg/m(2) ), healthy non-NAFLD controls (normal ALT and BMI), or indeterminate.

16 dividuals with normal Abeta42 in the CSF and normal amyloid PET who subsequently convert to having ab

17 ibody for protein expression profiling in 44 normal and 21 malignant human tissues, we detect ERbeta

18 reveal that conformational switches modulate normal and abnormal information transfer and that intima

19 ns in epidermal and serum cytokine levels in normal and athymic mice, suggesting that T cells play a

20 ion is downregulated in ACC as compared with normal and benign adrenocortical tissues, which is a res

21 However, TGF-beta induced apoptosis in normal and benign but not in carcinoma cultures.

22 ibrocystic and metastatic states) as well as normal and cancer cells in tissue slices with high accur

23 essential aspects of Ca signaling under both normal and diseased conditions.

24 tin and its cognate receptor were present in normal and diseased parathyroid glands, and if so, wheth

25 e comparison of placental vessel networks in normal and fetal growth restriction (FGR) complicated pr

26 peline and allows us to discriminate between normal and human breast cancer cell lines (fibrocystic a

27 F to bind DNA at consensus ETS sites both in normal and in cancerous prostate cells.

28 vily glycosylated Notch receptor involved in normal and malignant development.

29 l roles of METTL14 and m(6)A modification in normal and malignant hematopoiesis.

30 However, monocyte phagocytosis was normal and oxidative burst was augmented, suggesting tha

31 across multiple anatomical targets to study normal and pathologic brain function.

32 on of placental and fetal oxygenation during normal and pathologic pregnancies in mice.

33 will likely exert significant impact on both normal and pathological DAergic homeostasis.

34 present study we investigated the uptake of normal and PE STBEVs by primary human coronary artery en

35 Herein, by using paired normal and prostate cancer-associated stromal fibroblast

36 rovide the intimate structural basis for the normal and reverse prenylations catalyzed by a single en

37 oarray analyses of DF-1 and CEFs, under both normal and stimulated conditions using chicken interfero

38 exploited as a tool to differentiate between normal and tumor vessels.

39 The rates of nonresponse and low, normal, and high response were 3.80%, 10.13%, 45.57%, an

40 Normal appearing single crypts were laser microdissected

41 identify subthreshold structural disease in normal-appearing lung regions in smokers.

42 tside the plaque areas, that is, in areas of normal-appearing white matter (NAWM) and gray matter (GM

43 d nonenhancing regions, respectively) and in normal-appearing white matter (P < .001 for both contras

44 Normal-appearing white matter distribution volume ratio

45 d 1-18 years with newly diagnosed cancer and normal audiometry were randomly assigned (1:1) to receiv

46 m specimens from individuals with documented normal auditory and vestibular function and surgical spe

47 in sufficient vestibular recovery to support normal balance behaviors, suggesting a therapeutic benef

48 lecular landscape of insulinomas relative to normal beta cells.

49 ers when an abnormal immune response targets normal biological components.

50 5% CI, 0.6-6.3 mum; P = .02) thinner than in normal-birth-weight children after adjustment for all va

51 rized by weak gamma activity despite showing normal blood flow.

52 he extravasation of sub-nanometre AuNCs from normal blood vessels and enhances their passive targetin

53 Gpr119(-/-) mice displayed normal body weight and glucose tolerance on a regular ch

54 milk or the dairy equivalent is adequate for normal bone gain between ages 8 and 16 y.

55 s cell volume in other brain pathologies and normal brain function.

56 stems use homeostatic plasticity to maintain normal brain functions and to prevent abnormal activity.

57 ar mechanisms responsible for transforming a normal brain into an epileptic one remain largely unknow

58 re builders and custodians of the BBB in the normal brain, their impact on BBB integrity during ische

59 hase III trial, 2,012 women with early TOP2A-normal breast cancer and at least one high-risk factor w

60 anthracyclines in patients with early TOP2A-normal breast cancer.

61 T474, T47D, ZR-75-1, SKBR3, MDA-MB-468) than normal breast cells (MCF-10A) or cell lines derived from

62 Both tumor and normal breast contain high-abundance "enriched" sequence

63 oxetine, a 5-HT reuptake inhibitor, restored normal breathing.

64 The OCT imaging was generally normal, but in 6 subjects subtle irregularities at the i

65 ad before and after pericardial resection in normal canines with open (n=3) and closed chest (n=5) an

66 will first review the key role of Ca(2+) in normal cardiac function-in particular, excitation-contra

67 Consistently, BCOR knock-down (KD) in normal CD34(+) progenitors modifies their granulocytic a

68 been evaluated in patients who do not regain normal CD4 T cell counts after virologically successful

69 could constitute a "stemness marker" of the normal cell and a possible target for immunotherapeutic

70 of Rad51 requires TCTP in MCF-7 cells under normal cell culture conditions.

71 are histone demethylases that both regulate normal cell fates during development and contribute to t

72 ce because of the critical role of folate in normal cell function and the wide range of disorders, in

73 hey are resistant to tumorigenesis, and most normal cells isolated from them grow slowly in culture.

74 exhibit shorter telomere length compared to normal cells, but it is not fully understood how WRN def

75 In normal cells, Ki-67 was a late marker of cell-cycle entr

76 ectively kills tumor cells, without damaging normal cells.

77 y that is required for cell proliferation of normal cells.

78 at knockdown of EmMBD2/3 expression disrupts normal cellular architecture and development of E. muell

79 ts on the Montreal Cognitive Assessment) and normal cerebellar, sensory, cranial nerve, and autonomic

80 We studied whether continuous lower normal cerebrospinal fluid (CSF) amyloid beta1-42 (>/=64

81 but not detectable at appreciable levels in normal childhood tissues.

82 000 p53 immunopositive cells in size, within normal chronically exposed skin contain mutations in mul

83 ls without dementia, including a cognitively normal (CN) subsample of 144 adults, enrolled in the Gin

84 in 309 individuals (191 AD, 118 cognitively normal [CN] controls) from the San Francisco-based Unive

85 Examination revealed normal cognition (29 of 30 points on the Mini-Mental Sta

86 formation of Ang-(1-7) from Ang II, in both normal conditions and in disease states, remains only pa

87 R1 expression was limited to trichomes under normal conditions, addition of methyl jasmonate, a bioti

88 s the majority of proteins in the cell under normal conditions.

89 an proteinuric kidney diseases compared with normal conditions.

90 porting a major neuroscience hypothesis in a normal context for an adult animal.

91 CSU patients, 10 AD patients, and 10 healthy normal controls (NCs) and measured contents of FBPs (pyr

92 n their peripheral blood, in comparison with normal controls.

93 n referred for noninvasive testing will have normal coronary arteries and no long-term clinical event

94 cells among themselves as well as from their normal counterparts.

95 tly lower in PSE-induced samples than in the normal counterparts.

96 d in prostate cancer cells relative to their normal counterparts.

97 nergic nigral afferents is essential for the normal cycling and maintenance of neural stem cells (NSC

98 accounted for 13% of HPV-positive WHIV with normal cytological findings, but this proportion increas

99 The function of the polyQ tracts in many normal cytoplasmic proteins is unclear.

100 tal binding ratios were quantified against a normal database.

101 an increase in sox9b expression during both normal development and AHR2 activation, which suggests r

102 ement membrane barriers is important in both normal development and cancer metastasis.

103 endent transcription switches that determine normal development and oncogenesis.

104 acquire such stemness, and to which stage of normal development do PGCCs correspond.

105 contributions of TGFbeta family signaling to normal development, adult homeostasis and disease, and a

106 L proteins being postulated as essential for normal development, little is known about the specific f

107 echanisms to regulate heme metabolism during normal development.

108 helial-mesenchymal interactions required for normal development.

109 rn neurons to escape Notch activation during normal development.

110 olesterol atherogenic diet (HCD) or matching normal diet (ND), respectively.

111 (normal ageing, n = 13), and neurologically normal elderly with cortical amyloid-beta accumulation (

112 mer's disease cases (n = 19), neurologically normal elderly without amyloid-beta accumulation (normal

113 ticular, excitation-contraction coupling and normal electric rhythms.

114 the absence of apical TGF-beta signaling in normal epithelia is primarily a reflection of domain-spe

115 ), which is distinct from the ECM within the normal epithelial microenvironment.

116 udy, we investigated radiosensitivity in the normal esophagus using an imaging biomarker of radiation

117 Steered simulations along the bilayer normal establish the metastable nature of the inserted p

118 ta and compares them with large data sets of normal expression profiles compiled from public sources,

119 e statistically higher (P < 0.01) in KC than normal eyes.

120 abetes to <40 mg/dL, which is well below the normal fasting plasma glucose concentration.

121 of stress at the studied wellbore is in the normal faulting stress regime within the Tarim Basin rat

122 im Basin, which explains the presence of the normal faults interpreted in 3-D seismic profiles collec

123 quality of mesopic vision in the apparently normal fellow eye (forme fruste) to detect the earliest

124 vere AS and LV remodeling than patients with normal-flow high-gradient.

125 This disrupts the normal fluid flow intensity and pattern, with consequent

126 eding the refolding and incorporation of the normal form of the given protein.

127 of virus-encoded factories, interrupting the normal formation of SGs.

128 al macular function in 17 of 19 subjects and normal full-field retinal function in all subjects.

129 The normal function of the human myocardium requires the pro

130 complex metabolic processes to achieve this normal function.

131 SNARE heptad-repeat domain, is required for normal fusion activity with HOPS.

132 We further observe a higher intolerance to normal genetic variation of the identified genes compare

133 Probabilities of having an IQ in the normal (>/=70) or intellectual disability (<70) range we

134 These data demonstrate that disruption of normal HA catabolism in Hyal2(-/-) mice causes increased

135 varian cancer cell lines (OVCAR3 and A2780), normal hamster ovary control cells (CHOK1) and alphavbet

136 tent in individual calf muscles in obese vs. normal healthy human subjects.

137 recently been identified in blood cells from normal, healthy elderly individuals with clonal hematopo

138 kgrounds) that is evident for listeners with normal hearing (NH) is generally reduced or absent for l

139 Forty young normal-hearing listeners (20 musicians and 20 nonmusicia

140 sing cells and their cell fate potentials in normal hearts and during cardiac remodeling following my

141 or growth without compromising the health of normal hepatocytes.

142 ved in 4.2% of patients with prior (6 weeks) normal histology, in 3.4% with inflammation, in 13.8% wi

143 where they reside, and how they function in normal homeostasis and wound repair.

144 ulatory mechanisms and clinical relevance in normal human bronchial epithelial cells (NHBEs) and nasa

145 In an ex vivo human model of BP, normal human skin cryosections were incubated with purif

146 hed malignancy can also occur in PIPs within normal human skin.

147 e a lesser degree of interaction, leading to normal hydrogen bonds of type YH-X analogous to secondar

148 356 (39.3%) participants were graded with a normal image.

149 phate concentrations and ATP flux rates were normal in HFrEF and HFpEF patients.

150 duction, degranulation, and phagocytosis are normal in the absence of STIM2, suggesting STIM1 is the

151 imultaneously and is able to couple light at normal incidence and near normal incidence.

152 to couple light at normal incidence and near normal incidence.

153 The study comprised 265 cognitively normal individuals (135 women and 130 men; mean [SD] age

154 f 2530 related and unrelated hematologically normal individuals (ages 55 to 101 years).

155 cohort of multiple myeloma (MM) patients and normal individuals using global reasoning on the RN caus

156 Chd1 restores nucleosomal dynamics, promotes normal induction of protective stress genes, and rescues

157 se hemangioma course and its relation to the normal iris microvasculature.

158 ssion of osteogenic transcription factors in normal jaw bone MSCs.

159 Normal kidney function involves numerous different cell

160 In patients with initial normal lactate (< 2.2 mmol/L), elevated lactate (>/= 2.2

161 artery endothelial cells under oscillatory, normal laminar and elevated laminar shear stress for a p

162 ate cell proliferation, the development of a normal leaf lamina requires photomorphogenesis-like horm

163 with asymptomatic severe aortic stenosis and normal left ventricular function, current practice guide

164 nteracted such that methylation returns to a normal level over four generations.

165 Although Enpp1 (-/-) mice generated normal levels of germinal center B cells and plasmablast

166 with IBS (with visceral hypersensitivity or normal levels of sensitivity).

167 t-induced secretion of bFGF and VEGF to near normal levels.

168 episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly.

169 AnkB variants that fail to restore normal lipid accumulation and GLUT4 localization in adip

170 BV) e antigen-positive viremic patients with normal liver function and the incorporation of new bioma

171 A-4 in some HCC tissues and their absence in normal liver was established by immunohistochemistry sta

172 tion and recovery one of the following: 1) a normal low fat (13% kcal) diet, 2) a low fat diet contai

173 parameters for NSCLC lesions as well as for normal lung and muscle.

174 ereas VBRBP is reduced in LuADCs compared to normal lung tissues.

175 olar macrophages from fibrotic compared with normal lungs.

176 Electrophysiologic studies identified normal macular function in 17 of 19 subjects and normal

177 nts executed normally accurate saccades with normal main sequence relationships, indicating that the

178 less, and when MS1 neurons are silenced, the normal male sleep suppression in female presence is atte

179 d the tyrosine kinase receptor ErbB2/HER2 in normal mammary epithelial cells and breast cancer cells.

180 This excludes normal measurements of a ferroelectric hysteresis loop,

181 two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at the tips of th

182 studies further illustrate the importance of normal membrane trafficking in the physiology and pathog

183 Nicotine Metabolite Ratio (NMR) status (slow/normal metabolism) may improve smoking cessation rates.

184 eart failure in both vitamin D deficient and normal mice without inducing significant hypercalcemia.

185 th of electrically conductive fascicles with normal microanatomy.

186 d as an intermediary step in MV reversion to normal microvessels.

187 in in the tooth and fail to degrade and thus normal mineral volume is never completely restored.

188 to AT bias characteristic of organisms with normal MMR function.

189 nt excitation by way of selected vibrational normal modes resulted in either Direct or Delayed reacti

190 result in the same ratio of double-headed to normal morphology, revealing a cryptic phenotype that is

191 ovides allosteric resistance to the membrane-normal motion associated with the switchblade model of i

192 ort that SMN:HuD complexes are essential for normal motoneuron development and indicate that mRNA han

193 n's disease (PD) patients experience loss of normal motor function (hypokinesia), but can develop unc

194 in g/mL. min) for (18)F-FTT was assessed in normal mouse organs before and after treatment with olap

195 ll development, but it does not underlie the normal MT current.

196 rom 11 primary colorectal tumors and matched normal mucosa.

197 hin protein results in excessive damage from normal muscle use due to the compromised structural inte

198 ation, with low event rates in patients with normal myocardial perfusion.

199 te, n=217 [4.7%]; severe, n=365 [7.9%]; CAC: normal, n=1457 [34.6%]; mild, n=1340 [31.8%]; moderate,

200 nificantly different between FT and CAC (FT: normal, n=3588 [78.0%]; mild, n=432 [9.4%]; moderate, n=

201 The bimodal distribution of the log-normal [Na]shoot of species within the Caryophyllales su

202 ar receptor is DAF-12, which is required for normal nematode development, including the all-important

203 ate inputs from multiple sources to generate normal neuronal functions.SIGNIFICANCE STATEMENT Critica

204 application on 206 subjects (411 eyes): 210 normal (NL), 183 glaucoma (GL), and 18 diabetic retinopa

205 39: 0.83 +/- 0.92 and 1.05 +/- 0.99 in 10(8) normal nucleotides, respectively).

206 ere 1.94 +/- 1.20 and 2.10 +/- 1.77 in 10(8) normal nucleotides, respectively, which were significant

207 Women (N = 40) with a normal Nugent score at all visits had a stable lactobaci

208 ep learning could be utilized to distinguish normal OCT images from images from patients with Age-rel

209 mented their goal-directed echocardiogram as normal or abnormal for right ventricular size and functi

210 We divided the literature based on whether normal or failing rat heart models were used.

211 myocardial ischemia compared with those with normal or hypotensive BP responses but are not more like

212 Overall, the distribution of normal or mildly, moderately, or severely abnormal test

213 mal (consolidation and/or other infiltrate), normal, or uninterpretable.

214 Normal-organ biodistribution and tumor uptake were quant

215 abolic profiles of microtissues derived from normal organs (heart, kidney) were relatively consistent

216 d much higher accumulation in tumors than in normal organs, as shown by near-infrared fluorescence (N

217 xpression from 67 ovarian CAF samples and 10 normal ovarian fibroblast (NOF) samples were analysed to

218 ted morphine treatment and has no bearing on normal P2X7R function.

219 colorectal tumor tissues compared with their normal pairs.

220 Eda and Edar-related genes are expressed in normal palatal tissues and that the Eda/Edar signaling p

221 A total of 209 cognitively normal participants had data on neurodegeneration biomar

222 s and less than half of RNFL measurements in normal patients.

223 balance and partial genome loss disrupts the normal pattern of embryonic gene expression blocking dev

224 derstanding of human intestinal transport in normal physiologic conditions and the pathophysiology of

225 NA translation, with peak rates occurring at normal physiological abundance.

226 an injury severity score between 2 and 8 and normal physiology as defined by a triage-Revised Trauma

227 lation significantly improved repeatability, normal population variation, and correlation with VF and

228 eltaPo2 were significantly different between normal pregnancies and those complicated by severe FGR.

229 by lipid interactions, given the location of normal prion protein (PrP(C)) in lipid rafts and lipid c

230 As a result, normal production and secretion of appetite control horm

231 s in maternal supplies, and is essential for normal progression of embryogenesis.

232 A activity, improved lymphocyte numbers, and normal proliferative responses to mitogens.

233 that reactivity to intestinal bacteria is a normal property of the human CD4(+) T-cell repertoire, a

234 es a unique resource and deeper insight into normal pulmonary development.

235 ontaining but unspliced M1 mRNA bypasses the normal quality-control checkpoints.

236 tional signature tracking to amplifying weak normal Raman scattering signals.

237 ndary outcomes were derived using a binomial-normal random-effects model.

238 However, levels were within the normal range and were inconsistent with a role in the pa

239 sponse ranged from 0 to 60 ppm, covering the normal range of nitrate in soil.

240 n in an electrochemical device at lower than normal reforming temperatures.

241 ubsequent amputations of the morphologically normal regenerates in water result in the same ratio of

242 this review will provide an overview of the normal regulation and function of Runx factors in hemato

243 herited with half the mother's genome during normal reproduction, a genome that it is relatively comp

244 re prevalent in individuals born to MRT than normal reproduction, particularly in a species such as h

245 Normal responses following induction of cystitis by cycl

246 owever, PE is generally sequestered inside a normal resting cell, and the mechanism by which circulat

247 NCKX4(-/-) mice or CNGB1(DeltaCaM) mice show normal resting sensitivity, as determined by their uncha

248 Given that prolonged disruptions of normal rhythms are highly detrimental to health, deeper

249 creased carnitine palmitoyl transferase I in normal rodent hearts has been shown to recapitulate the

250 p pathologic eye oscillations while allowing normal saccadic shifts of gaze.

251 e groups in blocks of 15 to receive placebo (normal saline), low-dose ketamine (0.5 mg/kg), or high d

252 fter bolus injection of gadoxetate disodium, normal saline, and gadoterate meglumine, administered in

253 hanges from a larger cohort of the tumor and normal samples with RNA-Seq data.

254 Within the 16 miRNA signature for the normal SC niche, we found that miR-206, miR-007-3, and m

255 regulation had no impact on wound healing in normal scratch assays, but after subjecting the cells to

256 that protein O-mannosylation is required for normal sensory feedback to control coordinated muscle co

257 ugh which we have compiled tumor and matched normal sequence data from a unique cohort of more than 1

258 emia-induced lncRNAs were dispensable in the normal setting.

259 red to the standard and commonly used Target Normal Sheath Acceleration technique (TNSA), or more exp

260 ce) expressing about 50% of GRP78 maintained normal sizes during the early months, with reduced proli

261 levels detected in metastatic tumours versus normal skin or benign skin lesions.

262 ighly expressed in skin cancer compared with normal skin tissues.

263 These rare taxa of normal skinfold microbiota were associated with lesions

264 However, these transgenic mice displayed normal social approach, social interactions, and repetit

265 or neuron-derived progranulin in maintaining normal social function.

266 iated and differentiated cell populations of normal, spontaneously immortalized keratinocytes (NIKS)

267 A reentrant temperature dependence of the normal state resistance often referred to as the N-shape

268 5 normal subjects wore Bangerter foil goggles to simulate

269 D were significantly higher compared to the normal subjects, whereas the corneal pachymetry and Ambr

270 rved soft tissues, in pronounced contrast to normal survival and early recovery faunas.

271 In normal T cells, the CDR3 sequences were extremely divers

272 trast to Lrrc8a(-/-) mice, ebo/ebo mice have normal T-cell development and function and intact antibo

273 dividuals lead to optic neuropathies such as normal tension glaucoma.

274 Both the prevalence of normal test results and incidence rate of events in thes

275 cancer cells while not affecting survival in normal thyroid cells.

276 hose from microbes, damaged tissues, and the normal tissue environment.

277 eded during RT, leading to severe damages to normal tissues adjacent to tumors.

278 sis of RD3 transcriptional expression across normal tissues confirmed tissue-specific RD3 mRNA levels

279 dose and irradiated area in the response of normal tissues outside the irradiated field at 1 and 4 d

280 Unfortunately, these cells also attack host normal tissues through the often fatal graft-versus-host

281 cytoskeleton in prostate epithelial cells in normal tissues, but not in prostate cancers.

282 eat me" signal CD47 expressed on tumors and normal tissues.

283 late the continuous remodeling of ECM in the normal TM.

284 udies demonstrate that DDR2 is necessary for normal TMJ condyle development and homeostasis and that

285 cone electroretinograms (ERGs) ranging from normal to absent in an extended RPGRIP1 (ins/ins) canine

286 tivated NFkappaB increased dramatically from normal to cirrhotic to HCC tissues from human patients.

287 s predicted to result in read through of the normal translational termination codon.

288 se of at least 1.67 times the upper limit of normal (ULN) despite treatment with ursodeoxycholic acid

289 Whether regions of the lung that appear normal using traditional computed tomography criteria ha

290 lack of reproducibility, its lack of a clear normal value, and the fact that it is not specific for t

291 46%-74%) compared with women (n = 660) with normal values (62%; 95% CI, 58%-66%) or after 12 cycles

292 In arterial SMCs, CXCR4 sustained normal vascular reactivity and contractile responses, wh

293 genes between regions that were proven to be normal via histopathologic analysis (34 mutations per sa

294 Mental status (normal vs. delirium vs. coma) was assessed daily with th

295 e cortex and ventral striatum, such that the normal (vs. slow) genotype individuals showed greater fu

296 iest ("dry"), wettest ("wet"), and average ("normal") weather years.

297 They achieved normal weight by 12 months, a significant improvement ov

298 mal stem cells (uMSC) from offspring born to normal-weight and obese mothers, we tested the hypothesi

299 e in obese children with asthma with that in normal-weight children with asthma to identify key diffe

300 ither PARP1 or PARP2 are sufficient for near-normal XRCC1 recruitment at oxidative single-strand brea