ライフサイエンスコーパス: normal development

1 ucial in apoptosis and growth control during normal development.

2 rs, drug resistance in fungal infection, and normal development.

3 e importance of this localization pattern in normal development.

4 nt defective in both vacuole trafficking and normal development.

5 occurs when protein production peaks during normal development.

6 nts of GlcCer in excess of that required for normal development.

7 t developmental stages, suggesting a role in normal development.

8 tic physiological functions during and after normal development.

9 retrotransposon expression is essential for normal development.

10 sympathetic neuroblast proliferation during normal development.

11 of sporadic carcinogenesis and often inform normal development.

12 taining microtubule and genome integrity and normal development.

13 e severe neurodegeneration after a period of normal development.

14 ve SMN knockdown follows variable periods of normal development.

15 scale complex chromosomal errors that impede normal development.

16 h hypnozoites persist and activate to resume normal development.

17 helial-mesenchymal interactions required for normal development.

18 the regulation of non-apoptotic genes during normal development.

19 somatic support cells and depend on them for normal development.

20 TICs), whereas it is largely dispensable for normal development.

21 e somatic-embryo dormancy and promoted their normal development.

22 ing and the acquisition of new cell fates in normal development.

23 yo absolutely requires Hif1alpha to continue normal development.

24 the source of parasympathetic neurons during normal development.

25 conserved morphogens that are essential for normal development.

26 s, which appear after a period of apparently normal development.

27 e challenged by limited understanding of its normal development.

28 roved; currently, she is well and is showing normal development.

29 and in the mouse embryo--without perturbing normal development.

30 alian cellular identity and is essential for normal development.

31 The Hedgehog (Hh) pathway is critical in normal development.

32 and loss of genomic imprinting, compromising normal development.

33 plane roughly orthogonal to that seen during normal development.

34 ability of eggs and oocytes is essential for normal development.

35 coding lncRNAs may affect gene expression in normal development.

36 rn neurons to escape Notch activation during normal development.

37 st-transcriptional regulators is crucial for normal development.

38 pattern of selection different from that of normal development.

39 tic activities of TET1 that is essential for normal development.

40 echanisms to regulate heme metabolism during normal development.

41 te numerous cellular functions essential for normal development.

42 eserve the progenitor state and/or interrupt normal development.

43 any of the experiences that are required for normal development.

44 ld help to identify critical checkpoints for normal development.

45 ne motility and must be restrained to ensure normal development.

46 fferentiation pathways and are essential for normal development.

47 is key for cell-cycle control and needed for normal development.

48 apoptosis, all of which are also critical to normal development.

49 g cellular homeostasis and remodeling during normal development.

50 r identifying local gene interactions during normal development.

51 contributions of TGFbeta family signaling to normal development, adult homeostasis and disease, and a

52 ism resembling some of the broad features of normal development, an initial overproduction of functio

53 of Yap in retaining tissue junctions during normal development and after fetal brain injury.

54 programmed cell death, plays a vital role in normal development and ageing.

55 d that the trajectory of gyrification during normal development and aging was not linear and could be

56 sensitive to intracortical myelin content in normal development and aging, relates to cognitive funct

57 an increase in sox9b expression during both normal development and AHR2 activation, which suggests r

58 ular polyploidy plays important roles during normal development and also contributes to human disease

59 Stiffness increases with age during normal development and approaches adult values during ad

60 e control of gene expression programs during normal development and are disrupted in specific disease

61 ycomb repressive complexes (PRCs) are key to normal development and are frequently deregulated in hum

62 ) superfamily members play critical roles in normal development and become disrupted in human disease

63 notable level of overlap that is crucial for normal development and behavior.

64 improved our understanding of their role in normal development and breast tumorigenesis.

65 Alternative splicing has critical roles in normal development and can promote growth and survival i

66 ome that are relevant for understanding both normal development and cancer and may be of use as epige

67 ignaling and diverse biological processes in normal development and cancer biology.

68 Though critical to normal development and cancer metastasis, how cells trav

69 ement membrane barriers is important in both normal development and cancer metastasis.

70 -2alpha (Epas1) have a critical role in both normal development and cancer.

71 ficance in cell proliferation control during normal development and cancer.

72 These results have implications for normal development and carcinogenesis where both nuclear

73 the hedgehog pathway, which is implicated in normal development and carcinogenesis.

74 he Hedgehog (Hh) signaling pathway regulates normal development and cell proliferation in metazoan or

75 ifications control fate determination during normal development and dedifferentiation during disease.

76 Messenger RNA expression is important in normal development and differentiation, as well as in ma

77 nscriptome in a spatiotemporal manner during normal development and differentiation.

78 s whereby periconceptional folate influences normal development and disease are poorly understood: ep

79 ling and homeostasis of other tissues during normal development and disease.

80 rtant for regulating gene expression in both normal development and disease.

81 m to further unravel the functions of DCX in normal development and disease.

82 of cell lineage in multicellular systems for normal development and disease.

83 sect the regulation of genomic imprinting in normal development and disease.

84 his fine-tuning mechanism is critical during normal development and diseases, particularly in relatio

85 nd the functional role of this miR family in normal development and diseases.

86 MYC genes have both essential roles during normal development and exert oncogenic functions during

87 ene regulation and cell behaviour, impacting normal development and fertility.

88 nderstanding of the functions of IMPs during normal development and focuses on a series of recent obs

89 t give rise to the wing-imaginal disc during normal development and following compensatory growth cau

90 require high levels of SMN protein for their normal development and function in vivo, with reduced le

91 ion of the actin cytoskeleton is crucial for normal development and function of the immune system, as

92 lum kinase (PERK) (EIF2AK3) is essential for normal development and function of the insulin-secreting

93 atus of MeCP2 in neurons is critical for the normal development and function of the mammalian brain.

94 perties of their apical plasma membranes for normal development and function.

95 tion to collaborate with nuclear ERalpha for normal development and function.

96 understanding the role of DNA methylation in normal development and function.

97 n in eIF4E expression, while compatible with normal development and global protein synthesis, signifi

98 in states and genomic stability is vital for normal development and health across a range of organism

99 crobiome, are complex ecologies critical for normal development and health.

100 e correct number of chromosomes is vital for normal development and health.

101 C. trachomatis require mitochondrial ATP for normal development and hence postulate that they preserv

102 de of this, how ADAR1 editing contributes to normal development and homeostasis is uncertain.

103 ATX-LPA receptor signaling is essential for normal development and implicated in various (patho)phys

104 netic regulator of stem cell function during normal development and in adult organ systems.

105 maintenance of epigenetic inheritance during normal development and in cancer.

106 gration and differentiation are important in normal development and in demyelinating/remyelinating co

107 mGlu5 receptors play important roles in both normal development and in disorders such as Fragile X sy

108 tor receptor (EGFR) plays a critical role in normal development and in human cancer.

109 ffectors of canonical Notch signaling during normal development and in N2IC-expressing models.

110 each cell class to neocortical growth during normal development and in neurodevelopmental disorders h

111 onents of the Shh transcriptional network in normal development and in oncogenesis.

112 es to epithelial tissue morphogenesis during normal development and in tumor invasiveness and metasta

113 endent cellular reprogramming is integral to normal development and is central to production of induc

114 are cell adhesion junctions required for the normal development and maintenance of mammalian tissues

115 hanism by which epithelial Wnts regulate the normal development and maintenance of pulmonary vasculat

116 r transcription factor with crucial roles in normal development and malignancy.

117 MA-S tumor formation in vivo, despite having normal development and maturation markers.

118 methylation that regulates genes involved in normal development and neoplastic diseases.

119 lial cells with many important functions for normal development and neural functioning.

120 rikingly, Hdac1(-/-)Hdac2(+/-) brains showed normal development and no obvious phenotype, whereas Hda

121 alternative splicing, a process important in normal development and often dysregulated in disease.

122 endent transcription switches that determine normal development and oncogenesis.

123 orphogenesis and stability are essential for normal development and organ homeostasis.

124 ular localization may impact its function in normal development and pathologic conditions such as NB

125 e multifaceted roles of Wnt signaling in the normal development and pathology of skin, including the

126 e genes, regulated by VHL, are essential for normal development and physiologic adaptation of renin-p

127 Directional cell motility is essential for normal development and physiology, although how motile c

128 dation and recycling pathway is important in normal development and physiology, and defects in this p

129 expression whose functions are critical for normal development and physiology.

130 essential not only for survival but also for normal development and physiology.

131 cluding HIF1alpha, ATF4, and p53, are key to normal development and play critical roles in disease, i

132 ing reinforces Tcf-1 activity to both ensure normal development and prevent thymocyte neoplasia.

133 ine RNA editing, and editing is required for normal development and proper neuronal function of anima

134 ellent tools for dissecting SFK functions in normal development and signaling and to interfere with a

135 The human cerebral cortex depends for its normal development and size on a precisely controlled ba

136 vastating impact caused by such mutations on normal development and somatic growth.

137 We conclude that HDAC3 is essential for the normal development and suppressive functions of thymic a

138 critical for ciliary functions essential to normal development and survival, most probably as a prev

139 m TGCTs may illuminate reprogramming in both normal development and testicular tumorigenesis.

140 itiated axon wrapping were stabilized during normal development and that initiation did not require a

141 s has advanced our understanding of both the normal development and the pathobiology of ocular neovas

142 ial roles for RNA regulatory networks in the normal development and their implications in a variety o

143 by Wnt proteins is finely balanced to ensure normal development and tissue homeostasis while avoiding

144 Primary cilia, which are essential for normal development and tissue homeostasis, are extension

145 defective cells from metazoans occurs during normal development and tissue homeostasis, as well as in

146 ons are robustly regulated in the context of normal development and tissue homeostasis.

147 d cell-cell communication pathway regulating normal development and tissue homeostasis.

148 ntaining fork progression, genome stability, normal development and tumor suppression.

149 The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be deter

150 rate Tob/BTG proteins and their influence on normal development and tumorigenesis.

151 m is essential for a better understanding of normal development and tumorigenesis.

152 behavior of dying cells that is seen both in normal development and under pathological conditions.

153 ssociated isoform eIF-5A2 is dispensable for normal development and viability.

154 tioning and occurs with disease progression, normal development, and aging.

155 ng expression patterns of genes required for normal development, and generating small interfering RNA

156 onal regulators identified as key players in normal development, and in identifying conditions that i

157 hology following unexpected cell loss during normal development, and may also be a contributing facto

158 imately 92 microRNA (miRNA) is essential for normal development, and overexpression of certain miRNAs

159 marks on DNA and histones is fundamental to normal development, and perturbations contribute to a va

160 ased exchange is essential for signaling and normal development, and that morphogen distribution and

161 aintaining microtubule and genome integrity, normal development, and tumor suppression.

162 ease complex essential for genome stability, normal development, and viability in mammals.

163 s the utility of genetic characterization of normal development as an integral part of a disease gene

164 potential for improving our understanding of normal development as well as disease.

165 the specific articulations that close during normal development as well as in pathological conditions

166 e expression and are essential components of normal development as well as modulators of disease.

167 rs, regulate the transcriptomic landscape in normal development as well in diseases such as cancer.

168 on of a small number of genes is crucial for normal development, as these genes often directly regula

169 gs and children of fathers with epilepsy had normal development at 6 months.

170 ealthy but slightly premature offspring with normal development at age 27 months.

171 cate that the change in NCoR splicing during normal development both helps drive normal adipocyte dif

172 R-10b is shown to be largely dispensable for normal development but critical to tumorigenesis.

173 epend on cellular hierarchies reminiscent of normal development but superimposed on underlying geneti

174 This repression contributes to normal development by confining the xCR1 protein, a regu

175 to extend the physiological range over which normal development can occur.

176 ion of adaptive immune responses, regulating normal development, changes the paradigm for studying pl

177 vidence that specific HARs are essential for normal development, consistent with suggestions that the

178 nonroot tissue and are produced both during normal development (crown roots on cereals and nodal roo

179 Within the mature peripheral nerve the normal development, differentiation and maintenance of m

180 acquire such stemness, and to which stage of normal development do PGCCs correspond.

181 Our findings indicate that normal development does not require the C-terminal SH3 d

182 of environmental stressors as part of their normal development, during which they undergo a dramatic

183 disorder typified by a period of apparently normal development followed by loss of cognitive and psy

184 RTT is characterized by a period of largely normal development followed by regression in language an

185 ients with Rett syndrome exhibit a period of normal development followed by regression of brain funct

186 haracterized by a brief period of apparently normal development followed by the loss of purposeful ha

187 itical for cell-lineage specification during normal development; functions that often become deregula

188 However, the role of this region in normal development has not been addressed.

189 ny organs and cells, with unclear impact for normal development, health, and disease.

190 tebrate trunk neural crest cell fates during normal development, highlight the likely primitive skele

191 sion in GATA1s mutant megakaryocytes rescued normal development, implicating this morphogenetic pathw

192 Some cells activated caspase-3 during their normal development in every cell and in every animal wit

193 ylase (NuRD) complex, which is essential for normal development in higher organisms, is one such macr

194 ned spine morphology at the nanoscale during normal development in mice, and tested the hypothesis th

195 RAD52, a gene dispensable for normal development in mice, was among the top hits.

196 Embryos display key landmarks of normal development, including epiblast expansion, lineag

197 oproteinases (MMPs) plays important roles in normal development, inflammation, and cancer.

198 gain access to medullary areas during their normal development is not clear.

199 are an unexpected source of VEGFA and their normal development is required for alveolar angiogenesis

200 mportance of maternal folate consumption for normal development is well established, yet the molecula

201 However, during normal development, JNK signaling controls a variety of

202 Blood vessels are crucial for the normal development, lifelong repair and homeostasis of t

203 L proteins being postulated as essential for normal development, little is known about the specific f

204 Senescence plays roles in normal development, maintains tissue homeostasis, and li

205 In normal development nodal activity becomes localized to t

206 Apoptotic cell death is important for the normal development of a variety of organisms.

207 primary visual cortex (V1) and disrupts the normal development of acuity.

208 f ghrelin during postnatal life impaired the normal development of ARH projections and caused metabol

209 u receptor with specificity for PE supported normal development of B cells, whereas a VLR:Tmu recepto

210 (y442) homozygous mutant zebrafish displayed normal development of blood and lymphatic vasculature.

211 opriate regulation of ARID3a is critical for normal development of both myeloid and B lineage pathway

212 indicate that CRKL is intimately involved in normal development of both the upper and lower GU tracts

213 ion of Rab43 are viable and fertile and have normal development of cDCs but show a defect for in vivo

214 transcription factors are essential for the normal development of eukaryotes and are the downstream

215 ation, whole-body metabolic homeostasis, and normal development of fat-containing tissues.

216 hat early-onset depression adversely affects normal development of functional brain networks.

217 ect biosynthesis of proteins involved in the normal development of gonads and external genitalia.

218 e, we demonstrate that Nfil3 is critical for normal development of gut-associated ILC3s in a cell-int

219 sh results in impaired myelopoiesis, despite normal development of haematopoietic stem cells (HSCs).

220 RID3a, in mouse stem cells was important for normal development of hematopoietic lineages; however, p

221 ent for signaling through IL-2RG and JAK3 in normal development of human lymphoid progenitors.

222 scription factor Runx3 was essential for the normal development of ILC1 and ILC3 cells but not of ILC

223 Mice lacking IL-33 signaling had normal development of ILC2s but retained significantly m

224 caregivers and society in general concerning normal development of infants and the significance of ea

225 miRNAs has been shown to interfere with the normal development of insects.

226 d deletion of a peripheral sensor alters the normal development of local and global features of twitc

227 major role in iron detoxification and, thus, normal development of malaria parasites in their mammali

228 med dosage compensation, is required for the normal development of mammalian embryos.

229 However, the normal development of many receptive field properties ha

230 r-dependent canonical pathway to orchestrate normal development of many tissues.

231 riented cell division and is crucial for the normal development of many tissues.

232 ruption by homologous recombination leads to normal development of motile ookinetes that exhibit a se

233 ng transcription factor, is required for the normal development of mouse and human enteroendocrine ce

234 ranscription factor that is important in the normal development of multiple tissues, including both t

235 xpression of the dev operon is important for normal development of Myxococcus xanthus.

236 urrounding somatic cells is critical for the normal development of ovarian follicles, perturbations i

237 omatin remodeling factor LSH is critical for normal development of plants and mammals.

238 f basal epithelial cells and is required for normal development of several epithelial tissues, includ

239 he Dsc2 and Dsc3 genes is a prerequisite for normal development of skin appendages.

240 on of the neural crest, which is crucial for normal development of the aortic arch arteries and crani

241 by complex genetic mechanisms affecting the normal development of the brain.

242 ized that the molecular regulators governing normal development of the breast epithelium may double a

243 provide insight into the role of DSPP in the normal development of the calvaria, alveolar bone, and d

244 amily zinc finger 2 (Fezf2) is necessary for normal development of the cerebral cortex.

245 membrane proteins that are necessary for the normal development of the CNS.

246 ow that both Mafb and Magi2 are required for normal development of the embryonic zebrafish kidney.

247 nce of thyroid hormones during pregnancy for normal development of the fetal pancreas.

248 These results confirm a role for GATA4 in normal development of the human pancreas.

249 se data indicate that disc1 is essential for normal development of the hypothalamus and for the corre

250 melanin production and transportation and in normal development of the integumentary system.

251 may cause severe damage to maize, affecting normal development of the plant and decreasing grain yie

252 ptotic activity of Tctp is necessary for the normal development of the retinotectal projection.

253 cells bordering the internal capsule for the normal development of the striatonigral pathway involvin

254 In the companion article we described the normal development of the trigeminal lemniscal pathway i

255 singly, alphavbeta3-deficient mice displayed normal development of the virgin gland with no effect on

256 isually evoked activity is necessary for the normal development of the visual system.

257 Notch is required in type II neuroblasts for normal development of their transit amplifying progeny,

258 ords over a time frame that aligned with the normal development of these cells in humans.

259 As such, the normal development of this region may be disrupted by so

260 racellular matrices (ECMs) is crucial to the normal development of tissues and organs and in disease

261 3D extracellular matrices is critical to the normal development of tissues and organs and in disease

262 ions revealed that CD81 was not required for normal development of Treg and MDSC but was essential fo

263 ur data show that CX3CR1 is not required for normal development of V1 responses to visual stimulation

264 ial in different cell types and required for normal development of various tissue types.

265 tein for multiple splicing 2 (RBPMS2) during normal development of visceral smooth muscle in chicken

266 me localization block cell proliferation and normal development of zebrafish.

267 Understanding the relationships between the normal development of-and the schizophrenia-associated a

268 nia genetic risk variants is related to the (normal) development of white matter.

269 emonstrate that p300 is not required for the normal development or functioning of adult skeletal musc

270 where its phosphorylations are necessary for normal development or homeostasis.

271 response to changes in oxygen tension during normal development or pathologic processes is, in part,

272 nderstanding of the epigenetic regulation of normal development, our work will be useful in decipheri

273 sly, or, sequentially, in tumourigenesis and normal development per cell differentiation, indicating

274 ll fate decisions, identity, and function in normal development, physiology, and disease.

275 olecules that maintain these fates stably as normal development proceeds or how their dysregulation m

276 Although miR-155(-/-) BMMCs show normal development, proliferation, and survival, miR-155

277 ll fate maintenance and reprogramming during normal development, regeneration and oncogenic transform

278 The importance of these roles during normal development remains untested.

279 contrast to common belief, we find that, in normal development, spine heads become smaller, while th

280 eIF4E is maintained at levels in excess for normal development that are hijacked by cancer cells to

281 Here, we show that during normal development the Drosophila sHsp CryAB [L(2)efl] i

282 Although PTCHD1 is probably critical for normal development, the connection between its deletion

283 eased proliferation, indicating that, during normal development, the growth of the tooth germ is cons

284 In comparison to their defined role in normal development, the miR-183 family is frequently hig

285 oup of genes has been extensively studied in normal development, the second finding suggests importan

286 llular functions and serve distinct roles in normal development throughout life.

287 Collective cell migration is critical for normal development, tissue repair and cancer metastasis.

288 the types of mechanisms that are used during normal development to ensure that division timing and fa

289 ing in severity from epilepsy with otherwise normal development to epileptic encephalopathy resulting

290 ical roles in various processes ranging from normal development to human diseases such as cancer prog

291 remains to be learned about this process in normal development, two recent studies in Cell (Groschel

292 In contrast, Pcbp2-null embryos undergo normal development until midgestation (12.5 to 13.5 days

293 bly, in a self-organized process that mimics normal development, vesicles containing prosensory cells

294 ular trafficking genes affected by AS during normal development (when Celf1 is downregulated) show a

295 tions not only under stress, but also during normal development, when they are expressed in organ-spe

296 gulatory hierarchy of HOX control of LMO2 in normal development, which can be resurrected during leuk

297 iated variant nonketotic hyperglycinemia had normal development with childhood-onset spastic parapleg

298 tubule (MT) motor kinesin-1 is essential for normal development, with key roles in the nervous system

299 hood exposure to some phthalates may perturb normal development, with several studies consistently re

300 orm of directed cell migration important for normal development, wound healing, and cancer metastasis