ライフサイエンスコーパス: normal human

1 obiota are observed in certain diseases, the normal human adaptive immune response to intestinal micr

2 Compared to normal human adipocytes, all LPS cell lines showed signi

3 in mice subjected to DDC or BDL, but not in normal human and mouse livers.

4 Inhibition or deletion of NFAT5 in normal human and murine cells recapitulated several of t

5 We conclude that SMG9 is required for normal human and murine development, most likely through

6 Normal human and murine fibroblasts can inhibit prolifer

7 ich is localized to bulge stem cells in both normal human and murine skin.

8 anscriptomics and cytokine data derived from normal human and rat bronchial epithelial cells exposed

9 human infection and appears adept at evading normal human antiviral responses, yet it remains poorly

10 We found that the normal human appendix harbors populations of Fusobacteri

11 ion in NK cell-mediated cytotoxicity against normal human articular chondrocytes.

12 to be affected in U87 glioblastoma cells or normal human astrocyte (NHA) cells expressing mutant IDH

13 In immortalized normal human astrocytes (NHAs) and syngeneic mouse gliom

14 he preimmune ancestor IgG bound intensely to normal human B cells bearing I/i antigen.

15 are significantly up-regulated compared with normal human B-cell lines and mouse B cells, respectivel

16 91%, across models for all chromosomes of a normal human B-cell.

17 us sequence from human band 3, including the normal human band 3 deoxyHb-binding site.

18 ted and myelin-related genes co-expressed in normal human basal ganglia.

19 We show that purified normal human basal mammary epithelial cells maintain low

20 gen species (ROS) is a fundamental aspect of normal human biology.

21 ow that MASP-1/C1-INH complexes circulate in normal human blood.

22 mentally regulated, because it was active in normal human bone marrow, multiple leukemia cell lines,

23 data from both breast cancer cell lines and normal human bone marrow.

24 ll lines, and stem cells (GSC) compared with normal human brain and astrocytes.

25 Here we show that freshly biopsied normal human brain contains abundant alphaS tetramers.

26 ises new questions about the role of APOE in normal human brain development, the extent to which thes

27 f polymorphisms altering OPRM1 expression in normal human brain tissue to nominate and then test asso

28 pressed in glioblastoma tissue compared with normal human brain tissue.

29 Transcriptome profiles of normal human brain tissues showed that the novel candida

30 distribution of Kv3.1b and Kv3.2 protein in normal human brain, showing that Kv3.1b is limited to ne

31 publicly available expression datasets from normal human brains, one comprised of four brain regions

32 We analyzed and compared the normal human breast cell line MCF10A in control conditio

33 n breast TMA showed that LASP-1 is absent in normal human breast epithelium but the expression increa

34 atients, and depletion of these factors from normal human breast fibroblasts increased proliferation

35 ns, EcSOD protein expression was observed in normal human breast tissues, suggesting that the 2D-cult

36 avily on defining a lineage blueprint of the normal human breast.

37 breast cancer, as well as two immortalized ("normal") human breast cell lines.

38 ted, pseudostratified epithelia derived from normal human bronchial basal cells.

39 both HEp-2 cells and in well-differentiated normal human bronchial cells grown at air-liquid interfa

40 We employed normal human bronchial epithelial (NHBE) cells in air-li

41 replicative capacity and relative fitness in normal human bronchial epithelial (NHBE) cells of recomb

42 Whereas, normal human bronchial epithelial (NHBE) cells with poor

43 Here we used normal human bronchial epithelial (NHBE) cells, a model

44 viral titers in both A549 and differentiated normal human bronchial epithelial (NHBE) cells.

45 proteomic and transcriptomic measurements of normal human bronchial epithelial (NHBE) primary cells u

46 ) in lung epithelial cells (A549 and primary normal human bronchial epithelial [NHBE]) cells and macr

47 S6K) signaling path on regulation of primary normal human bronchial epithelial cell-derived matrix me

48 bronchial epithelial 16HBE cells and primary normal human bronchial epithelial cells (NHBE) at 4-24 h

49 ulatory mechanisms and clinical relevance in normal human bronchial epithelial cells (NHBEs) and nasa

50 ts of OSM stimulation on barrier function of normal human bronchial epithelial cells and nasal epithe

51 rentiation induced by insulin deprivation in normal human bronchial epithelial cells cultured in orga

52 demonstrate that reduced levels of CARMA3 in normal human bronchial epithelial cells decreases the pr

53 Normal human bronchial epithelial cells were grown to go

54 low-1 is significantly inhibited by mucus in normal human bronchial epithelial cells whereas pH1N1-1

55 In normal human bronchial epithelial cells, IL-8 secretion

56 In normal human bronchial epithelial cells, pH1N1low-1 was

57 enescence in mouse embryonic fibroblasts and normal human bronchial epithelial cells.

58 Normal human bronchial epithelials were stimulated with

59 s without causing cytotoxic activity against normal human CD34(+) progenitors.

60 eals that Epstein-Barr virus interferes with normal human cell life, such as cholesterol homeostasis,

61 , how many such mutations are required for a normal human cell to progress to an advanced cancer?

62 Since cells derived from other normal human cell types are fully supportive of FeLV rep

63 point and ATM signaling promoted recovery of normal human cells after low-dose FA.

64 t telomeres triggers a prolonged anaphase in normal human cells and cancer cells.

65 using mutant forms of MAPT in karyotypically normal human cells and found that they cause aneuploidy

66 dings suggest that extending the lifespan of normal human cells due to inactivation of STAG2 could pr

67 that the p53 populations that accumulate in normal human cells exposed to etoposide or infected by a

68 p53 populations that accumulate in infected normal human cells in the absence of both mechanisms of

69 , small intestine and colon, was analyzed in normal human cells of colon mucosa.

70 ed here indicated that depletion of c-MYC in normal human cells reduced the transforming activity of

71 STAG2 silencing in normal human cells that lack telomerase led to increased

72 insights into development and mutagenesis of normal human cells will be possible.

73 In normal human cells, centrosome loss induced by centrinon

74 ntly more toxic to human melanoma cells than normal human cells.

75 tional processes that have been operating in normal human cells.

76 ption and post-transcriptional regulation in normal human cells.

77 tivity of the ITPR3 promoter was measured in normal human cholangiocyte (NHC) cells and primary mouse

78 determined by measuring calcium signaling in normal human cholangiocyte cells and secretion in isolat

79 cholangiocarcinoma cell lines compared with normal human cholangiocytes.

80 ncogenic proteins compared to EV released by normal human cholangiocytes.

81 t cytotoxicity as measured using an in vitro normal human colon cell (NCM460) assay, compared to chlo

82 In the normal human colon, we show that integrin alpha5 localiz

83 olated and biological effects tested using a normal human colonic epithelial cell line (CRL 1790) and

84 a sets using Affymetrix U133 + gene chips on normal human colonic mucosa (NR), adenomas (ADs), and co

85 ll death-1 (PD-1) ligand-expressing cells in normal human colonic mucosa.

86 identified miRNA expression patterns in the normal human colonic SC niche to understand how cancer s

87 System image stacks from either cancerous or normal human colorectal specimens.

88 s study aims (1) to define the limits of the normal human conjunctival fornices and how these alter w

89 ls in human cholangiocarcinoma compared with normal human control liver samples.

90 stem or due to a more generalized deficit.In normal human cortex, we found evidence for N-glycosylati

91 s define PRUNE as a molecule fundamental for normal human cortical development and define cellular an

92 Furthermore, normal human dermal fibroblasts (primary cells) are also

93 concentration, etc.), in primary cultures of normal human dermal fibroblasts exposed to visible and n

94 mall cell lung cancer (NSCLC) cell lines and normal human dermal fibroblasts were co-cultured.

95 ive method for inducing apoptosis of primary normal human dermal fibroblasts without affecting the ov

96 Here, we show that in primary normal human dermal fibroblasts, A2AR stimulation with C

97 othelial electrical resistance compared with normal human dermal microvascular ECs.

98 Cilia play essential roles in normal human development and health; cilia dysfunction r

99 ignificance of histone lysine methylation in normal human development and the importance of this proc

100 depletion in U2OS cells or TERT-immortalized normal human diploid fibroblasts results in decreased ex

101 In normal human diploid fibroblasts, TGF-beta1 induces Hic-

102 study (GWAS) screen was performed to explore normal human diversity in responses to rapamycin, a micr

103 tal cortex, hippocampus and cerebellum of 18 normal human donor brains spanning infancy through adole

104 with macular flat mounts and sections from 1 normal human donor eye and 2 normal primate eyes (Macaca

105 ed CRP, prepared to GMP standard from pooled normal human donor plasma was infused as an intravenous

106 successful hematopoietic engraftment with a normal human donor to model allogeneic stem cell rescue.

107 and specific CD8 T-cell memory responses in normal human donors.

108 We found that normal human electrophysiology is preserved in slice pre

109 Consequently, HERVK is transcribed during normal human embryogenesis, beginning with embryonic gen

110 In scarce normal human embryos, crypts were sometimes present.

111 Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-

112 ers, it was feasible to discriminate between normal human epidermal keratinocytes (NHEK) and dermal f

113 d 10 (K1/K10), in a dose-dependent manner in normal human epidermal keratinocytes (NHEKs).

114 epidermal stem cells in Terc(-/-) mice, and normal human epidermal keratinocytes are also ALT-positi

115 irus 16 (HPV 16) E6 and E7 gene-immortalized normal human epidermal keratinocytes, we demonstrated in

116 concentrations in B16 mouse melanoma cells, normal human epidermal melanocytes, and in a reconstruct

117 In normal human epidermis, TIG3 is present in the different

118 studies demonstrated that ELF3 silencing in normal human epithelial cells enhances their motility an

119 Normal human epithelial cells remain unaffected by this

120 is of actively dividing and deeply senescent normal human epithelial cells.

121 We have previously demonstrated that normal human erythroid maturation requires a transient a

122 d sequenced the CHRFAM7A transcript found in normal human fetal small intestine epithelial (FHs) cell

123 f the fetal circulation in 40 late-gestation normal human fetuses using phase-contrast MRI (mean gest

124 f abnormal spindle, which did not affect the normal human fibroblast cells NB1, Mrc-5 and IBR3.

125 ls, but instead cGAS is partially nuclear in normal human fibroblasts and keratinocytes, interacts wi

126 with little to no detectable cytotoxicity in normal human fibroblasts and with no genotoxicity.

127 ) is a stress response protein that protects normal human fibroblasts from oxidative stress.

128 In normal human fibroblasts its expression increases during

129 Normal human fibroblasts normally derive 25-30% of their

130 ruses do not evoke an interferon response in normal human fibroblasts, glia, or melanocytes.

131 Using a panel of normal human fibroblasts, we characterized molecular dif

132 , and H1975 NSCLC cells and MRC-9 and CCD-16 normal human fibroblasts.

133 xpression of the AsiSI restriction enzyme in normal human fibroblasts.

134 in U2OS and A549 cancer cells as well as in normal human fibroblasts.

135 Lactobacillus spp. are part of the normal human flora and are generally assumed to be nonpa

136 servable decrease of IFI16 protein levels in normal human foreskin fibroblasts (HFFs), normal oral ke

137 nesis, and there is no experimental model of normal human gastric mucosa.

138 Although they are part of the normal human gastrointestinal and vaginal flora, they ca

139 In normal human glia, fibroblasts, or melanocytes, vesicula

140 ovirus (MVMp, LuIII, and H-1) infectivity in normal human glia, fibroblasts, or melanocytes.

141 transformed cells, shows no toxicity towards normal human hematopoiesis at concentrations that inhibi

142 s, MX69, showed minimal inhibitory effect on normal human hematopoiesis in vitro and was very well to

143 To explore the requirement for ARID3a for normal human hematopoiesis, hematopoietic stem cell prog

144 e obtained when human CML were cultured with normal human hematopoietic progenitor cells.

145 ared with littermate control mice expressing normal human hemoglobins.

146 MGLL expression was detected in normal human hepatocytes and mouse liver, although it wa

147 ic analysis to date comparing epileptic with normal human hippocampi.

148 estigated global transcriptomic profiling of normal human HSC/hematopoietic progenitor cells [HPCs],

149 DE4 inhibitors also blocked TLR signaling in normal human immune cells.

150 tivity and long-term telomere maintenance in normal human immune cells.

151 amic vestibular stimulation (MVS) by placing normal humans in a 7T MRI for 90 min.

152 fetime cognitive activity in 118 cognitively normal human individuals (mean age: 76.13 +/- 5.56 years

153 ing fucosylated glycoproteins are present in normal human intestinal epithelia and could play a role

154 In normal human keratinocytes and mouse skin SIRT1 knockdow

155 The addition of recombinant TIP39 to normal human keratinocytes in culture induced an increas

156 Here, we show that AKR1B10 transfection into normal human keratinocytes reproduced the abnormal retin

157 In normal human keratinocytes YIPF4 expression was down-reg

158 at UVB radiation induces Sesn2 expression in normal human keratinocytes, mouse skin, normal human mel

159 hat was reproduced by overexpressing RAC1 in normal human keratinocytes.

160 ne, and circulating antibodies reactive with normal human kidney proximal tubular brush border.

161 ANCA-negative patients bound specifically to normal human kidney sections and to human glomerular end

162 provided data comparable with prior data for normal human kidney transplant donors.

163 the patient reacted with the brush border of normal human kidney, in contrast with the negative resul

164 DPKD tissue and cells compared with those of normal human kidneys (NHKs), whereas PDE1 levels are not

165 m injured human kidneys than in samples from normal human kidneys, and in mouse and rat kidneys, ANG

166 Finally, acylcarnitines are detectable in normal human lavage fluid.

167 and sphingosine-1-phosphate phosphatase 1 in normal human liver and cirrhotic liver from patients wit

168 s an essential nutrient that is required for normal human liver and muscle functions and important fo

169 cells (BR+) as well as L1210 cells and WI38 normal human lung fibroblast cells (biotin-receptor nega

170 lid tumor cell lines and are less toxic in a normal human lung fibroblast, WI38.

171 lein induces cellular senescence in cultured normal human lung fibroblasts (NHLF).

172 We evaluated the response of normal human lung fibroblasts (NHLFs) to stimulation wit

173 PV4 activation in a PI3K-dependent manner in normal human lung fibroblasts in vitro Mechanistically,

174 Asc restoration in human lung H460 cells and normal human lung fibroblasts on the activation and func

175 small airway epithelial cells, NCI-H441, and normal human lung fibroblasts.

176 nced differentiation potential compared with normal human lung fibroblasts.

177 441, small airway epithelial-like cells, and normal human lung fibroblasts; and their ability to stim

178 nd BAY 60-2770, triggered bronchodilation in normal human lung slices and in mouse airways.

179 Staining of fibrotic and normal human lung tissue localized DSP to airway epithel

180 is lungs but has limited or no expression in normal human lungs.

181 tivities of reactive oxygen species (ROS) in normal human mammary cells are poorly understood.

182 mechanisms operating in different subsets of normal human mammary cells could have differentiation st

183 analysis of total cell lysate obtained from normal human mammary epithelial (HME-1) cells treated wi

184 HACE1 downregulation in normal human mammary epithelial cells (HMECs) results in

185 ty of breast cancer cell lines compared with normal human mammary epithelial cells (HMECs).

186 which harbor lower hsa-miR-125b levels than normal human mammary epithelial cells (HMECs).

187 ecture of these cell types was compared with normal human mammary epithelial cells and LNCaP prostate

188 470 (Amuvatinib) reversed EMT in mesenchymal normal human mammary epithelial cells and murine BCSCs a

189 xpression of the antioxidant enzyme EcSOD in normal human mammary epithelial cells was not recognized

190 nescence-associated microRNAs (SA-miRNAs) in normal human mammary epithelial cells.

191 es, whereas it has minimal or less effect on normal human mammary gland epithelial cells (HMECs) and

192 , HeLa cervical and CaCo-2 colon, as well as normal human MCF10A mammary epithelial and human periphe

193 and MPL, which progressively increases along normal human megakaryopoiesis, is decreased in platelets

194 d the human vitiligo cell line PIG3V and the normal human melanocyte line HEM-l by RNA sequencing, ta

195 d that AC expression is markedly elevated in normal human melanocytes and proliferative melanoma cell

196 MSX1-reprogrammed normal human melanocytes express the neural crest marker

197 n in normal human keratinocytes, mouse skin, normal human melanocytes, and melanoma cells.

198 Whereas FES is highly expressed in normal human melanocytes, FES expression is strongly dec

199 Compared to normal human melanocytes, miR-211 expression is signific

200 levated in melanoma cell lines compared with normal human melanocytes.

201 nantly with the HPS-5 component of BLOC-2 in normal human melanocytes.

202 ost human melanoma cell lines, as well as in normal human melanocytes.

203 imilarly, the ATP synthase F0 subunit 6 from normal human mitochondria encodes a 9-mer with a single

204 ereas filarial antigens mediate apoptosis of normal human monocytes through TLR4, those of infected s

205 Normal human monocytes were found to be qualitatively di

206 BpA induced significant apoptosis of normal human monocytes, primarily through Toll-like rece

207 in human colon carcinoma cells (HT29) versus normal human mucosa cells (NCM460) and its contribution

208 CART123 also eradicated normal human myelopoiesis, a surprising finding because

209 CCDC88A is essential for multiple aspects of normal human neurodevelopment.

210 and define kaptin as a molecule crucial for normal human neuromorphogenesis.

211 proteins were also separately purified from normal human neutrophils and used to reconstitute chroma

212 ction of two types of oral epithelial cells, normal human oral keratinocytes (NHOKs) and papilloma-im

213 but also determined the efficiency by which normal human oral keratinocytes could be reprogrammed to

214 LMX1B is not expressed in normal human ovary, but is expressed in many human OVCA

215 In gene complementation studies, normal human p53 alleles suppressed transposons, but mut

216 In mixed lymphocyte co-cultures between normal human peripheral blood lymphocytes, (1) frequenci

217 oach recognizes microbiota to be integral to normal human physiology, and microbiota being used in FM

218 tiple times per day, an important element of normal human physiology.

219 ssay by their ability to neutralize FVIII in normal human plasma.

220 and protein phosphorylation when compared to normal human plasma.

221 Importantly, our screen of a normal human population for single nucleotide polymorphi

222 ome expression analysis on a series of eight normal human postmortem eyes by RNA sequencing.

223 s are effective at seeding the conversion of normal human prion protein to an amyloid conformation, p

224 nts were shorter in length than those of the normal human productive repertoire.

225 avbeta6 integrin, which is not detectable in normal human prostate but is highly expressed in human p

226 This work also shows that the normal human prostate gland contains tissue-derived MSCs

227 me to our knowledge, the characterization of normal human prostate-derived mesenchymal stem cells (MS

228 Controlled stiffening of normal human red blood cells (RBCs) in different shapes

229 nd proto-oncogene expressed at low levels in normal human reproductive tract tissues and at higher le

230 ld not confirm the presence of Bestrophin in normal human retina.

231 +) nanomaterials can stimulate the growth of normal human retinal pigment epithelium (ARPE-19) cells.

232 tgen sequence 2 colorectal cell lines and 16 normal human samples to illustrate its utility in identi

233 pth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 feta

234 n human vestibular schwannomas compared with normal human Schwann cells (SCs).

235 Normal human sera contain IgG antibodies that specifical

236 tained with IgHPolyFab and FcMonoIgG against normal human sera, IVIg, and allograft recipients' sera,

237 totropic viruses were detected in the tested normal human sera.

238 aumannii strains are resistant to killing by normal human serum (NHS), an observation supported in th

239 of N. meningitidis group B strain H44/76 in normal human serum (NHS).

240 tely resistant to in vitro neutralization by normal human serum (NHS).

241 both MAP-1 and MASP-1 or -3 were detected in normal human serum and plasma, and depletion of the LCP

242 mutants were less able to compete with FH in normal human serum during complement activation on mGEnC

243 ose dolphins (Tursiops truncatus) and pooled normal human serum led to the discovery of 11 proteins t

244 lement activating pathways were triggered in normal human serum or plasma.

245 single protein, C-reactive protein (CRP), in normal human serum, displaying a calcium-dependent, high

246 equent C3b opsonization upon incubation with normal human serum.

247 with enhanced protection against killing by normal human serum.

248 ganism resistant to killing by complement in normal human serum.

249 A and mRNA profiling data from psoriatic and normal human skin and from murine miRNA knockout assays.

250 varied from 20% to 165% of that expressed in normal human skin and persisted for 3 months.

251 es were conducted after UV-A1 irradiation of normal human skin at an academic referral center.

252 Analyzing digested normal human skin by single-cell RNA sequencing, we expl

253 ific and quantitative approach to monitoring normal human skin cells (keratinocytes and fibroblasts)

254 In an ex vivo human model of BP, normal human skin cryosections were incubated with purif

255 )PPs] (at 5 and 20 min and 1, 2, and 4 h) in normal human skin fibroblasts.

256 As differ when M. sympodialis is cultured at normal human skin pH versus the elevated pH present on t

257 Psoriatic skin biopsy specimens, as well as normal human skin, blood, and primary cells, were used t

258 As compared with normal human skin, downregulation of SIRT1 is in paralle

259 In normal human skin, mTregs preferentially localized to ha

260 Analysis of 25 samples of normal human skin, nevi, and melanomas revealed a positi

261 Compared with normal human skin, SIRT1 is downregulated in both AD and

262 In normal human skin, the SDR9C7 was abundantly expressed i

263 ctivity of the biosensor was tested by using normal human skin-fibroblast.

264 hed malignancy can also occur in PIPs within normal human skin.

265 matically delineate the DEJ in RCM stacks of normal human skin.

266 d induced pluripotent stem cells (iPSC) from normal human small airway epithelial cells (SAEC) to inv

267 array analyses of mRNA isolated from primary normal human small airway epithelial cells indicated tha

268 e X-linked RHOX gene cluster may function in normal human spermatogenesis and we provide evidence tha

269 Normal human stem cells rely on low levels of active tel

270 BAB (R1 and R2) receptor subunits within the normal human STN.

271 two rejectors, compared with those from five normal human subjects and three nonrejectors.

272 Lactate in normal human subjects get cleared very quickly at a rate

273 dcn Clinically, compared with pathologically normal human subjects, patients with IPF presented local

274 ive trait loci (eQTLs) in platelets from 154 normal human subjects.

275 l basis of GABAergic transmission within the normal human subthalamic nucleus and evidence of GABA in

276 emagglutinin (PHA)-mediated proliferation of normal human T lymphocytes.

277 (particularly the absence of blinding), and normal human tendencies toward optimism and denial.

278 At ages approximately equivalent to normal human term birth, mouse cortex exhibits primarily

279 ell as in round and elongated spermatids, in normal human testes.

280 ding to their initial T2* below or above the normal human threshold of 35 ms (MIC, 0.59 mg/g dry weig

281 B cells inhabit the normal human thymus, suggesting a role in T cell selecti

282 fied in the bone marrow, are resident in the normal human thymus.

283 riant that was expressed at low abundance in normal human tissues but was significantly up-regulated

284 emonstrate that somatic mutational burden in normal human tissues can vary by several orders of magni

285 epatic stemness; because of its absence from normal human tissues except the testis, RBMY represents

286 ell-surface glycoprotein whose expression in normal human tissues is restricted to mesothelial cells.

287 n in cancer cell lines, xenograft tumors and normal human tissues, underscoring their biological rele

288 ase III drugs across a diverse collection of normal human tissues.

289 P) downstream of PTEN is highly expressed in normal human Treg cells and provides complementary phosp

290 depth proteomic analyses and EM showing that normal human urinary exosomes are significantly enriched

291 n endogenous straight chain fatty acid, is a normal human urinary metabolite and can be obtained as a

292 nstrated attenuated growth of the mutants in normal human urine as well as synthetic human urine cont

293 e reverse transcriptase (hTERT)-immortalized normal human urothelial (NHU) and bladder cancer cell li

294 cked the differentiation of non-immortalised normal human urothelial (NHU) cells grown in culture.

295 vestigated the direct effects of ketamine on normal human urothelium maintained in organ culture or a

296 copic analysis of capillaries located in the normal human utricular stroma showed vascular endothelia

297 an go unnoticed, underlie genetic disease or normal human variation, and may be transmitted to the ne

298 the optimal ventricular pacing site to mimic normal human ventricular physiology and best hemodynamic

299 imited NETosis of neutrophils collected from normal human volunteers and naive mice in an exchange pr

300 Our investigation in normal human volunteers revealed the presence of 2 to 4