ライフサイエンスコーパス: normoglycemic

1 750 IEQ (7% normoglycemic) and 1000 IEQ (30% normoglycemic).

2 ZF rats were obese, hyperlipidemic, and normoglycemic.

3 s of CRP at baseline than those who remained normoglycemic.

4 ns had normal pancreatic morphology and were normoglycemic.

5 eased significantly with PGA and 3/10 became normoglycemic.

6 lets with PGA polymers subcutaneously became normoglycemic.

7 diabetic by streptozotocin injection or kept normoglycemic.

8 al size and quantity, and these animals were normoglycemic.

9 mice receiving the vehicle control remained normoglycemic.

10 150 mg/kg extract-treated ob/ob mice became normoglycemic (137 +/- 6.7 mg/dl) and had significantly

11 Normoglycemic 2-week-old betaDKO mice manifest reduced b

12 rAd-GLP-1-treated diabetic ob/ob mice became normoglycemic 4 days after treatment, remained normoglyc

13 ecretion and insulin sensitivity in 49 white normoglycemic (4.99 +/- 0.51 vs. 4.95 +/- 0.41 mmol/l) n

14 ARgamma knockout mice (PANC PPARgamma(-/-)), normoglycemic 60% pancreatectomy rats (Px), normoglycemi

15 y patients as hyperglycemic (> 200 mg/dL) or normoglycemic (60-200 mg/dL).

16 Light and electron microscopy of normoglycemic 7-week-old ZDF rats showed thickened endot

17 ee of insulin resistance evidenced in young, normoglycemic adults with sex-specific fingerprints.

18 IGF-I levels were highest in normoglycemic African Caribbeans and declined with age (

19 These results suggest that under normoglycemic and hyperglycemic conditions, small human

20 effects of IGF-I on JNK and p38 kinase under normoglycemic and hyperglycemic conditions.

21 QTL genes, whose expression differed between normoglycemic and hyperglycemic individuals, siRNA of te

22 of exenatide inhibited thrombus formation in normoglycemic and hyperglycemic mice in vivo.

23 by 0.5, 1, and 3 h of recirculation in sham, normoglycemic and hyperglycemic rats.

24 normoglycemic 60% pancreatectomy rats (Px), normoglycemic and hyperglycemic Zucker fatty (ZF) rats,

25 mediated at the level of the VMH under both normoglycemic and hypoglycemic conditions.

26 rom hyperalimentation, all patients remained normoglycemic and insulin-independent 6-months posttrans

27 All recipients became normoglycemic and insulin-independent posttransplant.

28 Here we report that normoglycemic and insulinopenic 3-month-old LP progeny s

29 After 14 days of treatment, mice remained normoglycemic and islet allografts were functional for u

30 s with increased albumin excretion were both normoglycemic and normotensive (systolic/diastolic blood

31 RIP-M3 mice were normoglycemic and responded normally to glucose challeng

32 ated with ALS/PLNC, diabetic NOD mice become normoglycemic and tolerated minor antigen-disparate isle

33 All 1943 normoglycemic and transiently hypoglycemic infants (23-4

34 in the subcutaneous adipose tissue of obese normoglycemic and type 2 diabetic subjects compared with

35 groups that were implanted with 750 IEQ (7% normoglycemic) and 1000 IEQ (30% normoglycemic).

36 lus infarction) was larger in hyper- than in normoglycemic animals at 2 and 4 h of recirculation.

37 ion of bcl-2 and bfl-1 and reduced damage in normoglycemic animals but failed to protect the diabetic

38 In normoglycemic animals this damage usually consists of se

39 easing density of SNN in the caudoputamen of normoglycemic animals.

40 ic rats and accelerates bone regeneration in normoglycemic animals.

41 Hyperglycemic, but not normoglycemic, animals showed pan-necrotic lesions ('inf

42 Interestingly, castrated normoglycemic ApoE(-/-) mice developed larger atheroscle

43 ays), and three of the recipients were still normoglycemic at 100 days after transplantation.

44 islets, and all were insulin independent and normoglycemic at the time of study.

45 yperglycemic nonobese diabetic (NOD) and old normoglycemic BALB/c mouse strains.

46 levels increasing approximately 20% from the normoglycemic baseline (BLI reduction approximately 70%)

47 in response to hypoglycemia (P = 0.13 versus normoglycemic baseline; P = 0.007 versus untreated hypog

48 stance, most obese humans and rodents remain normoglycemic because of compensatory hyperinsulinemia.

49 s with diagnosed diabetes had slower PS than normoglycemics (beta = -0.12; P < 0.05); diabetes durati

50 Perfusion of the sciatic nerve with the normoglycemic buffer solution did not affect withdrawal

51 ion of the insulin receptor gene (MIRKO) are normoglycemic but have increased fat mass.

52 uman muscle biopsies from patients with T2D; normoglycemic but insulin-resistant subjects with a pare

53 received ALS at a time after transplant when normoglycemic but prompted by a reduction (approximately

54 cal mAb, 100% of B-cell-depleted mice became normoglycemic by 2 days, and 70% of them maintained a st

55 o rescue islet loss, diabetic mice were made normoglycemic by islet transplantation and immunization

56 Thirteen normoglycemic C57BL/6 mice were studied.

57 a small but significant inhibition of DHT in normoglycemic cells.

58 They underwent hyperinsulinemic-normoglycemic clamps with [6,6-(2)H2]glucose to assess w

59 slets of 1000 IEQ were sufficient to achieve normoglycemic condition (83%).

60 diabetes is maintenance of a long-term, near-normoglycemic condition and prevention of the onset or p

61 Pg LPS stimulated insulin secretion in the normoglycemic condition by approximately 1.5- to 3.0-fol

62 in cerebral cortex with (18)F-FDG PET under normoglycemic conditions (isoflurane and awake) were gen

63 Healthy control subjects were studied under normoglycemic conditions (n = 24).

64 wever, 2-DG infusion to the MAN or VMH under normoglycemic conditions had no systemic effect.

65 Underestimation of rCMR(glc) by (18)F-FDG in normoglycemic conditions may be due to partial-volume ef

66 lard oil and heparin into rats for 6 h under normoglycemic conditions resulted in a marked elevation

67 nd decreased insulin sensitivity, even under normoglycemic conditions.

68 ss caused by three different pro-oxidants in normoglycemic conditions.

69 proximately 3% of the filtered glucose under normoglycemic conditions.

70 et diabetes (diagnosed at <35 years) and 292 normoglycemic control subjects of French origin.

71 a family history of type 2 diabetes and 372 normoglycemic control subjects without a family history

72 hort of 327 type 2 diabetic subjects and 357 normoglycemic control subjects, the H611 allele and the

73 etic subjects compared with that of nonobese normoglycemic control subjects.

74 gion in 859 subjects with diabetes and 1,151 normoglycemic control subjects.

75 d inhibition of glucose output relative to a normoglycemic control.

76 of patients with T2D (n = 102) compared with normoglycemic controls (n = 87).

77 ines and proliferated more than T cells from normoglycemic controls after anti-CD3e or Ag stimulation

78 Hypoglycemic rats allowed to feed and normoglycemic controls both showed sparse Fos-positive (

79 induced by streptozotocin (STZ) injection or normoglycemic controls injected with citrate buffer alon

80 that are critical for healing compared with normoglycemic controls.

81 and increased immune pathology compared with normoglycemic controls.

82 s between the two solutions in the number of normoglycemic days (IGL-1: 11.5 +/- 6.2 versus UW: 8.5 +

83 eiving insulin implants and determined to be normoglycemic (DB-IN group), and 3) normal, nondiabetic

84 model of maternal low-protein (LP) diet are normoglycemic despite collapsed insulin secretion.

85 ndividuals will become diabetic; many remain normoglycemic despite profound obesity.

86 d were transplanted into abdominal cavity of normoglycemic (empty capsules) or streptozotocin induced

87 ion, thus contributing to the restoration of normoglycemic equilibrium.

88 All recipients were normoglycemic (fasting glucose: autograft recipients, 5.

89 d RBMEC were challenged with 1 h of normoxic-normoglycemic flow cessation (NNFC) followed by reperfus

90 eived transplants of porcine islets remained normoglycemic for 1 year with progressive weight gain.

91 10(9) infectious units) rAAV-IL-10 remained normoglycemic for at least 117 days, whereas diabetes re

92 Treated mice were healthy and normoglycemic for the duration of the experiment (>120 d

93 treatment, participants were categorized as normoglycemic (FPG <5.6 mmol/L), prediabetic (FPG 5.6-6.

94 The remaining patients are normoglycemic (glucose 92 +/- 23 mg/dl) and have a creat

95 .6+/-7.2, 54.0+/-7.8, 105.0+/-15.0 s for the normoglycemic group (n=7), and 49.2+/-33.0, 116.4+/-2.4,

96 Corresponding time intervals for the normoglycemic group were 1.86 and 1.14 min, respectively

97 In the normoglycemic group, ADCw declined to the same value as

98 a peak at 3h after ischemia relative to the normoglycemic group.

99 of donor-type (WF) islets became permanently normoglycemic (>100 days) while the third-party (BN) gra

100 splant, and all were insulin-independent and normoglycemic (HbA(1c), 5.8 +/- 0.2%).

101 The kidneys in normoglycemic humans filter 160-180 g of glucose per day

102 translocated, in soleus muscles of both (1) normoglycemic hyperinsulinemic obese/aged rats and (2) m

103 Compared with normoglycemic individuals (70-110 mg/dL), adjusted odds

104 Total vasodilator capacity was similar in normoglycemic individuals (IS, IR, and IGT), whereas it

105 ence interval [CI], 1.28-1.55) compared with normoglycemic individuals across all cancer types.

106 Among 2,422 normoglycemic individuals followed for 12 years, 201 dev

107 low-fat and high-carbohydrate diet, whereas normoglycemic individuals lost a mean of 0.43 kg (95% CI

108 ordic Diet than on the control diet, whereas normoglycemic individuals lost a mean of 2.20 kg (95% CI

109 than on the low-glycemic load diet, whereas normoglycemic individuals regained a mean of 1.44 kg (95

110 ese correlations were also evident when only normoglycemic individuals were included in the analyses

111 ulation at low genetic risk for disease, 181 normoglycemic individuals with no family history of diab

112 In a subset of 287 normoglycemic individuals, acute insulin secretion was m

113 In 12 normoglycemic individuals, reduced-function variants in

114 In a subset of normoglycemic individuals, we did not observe significan

115 etes experience worse fracture outcomes than normoglycemic individuals.

116 from exercise, we studied eight young, lean, normoglycemic insulin-resistant (IR) offspring of indivi

117 ed normal islets under the kidney capsule of normoglycemic insulin-resistant mice with two different

118 nce that occur in the muscle of young, lean, normoglycemic, insulin-resistant offspring of parents wi

119 Compared to rats with normoglycemic ischemia, numbers of beta-APP-immunopositi

120 ile a mild increase of cyt c was observed in normoglycemic ischemic animals after 1 and 3 h of reperf

121 cation sites did not differ among cohorts of normoglycemic lean or obese and type 2 diabetes mellitus

122 45+/-12 years) into 1 of 4 groups: (1) lean normoglycemic (lean), (2) overweight and obese normoglyc

123 onset of hyperglycemia and were not seen in normoglycemic, leptin receptor-deficient db/db mice.

124 reased sorbitol production can also occur at normoglycemic levels via rapid increases in aldose reduc

125 ne expression, and reduced ROS production to normoglycemic levels, both in vitro and in vivo.

126 n type-2 Zucker diabetic fatty (ZDF) rat and normoglycemic littermates, we investigated whether diabe

127 that islet-infiltrating B cells in long-term normoglycemic (Lnglc) NOD, which are naturally protected

128 he five dogs treated with pravastatin became normoglycemic (<150 mg/dL) and maintained this level dur

129 d three of six IT islet recipients, remained normoglycemic (mean FBG< or =250 mg%) immediately posttr

130 (9 mug/mL) days of hyperglycemia compared to normoglycemic mice (P < 0.001).

131 and caspase-3 activity in both diabetic and normoglycemic mice (P < 0.05).

132 3 activity by almost 50% in diabetic but not normoglycemic mice (P < 0.05).

133 T marker) were found in their wounds than in normoglycemic mice and healing was delayed.

134 However, there were no normoglycemic mice and no insulin-positive cells in the

135 By day 3, the levels were reduced in normoglycemic mice but remained significantly higher in

136 Diabetes could also be induced in normoglycemic mice expressing low levels of CCL2 by incr

137 All normoglycemic mice maintained graft function for 100 day

138 bral glucose metabolic rates obtained from 4 normoglycemic mice were 21.5 +/- 4.3 mumol/min/100 g (me

139 nfiltrate was noted in both the diabetic and normoglycemic mice.

140 n elimination t(1/2) of approximately 7 h in normoglycemic mice.

141 lowing transfer of T cells from HG mice into normoglycemic mice.

142 -A, which had no effect on beta cell mass in normoglycemic mice.

143 al gingiva of type 1 and type 2 diabetic and normoglycemic mice.

144 s in the time course of ADCw decline between normoglycemic (n = 8) and hyperglycemic (n = 6) groups.

145 rdiac mesenchymal cells (CMSC) obtained from normoglycemic (ND-CMSC) and type 2 diabetic patients (D-

146 fourth-grade achievement tests compared with normoglycemic newborns.

147 bral intracellular pH (pHi) were measured in normoglycemic (NM), acute hyperglycemic (AH), and chroni

148 during the study period, no diabetic became normoglycemic, no patient decreased their antihypertensi

149 serum-free conditions, and transplanted into normoglycemic NOD/SCID mice.

150 49 treatment did not lower glucose levels in normoglycemic, nondiabetic mice.

151 s in insulin-signaling events are present in normoglycemic, nonobese subjects with a strong family hi

152 Injection of the hyperimmune sera (IgG) into normoglycemic nude mice bearing porcine islets for > 70

153 Obese T2DM patients and normoglycemic obese and lean individuals (n = 48) were s

154 ponsible for some of the hyperinsulinemia in normoglycemic obese subjects; and 3) NA had no direct ef

155 Obese T2DM patients and normoglycemic obese versus lean subjects showed increase

156 rmoglycemic (lean), (2) overweight and obese normoglycemic (obese), (3) impaired glucose tolerance, a

157 no family history of diabetes (FH-) and 150 normoglycemic offspring of two type 2 diabetic parents (

158 In normoglycemic offspring of two type 2 diabetic parents,

159 ivalent human immune system development in a normoglycemic or chronically hyperglycemic environment,

160 rmoglycemic 4 days after treatment, remained normoglycemic over 60 days, and had reduced body weight

161 d 188 propensity-matched controls from 2,422 normoglycemic participants followed for 12 years in the

162 We studied 43 SNPs in 4,654 normoglycemic participants from the Finnish population-b

163 betes have poorer cognitive performance than normoglycemics, particularly in PS.

164 2-4 times more likely to suffer a stroke as normoglycemic patients and they also have worsened neuro

165 with the regular-size capsules, although the normoglycemic period was comparable between two groups o

166 Compared with normoglycemic persons, the adjusted relative risks for i

167 o incretins may contribute to the unexpected normoglycemic phenotype of Sur1KO mice versus the pronou

168 contrast to OLETF rats, possesses a lean and normoglycemic phenotype.

169 associated with reduced insulin secretion in normoglycemic Pima Indians.

170 notable, as, in this unselected and largely normoglycemic population, external influences on beta-ce

171 er the total dataset or when restricted to a normoglycemic population.

172 tered to hyperglycemic (therapeutic mode) or normoglycemic (prophylactic mode) NOD mice.

173 P-1 decreased diabetic glucose levels to the normoglycemic range with significant weight reduction in

174 sk factors, blood glucose levels outside the normoglycemic range, higher mean daily delta blood gluco

175 mice lowered blood glucose levels toward the normoglycemic range.

176 Brains of normoglycemic rats (n=11), by contrast, showed only weak

177 Accelerated bone formation in normoglycemic rats caused by SA-PAE/bone graft treatment

178 0) or allogeneic (n=12) islet equivalents or normoglycemic rats with 5000 xenogeneic human islet equi

179 % of the hyperglycemic rats, but none of the normoglycemic rats, developed tonic-clonic seizures with

180 nd Flt-1 was enhanced at 3 and 5 days in the normoglycemic recipients, while in the diabetic recipien

181 eous muscle biopsies were performed in eight normoglycemic relatives of type 2 diabetic patients (FH(

182 ion and intensive outpatient treatment, near-normoglycemic remission (fasting plasma glucose 6.1 +/-

183 retion have proven useful in predicting near-normoglycemic remission and long-term insulin dependence

184 ation of insulin therapy, the period of near-normoglycemic remission may last for a few months to sev

185 Near-normoglycemic remission may occur in up to 30% of black

186 ized the natural history of spontaneous near-normoglycemic remission off of antidiabetic medication i

187 , reversible beta-cell dysfunction, and near-normoglycemic remission.

188 diabetic polyneuropathy by restoration of a normoglycemic state.

189 I diabetes providing an insulin-independent, normoglycemic state.

190 ere measured in a respiratory chamber in 112 normoglycemic subjects (83 Pima Indians and 29 whites; 6

191 2 diabetes and impaired insulin secretion in normoglycemic subjects (P = 0.006 and 0.0001 for type 2

192 tolerance test and the minimal model in 138 normoglycemic subjects ages 53-61 years.

193 first-degree relative (controls), 39 healthy normoglycemic subjects with a history of type 2 diabetes

194 Normoglycemic subjects with a strong family history of t

195 ur age and sex comparable groups: 30 healthy normoglycemic subjects with no history of type 2 diabete

196 In conclusion, in normoglycemic subjects, insulin resistance (low SI) was

197 educe the oxidative susceptibility of LDL in normoglycemic subjects; however, there are few studies i

198 n the brain of insulin-resistant relative to normoglycemic Tg2576 mice.

199 f illness, autophagy was better preserved in normoglycemic than in hyperglycemic rabbits, which corre

200 In those animals that became normoglycemic, the glucose tolerance of the hyperoxicall

201 mpaired fasting glucose, and 1811 women were normoglycemic; the 2029 women without diabetes were foll

202 RIPCreER-EYFP (+TM) mice were normoglycemic throughout the study, and their glucose to

203 Most 1L-4Ralpha-/- mice remained normoglycemic to 36 weeks of age.

204 sion to levels similar to those of non-obese normoglycemic transgenic mice.

205 Normoglycemic transplanted rats and age-matched controls

206 ic hypoglycemia of infancy, but the mice are normoglycemic unless stressed.

207 POD 58 and remained insulin independent and normoglycemic until POD 264.

208 These islet-engrafted mice remained normoglycemic until removal of the graft-containing kidn

209 d recipients (n = 4, fifth recipient remains normoglycemic) versus 10.2 +/- 2.6 days for controls (n

210 00 IEQ of human, porcine, or NHP islets (75% normoglycemic) versus groups that were implanted with 75

211 ng resorption was 2.4- to 2.9-fold higher in normoglycemic vs. diabetic rats (P < 0.05).

212 ent cerebral ischemia when carried out under normoglycemic vs. hyperglycemic conditions.

213 In normoglycemic wild-type mice, hepatic expression of Ad36

214 ntent, or insulin mRNA levels in islets from normoglycemic Wistar rats.

215 The Goto-Kakizaki (GK) rat developed from normoglycemic Wistar-Kyoto (WKY) rat is a model for type

216 n-induced diabetic FVB/NJ mice were rendered normoglycemic with a therapeutic mass of syngeneic islet

217 c (diabetic), and STZ-diabetic kept hypo- or normoglycemic with insulin pellets (diabetic-normalized)

218 of the 400 islets (n = 5) recipients became normoglycemic within 8 days.

219 Whereas normoglycemic women at baseline had a decrease in glucos

220 ncreased risk for each outcome compared with normoglycemic women.

221 s, accelerated wound healing in diabetic and normoglycemic WT mice.

222 nitric oxide-mediated relaxation compared to normoglycemic WT or hyperglycemic MBL-null mice.

223 Islets from obese normoglycemic ZF rats had twofold increased PPARgamma an