ライフサイエンスコーパス: normothermic

1 plantation) and temperatures (hypo-, sub, or normothermic).

2 or 48 hrs and then were rewarmed or remained normothermic.

3 likely to develop an SSI than those who were normothermic.

4 imb was then attached to a custom-made, near-normothermic (30-33 degrees C) ex situ perfusion system

5 phorylated at 5 and 24 h after stroke in the normothermic (37 degrees C) brain; hypothermia augmented

6 rees C with 1 hour of circulatory arrest) or normothermic (37 degrees C) CPB for 2 hours.

7 olution during a 30-minute period of global, normothermic (37 degrees C) ischemia followed by 30 minu

8 on underwent ex situ viability testing using normothermic (37 degrees C) machine perfusion (NMP) afte

9 After normothermic (37 degreesC) ischaemia/reperfusion, signif

10 d to either hypothermic (32-34 degrees C) or normothermic (37-39 degrees C) conditions, and received

11 (over 400 recorded hours) were normal in all normothermic and hyperthermic control rats, and none of

12 Conversely, a minority of normothermic and hyperthermic controls had (brief) seizu

13 normal and elevated pressures and under both normothermic and hypothermic conditions.

14 aseline cerebral blood flow is similar after normothermic and hypothermic CPB, beta-adrenergic respon

15 ma patients and is a durable measure in both normothermic and hypothermic patient groups.

16 rease and increase CVC, respectively, during normothermic and whole-body heating conditions in restin

17 minute periods of data were examined during normothermic and whole-body heating conditions.

18 In normothermic animals and to a greater degree in hyperthe

19 Ten of 12 normothermic animals failed to survive the reperfusion p

20 Normothermic animals were maintained at 37 +/- 0.2 degre

21 Normothermic animals were maintained at 37+/-0.2 degrees

22 kt activity measured in an in vitro assay in normothermic animals.

23 d decreased blood flow were observed only in normothermic animals.

24 ardiac arrest characterized by 12 minutes of normothermic asystole and a high cardiopulmonary resusci

25 Patients receiving normothermic blood had less postoperative right ventricu

26 ediately upon reperfusion and 1 h later; all normothermic brains showed space immunoreactivity at 4 h

27 At the end of normothermic bypass diameter of cerebrocortical microves

28 parietal cerebral cortex underwent 10-minute normothermic bypass, 40-minute cooling on cardiopulmonar

29 HODS AND Mice were subjected to 8 minutes of normothermic CA and resuscitated with chest compression

30 ing (CABG) (n = 6; low SOE), hypothermic and normothermic CABG (n = 3; moderate to low SOE), or CABG

31 y-cerebral resuscitation following 9 mins of normothermic cardiac arrest in male vs. female dogs.

32 brain, heart, and organism (within 5 mins of normothermic cardiac arrest no-flow), which increases th

33 After normothermic cardiac arrest of 11 mins in dogs, mild res

34 to complete recovery after 10 to 15 mins of normothermic cardiac arrest without blood flow.

35 angendorff-perfused and exposed to 40-minute normothermic, cardioplegic global ischemia and 30 minute

36 ocrit supporting cerebral oxygenation during normothermic cardiopulmonary bypass (CPB) in dogs.

37 Previous studies have found that normothermic cardiopulmonary bypass (CPB) is associated

38 When epinephrine was administered during normothermic cardiopulmonary resuscitation, postresuscit

39 Epinephrine, when administered during normothermic cardiopulmonary resuscitation, significantl

40 the lungs with preservation of the abdominal normothermic circulation throughout the thoracic procure

41 Under normothermic conditions (34 degrees C) and at 39 degrees

42 igher during passive leg heating compared to normothermic conditions (FVC at highest dose of respecti

43 reases in FVC during leg heating compared to normothermic conditions (maximal decreases in FVC during

44 ypothermic animals (n = 12) were returned to normothermic conditions 120 minutes after clamp removal.

45 m 0 to 1000 mug/mL under subnormothermic and normothermic conditions in PS.

46 he hypothermic animals that were returned to normothermic conditions survived.

47 Under halothane anesthesia and normothermic conditions, 72 DNX inbred mice were subject

48 R is unclear, especially after the return to normothermic conditions.

49 h the addition of oxygen carriers; and under normothermic conditions.

50 dose of respective drugs during heating vs. normothermic conditions: PE: 3.7 +/- 0.4 vs. 2.0 +/- 0.3

51 ics, PS sustained bacterial growth under sub(normothermic) conditions, whereas growth was absent in c

52 gia for 5 minutes, followed by 60 minutes of normothermic continuous cardioplegic administration with

53 dioplegic arrest and rewarming compared with normothermic control (37 +/- 3 vs 69 +/- 3 microns/s, P

54 nd prolonged external cooling (21+/-14%) vs. normothermic control (61+/-32%) and brief external cooli

55 prolonged external cooling (18+/-9 secs) vs. normothermic control (74+/-17 secs) and brief external c

56 nd prolonged external cooling (score, 0) vs. normothermic control (score, 20) and brief external cool

57 Except for three normothermic control animals, all animals were resuscita

58 A historic normothermic control group was matched (one-to-one) by m

59 ere cooled to 30 degrees C for 1 hour; and a normothermic control group, in which mice were kept at 3

60 was severely impaired when compared with the normothermic control group.

61 myocyte velocity of shortening compared with normothermic control values (33+/-2 versus 66+/-2 microm

62 assigned to the following treatment groups: normothermic control, incubation in cell culture media f

63 Rats were randomized to a normothermic control, neurotensin-induced hypothermia, b

64 ytes were randomly assigned to 3 groups: (1) normothermic control: 37 degrees C x 2 hours (n = 116);

65 of spontaneous circulation compared to 9% in normothermic controls (*p < .01 vs. normothermia).

66 %*, and 0%, respectively, compared to 2% for normothermic controls (*p < .05 vs. normothermia).

67 te myocyte shortening velocity compared with normothermic controls (22.0 +/- 1.6 versus 57.2 +/- 2.6

68 , and 14%, respectively, compared to 17% for normothermic controls and survival with good neurologic

69 fluid and in homogenized lungs compared with normothermic controls but was associated with reduced ba

70 in rats treated with hypothermia compared to normothermic controls in both injury groups (P < 0.05).

71 ted (hyperthermic controls), as well as with normothermic controls.

72 Five animals served as normothermic controls.

73 spinal neurons (127% increase) compared with normothermic controls.

74 m uninstrumented controls (91+/-2%) or after normothermic CPB (84+/-4%).

75 79 men, mean age 63 (40 to 77) years)] with normothermic CPB and cardioplegic arrest of the heart or

76 Pigs (n = 6) were placed on normothermic CPB and hearts were arrested for 1 hour wit

77 Pigs were subjected to normothermic CPB for 90 minutes, followed by post-CPB pe

78 -dependent) was between 0.09 and 0.14 during normothermic CPB in dogs.

79 d by 8-bromo-cAMP was markedly reduced after normothermic CPB, and this change was directly related t

80 s are unchanged in the skeletal muscle after normothermic CPB.

81 A desensitizes alpha-adrenoceptors more than normothermic CPB.

82 arterial blood pressure (MAP) on CBF during normothermic CPB.

83 16) of change in MAP on change in CBF during normothermic CPB.

84 While normothermic, CVP was 6.3 +/- 0.2 mmHg and PCWP was 9.5

85 roup I and group II patients were maintained normothermic during OLT); and group III (n=5), had uncon

86 Seven subjects underwent 30 mmHg LBNP while normothermic, during passive heat stress (increased inte

87 negative pressure (LBNP) while subjects are normothermic, during skin-surface cooling, and during wh

88 f four groups: normothermic placebo control; normothermic epinephrine; hypothermic placebo control; a

89 C flush; target temperature, 15 degrees C); normothermic EPR (N-EPR; 38 degrees C flush); and contro

90 r lung reconditioning in a model of extended normothermic EVLP.

91 A program of normothermic ex situ liver perfusion (NESLiP) was develo

92 Normothermic ex situ liver perfusion enabled assessment

93 Normothermic ex situ liver perfusion has the potential t

94 Normothermic ex situ liver perfusion was performed using

95 rafts appeared viable after 24 hours of near-normothermic ex situ perfusion.

96 ith a novel technique of pressure-controlled normothermic ex vivo kidney perfusion (NEVKP) in heart-b

97 We compared continuous pressure-controlled normothermic ex vivo kidney perfusion (NEVKP) with stati

98 Normothermic ex vivo kidney perfusion might help to decr

99 Normothermic extracorporeal liver perfusion (NELP) has b

100 animals were resuscitated and submitted to a normothermic follow-up (control group) or to 3 hours of

101 rats were subjected to either 7 or 8 min of normothermic forebrain ischemia (bilateral carotid occlu

102 ental hearts were subjected to 30 minutes of normothermic global ischemia followed by 2 hours of repe

103 The hearts were then subjected to 20 min of normothermic global ischemia followed by 25 min of reper

104 minutes before being subjected to zero-flow normothermic global ischemia for 35 minutes and reperfus

105 mic group (35.4+/-0.1 degrees C) than in the normothermic group (36.7+/-0.1 degrees C) (P<.001) and r

106 posite Score versus 20.0% of patients in the normothermic group (p = 0.317).

107 test, compared with 55.5% of patients in the normothermic group (p = 0.865).

108 mic episode, glutamate concentrations in the normothermic group peaked at levels approximately three

109 rdiac events occurred less frequently in the normothermic group than in the hypothermic group (1.4% v

110 ycardia also occurred less frequently in the normothermic group than in the hypothermic group (2.4% v

111 r in the hypothermia group compared with the normothermic group.

112 bral organ damage were assessed at 96 hrs.In normothermic groups 1 and 4, all 12 dogs achieved sponta

113 Myocardial damage scores were worse in the normothermic groups compared with both hypothermic group

114 te Examination scores in the hypothermic and normothermic groups were 27.4 +/- 3.8 and 26.8 +/- 4.5,

115 idence of impairment between hypothermic and normothermic groups.

116 unused human kidneys in a series of ex-vivo normothermic haemo-reperfusion models.

117 unused human kidneys in a series of ex vivo normothermic hemoreperfusion models.

118 a nonhibernating mammal and that recovery of normothermic homeostasis ensues upon rewarming.

119 an 'area' control site has been described in normothermic humans.

120 ls were randomized into 4 groups (n=6 each): normothermic, hypothermic-2 hours, hypothermic-5 hours,

121 Langendorff method and subjected to global, normothermic I/R (20/40 minutes), with or without prior

122 tected the human donor proximal tubules from normothermic-induced cell swelling.

123 After normothermic infusions of dopamine at different doses (4

124 liver for 1 hour after a 15-minute period of normothermic intestinal ischemia.

125 el, 45 hearts underwent 30 minutes of global normothermic ischemia after infusion of 50 mL of cardiop

126 been shown to confer protection in models of normothermic ischemia and reperfusion injury and to init

127 icant sparing of CA1 neurons relative to the normothermic ischemia group was observed.

128 lmonary bypass, a 45-minute period of global normothermic ischemia was followed by 60 minutes of inte

129 d mechanism of effect have been primarily of normothermic ischemia where adenosine was given pre-isch

130 abbit hearts were subjected to 45 minutes of normothermic ischemia with cardioplegic arrest.

131 After global normothermic ischemia, significant decreases in cardiac

132 shown to enhance myocardial tolerance after normothermic ischemia-reperfusion.

133 istar rats were subjected to 30 or 60 min of normothermic ischemia.

134 groups before and after a 6-minute period of normothermic ischemia.

135 erformance deficits relative to shams in the normothermic ischemic group, with the postischemic hypot

136 hypothermic), after rewarming (hypotensive, normothermic) just before discontinuation of cardiopulmo

137 ASO when applied in normothermic kidney machine perfusion reduced renal miR-

138 urement of urinary biomarkers during ex vivo normothermic kidney perfusion (EVKP) may aid in the asse

139 We conclude that ex vivo normothermic kidney perfusion with a plasma-free red cel

140 While normothermic,LBNP reduced blood volume in all regions (t

141 stress + clamp successfully restored to the normothermic level (P = 0.99) and increased MCA V(mean)

142 ive heat stress with P(ETCO2) clamped at the normothermic level (using a computer-controlled sequenti

143 pidly (n = 6) or slowly (n = 5) increased to normothermic levels.

144 uent volume loading returned those values to normothermic levels.

145 ontaneous circulation, they underwent either normothermic life support (control group, n = 12) or hyp

146 sion, rabbits underwent either oxygen (Gas), normothermic liquid (Liquid Warm), or cold liquid (Liqui

147 Ex situ normothermic machine perfusion (NMP) can be performed af

148 sent the first patients transplanted using a normothermic machine perfusion (NMP) device that transpo

149 xperimentation, outcomes of a first clinical normothermic machine perfusion (NMP) liver trial in the

150 les, potentially administered during ex vivo normothermic machine perfusion of human organs, could be

151 Normothermic machine perfusion of the liver (NMP-L) is a

152 ted livers following viability assessment by normothermic machine perfusion of the liver (NMP-L).

153 tatic cold storage, the liver was subject to normothermic machine perfusion with a plasma-free red ce

154 d, preserved, and implanted under continuous normothermic machine perfusion.

155 ro (approximately 0.2 Hz) and in most intact normothermic mammals.

156 Following normothermic MCA occlusion, spectrin immunoreactivity wa

157 ed from 5 to >10 mins the previously longest normothermic no-flow time that could be reversed to comp

158 nesthetized, instrumented, and randomized to normothermic (Nor) or hypothermic (Hy) conditions.

159 is study included five treatment groups: (1) normothermic (Normo)-brain temperature was maintained at

160 e of the liver to ischemia-reperfusion under normothermic or hypothermic conditions.

161 re not modulated by arterial baroreflexes in normothermic or moderately heated individuals.

162 artery (MCA) occlusion and were either kept normothermic or rendered mildly hypothermic shortly afte

163 grees C throughout ischemia and reperfusion (Normothermic), or given 1 h of hypothermic conditions (2

164 se cefazolin be used for prophylaxis in (sub)normothermic organ preservation with PS.

165 olated working rat hearts were arrested with normothermic oxygenated potassium cardioplegia for 5 min

166 Intubated, anesthetized rats underwent normothermic parasagittal fluid-percussion brain injury

167 wer admission Glasgow Coma Scale scores than normothermic patients (p = .04) and tended to have highe

168 ermic patients were 3 times more likely than normothermic patients to develop MODS (21% vs. 9%, P = 0

169 try were performed every 6 hrs for 24 hrs in normothermic patients who were at rest for at least 30 m

170 were increased over time in hypothermic vs. normothermic patients.

171 nation for mortality in both hypothermic and normothermic patients.

172 ion, the 55-year-old female recipient of the normothermic perfused kidney had slow graft function but

173 A short period of ex vivo normothermic perfusion (EVNP) immediately before transpl

174 Ex vivo normothermic perfusion (EVNP) is a novel method of prese

175 Ex vivo normothermic perfusion (EVNP) prior to transplantation m

176 after perfusion and assessment using ex vivo normothermic perfusion (EVNP).

177 aastricht category III donors with abdominal normothermic perfusion and concomitant cold lung flushin

178 Normothermic perfusion failed to resuscitate porcine liv

179 After normothermic perfusion for 15 minutes and separation fro

180 WI group) were placed in an EVLP circuit for normothermic perfusion for 3 hours.

181 also reviews pulsatile machine perfusion and normothermic perfusion for pancreas preservation techniq

182 Normothermic perfusion has been shown to resuscitate and

183 Normothermic perfusion is an alternative but little stud

184 The authors report a case of preimplant normothermic perfusion of a suboptimal liver from a 57-y

185 We report ex vivo normothermic perfusion of human pancreases procured but

186 Preimplant ex situ normothermic perfusion of the liver appears to be a prom

187 Normothermic perfusion was continued for 2 hr before in

188 After 132 minutes, normothermic perfusion was stopped and implantation begu

189 x vivo viability assessment using postmortem normothermic perfusion, and overall macroscopic appraisa

190 rfusion (26 degrees C) interspersed by 3 min normothermic perfusion.

191 alternative preservation techniques, such as normothermic perfusion.

192 ipient outcomes were documented after 4 h of normothermic perfusion.

193 Normothermic, physiologically regulated male Sprague-Daw

194 it of autoregulation compared to postarrest, normothermic piglets.

195 hen randomly assigned to one of four groups: normothermic placebo control; normothermic epinephrine;

196 he effective antibiotic prophylaxis for (sub)normothermic preservation by investigating whether Staph

197 f Wisconsin solution for 4 hours followed by normothermic preservation for 20 hours (total preservati

198 gned to the following groups: group W (n=5), normothermic preservation for 24 hours; and group C (n=4

199 f short duration of cold preservation before normothermic preservation on the function of porcine NHB

200 postischemic hypothermia (30 degrees C); (c) normothermic procedures combined with delayed injections

201 To establish the role of P-selectin in normothermic pulmonary ischemia, mice were subjected to

202 In normothermic pups, Fos immunoreactivity peaked at early

203 ntusion volume was larger in hypothermic vs. normothermic rats (44.3 +/- 4.2 vs. 28.6 +/- 4.0 mm, p <

204 Conscious normothermic rats (n=12 per group) were also given RSR13

205 e (MK-801) was then constructed in conscious normothermic rats subjected to 75 min of MCAO.

206 Groups 1, 3 and 5 consisted of normothermic rats that underwent either 6 (for CBF measu

207 Corresponding to GSK 3beta activity in normothermic rats, beta-catenin phosphorylation transien

208 - and pCREB-immunoreactive cells compared to normothermic rats.

209 obal brain ischemia (12.5 min) in ventilated normothermic rats.

210 ced contusion volumes, compared with hypoxic normothermic rats.

211 fect on body temperature when given alone to normothermic rats.

212 opil and only selective neuronal necrosis in normothermic rats.

213 t the end of hypothermia in hypothermic (vs. normothermic) rats (p <.05), indicating that hypothermia

214 ncentrations were higher in hypothermic (vs. normothermic) rats at the end of both hypothermia and re

215 A period of normothermic regional perfusion (NRP) in the donor may r

216 We developed a novel protocol for in situ normothermic regional perfusion (NRP) which complied wit

217 Normothermic regional perfusion has been reported to imp

218 recovery and preservation include the use of normothermic regional perfusion in the donor and ex vivo

219 Normothermic regional perfusion used during DCD abdomina

220 rculatory arrest does not prevent successful normothermic regional perfusion.

221 Peroxynitrite anions may play a role in normothermic renal ischemia and reperfusion.

222 Herein, we report the first case of ex vivo normothermic renal transplant perfusion in man.

223 in the hippocampus were elevated at 16 h of normothermic reperfusion versus 48 h with BC reperfusion

224 hermia for 30 minutes followed by 2 hours of normothermic reperfusion.

225 University of Wisconsin solution after 1 hr normothermic reperfusion.

226 C) CP (St Thomas II) followed by 30 minutes normothermic reperfusion.

227 q/L K+, 4 degrees C) for 2 hours followed by normothermic reperfusion; and (3) preconditioning/cardio

228 tly better than delayed post-ROSC cooling or normothermic resuscitation.

229 protein level of beta-catenin degraded after normothermic stroke.

230 vs. 42%, p < .001), spent more percent time normothermic (T < or =37.2 degrees C, 59% vs. 3%, p < .0

231 72F) mutation regulates p53 stability at the normothermic temperature, but it is the increased recrui

232 with organ preservation steering toward (sub)normothermic temperatures, bacterial contamination may b

233 Compared with adults who were kept normothermic, those who underwent therapeutic hypothermi

234 cant difference between the hyperthermic and normothermic tissue; there was a large increase in sodiu

235 markedly greater when compared to LBNP while normothermic (torso: 73 +/- 2%; heart: 72 +/- 3%; spleen

236 thermic group and eight patients were in the normothermic treatment group.

237 ons, but did not change CVC in either of the normothermic trials.

238 lowing cardiopulmonary bypass (normotensive, normothermic) using mixed-model analysis of variance.

239 tility after PCO cardioplegia was similar to normothermic values in control (57+/-2 microm/s) and CHF

240 e 34 degrees C; and in group 4 (n = 5), with normothermic venovenous shunt.

241 Hearts were subjected to 30 min of normothermic, zero-flow ischemia followed by 30-min repe