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1 ISL1) in the secondary heart field (SHF) are normoxic.
2 al hemorrhage (49%) of whom 1,084 (38%) were normoxic, 1,316 (46%) were hypoxic, and 450 (16%) were h
3 or antagonist, while awake hamsters breathed normoxic (21% O(2) in N(2)), hypoxic (10% O(2)in N(2)) a
4 +/-SD) years old were randomly assigned to a normoxic (21% O2) and hypoxic (10% O2) trial with measur
5 tilated TBI patients, of whom 403 (33%) were normoxic, 553 (46%) were hypoxic and 256 (21%) were hype
7 f oxygen supplementation was equivalent to a normoxic 94% or higher target for infants admitted to ho
8 line rats are hyperproliferative and display normoxic activation of hypoxia-inducible factor-1alpha (
10 ps (n = 11/group), including air (controls), normoxic air with 5% CO2 (therapeutic hypercapnia), air
11 e volunteers were exposed to 10 min bouts of normoxic and hypoxic (FIO2 0.12) rest and exercise (100
12 cells and mediate the communication between normoxic and hypoxic areas of tumors to facilitate cance
13 ivity was induced by serum depletion both in normoxic and hypoxic cells and that activation of SREBP
15 hibited this hypertrophy response under both normoxic and hypoxic conditions (26% lower than control
16 sion of fur protected Salmonella grown under normoxic and hypoxic conditions against the bacteriostat
17 s, and stabilized HIF-1alpha protein in both normoxic and hypoxic conditions by blocking its proteaso
18 d delivery strategy was evaluated under both normoxic and hypoxic conditions in normal tissues as wel
20 min addition to these MCT-disrupted cells in normoxic and hypoxic conditions induced a rapid drop in
22 cine receptors in rat cortical neurons under normoxic and hypoxic conditions with major differences b
23 sformed human mammary epithelial cells under normoxic and hypoxic conditions, and applying in silico
24 formability, increasing sRBC occlusion under normoxic and hypoxic conditions, and increasing sRBC adh
25 ng, lowers HIF-1alpha protein levels in both normoxic and hypoxic conditions, consistent with a role
27 xic effects after 72 h of incubation in both normoxic and hypoxic conditions, unlike sulfonamide CA i
28 verexpressing CA IX and XII was tested under normoxic and hypoxic conditions, using 2D and 3D in vitr
45 ons achievable by dietary intervention under normoxic and hypoxic conditions; a moderate dose of nitr
47 lastoma), we quantified miR-124 abundance in normoxic and hypoxic regions in glioblastoma patient tis
48 ibrary from 4(th) instar larvae subjected to normoxic and hypoxic treatments (respectively), and perf
49 ion (NG-monomethyl-L-arginine; L-NMMA) under normoxic and normocapnic hypoxic (80% arterial O2 satura
51 Adult guinea pigs were divided into control (normoxic) and hypoxic groups; a separate group of hypoxi
53 ed ventilatory responses to acute hypoxia in normoxic animals without altering the output of the CB (
54 The expression pattern corresponded to the normoxic animals, as far as verifiable due to the existi
56 he animals were mechanically ventilated with normoxic artificial air with or without 2.5% methane.
57 tly increased fetal plasma SOD activity from normoxic baseline (-8.9 +/- 6.5 vs. 15.0 +/- 6.6% inhibi
58 concentration ratio of nitrate:nitrite from normoxic baseline (DeltaNO3(-):NO2(-); 0.15 +/- 0.30 vs.
59 he 3rd week of hypoxia regressed back toward normoxic baseline as the duration of re-oxygenation cont
60 mory (EM) CD4(+) T cells recirculate between normoxic blood and hypoxic tissues to screen for cognate
61 rat hearts (n = 5/group) were perfused with normoxic buffer for 30 min and then hypoxic buffer for 4
62 d acclimatization using four groups of rats: normoxic, caffeine-treated normoxic, chronically hypoxic
63 thetic pathway activation, favor hypoxic and normoxic cancer cell survival and correlate with pancrea
68 in hypoxic cells, whereas STAT3 knockdown in normoxic cells also reduces cell proliferation, motility
69 alised to distinct cytoplasmic aggregates in normoxic cells and underwent redistribution to the leadi
73 cells, and we propose that, via this route, normoxic cells supply hypoxic neighbors with acid-neutra
74 ubicin-induced accumulation of HIF-1alpha in normoxic cells was caused by increased expression and ac
75 generate both DNA breaks and cross-links in normoxic cells, a low oxygen environment represses the f
77 f fluorescent CA IX signal in hypoxic versus normoxic cells, which could be blocked by 60%-70% with u
81 r groups of rats: normoxic, caffeine-treated normoxic, chronically hypoxic (12% O(2), 15 days), and c
83 proteins, BAX and BIM, down-regulated under normoxic condition; (2) beta1 Integrin/FAK signaling pat
84 ion of NF-kappaB, S6, c-Myc, and c-Jun under normoxic condition; (2) blocked myeloma cell migration a
86 is up-regulation of HIF-1 alpha occurs under normoxic conditions and could be inhibited with wortmann
87 egradation, stabilized HIF-1 activity during normoxic conditions and elevated miR-429 levels, demonst
88 the alpha subunit of HIF1 (HIF1alpha) under normoxic conditions and enhances HIF1alpha accumulation
89 n results in myocardial ischemia under basal normoxic conditions and in acute cardiac decompensation
90 ominant HIF-hydroxylase in neutrophils under normoxic conditions and link intrinsic regulation of gly
91 rexpressing cancer cells stabilize HIF under normoxic conditions and require HIF-1 for ERBB2-mediated
92 ive oxygen species-mediated phototoxicity in normoxic conditions and small molecule uncaging in hypox
93 ence and respond to CD44-ICD induction under normoxic conditions and therefore independent of Hif1alp
94 rom GBM cells grown at hypoxic compared with normoxic conditions are potent inducers of angiogenesis
95 erfused with 26 mm [1,6-(13)C2]glucose under normoxic conditions at 37 degrees C and monitored by (13
96 HIF-1 activity is usually suppressed under normoxic conditions because of rapid oxygen-dependent de
98 1 promoter silencing persisted in subsequent normoxic conditions but could be reversed by treatment w
99 axis that is dispensable for survival under normoxic conditions but is critical for non-replicating
101 RNA and protein, the reversal of which under normoxic conditions decreased T-cell-suppressive effects
102 ntra-arterially with 3.4 mug.g(-1) FLX under normoxic conditions displayed a transient tachycardia an
103 e slowed in metastatic melanomas, even under normoxic conditions due to the persistence of a high nuc
104 itrogen in the presence of acetate and under normoxic conditions is accompanied by a marked increase
105 ic inhibition of complex II by atpenin A5 in normoxic conditions mimics hypoxia and induces hypoxic t
106 tag), we found that exposure to NO2(-) under normoxic conditions or exposure to ischemia alone result
108 eriods of hypoxia and recover development if normoxic conditions resume, an ability rarely found in m
109 exosomes derived from hypoxic compared with normoxic conditions showed increased autocrine, promigra
110 tion of HIF1A transcriptional activity under normoxic conditions through regulation of succinate dehy
111 f HIF-1alpha using Ad-VP16- HIF-1alpha under normoxic conditions up-regulated miR-210 expression, dow
112 , human RBCs constitutively produce NO under normoxic conditions via an active eNOS isoform, the acti
114 d factor 1alpha (HIF1alpha) mRNA, even under normoxic conditions, and markedly upregulate HIF1alpha p
115 le, even under deviations from physiological normoxic conditions, and show minimal interference from
116 ncreased HIF-2alpha protein expression under normoxic conditions, and up-regulated HIF-dependent gene
118 e indistinguishable from control cells under normoxic conditions, but are unable to survive and proli
119 ly more able to exploit food resources under normoxic conditions, but at the cost of being more sensi
120 marginally important to generate LG3 during normoxic conditions, cathepsin B activity was found to b
121 yl-hydroxylated by EglN family members under normoxic conditions, causing its rapid degradation.
122 end to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect
123 eactive oxygen species in these cells and in normoxic conditions, decreased the mitochondrial oxygen
134 ctivity and trigger a hypoxic response under normoxic conditions, such as iron chelators and inhibito
135 or of this process, but its activation under normoxic conditions, termed pseudohypoxia, is not well d
136 ogenesis of renal cell carcinoma (RCC) under normoxic conditions, through the loss of the Von Hippel-
137 rogenase lead to the inactivation PHDs under normoxic conditions, which can be overcome by treatment
138 hance MDSC-mediated T-cell suppression under normoxic conditions, while targeting hypoxia-induced miR
139 (+) and the accumulation of HIF-1alpha under normoxic conditions, with parallels to Warburg reprogram
140 pression induced CD24 mRNA and protein under normoxic conditions, with this effect traced to a recrui
175 metabolism were compared under hyperglycemic normoxic conditions; 51% of the energy came from oxidati
176 TSM provided significant gains in hypoxic-to-normoxic contrast (14:1 for (64)Cu-2,3-butanedione bis(t
177 hold, only (64)Cu-CTS delivered a hypoxic-to-normoxic contrast of 3:1, and it therefore warrants in v
180 stress (4-hydroxynonenal, 141.1 +/- 17.6% of normoxic control), reduced superoxide dismutase (60.7 +/
181 immunohistochemistry in four groups of ewes: normoxic control, normoxia + ketamine, hypoxic control a
182 er and lesser, respectively, relative to the normoxic control, thus leading to an increased T/E2 rati
190 lation whenever it was increased relative to normoxic controls; i.e. acute hypoxia in CON and CSH, an
192 We show that in Saccharomyces cerevisiae, normoxic COX activity measured in the presence of ATP is
199 sites was enhanced approximately 20-fold at normoxic DNAse1 hypersensitivity sites (irrespective of
201 gnaling was recapitulated in hypoxic but not normoxic endothelial cells, and was associated with decr
203 y increased value in comparison to that from normoxic ERYs of 0.60 +/- 0.04 microM (p < 0.001, n = 4
204 ons employed, NO and PGs have little role in normoxic exercise hyperaemia whereas combined NO-PG inhi
205 in DeltaFVC (% change compared to respective normoxic exercise trial) between the older subjects (pre
207 enhanced induction by hypoxic compared with normoxic exosomes of tumor vascularization, pericyte ves
212 as wash-in MR imaging during inhalation of a normoxic fluorinated gas mixture (perfluoropropane) and
216 ronment, we incorporated the interactions of normoxic glioma cells, hypoxic glioma cells, vascular en
218 ed function in neonatal hypoxic and neonatal normoxic groups compared with saline-treated controls.
219 rvival of class I nuclei are compatible with normoxic hESC derivation, and that chemical supplementat
220 r HIF1A in lung protection during ALI, where normoxic HIF1A stabilization and HIF-dependent control o
221 f succinate dehydrogenase (SDH) in mediating normoxic HIF1A stabilization, concomitant increases in g
224 In wakefulness, the ventilatory response to normoxic hypercapnia is higher in young SHRs (mean +/- S
225 e authors administered a series of identical normoxic hyperpolarized gas breaths to the subject; afte
227 mitochondria in vitro and in vivo, promoting normoxic hypoxia inducible factor-1alpha activation and
229 by retinal pigmented epithelial cells under normoxic, hypoxic, and lutein-pretreated conditions in a
231 ypoxia (three, 5 min hypoxic episodes, 5 min normoxic intervals) induced phrenic long-term facilitati
233 of dual-specificity phosphatase 16 increased normoxic levels of IL-6 and IL-1beta and reduced the hyp
236 d higher amounts of mature IL-1beta than did normoxic macrophages after treatment with crystalline ch
238 that the NK cell immune synapse formed with normoxic melanoma cells is more stable and contains a hi
239 metabolism following hypoxia due to abnormal normoxic metabolism, which was associated with a functio
242 cells derived ex vivo from hypoxic, but not normoxic, mice were able to form pluripotent, long-term
248 ed cardiac function; however, mechanisms for normoxic neonatal CPC exosomes improved function indepen
250 aining CB to maintain normal CB blood gases (normoxic, normocapnic perfusate), to inhibit (hyperoxic,
253 ts were divided into 3 groups (n = 5/group): normoxic (Nx), HI and HI pre-treated with Src kinase inh
258 ampal development and synaptic function in a normoxic or hypoxic environment, possibly by modifying c
259 xation to acetylcholine in aged offspring of normoxic or hypoxic pregnancy but not in young offspring
260 g (4 mo) and aged (15 mo) adult offspring of normoxic or hypoxic pregnancy with or without maternal a
261 aused phenylephrine pre-constricted UtA from normoxic or hypoxic pregnant mice to dilate and this dil
263 del simulating high-density encapsulation to normoxic or ischemic culture for 12 hours, after which v
266 dies suggest that iron chelators can prevent normoxic oxidative neuronal death through selective inhi
269 mining the effects of supplemental oxygen in normoxic patients with acute presentations of coronary a
270 osphatidylglycerol species were increased in normoxic pellets, whereas phosphatidylinositol species w
274 lphide-synthesis blockers on HPV and also on normoxic pulmonary vasoconstriction (NPV) stimulated by
282 n independently of polycythemia and enhanced normoxic respiration similar to Chuvash patients, furthe
283 ies in transformed cell lines suggested that normoxic stabilization of HIF-1alpha explains the persis
284 ns in von Hippel-Lindau (VHL) and subsequent normoxic stabilization of hypoxia-inducible factor (HIF)
285 n of VHL ubiquitin ligase is associated with normoxic stabilization of hypoxia-inducible factor-1alph
286 nt metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIF
288 e ATP-mediated regulation of COX through the normoxic subunit Cox5a, homologue of human COX4i1, in a
292 tion, doxorubicin enhanced VEGF secretion by normoxic tumor cells and stimulated tumor angiogenesis.
296 tocellular carcinoma cells recapitulated the normoxic up-regulation of HIF-1 alpha observed in HEK ce
297 e in an Illumina HumanWG-6 v3.0 48k array of normoxic vs. hypoxic osteoclasts differentiated from hum
298 that in systems with MeHg production in the normoxic water column eutrophication can increase phytop
299 tic Sea MeHgT budget, we inferred an average normoxic water column Hg(II) methylation rate constant o
300 hypoxia was not significantly different from normoxic WT mice and much lower than the RVSP values see
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