ライフサイエンスコーパス: noscapine

1 g]isoquinolin-5-yl)isobenzo-furan-1(3H)-one (noscapine).

2 tic arrest and then apoptosis in response to noscapine.

3 involved in the formation of papaverine and noscapine.

4 looxygenase-2 promoter was also inhibited by noscapine.

5 e antiproliferative and apoptotic effects of noscapine.

6 1 in the cellular response to treatment with noscapine.

7 fect tubulin polymerization differently from noscapine.

8 at mitosis at concentrations much lower than noscapine.

9 bserved arrest in mitosis in the presence of noscapine.

10 rt herein that two brominated derivatives of noscapine, 5-bromonoscapine (5-Br-nosc) and reduced 5-br

11 Here, we present one such analog, 9-nitro-noscapine (9-nitro-nos), which binds tubulin and induces

12 Noscapine, a benzylisoquinoline alkaloid derived from op

13 Noscapine, a microtubule-interfering agent, has been sho

14 Noscapine, a phthalideisoquinoline alkaloid derived from

15 We now show that noscapine, a tubulin-binding agent, increases the time t

16 ndantly expressed in opium poppy stems where noscapine accumulation is highest among plant organs.

17 families, that were tightly correlated with noscapine accumulation.

18 levels resulted in a significant decrease in noscapine accumulation.

19 n vivo, and we describe a novel mechanism of noscapine action through EP2 prostaglandin E2 receptor-m

20 Noscapine alone suppressed proliferation of human leukem

21 Noscapine also abrogated the inducible expression of pro

22 Importantly, noscapine also demonstrated the ability to significantly

23 Noscapine also suppressed phosphorylation and nuclear tr

24 is study, we found that apoptosis induced by noscapine, an anti-microtubule drug previously shown to

25 Here we demonstrate that a tubulin-binding noscapine analog, (R)-9-bromo-5-((S)-4,5-dimethoxy-1,3-d

26 Thus, many noscapine analogs with different functional moieties at

27 A number of noscapine analogues possessing various modifications hav

28 ), have higher tubulin binding activity than noscapine and affect tubulin polymerization differently

29 lytic activity toward oxidation of morphine, noscapine and heroin at reduced overpotentials in wide p

30 ulse voltammetric determination of morphine, noscapine and heroin yields calibration curves with the

31 for simultaneous determination of morphine, noscapine and heroin.

32 these compounds bound to tubulin shows that noscapine and its 7-aniline derivative do not compete fo

33 Noscapine and its 7-hydroxy and 7-amino derivatives were

34 of three major narcotic components, heroin, noscapine and morphine at micromolar concentration witho

35 pharmaceutical compounds codeine, morphine, noscapine and papaverine.

36 ive discusses the advancing understanding of noscapine and related analogues in the fight against mal

37 improvement in the commercial production of noscapine and related bioactive molecules.

38 isiae to achieve the microbial production of noscapine and related pathway intermediates, complementi

39 Nevertheless, noscapine and the two derivatives all affect the attachm

40 Cells treated with noscapine arrest at mitosis with nearly normal bipolar s

41 Interestingly, whereas noscapine-arrested cells have nearly normal bipolar spin

42 ave previously discovered the opium alkaloid noscapine as a microtubule interacting agent that binds

43 ave previously identified the opium alkaloid noscapine as a microtubule interacting agent that binds

44 the naturally occurring antitussive alkaloid noscapine as a tubulin-binding agent that attenuates mic

45 We show that noscapine binds stoichiometrically to tubulin, alters it

46 eviously that an antitussive plant alkaloid, noscapine, binds tubulin, displays anticancer activity,

47 mits set for morphine, codeine, thebaine and noscapine by Hungarian legislation.

48 Furthermore, noscapine causes apoptosis in many cell types and has po

49 Consequently, noscapine could be a valuable chemotherapeutic agent, al

50 In contrast, noscapine did not activate PKA in human bronchial or alv

51 Noscapine did not affect gross microtubule content in HL

52 ies reveal that even at high concentrations, noscapine does not alter the tubulin polymer/monomer rat

53 Here we show that noscapine does not compete with paclitaxel for tubulin b

54 t, unlike many other microtubule inhibitors, noscapine does not significantly promote or inhibit micr

55 required for subsequent apoptosis induced by noscapine, establishing a link between the two events.

56 cence staining of microtubules after 24 h of noscapine exposure at 20 muM elucidated chromosomal abno

57 constitute a 14-step biosynthetic pathway of noscapine from the simple alkaloid norlaudanosoline by e

58 Here, we reconstitute the noscapine gene cluster in Saccharomyces cerevisiae to ac

59 more than a century ago, the biosynthesis of noscapine has not been established.

60 Noscapine has since been discovered to arrest cells at m

61 ing enzymes responsible for the synthesis of noscapine have been recently discovered to be clustered

62 ved in the conversion of N-methylcanadine to noscapine have not been identified.

63 vation of PKA and the antifibrotic effect of noscapine in HLFs were blocked by the EP2 prostaglandin

64 ), which mediated the antifibrotic effect of noscapine in HLFs, as assessed with the PKA inhibitor, P

65 c and Rd 5-Br-nosc are also more active than noscapine in inhibiting the proliferation of various hum

66 However, the biosynthesis of noscapine in opium poppy has not been established.

67 the first committed step in the formation of noscapine in opium poppy.

68 ioavailable and is 250-fold more potent than noscapine in reducing cell proliferation in rapidly divi

69 MT3 that correlated with the accumulation of noscapine in the eight cultivars.

70 findings thus indicate a great potential for noscapine in the treatment of paclitaxel-resistant human

71 or the first time the antifibrotic effect of noscapine in vitro and in vivo, and we describe a novel

72 posed pathway leading from (S)-reticuline to noscapine includes (S)-scoulerine, (S)-canadine, and (S)

73 ansfection with dominant-negative JNK blocks noscapine-induced apoptosis.

74 Noscapine inhibited TGF-beta-induced differentiation of

75 Thus, noscapine inhibits the proliferation of leukemia cells a

76 Noscapine is a benzylisoquinoline alkaloid produced in o

77 Noscapine is a phthalideisoquinoline alkaloid investigat

78 Noscapine is a potential anticancer drug isolated from t

79 Noscapine is an antitumor alkaloid from opium poppy that

80 Radiotracer studies have shown that noscapine is derived from the protoberberine alkaloid (S

81 Because noscapine is water-soluble and absorbed after oral admin

82 An alkaloid from opium, noscapine, is used as an antitussive drug and has low to

83 a necessary but not sufficient condition for noscapine-mediated apoptosis.

84 angiogenesis in tumors, we hypothesized that noscapine mediates its effects by modulating the NF-kapp

85 sed a significant reduction in the levels of noscapine, narcotoline, and a putative downstream secobe

86 investigated the chemo-sensitizing effect of Noscapine (Nos) at low concentrations in conjunction wit

87 We studied in silico docking of noscapine onto tubulin, combined with calculations of su

88 pium alkaloids (morphine, codeine, thebaine, noscapine, papaverine and narceine) in poppy seeds and b

89 We found that noscapine potentiates apoptosis induced by cytokines and

90 t were most abundant in aerial organs, where noscapine primarily accumulates.

91 oding five distinct enzyme classes in a high noscapine-producing poppy variety, HN1.

92 ntifibrotic effects of the antitussive drug, noscapine, recently found to bind microtubules and affec

93 vative, thereby advancing protoberberine and noscapine related drug discovery.

94 mitosis and resume a normal cell cycle after noscapine removal.

95 r results demonstrate that p.o.-administered noscapine significantly inhibits the progression of mela

96 Furthermore, noscapine stimulated a rapid and profound activation of

97 Noscapine suppressed both inducible and constitutive NF-

98 ates, allowing gene function to be linked to noscapine synthesis and a novel biosynthetic pathway to

99 We demonstrate that noscapine-treated murine melanoma B16LS9 cells do not ar

100 y, cell cycle distribution, and apoptosis on noscapine treatment in four cell lines derived from the

101 Our results show that noscapine treatment increases the expression of p53 over

102 Therapeutic noscapine treatment resulted in a significant attenuatio

103 c murine model of established s.c. melanoma, noscapine treatment resulted in an 85% inhibition of tum

104 ly, these cells undergo apoptotic death upon noscapine treatment, accompanied by activation of the c-

105 n accumulation in a time-dependent manner on noscapine treatment.

106 the inhibition of tumor volume observed when noscapine was combined with paclitaxel.

107 Analogues of the natural product noscapine were synthesized and their potential as antitu

108 Analogues of the natural product noscapine were synthesized, and their potential as antit

109 higher affinity than the founding compound, noscapine, without changing total microtubule polymer ma