ライフサイエンスコーパス: notum

1 tinguish the future wing from the body wall (notum).

2 teroposterior axis of the Drosophila thorax (notum).

3 uch, but grow normally in the wing hinge and notum.

4 veins in the wing and of macrochaete in the notum.

5 neural structures in the eye, wing, leg and notum.

6 rning sensory precursor cells in the lateral notum.

7 velopment of sensory bristles in the lateral notum.

8 ensory bristles in the lateral domain of the notum.

9 organ precursor cells of the wing margin or notum.

10 n restriction of JAK/STAT signaling from the notum.

11 of the hinge, and restricts expansion of the notum.

12 relative expansion of the pouch, hinge, and notum.

13 , the hinge, the surrounding pleura, and the notum.

14 romised wing growth and the formation of the notum.

15 mediate activation at specific sites on the notum.

16 idia in the eye, and sensory bristles on the notum.

17 is specific to Notum 2, as overexpression of Notum 1a does not affect PMN axon trajectory.

18 Notum 1a does not interact with Glypican 4, an essential

19 Our work shows that zebrafish Notum 1a, an ortholog of mammalian Notum, contributes to

20 While homologs of Notum, including zebrafish Notum 1a, negatively regulate the Wnt/beta-catenin signa

21 Ectopic expression of Notum 2 by cells contacting the growing CaP axon induced

22 ency of branching, suggesting that localized Notum 2 expression affects axon behavior.

23 We propose a model where Notum 2 expression at the MPs provides a cue to release

24 g pathway, we discovered a novel function of Notum 2 in regulating motor axon guidance.

25 In contrast, mosaic Notum 2 overexpression induced branching of PMN axons.

26 Knockdown of Notum 2 resulted in a failure of caudal primary (CaP) ax

27 This effect is specific to Notum 2, as overexpression of Notum 1a does not affect P

28 new member of the Notum family in zebrafish, Notum 2, which is expressed exclusively in the MPs durin

29 It does, however, require Notum, a conserved secreted feedback inhibitor of Wnt si

30 This is achieved in part by Notum, a highly conserved secreted feedback antagonist.

31 , at the active site of human and Drosophila Notum, a large hydrophobic pocket that accommodates palm

32 We further show that Notum, a negative regulator of Wg signaling, downregulat

33 In Drosophila, Notum, a secreted alpha/beta-hydrolase, antagonizes the

34 Follistatin and Notum, a Wnt inhibitor, are mutually required to reestab

35 copied by Wg overexpression, suggesting that Notum acts solely by inhibiting Wg trans-synaptic signal

36 ally, as well as its homolog dally-like, and notum affect Wingless distribution in the embryonic epid

37 o elicits a similar peripheral expression of Notum, an enzyme that limits the extent of Wg signaling.

38 y, stat92E activity is down regulated in the notum and distal pouch.

39 scs vn is first expressed in the presumptive notum and later in the wing-pouch and hinge regions.

40 activity of the E(spl)mgamma enhancer in the notum and margin territories of the wing disc can be ove

41 r embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation

42 ic EGFR hyperactivity phenotypes in the eye, notum and wing, and also leads to downregulation of Yan,

43 ired for expression of polarity determinants notum and wnt1 and for correct patterning of the structu

44 ters of the developing sensory organs in the notum, and are regulated by the signalling molecules Win

45 e identified three interacting genes: dally, notum, and brahma.

46 nly the mechanosensory bristles on the head, notum, and scutellum are affected by warthog mutations.

47 thorax but also broadly contiguous with the notum anteriorly and posteriorly (details unobservable i

48 Here, we use bristle patterning in the fly notum as a model system to explore the regulatory and fu

49 Here we use the fly notum as a model system to identify a novel process of c

50 rmation of the insect wing from the thoracic notum as well as the already known pleural elements of t

51 rting their overall origin from the thoracic notum as well as the expected medial, pleural series of

52 1) Vn/EGFR signaling directs cells to become notum by antagonizing wing development and by activating

53 A subset of the trichome-producing notum cells differentiate as "tendon cells," serving as

54 roquois Complex (Iro-C) genes in prospective notum cells, rendering them distinct from, and immiscibl

55 mplex (Iro-C) gene expression in prospective notum cells.

56 zebrafish Notum 1a, an ortholog of mammalian Notum, contributes to a self-regulatory loop that restri

57 enetic interaction studies show that dlp and Notum cooperate to restrict Wg signaling.

58 We suggest that Notum could amplify local differences in Wingless signal

59 y the Tiki protease in the Organizer and the Notum deacylase in presumptive neuroectoderm orchestrate

60 wn to be likely not to involve a gradient in Notum distribution, even though Notum is only expressed

61 Notum encodes a secreted protein that also limits Wg dis

62 ck inhibition between wnt11-6/wntA/wnt4a and notum, encoding conserved antagonistic signaling factors

63 roposterior planar polarization requires the notum epithelia to balance mechanical stress generated b

64 Here we show that in the Drosophila notum epithelium, each cell division is associated with

65 notum expression is itself controlled by Wnt signaling,

66 egative interactions between Stat92E and the notum factor Araucan, resulting in restriction of JAK/ST

67 We have identified a new member of the Notum family in zebrafish, Notum 2, which is expressed e

68 Notum has been thought to act as a phospholipase, sheddi

69 e organization of bristles on the Drosophila notum has long served as a popular model of robust tissu

70 and specific roles in the development of the notum, hinge, longitudinal vein 4, and all intervein reg

71 s work demonstrates an unexpected role for a Notum homolog in regulating growth cone migration, separ

72 from the well established functions of other Notum homologs in Wnt signaling.

73 Here, we report that Notum hydrolyzes the Wnt palmitoleoylate adduct extracel

74 o specify dorsal pleura identity and inhibit notum identity to properly subdivide the body wall.

75 esults suggest a surprising specific role of Notum in the developing vertebrate embryo.

76 The role of Notum in the setup of the Wg gradient is also shown to b

77 specificity in cell culture, but the role of Notum in vertebrate development has not been studied.

78 While homologs of Notum, including zebrafish Notum 1a, negatively regulate

79 the spatial expression of these genes on the notum increased in the lineage leading to the higher Dip

80 Studies of mammalian Notum indicate promiscuous target specificity in cell cu

81 d, and double-RNAi experiments indicate that notum inhibits Wnt signaling to promote head regeneratio

82 ometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential pa

83 These findings suggest that Notum is a prerequisite for the "default" neural fate an

84 Notum is a secreted Wnt antagonist that belongs to the a

85 Thus, Notum is a Wnt deacylase, and palmitoleoylation is oblig

86 typed arrangement of sensory bristles on the notum is determined by the tightly regulated control of

87 Notum is expressed in naive ectoderm and neural plate in

88 gradient in Notum distribution, even though Notum is only expressed close to the source of Wg synthe

89 incides temporally with that of ac-sc in the notum, is Wingless (Wg; also known as Wnt).

90 evels in Notum null mutants, indicating that Notum normally functions to coordinate synaptic structur

91 In Notum null flies, we find upregulated extracellular Wg l

92 essed by genetically correcting Wg levels in Notum null mutants, indicating that Notum normally funct

93 macrochaete (sense organ) patterning on the notum of Drosophila melanogaster.

94 d sensory organ precursor (SOP) cells on the notum of some but not all flies.

95 This requires the polarity determinant notum Our work establishes planarians as a suitable mode

96 ding elicits expression of the Wnt inhibitor notum preferentially at anterior-facing wounds.

97 l (DV) compartments and limb-body wall (wing-notum) primordia depends on Epidermal Growth Factor Rece

98 compartments and limb (wing) and body wall (notum) primordia.

99 axis of the dorsal mesothoracic segment: the notum, proximal wing, and wing blade.

100 provide genetic evidence in Drosophila that Notum requires glypicans to suppress Wnt signalling, but

101 ing in posterior and anterior regions of the notum, respectively.

102 uscular junction (NMJ) synapse, we find that Notum secreted from the postsynaptic muscle acts to stro

103 structive role in organizing the DV and wing-notum segregations, implying the existance of other loca

104 ssed mir-279/996 cluster, with a majority of notum sensory organs exhibiting transformation of sheath

105 Wnt/Notum signaling tunes numbers of differentiated brain ce

106 agonizing wing development and by activating notum-specifying genes; (2) Vn/EGFR signaling directs ce

107 e present evidence that both the DV and wing-notum subdivisions are specified by activation of the Dr

108 chas is expressed in notum tendon cells, and its loss of function disturbs ce

109 MyosinII to modulate the mechanoresponse of notum tendon cells.

110 ngless produce a negative signal (encoded by notum) that inhibits Wingless signaling in nearby cells.

111 The Drosophila notum, the dorsal body wall of the thorax, is subdivided

112 gs representing an extension of the thoracic notum, the other stating that they are appendicular deri

113 t establishes a proximal appendage fate over notum, then the downstream response changes to direct th

114 binding sites on Notum, which probably help Notum to co-localize with Wnt proteins.

115 When expressed in the notum, truncated Mam results in failure of lateral inhib

116 Only one gene, notum, was differentially expressed early between anteri

117 etal regulators in the developing Drosophila notum, we have identified a critical role for Cdc42-aPKC

118 as mediated by direct inhibition of Axin and Notum, which encode essential, negatively acting compone

119 es reveal glycosaminoglycan binding sites on Notum, which probably help Notum to co-localize with Wnt

120 ions of the secreted extracellular deacylase Notum, which restricts Wg signaling by cleaving an essen

121 structive EGFR signal(s), in contrast to the notum-wing boundary, which continues to be defined by EG

122 Inhibition of notum with RNA interference (RNAi) causes regeneration o