1 culturally shaped and likely evolutionarily
novel.
2 elimination sequence was developed to access
novel 1,4,6,7-tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridi
3 A
novel 3D Co-Nx |P-complex-doped carbon grown on flexible
4 In an attempt to identify
novel actin signaling pathways regulated by NPM-ALK, a c
5 A paucity of
novel acting antibacterials is in development to treat t
6 14 resolved to individual genes, six encode
novel activities affecting tocochromanols in plants.
7 Using a
novel activity-dependent technology called CANE develope
8 establishes hyperpolarized [(13)C]-Glyc as a
novel agent for clinically relevant (13)C MRS studies of
9 m of WNT3A, where WNT3A antagonists could be
novel agents for the treatment of metastasis and for ske
10 Additionally, a suggested
novel algorithm for p53-based diagnostic workup in AML i
11 Small molecules with
novel and defined mechanisms of inhibition are thus need
12 A
novel and efficient route for the preparation of (2S)-2-
13 Noninvasive mobility sensor is a
novel and feasible method for automating evaluation of I
14 We set out to identify
novel and functionally important endothelial lncRNAs.
15 four modules that encode 80 genes, including
novel and known virulence factors associated with adhere
16 targeting HDAC1/HDAC2 and MYC may present a
novel and molecularly defined strategy to target mutant
17 Five of these are
novel,
and four sites are consistently dephosphorylated
18 biomarker in the blood of patients provides
novel,
and less invasive, opportunities for disease diag
19 F1) E3 ligase, which represents a target for
novel anti-human immunodeficiency virus (HIV) drug devel
20 rception and, thus, allow the development of
novel antibacterial compounds.
21 uman cells, a prerequisite for using them as
novel antibiotic drugs.
22 Commonly used methods to obtain
novel antibodies typically yield several candidates capa
23 significant importance to the development of
novel antibody-based therapies, and heavy chain (Hc) het
24 ion is being devoted to the investigation of
novel anticancer strategies.
25 should occur in parallel with development of
novel antiviral and immune modulatory therapies such tha
26 In contrast,
novel appetitive odor learning is sensitive to inactivat
27 This
novel application of MGE not only offers a noninvasive t
28 xplore new physical phenomena and to foresee
novel applications in the fields of electronics and opto
29 ments in SI-CRP, as well as the emergence of
novel applications such as catalysis, electronics, nanom
30 Herein, a
novel approach for rapid, simple and cost-effective disc
31 e modulation of Kv3.1 channels may provide a
novel approach to the treatment of bipolar mania.
32 gest that targeting this molecule could be a
novel approach to treat allergic asthma.
33 In this paper, a
novel array of quasi-three-dimensional (quasi-3D) bowtie
34 work uncovered 16S rRNA genes belonging to a
novel,
as-yet-uncultivated mycoplasma (lineage 'Mnola')
35 es to a mutation in fgf8a Our data highlight
novel aspects of SHF, OFT and HM development in zebrafis
36 To investigate this claim, we developed a
novel assay that allows for parallel profiling of activi
37 A5-CHRNA3-CHRNB4 genes and further yielded a
novel association in the DNA methyltransferase gene DNMT
38 image analysis, with the implementation of a
novel automatic detrending algorithm.
39 sequencing and RNA sequencing, we identify a
novel B-lymphoid program for transcriptional repression
40 These inhibitors were shown to possess a
novel binding mode by X-ray crystallography, in which th
41 Microbial fuel cells (MFCs) are
novel bio-electrochemical device for spontaneous or sing
42 creasing interest in the construction of the
novel biointerfaces for biosensing applications.
43 These loci highlight
novel biological functions, including response to oxidat
44 We propose a
novel,
biologically motivated, Bayesian multitask approa
45 is remains unknown, hampering the search for
novel biomarkers and treatments.
46 Development of standardized assays for
novel biomarkers toward better defining hepatitis B viru
47 In this
novel biosensor matrix, amino groups in HKCN were used f
48 In particular, these
novel biosensors can be used to reveal potentially thera
49 This work provides a
novel biospectroscopy approach to characterize the chemo
50 nd N-heterocyclic carbene (NHC) chemistry, a
novel C-N bond activation and ring-opening process is de
51 ke domain associated with DSD activity and a
novel C-terminal hydroxyphenylpyruvate dioxygenase-like
52 We report
novel C. jejuni factors essential throughout its life cy
53 -related molecular mechanisms and to develop
novel cancer therapies.
54 Our findings identify RCL1 as a
novel candidate gene for depression and offer insights i
55 These results suggest a
novel candidate mechanism linking histone modifications
56 scriptional profiling and identified several
novel candidate retinotectal guidance molecules.
57 We further detected
novel cardiac chemical signatures related to the severit
58 these activated T cells were determined by a
novel CD154 T cell epitope mapping assay.
59 Despite no
novel chemical marker has been identified, the (1)H NMR
60 on and phylogenetic analyses we identified a
novel class of Arabidopsis thaliana pollen-borne CRPs, t
61 en developed for the rapid construction of a
novel class of densely functionalized picolinates.
62 INTERPRETATION: We developed and validated a
novel clinical prediction model with good discriminative
63 derivatives of kynurenine and identified two
novel,
closely related condensation products, named trac
64 , 281, and 284 of the STING protein define a
novel cluster of amino acids with functional importance
65 Here, we identify several
novel CO2-dependent changes in the NF-kappaB pathway.
66 It comprises a
novel combination of two powerful technologies: deep con
67 stributions will not allow extrapolations to
novel community assemblages in future climates, which wi
68 molecule agonists of TFEB and discover three
novel compounds that promote autophagolysosomal activity
69 In our
novel,
computationally tractable approach to RNA-ligand
70 Here, we outline a
novel concept of functional connectome-wide alterations
71 Novel concepts and paradigms are described here that hav
72 ferent subsets of driver genes, we propose a
novel consensus-based approach, ConsensusDriver, which s
73 epetitive firing of lower motor neurons as a
novel contributor to intensive care unit acquired weakne
74 series of push-pull chromophores based on a
novel coumarin scaffold in which the carbonyl of the lac
75 These results identify a
novel cross talk between a key family of miRNAs and proa
76 ning under expected outcome uncertainty in a
novel delay-based task that incorporates both predictabl
77 The first two talks discuss
novel developmental and neuronal subtype-specific contri
78 This includes
novel developments in SI-CRP, as well as the emergence o
79 ned microenvironments can be used to develop
novel devices and methods in protein biophysics for samp
80 A
novel DNA adenine modification, N(6)-methyladenine (6mA)
81 fic loop formed between its promoter and the
novel DRE.
82 ncoded in each of the omics data to identify
novel driver genes through an integrative framework.
83 lds promise as a biomarker for diagnosis and
novel drug discovery.
84 In this study, we performed a
novel drug-repurposing screening to identify Food and Dr
85 Here we introduce silyl ether linkage as a
novel dynamic covalent motif for dynamic material design
86 ers and to help medicinal chemists to design
novel dynamin ligands, which could be useful in the trea
87 gh its N terminus and microtubules through a
novel dynein interacting site near its C terminus.
88 eased calcium signaling, transformation, and
novel E-cadherin-RalBP1 interaction.
89 ), a pollen-specific phospholipase, and that
novel edits in MTL lead to a 6.7% haploid induction rate
90 The
novel effect of pedalism suggests that, if right pSTS co
91 Here, we propose Gracob, a
novel,
efficient graph-based method that casts and solve
92 Thus, in ReRh rats, exploration of a
novel environment appears to interfere with the represen
93 enetic backgrounds (inbred - outbred) into a
novel environment at three founding sizes (2-32), and tr
94 To study the degree of CRS control using
novel EPOS control criteria at 3-5 years after a functio
95 velopment of antimicrobials that target this
novel,
essential pathway.
96 Our results provide
novel evidence of associations between exposure to some
97 ct criteria to identify a large set (649) of
novel,
evolutionarily restricted miRNAs.
98 Using a
novel ex vivo spinal cord preparation, here we identify
99 Our results provide a
novel example of a potentially general mechanism whereby
100 Our
novel experimental approach accurately models human NBL
101 cteristics of animal and plant cells provide
novel explanations regarding how pH may drive cellular p
102 Liposomal bupivacaine is a
novel extended-duration anesthetic that has recently bee
103 CL engages in a particularly interesting and
novel face-on halogen-pi interaction between the ligand'
104 We applied
novel fetal resting-state functional MRI to measure brai
105 This
novel field asymmetric time of flight ion mobility spect
106 Our
novel findings, including T-tubule dilatation and disorg
107 We report three
novel findings.
108 Varlilumab is a
novel,
first-in-class, agonist CD27 antibody that stimul
109 These changes were monitored using a
novel fluorescent reporter gene, pMitoTimer, that allows
110 Finally, we describe a
novel form of activity-dependent intrinsic plasticity th
111 ide unique surface interactions for enabling
novel forms of guided molecular assembly.
112 PA101 is a
novel formulation of sodium cromoglicate delivered via a
113 Our data thus reveal a
novel function for Nesprin-1alpha/Nesprin-1 in nuclear p
114 of JEM, Marciniak et al. identify a putative
novel function of tau protein as a regulator of insulin
115 This
novel functional dissociation of pain processing within
116 We also found a
novel fusion involving USP9X-ERAS formed by chromothrips
117 Expression levels of four
novel GAD1 transcripts (8A, 8B, I80 and I86) showed a li
118 controlled trial examined the efficacy of a
novel gaze-contingent music reward therapy for social an
119 e was improved in over 13% of genes, and 651
novel genes were predicted by the GC-specific MAKER prot
120 saccharide epitopes can aid in the design of
novel glycoconjugate vaccines.
121 We thus developed
novel glycylation-specific antibodies with which we dete
122 Ebselen, a
novel GPx1 mimic, has been shown to reduce both temporar
123 th bioinformatics methods.We discovered five
novel heart rate loci, and one new independent low-frequ
124 and genetic studies, we identify FKBP12 as a
novel hepcidin regulator.
125 Valbenazine (NBI-98854) is a
novel,
highly selective vesicular monoamine transporter
126 we designed and synthesized a collection of
novel hydroxy-substituted heteroarylpiperazines and hete
127 This suggests a
novel hypothesis which proposes that the reduced adipose
128 knowledge of the affected sequences provides
novel information for a better characterisation of prote
129 Together, our results provide
novel insight into the role of Nt17 post-translational m
130 icularly single cell analyses) are providing
novel insights into the genetic, environmental, and cell
131 ansport in synaptic transmission and provide
novel insights into the role of Unc-104 in synapse matur
132 These studies have raised several
novel insights on transcriptional regulation such as the
133 To test this hypothesis, we used a
novel intense stimulus (high-intensity exercise) to demo
134 tein interaction method, we identified eight
novel interaction partners of EGFR, of which half strong
135 observed alterations in chronic pain offer a
novel interpretation of aberrant pain processing as dist
136 Novel intradermal devices, including intradermal adapter
137 In order to develop
novel kappa agonists restricted to the periphery, a dias
138 These findings reveal a
novel link between endothelial glutamine and asparagine
139 that inflorescence branching is regulated by
novel localized signaling centers.
140 These 11
novel loci include GATAD2B, ASCC3, DSCAML1, and HELZ, wh
141 We also identify SNPs at
novel loci including GCKR, CADM2 and FAM69C.
142 an samples, we identified an additional nine
novel loci.
143 nal identification and characterization of a
novel long intergenic non-coding RNA with MyoD-regulated
144 residue 137 and that residues 90-125 form a
novel loop that links Sac3 to Thp1.
145 We present here the development of a
novel lysozyme sensing concept based on the use of Micro
146 vide opportunities for unbiased discovery of
novel markers to improve diagnostic or predictive accura
147 However, it remains unclear whether
novel mcrA genes associated with the Bathyarchaeota and
148 es, present in male and female mice, provide
novel means for examining the genetic and molecular base
149 A
novel measurement system was developed to quantify metha
150 lated cardiac mitochondria, we demonstrate a
novel mechanism by which antimycin-inhibited complex III
151 Together, our findings reveal a
novel mechanism by which Ca(2+) overload disrupts myofib
152 er their initial activation and identifies a
novel mechanism for controlling thrombosis.
153 unveil a CDK4-PIN1-p53-RS-c-Myc pathway as a
novel mechanism for the GOF of p53-RS in HCC.
154 Taken together, these findings identify a
novel mechanism linking IL-6 trans-signaling and angioge
155 Our results implicated a
novel mechanism of exosome-mediated intercellular commun
156 eddase has allowed the characterization of a
novel mechanism of ICOS regulation.
157 This study therefore defines a
novel mechanism of MAPK activation requiring binding of
158 anscription and, more importantly, uncover a
novel mechanism of TFIID recruitment and gene activation
159 In this study, we report on a
novel mechanism that promotes the proinflammatory functi
160 , the piRNA-rich nict-1 locus could define a
novel mechanism underlying phoretic interactions.Nematod
161 Our results suggest a
novel mechanism(s) by which HNK exerts its anti-tumor ac
162 t homeostasis and disease, and also revealed
novel mechanisms by which TGFbeta signals are transduced
163 New drugs with
novel mechanisms of action, such as cardiac myosin activ
164 at H. pylori deregulates mitochondria by two
novel mechanisms, both rather associated with host cell
165 the hypothesis that N-cadherin is part of a
novel mechanosensory mechanism in VSMCs and plays an act
166 We present here a
novel method (RS3D) that can assimilate the RNA secondar
167 We present a
novel method for extracting uncertainty from the literat
168 We describe a
novel method of kinetic analysis of radioligand binding
169 For this purpose, this paper introduces a
novel methodology based on dispersive liquid-liquid micr
170 We developed a
novel methodology for burden estimation and present firs
171 lthough currently the ubiquitous use of this
novel methodology is still limited to soils with high or
172 vectors could potentially aid development of
novel methods to control spirochete transmission.
173 approach, we introduce versatility, V, as a
novel metric of nodal affiliation: V approximately 0 mea
174 We characterize 21
novel microRNAs, one of which may trigger phasiRNAs from
175 These data unveil two
novel mitochondrial effectors in H. pylori-host interact
176 ng tin iodide perovskite cells employing the
novel mixed-cation ethylenediammonium/formamidinium with
177 er to form a ternary complex, representing a
novel mode of regulation of G protein-coupled receptor s
178 Novel models are required that maintain physiological le
179 anding the eukaryotic proteome and revealing
novel modes of cap-independent translation.
180 and in vivo imaging analysis, and identified
novel molecular candidates for TM formation and function
181 Thus far, most trials of
novel molecular imaging in oncology have been small, sin
182 Our study uncovers a
novel molecular mechanism for regulating PD-L1 protein s
183 P. pastoris and C. albicans, and it may have
novel moonlighting functions in the nucleus.
184 Here, we generated a
novel mouse model (eAA) with the erythroid-specific abla
185 In this study, we combine
novel mouse reporters and single-cell RNA sequencing to
186 ayer two-dimensional materials could lead to
novel multi-functionalities.
187 Finally, a
novel multiplex PCR assay, based on random amplified pol
188 effects of ARHGAP29 in vivo, we generated a
novel murine allele by inserting a point mutation identi
189 We generated a
novel mutant mouse (Dclre1c(leaky)) that develops a LS p
190 ntify the H3K9 methyltransferase SETDB1 as a
novel,
negative regulator of innate immunity.
191 inal injury after alkali burn and explored a
novel neuroprotective regimen suitable for prompt admini
192 ylated cluster [Ge9{Si(TMS)3}3](-) yield the
novel neutral cluster compounds [Ge9{Si(TMS)3}3PR2] (R:
193 the discovery and development of improved or
novel new compounds, including D1 agonists with better p
194 ed papillomas in the context of p53 loss and
novel NF-kappaB expression, whereas increased tissue rig
195 salvage radiopharmaceutical therapy with the
novel NTR1 antagonist (177)Lu-3BP-227.
196 ognitive alterations, including defects in a
novel object recognition task.
197 subjects of both sexes encoded and retrieved
novel objects during periods of safety and threat of unp
198 This
novel observation warrants further studies.
199 The mechanism of this
novel observation was further investigated through the m
200 Ribo-TISH can also predict
novel open reading frames (ORFs) from regular ribosome p
201 agulation (P for heterogeneity = .49) or the
novel oral anticoagulant type (P for heterogeneity = .15
202 bly lower risks of intraocular bleeding with
novel oral anticoagulants were seen in subgroup analyses
203 We propose a
novel paradigm of atrial ECC that is based on tandem act
204 Here, we created a
novel paradigm optimized to dissociate the subtypes of r
205 e of plant cell specialization and to reveal
novel participants potentially involved in fibre metabol
206 In summary, we identified a
novel pathway for regulation of beta-catenin levels and
207 Last, we identified and studied three
novel patient XIAP mutations and used this system to cha
208 A
novel phenylpiperazine acrylamide monomer was synthesize
209 Here, we present a
novel photoconductive terahertz source that offers a sig
210 of PCP signaling by inhibiting Dvl through a
novel polyubiquitination mechanism.
211 n vivo Taken together, our findings reveal a
novel posttranslational modification of HBx by HDM2 whic
212 Thus, R. typhi(GFPuv) bacteria are a
novel,
potent tool to study infection with the pathogen
213 in, we report for the first time a series of
novel,
potent, and selective inhibitors of IKKalpha.
214 Administration of bictegravir, a
novel,
potent, once-daily INSTI designed to improve on e
215 bolic alterations after burn injury and as a
novel potential molecular target to improve the clinical
216 into T. brucei-host interaction and reveals
novel potential protein kinase drug targets.
217 Validation of this
novel predictive score is needed to confirm clinical uti
218 A
novel predictor of bullying may be underlying regional w
219 IL-37 is a
novel pro-angiogenic cytokine that potently promotes end
220 enesis, but it also puts forward a potential
novel prognostic biomarker to predict high-risk tumors b
221 Collectively, this work identifies a
novel protein that plays a role in the assembly of the m
222 We also report a
novel protein-coding gene evolution-D6Ertd527e-in which
223 Recently, a
novel pyro-phototronic effect is invented as an alternat
224 f cellular heterogeneity through discovering
novel quality attributes, optimizing manufacturing, and
225 These
novel quasi-particles arguably explain a range of poorly
226 ese studies demonstrate that HIF-2alpha is a
novel regulator of neutrophil recruitment to colon tumor
227 ntial enrichment at oncogenic enhancers is a
novel regulatory mechanism in human pancreatic cancer.
228 ogether, these findings identify Sema3E as a
novel regulatory molecule in allergic asthma that acts u
229 cent studies have shown that sarcopenia is a
novel risk factor for developing NAFLD.
230 etuin-A is a hepatic secretory protein and a
novel risk factor for diabetes.
231 Areas of increased lung attenuation are a
novel risk factor for ILD hospitalization and mortality.
232 MARGI technology should facilitate revealing
novel RNA functions and their genomic target regions.
233 These results suggest a
novel role for EMCN as a potent regulator of angiogenesi
234 on, and differentiation, these data reveal a
novel role for Osr2 in regulation of palatal morphogenes
235 Collectively, our study demonstrates a
novel role of FANCD2 in governing cellular ATP productio
236 Our data demonstrated a
novel role of Pik3r1 that was independent of the regulat
237 We devised a
novel room-temperature-phosphorescence (RTP)-based oxyge
238 This finding clearly demonstrates a
novel route to the enhanced functional properties in the
239 , identifying distinct responses will enable
novel routes for PTP-selective drug design, important fo
240 The
novel score was assessed within patients randomised to d
241 e we show the cross-catalyzed emergence of a
novel self-replicator from a dynamic combinatorial libra
242 In this study, we describe and characterize
novel sensors based on the Systematic Protein Affinity S
243 Y6 receptors to suppress GC growth through a
novel SOCE/Ca(2+)/beta-catenin-mediated anti-proliferati
244 s) have shown that some can learn to produce
novel sounds by configuring different orofacial movement
245 echolamines, and identified eosinophils as a
novel source of these mediators.
246 We identified a
novel splice mutation in IKBKG (c.518+2T>G, resulting in
247 his study not only expanded our knowledge on
novel sRNAs but would also give us new insight into sRNA
248 Novel strategies are needed to enhance muscle repair and
249 g the function of these cells and developing
novel strategies for enhancing host defense to infection
250 (TRanslational Initiative on Unique and
novel strategies for Management of Patients with Heart f
251 he immune response is crucial to identifying
novel strategies to effectively address highly pathogeni
252 The emergence of species-specific traits and
novel structures results from evolutionary changes in GR
253 By utilizing these
novel structures we show that (i) the detection limit fo
254 In this
novel study, we focused on a relationship between endopl
255 erates predictions of behavioral measures in
novel subjects, accounting for a considerable amount of
256 ituril chemistry, but also for the design of
novel supramolecular architectures.
257 We therefore developed InFlo, a
novel systems biology approach for characterizing comple
258 Although the introduction of
novel targeted agents has improved patient outcomes in s
259 that bind to mutated EGFR can help identify
novel targets for drug discovery.
260 h suggests that these pathways are potential
novel targets for host directed therapy in CNS TB.
261 Developing
novel targets for SE therapy and diagnosis is important
262 ibiting inflammasome activation may serve as
novel targets for the prevention and treatment of HF in
263 have opened the window to a diverse array of
novel targets whose potential efficacy is tied to specif
264 mining for antibiotics with interesting and
novel targets.
265 leep and impaired behavioral adjustment to a
novel task after sleep deprivation.
266 This study reports a
novel technique that analyses long-distance subionospher
267 In this study, we present a
novel technique that combines large-scale micro-electrod
268 Novel techniques of MIP deposition as thin films, surfac
269 e-pot [Pd]-catalysis for the construction of
novel tetracyclic compounds was described.
270 Based on these results, we suggest a
novel theory for oculomotor learning: a distributed repr
271 r MEK inhibitors is probably inevitable, and
novel therapeutic approaches are needed to target dorman
272 g of pathogenic pathways in AKI may identify
novel therapeutic approaches.
273 Combining ALK inhibition with other
novel therapeutic modalities should prove even more effe
274 r affinity for integrin VLA-3, which reveals
novel therapeutic possibilities.
275 aintenance of T-cell homeostasis and outline
novel therapeutic strategies tailored to manipulate cell
276 g PARP-associated DNA repair may represent a
novel therapeutic strategy for gliomas.
277 potential to activate latent plasticity as a
novel therapeutic strategy to restore synaptic strength.
278 siological role after SCI, and may provide a
novel therapeutic target for SCI.
279 Our findings highlight TBX2 as a
novel therapeutic target upstream of WNT3A, where WNT3A
280 Our data identified Runx1 as a
novel therapeutic target with translational potential to
281 inforcement, we serendipitously identified a
novel therapeutic target: DAT oligomer complexes.
282 disruption and AD, and therefore we present
novel therapeutic targets for this disease.
283 Novel therapies are needed for patients with relapsed or
284 isk patients, and clinical trials evaluating
novel therapies should be focused on these patients.
285 Finally,
novel therapies that might restore homeostasis in the GI
286 utic development with the intent of bringing
novel therapies to this patient population years before
287 the issues raised in the report were hardly
novel,
they gave a new and powerful voice to the cancer
288 Previously, we reported a
novel thienopyrimidinone SIRT2 inhibitor with good poten
289 l behavior and vascular healing profile of a
novel thin-walled (115 microm) sirolimus-eluting ultrahi
290 e analyze 563 full genomes, 455 of which are
novel,
to show that the history of the species comprises
291 This study provides a
novel tool to study dynamics in ordered and disordered s
292 These studies will help identify
novel treatment strategies.
293 HCMV replication is important for developing
novel treatments.
294 The paper presents a
novel two-stage particle swarm optimization (PSO) for th
295 cribes its late genes, and thus represents a
novel type of bacteriophage RNAPs.
296 thetic approaches and how the development of
novel Ub-based reagents is greatly assisting in uncoveri
297 +) imaging of dentate granule neurons with a
novel,
unrestrained virtual reality system for rodents,
298 lity to generalize to a number of untrained,
novel videos depicting grasps or other manual motor acts
299 active during the early stage of learning a
novel vocabulary.
300 Two clinical trials to define
novel ways of using an existing antibiotic, fosfomycin,