ライフサイエンスコーパス: novel gene

1 portions of two different genes to create a novel gene.

2 Half were in novel genes.

3 d conserved promoters, splice junctions, and novel genes.

4 structure of gene networks, epigenetics, and novel genes.

5 ns, may act as catalysts for the creation of novel genes.

6 within the rice genome were considered to be novel genes.

7 These ITFs are likely parts of novel genes.

8 ehensive approach, we identified hundreds of novel genes.

9 different stages of LOS biosynthesis for 10 novel genes.

10 rived miRNAs, the vast majority of which are novel genes.

11 known importance to osteosarcoma, as well as novel genes.

12 e list of mouse imprinted genes including 18 novel genes.

13 rostin-expressing cells identified known and novel genes.

14 confirming the domain-specific expression of novel genes.

15 y 11,000 expressed genes and more than 2,100 novel genes.

16 tinct structures with a higher proportion of novel genes.

17 ies to influence the (long-term) survival of novel genes.

18 he level of lung function identified several novel genes.

19 infected murine macrophages identified three novel gene 50 transcripts initiating from 2 transcriptio

20 ir host organisms through the acquisition of novel genes, a process called lysogeny.

21 Novel gene acquisitions include a gene for a putative ex

22 ildren aged 3 to 12 yr and nominated several novel genes: ACTN2, EDARADD, EPHA7, LPO, MPPED2, MTR, an

23 on studies have identified several potential novel genes affecting red cell indices, which are not me

24 dy on the Genetics of Alcoholism to identify novel genes affecting risk for alcohol dependence (AD).

25 Overall, we have characterized a novel gene and corresponding set of neurons that regulat

26 Finally, 289 novel genes and 22 proteins, several important in immuno

27 Numerous novel genes and candidate biomarkers were upregulated du

28 These results identify novel genes and cellular pathways related to senataxin f

29 our functional genomics analysis highlighted novel genes and critical pathways associated with kidney

30 sity, allow for the large-scale discovery of novel genes and functions, and lead to an improved under

31 s cancers and to facilitate the discovery of novel genes and gene isoforms that are potentially impor

32 hnologies, such as metagenomics, to identify novel genes and gene transfer mechanisms.

33 The comparison with MneRV2 has revealed novel genes and important conservation of protein coding

34 Importantly, the large majority of novel genes and isoforms are supported by direct evidenc

35 ly improves genome annotation and identifies novel genes and isoforms in the rat.

36 xpression cues, tomo-seq can serve to reveal novel genes and key transcription factors involved in sp

37 alysis provides a reliable method to uncover novel genes and mechanisms related to phenotypes, althou

38 Exome sequencing discovered 2 novel genes and mechanisms, PDE4DIP and ACOT4, associate

39 d with oxidative stress, but also identified novel genes and metabolic pathways controlled by Spx dur

40 We are particularly interested in novel genes and observed multiple lines of supporting ev

41 Novel genes and pathways can be identified using the gen

42 icant progress made in the identification of novel genes and pathways involved in the pathogenesis of

43 Finally, by revealing novel genes and pathways not previously associated with

44 NA (shRNA)-based drop-out screen to identify novel genes and pathways that could reverse resistance t

45 rrence of distinct diseases, to highlighting novel genes and pathways that unsupervised learning sugg

46 stems, constitutes a significant resource of novel genes and pathways with potential biotechnological

47 ation studies often identify loci containing novel genes and there is a need to infer their functions

48 protocol plays a central role in identifying novel genes and transcripts as well as in studying gene

49 nd cost-effective tools for the discovery of novel genes and transcripts compared with expressed sequ

50 remain genetically unexplained, implicating novel genes and unrecognized mutations in known genes.

51 whole genome or exome sequencing to identify novel genes and variants.

52 Among those, the 10 identified novel genes are part of pathways of kidney development,

53 r, other modes have also been found, such as novel genes arising from non-coding DNA, chimeric fusion

54 Our analysis presents an array of novel genes as putative corneal stem cell markers.

55 This signature includes 34 novel genes, as well as 44 known genes expressed at the

56 Importantly, we identified Pcsk6 as a novel gene associated with ASD via a human genotyping st

57 n airway inflammation and identify FHL2 as a novel gene associated with asthma severity in human.

58 A novel gene associated with nanophthalmos, TMEM98 most li

59 Here we report a novel gene associated with PCD but without ciliary ultra

60 We identified 2 novel genes associated with an increased risk of ischemi

61 Our goal was to identify novel genes associated with atopy in asthma-ascertained

62 enetic variants and has revealed a number of novel genes associated with blood and other diseases.

63 informative samples enable the discovery of novel genes associated with cancer, the network of relat

64 rm an exome-wide search for rare variants in novel genes associated with CRP levels.

65 s a fundamental step toward the discovery of novel genes associated with human disorders, especially

66 quencing data and use this model to identify novel genes associated with important biological functio

67 ical information and can be used to identify novel gene associations and function.

68 l metabolizing genes and KLB, and identifies novel gene associations that should be the focus of futu

69 We identified a novel gene based on its sequence identity with ccm2, whi

70 er on the promise of informative mechanisms, novel gene-based diagnostics, and therapies for distinct

71 This inquiry did not elucidate novel genes, but instead demonstrated that variants dist

72 Each ant lineage contains approximately 4000 novel genes, but only 64 of these genes are conserved am

73 We validate gland cell expression in two novel genes by in situ hybridisation and catalogue dorsa

74 at loss-of-function recessive mutations in a novel gene, called isoprenoid synthase domain containing

75 The novel gene candidates discovered in this study by genome

76 at nano-LDHs have potential application as a novel gene carrier to plants.

77 B. longum SC596 contains a novel gene cluster devoted to the utilization of fucosyl

78 Further, we developed a novel gene cluster expression summary score (GCESS) to q

79 Each of the seven novel genes code for proteins associated with one or mor

80 esults will facilitate the identification of novel genes controlling crop timing and quality traits i

81 sed a classical genetic approach to identify novel genes controlling nerve conduction.

82 omparative analysis showed that few of these novel genes could be discovered by other existing method

83 significant extension in the development of novel gene delivery platforms.

84 s offer a preclinical proof-of-concept for a novel gene delivery system that offers an effective intr

85 ltaG] is a frameshift variant that creates a novel gene, designated IFNL4, encoding the interferon-la

86 Among the novel genes discovered, WNT3, KANSL1, CRHR1, BOLA2, and

87 r diseases has recently increased because of novel gene discoveries and advancements in DNA sequencin

88 families; however, none of these represented novel gene discoveries.

89 dologies that group genes for the purpose of novel gene discovery fail to acknowledge the dynamic nat

90 We identified 3 factors that limited novel gene discovery: (1) imperfect sequencing coverage

91 Here, we used a novel gene disruption strategy to generate the whole bod

92 Curiously, novel genes dominate viral genomes and metagenomes, whic

93 oma-MPNST progression useful for identifying novel genes driving neurofibroma and MPNST pathogenesis.

94 , also allows for extraction of reproducible novel gene-drug interaction signatures as well as accura

95 et serves as a valuable tool for identifying novel genes during plant anther and pollen development.

96 Our method identifies novel genes dysregulated in PTB and provides a generaliz

97 ing methods of cell reprogramming, and using novel gene editing techniques for generating genetically

98 Thus, CRISPR/Cas9 technology represents a novel gene-editing strategy with compelling robustness,

99 The genes of interest include known and novel genes encoding secreted enzymes, proteases, G-prot

100 tive approaches can empower the discovery of novel gene-environment interactions and discuss specific

101 in model organisms are vital for identifying novel genes essential for developmental or disease proce

102 Thus the method is capable of predicting novel genes even for well-characterized diseases.

103 RNA-seq data identified several expected and novel gene expression changes associated with early drug

104 Application of novel gene expression classifiers identified two new DLB

105 Higher rates of transgressive and novel gene expression patterns as well as homoeolog sile

106 and genomic imprinting intersect to produce novel gene expression patterns in seeds.

107 Our method integrates novel gene expression profiles from each major non-malig

108 Additionally, expression of a novel gene expression program involving sonic hedgehog (

109 n or survival of TAMs, but rather controls a novel gene expression signature associated with cytoskel

110 A novel gene expression signature identified severely inju

111 In this study, we describe a novel gene expression signature of platelet-derived grow

112 s of our profiling results, we introduce two novel, gene expression-based scores, the gamma activatio

113 mparative genomics cluster analyses revealed novel gene families (clusters) in existing brown alga ex

114 Novel gene families that are not well studied in other a

115 POC1B is a novel gene for a new disease typical of CORD except that

116 We report a novel gene for a parkinsonian disorder.

117 AS have been useful and continue to identify novel genes for allergic diseases through increased samp

118 We nominate these novel genes for future study.

119 e permanent dentition, and nominates several novel genes for investigation.

120 This work reveals two novel genes for OS, KCNT1 and PIGQ.

121 CryptoNet effectively identified novel genes for pathogenicity and drug resistance using

122 In an attempt to unravel novel genes for the persistence of ADHD into adulthood,

123 The classic model for the evolution of novel gene function is through gene duplication followed

124 anism where incomplete duplication created a novel gene function-antagonizing parental SRGAP2 functio

125 es increased the sensitivity for associating novel gene function.

126 of genetic studies in C. hirsuta to uncover novel gene functions.

127 ception is accomplished by the function of a novel gene fusion (BeGC1) of a type I (microbial) rhodop

128 d of protein domain components arranged as a novel gene fusion architecture and of distant evolutiona

129 dentification of a rapidly growing number of novel gene fusions caused by tumour-specific chromosomal

130 RNA sequencing facilitates the discovery of novel gene fusions in cancer.

131 ta to discover and subsequently PCR validate novel gene fusions missed by other algorithms in the ova

132 As proof of principle that MACHETE discovers novel gene fusions with high accuracy in vivo, we mined

133 synthase (LIAS), BolA type 3 (BOLA3), and a novel gene glutaredoxin 5 (GLRX5).

134 cs platforms for the rapid identification of novel genes governing pathogenicity and drug resistance

135 ERE NEXT?: The identification of these seven novel genes has been important in unravelling the molecu

136 However, the effects of these novel genes have not yet been investigated in animal mod

137 ent signal in this region, and SNPs near two novel genes: HDGFL1 on chromosome 6 and MAF on chromosom

138 This method identified nine novel genes highly associated with MAE.

139 known gene associations, and for predicting novel genes, i.e. genes that are previously not linked t

140 arative genomics is a powerful technique for novel gene identification/prioritization.

141 tebrate eye development, the large number of novel genes identified as potential targets of Ey+signal

142 dentify functionally and clinically relevant novel genes implicated in LFS.

143 Novel genes important at distinct stages of the meiotic

144 Our study establishes SCN8A as a novel gene in which a recurrent mutation causes BFIS/ICC

145 ers to exploit genome-wide datasets to infer novel genes in any biological function and to explore de

146 We identified differential expression of novel genes in monocyte and DC subsets including genes r

147 OXE1 (TTF-2), DARC, CCR3, ABO); 2) localized novel genes in plausible biological pathways (PCSK2, ARH

148 coupled with Sanger sequencing, may identify novel genes in primary congenital glaucoma patients who

149 studies have convincingly implicated several novel genes in susceptibility to schizophrenia and bipol

150 is further supported by the large number of novel genes in the complete and partial genomes showing

151 Using the chick embryo, we uncover novel genes in the gene regulatory network underlying ot

152 These data provide supportive evidence for novel genes in the pathogenesis of CDH associated with o

153 We identify ALG14 and ALG2 as novel genes in which mutations cause a congenital myasth

154 s found in some other herpesviruses, plus 10 novel genes, including a single large putative transcrip

155 Many novel genes, including ACSM2A/2B, FAM47E, and PLXDC1, we

156 Here, we present the application of a novel, gene-independent and signature-based metagenomic

157 In summary, we have identified several novel genes influencing the major clinical risk predicto

158 study, we applied this strategy to identify novel gene interactions in KRAS-mutant cancer cells.

159 These findings thus describe a novel gene involved in cellular lipid homeostasis, which

160 ur findings suggest that PMVK is a potential novel gene involved in the pathogenesis of DSP and PMVK

161 dinate during the M/E switch and to identify novel genes involved in follicle cell differentiation, w

162 Novel genes involved in secondary metabolism, including

163 To identify novel genes involved in seed Fe homeostasis, we screened

164 We can perform genetic screens to identify novel genes involved in specific disease processes and c

165 DyNB identifies several known and novel genes involved in Th17 differentiation.

166 ggesting that the other 28 genes were likely novel genes involved in the mood disturbance mechanism.

167 ssisted predictions can effectively identify novel genes involved in virulence and antibiotic resista

168 Among a number of novel genes, isocitrate dehydrogenase (IDH) is recurrent

169 Our study identified the association of a novel gene, KCNK3, with familial and idiopathic pulmonar

170 Our findings reveal a dual role for the novel gene Kdf1 both as a repressive signal for progenit

171 ree those in the equivalent Bmpr1a mutant, a novel gene knock-in model in which Bmpr1a was expressed

172 ype III RNA-targeting CRISPR-Cas system as a novel gene knockdown platform to investigate gene functi

173 We identify 6 novel gene loci for height, 2 for BMI, and 3 for schizop

174 isoforms of known genes and 3% correspond to novel gene loci.

175 itional polymorphic markers, we identified a novel gene locus on chromosome 3q in this PRRT2-mutation

176 set of opportunities for the colonization of novel genes manifesting weakly advantageous or even tran

177 ne expression analysis performed to identify novel gene modulations associated with cell cycle dysreg

178 ecific gene expression markers, as well as a novel gene module whose overexpression in blood endothel

179 The analysis revealed known and novel gene modules regulated by the NF-Y motif.

180 Many variants in novel genes, most at low frequency, are associated with

181 Despite advances in the identification of novel gene mutations, 80% of patients with dHMN have a m

182 urate, fast, and can identify both known and novel gene mutations.

183 to how the probiotic interacts to regulate a novel gene network involved in glucose metabolism and ap

184 dulation of the gut microbiome, highlights a novel gene network involved in lipid metabolism, provide

185 Our novel gene network provides a unique and comprehensive r

186 We first constructed a novel gene network via a pairwise comparison of all yeas

187 stitute proto-oncogene (Ski) and Ski-related novel gene, non-Alu-containing (SnoN) signaling and abro

188 The Marvin genome is replete with novel genes not present in other mycobacteriophage genom

189 ady known serum resistance factors, and many novel genes not previously associated with serum resista

190 le rare or novel variants were identified in novel genes not previously linked with neuropathy.

191 , using genome-wide strategies, may identify novel genes not previously recognized as playing a role

192 PWS, as well as alterations in several other novel genes of possible importance in the pathogenesis o

193 ted single-gene deletion mutants to identify novel genes of Salmonella Typhimurium required for survi

194 ng signal detection power via uncovering (a) novel genes or (b) known associated genes in smaller coh

195 itness, possibly associated with the gain of novel genes or mutations.

196 ency, respectively], we did not identify any novel genes or single variants that reached significance

197 ccelerate the determination of causality for novel genes or variants.

198 Here, we describe a novel gene, OSTL (annotated as RNF217 in Genbank), which

199 e also suggesting the presence of underlying novel gene pathways relevant to these phenotypes.

200 e automated methodology for the discovery of novel genes, pathways and experimental phenotypes.

201 levels (P-value < 4.2 x 10-10), including 16 novel gene-peptide pairs.

202 Our method identifies novel gene-phenotype associations in human diseases and

203 tures of positive selection, indicating that novel genes play a disproportionately large role in adap

204 p carriage isolates has been found to have a novel gene, pneumococcal surface protein K (pspK), which

205 6 diverse prokaryotic genomes by discovering novel genes, post-translational modifications and correc

206 f the mutational landscape of ATC identifies novel genes potentially associated with ATC tumorigenesi

207 We have identified chodl and other novel genes potentially involved in motor axon different

208 icroarray studies, we discovered hundreds of novel genes preferentially expressed in the immune syste

209 The identification of this novel gene provides a wider role for the inhibitor of ap

210 covery rate (FDR) </=0.05 were mapped to one novel gene PRPF6 and two previously reported genes (DHX1

211 -R mutant shoot apical meristem identified a novel gene, PUNCTATE VASCULAR EXPRESSION1 (PVE1), that i

212 We further identified a number of novel genes recurrently mutated in patients with MCL inc

213 The findings identify Vegfb as a novel gene regulated by the PGC-1alpha/ERR-alpha signali

214 IS and invasive breast cancer, which include novel genes regulating tumor progression.

215 ay lead to their induction, and describe how novel gene regulatory and immune-related functions of th

216 ome-wide fitness data can be used to uncover novel gene regulatory interactions, when compared with r

217 Our findings thereby reveal a novel gene regulatory mechanism and a previously unappre

218 ribute most significantly to the assembly of novel gene regulatory networks.

219 Taken together, our results demonstrate a novel gene-regulatory mechanism in which HCV-induced cha

220 re, we demonstrate the powerful utility of a novel gene reporter system to permit studies of the dyna

221 l phenotypes as known genes, suggesting that novel genes represent a rich resource for investigating

222 ggesting that NL-association may represent a novel gene repression pathway.

223 Our results reveal a novel gene required for mycobacterial Esx-1 export.

224 Forced expression of these novel genes resulted in IL3-independent growth in vitro

225 ere, we show that targeted disruption of the novel gene Rnase10 encoding a secreted proximal epididym

226 The constructed masks along-with a novel gene score are exploited to produce the selected s

227 This paper proposes a novel gene selection method with rich biomedical meaning

228 A novel gene selection method, POS, is proposed.

229 gene expression in these cells identified a novel gene set composed of 80 differentially expressed g

230 breast cancer studies, where iBBiG extracted novel gene set-phenotype association that predicted tumo

231 The novel gene sets are indeed more correlated than the conv

232 Novel gene sets defined on the basis of regulatory inter

233 Because these novel genes share common disease pathways with other gen

234 We used a novel gene shuffling method called synthetic template sh

235 Here we present xCell, a novel gene signature-based method, and use it to infer 6

236 We identified novel gene-smoking interaction for a variant upstream of

237 indings thus establish miRNA regulation as a novel gene-specific dosage compensation mechanism.

238 We demonstrate here a novel gene stacking strategy by combining bidirectional

239 utions of alternative splicing in generating novel gene structures.

240 atic and the dynamic networks, we identified novel genes (such as OSBP2 and PDZK1IP1) that are potent

241 ng-Induced Paralysis (Swip), we identified a novel gene, swip-10, the expression of which in glia is

242 or ethanol sedation mutants, we identified a novel gene, tank (CG15626), the homolog of the mammalian

243 We therefore establish Fgf21 as a novel gene target of Fenretinide signalling via a retino

244 e report an in vivo assay that is based on a novel gene-targeted mouse strain, S100a5-tauGFP, in whic

245 ulation of proliferative genes and uncovered novel gene targets and functions coregulated by Sap-1 an

246 tify mechanisms of degeneration, and provide novel gene targets for therapeutic interventions.

247 We identify a large number of novel gene targets for these miRNAs, with only 32% of hi

248 In addition to carboxysome genes, two novel genes (Tcr_1019 and Tcr_1315) present in other org

249 Another novel gene, TEAD2, is found to be associated with high-d

250 Our data identifies ADAMTS3 as a novel gene that can be mutated in individuals affected b

251 gene-9 (MDA-9), also known as syntenin, is a novel gene that positively regulates cancer cell motilit

252 While these lists have identified many novel genes that are altered during the disease process,

253 ot only new genomes being sequenced but also novel genes that are crucial to the overall gene chips i

254 In this study, we aimed to identify novel genes that are involved in the cause of RP.

255 Recent studies in zebrafish have revealed novel genes that are required for HSC induction and nich

256 otation of a complete repertoire of thirteen novel genes that belong to the L1L paralogous gene famil

257 y of fast neutron mutagenesis in identifying novel genes that contribute to soybean agronomic traits.

258 ve been used as an unbiased tool to identify novel genes that contribute to variations in LDL cholest

259 creened >10,000 blood samples and discovered novel genes that contribute to vertebrate genome mainten

260 ssential genes in mES cells, and to identify novel genes that control sprouting angiogenesis and line

261 mplicated in other human cancers, as well as novel genes that could allow new therapeutic options.

262 yses and experimental investigation to infer novel genes that could modulate biological pathways.

263 ng a Bayesian hierarchical model to identify novel genes that could potentially influence the pathway

264 cancer genomes and enabled the discovery of novel genes that drive and maintain tumorigenesis.

265 is approach led to the identification of 553 novel genes that encode proteins and/or microRNAs.

266 dentified by GWAS and CNV analyses suggested novel genes that match the criteria.

267 s provide new candidate genes for ataxias or novel genes that may be critical for cerebellar function

268 r variable regions allow for the creation of novel genes that may diversify the repertoire of such ge

269 ng non-coding RNAs (lncRNAs) are a family of novel genes that regulate gene transcription and transla

270 hus, this analysis reveals a large number of novel genes that regulate human growth plate chondrogene

271 cellularization and proliferation as well as novel genes that will be useful candidates for biotechno

272 In this study, we applied a novel gene-therapeutic approach using recombinant adeno-

273 We developed a novel gene therapy approach based on the use of the pigg

274 This novel gene therapy approach opens the prospect of NIS-me

275 promising strategy for the development of a novel gene therapy approach.

276 This novel gene therapy construct demonstrated an enhanced ex

277 As such, the miR-106b-25 cluster could be a novel gene-therapy target in AF associated with enhanced

278 omeric heterochromatin assembly, including a novel gene tls1+.

279 h state-of-the-art SVM classifier to predict novel genes to 11,000 biological processes across six di

280 assical candidate gene identification, links novel genes to IBD and can be applied to any existing GW

281 A novel gene (TOMM40) has been consistently associated wit

282 reviously reported in related disorders, and novel genes TRIP12 and PAX5.

283 In particular, we identify Abcc6 as a novel gene underlying a fibrosis locus by validating tha

284 sed this technique in an attempt to identify novel genes underlying monogenic dyslipidemias.

285 individual cohorts, and GWAS have identified novel gene variants, most notably PEAR1, that participat

286 Several novel genes were identified with high weighted connectiv

287 e was improved in over 13% of genes, and 651 novel genes were predicted by the GC-specific MAKER prot

288 MHC-II genes and a few novel genes were regulated by CIITA; however, most other

289 Our results highlight a novel gene which regulates coffee consumption by regulat

290 We identified a novel gene with coding regions, termed DUNQU1, which has

291 ressive lymphoma cells and define NR4A1 as a novel gene with tumor suppressor properties involved in

292 Many novel genes with poorly defined functions were also diff

293 of the differentially methylated genes were novel genes with respect to biological effects of smokin

294 c/GalN utilization pathways include multiple novel genes with specific functional roles.

295 (PCSK2, ARHGAP11A, CHRNA3); and 3) revealed novel genes with unknown function in obesity pathogenesi

296 This study identified novel genes within the neuronal projection guidance path

297 They are replete with novel genes without known relatives.

298 er, this is not a feasible option where many novel genes, without pre-existing models, would need to

299 irm the regulatory role of our top predicted novel gene, wnt5b, in leftward cell migration during hea

300 lex phenotypes in the mutants and identified novel gene x environment interactions.