ライフサイエンスコーパス: novel mechanism

1 ion of the Notch receptor to the lysosome, a novel mechanism.

2 itigating exaggerated inflammation through a novel mechanism.

3 in, and promotion of tissue regeneration via novel mechanisms.

4 Our data suggest a novel mechanism and model in which CAV1 phosphorylation

5 40 interaction in Tregs responsible for this novel mechanism are not understood.

6 Taken together, our results reveal a novel mechanism as to how WRN protects telomere integrit

7 lps to understand their function and reveals novel mechanisms at the single-cell resolution.

8 ation downstream of the PAFc and revealing a novel mechanism between the PAFc and Prmt5.

9 at H. pylori deregulates mitochondria by two novel mechanisms, both rather associated with host cell

10 This study reveals a novel mechanism by which a capsid-targeting small molecu

11 These data reveal a novel mechanism by which a helminth-modified metabolome

12 These results suggest a novel mechanism by which a metabolic disorder induces ep

13 This finding suggested a novel mechanism by which activated HSCs impair NK cells'

14 Our data reveal a novel mechanism by which an obligate intracellular bacte

15 the reduction in intratumoral androgens is a novel mechanism by which antiandrogens mediate their eff

16 lated cardiac mitochondria, we demonstrate a novel mechanism by which antimycin-inhibited complex III

17 oxidative stress gene programs, supporting a novel mechanism by which ATF6 decreases myocardial I/R d

18 These findings present a novel mechanism by which attention modulates neural popu

19 Together, our findings reveal a novel mechanism by which Ca(2+) overload disrupts myofib

20 Taken together, our results reveal a novel mechanism by which CAMK2gamma antagonizes mTORC1 a

21 These findings reveal a novel mechanism by which cancer cell-derived MVs influen

22 f1 and Nanog, pointing to the existence of a novel mechanism by which CDX2 maintains repression of OC

23 ollectively, our results have demonstrated a novel mechanism by which cell-free CD34Exo mediates isch

24 In this study, we identify a novel mechanism by which cells prevent the toxic accumul

25 The results of the present study identify a novel mechanism by which changes of the amplitude of the

26 This identifies a novel mechanism by which changes of the amplitude of the

27 f warming on marine ecosystems, suggesting a novel mechanism by which diversity confers resilience.

28 Here, we identify a novel mechanism by which drug-target interactions in res

29 Together, our results have revealed a novel mechanism by which dynamic enrichment of G-actin i

30 Together, these results reveal a novel mechanism by which EBF2 cooperates with a tissue-s

31 LDLR) degradation, this study investigates a novel mechanism by which ER stress plays a role in lipid

32 These data revealed a novel mechanism by which Gp1 mGluR and FMRP mediate prot

33 Here we describe a novel mechanism by which HHV-6A, a member of the human h

34 Our study provides a novel mechanism by which HN exerts its cardioprotective

35 us replication in lungs, thereby providing a novel mechanism by which hosts with allergic asthma may

36 this transformation, as well as suggesting a novel mechanism by which hydrometalation proceeds.

37 Moreover, we uncovered a novel mechanism by which IL-37 suppressed tumor cell mig

38 We describe a novel mechanism by which increased Ca buffering can acco

39 The results of the present study highlight a novel mechanism by which increased Ca buffering decrease

40 regulation and Ca(2+) signaling and reveal a novel mechanism by which ISCs detect stress signals.

41 In brief, our findings reveal a novel mechanism by which KDM3A promotes ovarian CSCs, pr

42 These results demonstrate a novel mechanism by which Kdm4d regulates DNA replication

43 t that the JAK2/STAT3 signaling pathway is a novel mechanism by which ketamine exerts its therapeutic

44 Together, our results demonstrate a novel mechanism by which laminins modulate vascular bran

45 nsitional epithelial carcinoma and uncover a novel mechanism by which loss of TGFbeta receptor II (Tg

46 We report a novel mechanism by which M1-polarized macrophages induce

47 Our results uncover a novel mechanism by which MALAT1 regulates the activity o

48 Our findings provide a novel mechanism by which microbial-derived butyrate prom

49 In the present study, we identified a novel mechanism by which miR93 regulates macrophage pola

50 These results establish a novel mechanism by which mTORC1 regulates Th1 differenti

51 The results of the present study prove a novel mechanism by which n-3 PUFAs exert protective role

52 lational modification, O-GlcNAcylation, is a novel mechanism by which neuronal and synaptic excitabil

53 These results establish a novel mechanism by which NF-kappaB and Akt contribute to

54 ccessibility and underscores the role of the novel mechanism by which nucleosomes control DNA-protein

55 Taken together, our work reveals a novel mechanism by which Pdcd4 inhibits Sin1 translation

56 Finally, our findings suggest a novel mechanism by which phosphorylation at the C termin

57 Our findings highlight a novel mechanism by which PINK1-dependent signalling prom

58 Thus, these findings uncover a novel mechanism by which PML loss may contribute to mTOR

59 Our study identifies a novel mechanism by which Polycomb directs the developmen

60 These results demonstrate a novel mechanism by which STAT1 negatively regulates ULK1

61 predator scent stress, our results provide a novel mechanism by which stress-induced anxiety alters c

62 ulating carbohydrate metabolism, revealing a novel mechanism by which sugar-sweetened beverages influ

63 Therefore, cathelicidins provide a novel mechanism by which the immune system can discrimin

64 Overall, our data unravel a novel mechanism by which the MAPK signaling network cont

65 This study has revealed a novel mechanism by which the skin microbiota signals the

66 metastasis in vivo This study demonstrates a novel mechanism by which TWIST1 regulates chromatin and

67 This new Drosophila model uncovers a novel mechanism by which upregulated expression of APOL1

68 These findings indicate a novel mechanism by which viruses alter normal FM immune

69 1 in the RLR signaling pathway and reveals a novel mechanism by which WNV evades the host innate immu

70 Taken together, our results reveal a novel mechanism by which WNV NS1 interferes with the hos

71 n and gastrointestinal tract, and identifies novel mechanisms by which epicutaneous tolerance can sup

72 The goal of this study was to identify novel mechanisms by which LRP1 may regulate microglial a

73 These data illustrate novel mechanisms by which nutrients modulate ART activit

74 t homeostasis and disease, and also revealed novel mechanisms by which TGFbeta signals are transduced

75 We report novel mechanisms by which TRMs regulate T cell activitie

76 larval development in helminths, providing a novel mechanism contributing to intestinal nematode resi

77 changes by RNA editing in cancer represent a novel mechanism contributing to sequence diversity indep

78 B1 generation, thus highlighting a potential novel mechanism contributing to therapeutic effects.

79 This novel mechanism could open new possibilities for therape

80 impairment of GRalpha function represents a novel mechanism driving GC insensitivity in ASM in sever

81 nd LOXL2 by the miR-200/ZEB1 axis, defines a novel mechanism driving tumor metastasis, delineates col

82 Ajuba provides a novel mechanism due to its ability to bind to CdGAP and

83 Our findings reveal a novel mechanism establishing adequate endometrial glycog

84 This novel mechanism expands our understanding of PKS assembl

85 This novel mechanism explains how CDK4 promotes anabolism by

86 c-5 regulates GR binding site selection by a novel mechanism, exploiting gene-specific requirements f

87 in neoplastic transformation, and revealed a novel mechanism facilitating oncogenic signalling by Ras

88 In conclusion, we have identified a novel mechanism for C9ALS/FTD pathogenesis highlighting

89 This novel mechanism for CNS cell plasticity may operate in w

90 n of deep aqueous fluids with silicates is a novel mechanism for controlling the composition of subdu

91 er their initial activation and identifies a novel mechanism for controlling thrombosis.

92 Taken together, our data reveal a novel mechanism for disease-associated SNVs and provide

93 Here, we introduce a novel mechanism for emergence of multiple band gaps with

94 Our results highlight a novel mechanism for error-free bypass of deoxyuridines g

95 ulatory modification of STAT1 and identify a novel mechanism for gain-of-function STAT1 disease in hu

96 In conclusion, we revealed a novel mechanism for H2S-mediated regulation of homocyste

97 molecular understanding of T3S and reveal a novel mechanism for hierarchical trafficking regulation

98 bits the IL-23 receptor pathway, providing a novel mechanism for how ILC3s could be manipulated to re

99 In conclusion, we report here a novel mechanism for how sustained activation of PERK axi

100 propose direct stimulation of autophagy as a novel mechanism for IL-6-mediated protection of beta cel

101 n diabetic wound healing, which represents a novel mechanism for impaired re-epithelization in diabet

102 yelinase inhibition in stored pRBCs offers a novel mechanism for improving the quality of stored bloo

103 bject to target cell-mediated activation - a novel mechanism for manipulating hormone activity.

104 These findings provide a novel mechanism for mitochondrial dysfunction in lipotox

105 n spinal dynorphin/KOR signaling represent a novel mechanism for modulating analgesic responsiveness

106 This closure holds the potential to define a novel mechanism for regulation of glymphatic flow.

107 lymphatic system and migraine, and suggest a novel mechanism for regulation of glymphatic flow.SIGNIF

108 Here, we describe a novel mechanism for regulation of ubiquitin homeostasis

109 ng complementary strategies, we identified a novel mechanism for sigma1R regulation of dopamine neuro

110 Taken together, we have uncovered a novel mechanism for Smo activation by sumoylation that i

111 Thus, our studies reveal a novel mechanism for synaptic regulation via pre-synaptic

112 These studies demonstrate a novel mechanism for the direct regulation of CD4(+) T ce

113 Our results suggest a novel mechanism for the disruptive effects of the absenc

114 These data provide a novel mechanism for the encoding of multiple movement re

115 unveil a CDK4-PIN1-p53-RS-c-Myc pathway as a novel mechanism for the GOF of p53-RS in HCC.

116 We present: (i) a novel mechanism for the inhibition of eIF2B activity, wh

117 We find a novel mechanism for the reaction that is initiated by a

118 Our findings provide a novel mechanism for the well-established beneficial card

119 In this communication, we propose a novel mechanism for this reaction involving the addition

120 molecular dynamics simulations, we propose a novel mechanism for toxic peptide ABC exporters that onl

121 lesions on a genome-wide scale and suggest a novel mechanism for transcription-associated mutation as

122 ein destabilization, but they also suggest a novel mechanism for TREX1-mediated suppression of innate

123 Here we identified a novel mechanism for VHL suppression in tumors that do no

124 e shelterin protein TRF1 and demonstrating a novel mechanism for WRN's role in telomere protection.

125 icating that tardigrades possess potentially novel mechanisms for surviving desiccation.

126 These findings provide evidence for a novel mechanism guiding the consolidation of memories fo

127 This work reveals a novel mechanism how plants may regulate auxin levels and

128 anges in morphogen diffusion, representing a novel mechanism in this tissue context, and we propose t

129 pmentally regulated, but also demonstrates a novel mechanism in which IL-4-dependent regulation of Co

130 Our findings uncovered a novel mechanism in which INT-767 activation of FXR induc

131 This work demonstrates a novel mechanism in which mGluR signals release AMPA rece

132 This novel mechanism indicates how a ubiquitin ligase maintai

133 l regulation of Cyp27b1 This work provides a novel mechanism indicating differential regulation of Cy

134 potentiation of gamma activity, suggesting a novel mechanism initiating activity-dependent plasticity

135 tivity-dependent plasticity and we report on novel mechanisms involved in both induced and critical p

136 ow the study of diverse bacteria may uncover novel mechanisms involved in regulating bacterial cell p

137 Here, we sought to identify novel mechanisms involved in SCLC chemoresistance.

138 In conclusion, the present study elucidates novel mechanisms involved in the genesis of acute herpet

139 This study elucidates novel mechanisms involved in the genesis of acute herpet

140 fasting-induced hepatic steatosis through a novel mechanism involving activation of the GH-Stat5 sig

141 udy, alkyne 1,2-hydrocarbation proceeds by a novel mechanism involving alkyne dehydrocarbation with a

142 We demonstrated a novel mechanism leading to the concealing and revealing

143 PL as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an a

144 Taken together, these findings identify a novel mechanism linking IL-6 trans-signaling and angioge

145 identified SPP1 up-regulation as a potential novel mechanism linking Pb exposure with neural stem cel

146 These data define novel mechanisms linking environmental cues to the acqui

147 Our data uncover novel mechanisms linking MITF-dependent inhibition of in

148 This novel mechanism may enable morphine administration to pr

149 This novel mechanism may have important implications in the r

150 This novel mechanism might be specific to the maintenance of

151 Our analyses demonstrate a novel mechanism of 5mC/T recognition in a methylation-de

152 FGFR3-TACC3 fusion proteins may represent a novel mechanism of acquired resistance in EGFR-dependent

153 This novel mechanism of action also may be occurring in norma

154 Our findings unveil a novel mechanism of action for the drug metformin with im

155 rtate receptor antagonist with a potentially novel mechanism of action for the treatment of anxiety d

156 tion inhibitor, modulates tau acetylation, a novel mechanism of action for this class of compounds.

157 This first-in-class agent, with its novel mechanism of action of disrupting critical protein

158 These results suggest a novel mechanism of action that may avoid the common rout

159 This suggested a novel mechanism of action, which was confirmed by chemop

160 In aggregate, our results indicate a novel mechanism of alcohol craving that involves MMP-9-d

161 We identified a novel mechanism of catabolic reaction where TWIST1 up-re

162 er members of the SPOUT family, suggesting a novel mechanism of catalysis.

163 nhibition of chromatin assembly represents a novel mechanism of cell transformation induced by the en

164 eggs and preimplantation embryos first in a novel mechanism of cell volume regulation and second as

165 inst tissue injury, our data have revealed a novel mechanism of cellular defense involving de novo NR

166 Thus, this work reveals a novel mechanism of cellulosome assembly and challenges t

167 ingly incompatible, could be reconciled by a novel mechanism of coupled adaptation of signaling chann

168 Overall, our study reveals a novel mechanism of crosstalk amongst SDHD, PTEN and auto

169 Xu and McPherson now identify a novel mechanism of DENND3 intramolecular binding that is

170 We suggest a novel mechanism of dual memory stem cells; the establish

171 Thus, we propose a novel mechanism of DVT, whereby CLEC-2 and upregulation

172 Thus, our results reveal a novel mechanism of EBV in diverting the functions of MYC

173 ty and its contribution to 5-HT release is a novel mechanism of EC cell function.

174 silencing during tumorigenesis, revealing a novel mechanism of epigenetic alterations in inflammatio

175 Our results implicated a novel mechanism of exosome-mediated intercellular commun

176 esponse to chilling stress and may provide a novel mechanism of frost tolerance in pea.

177 Collectively, our results provide a novel mechanism of glucose regulation of beta-cell funct

178 hlights impaired K(+) binding to hEAAT1 as a novel mechanism of glutamate transport dysfunction in hu

179 Together, the data demonstrate a novel mechanism of GSH elevation by post-translational a

180 This suggests a novel mechanism of hippocampal remapping whereby rate ch

181 Collectively, these findings establish a novel mechanism of humoral protection in the eye involvi

182 eddase has allowed the characterization of a novel mechanism of ICOS regulation.

183 These studies identify a novel mechanism of IFN subversion by RV and reveal an un

184 ANCE STATEMENT: This manuscript focuses on a novel mechanism of inflammation-regulation following spi

185 stress-induced constitutive activation is a novel mechanism of kappaOR regulation that plays a criti

186 Here we report the identification of a novel mechanism of lysosomal trafficking regulation.

187 This study therefore defines a novel mechanism of MAPK activation requiring binding of

188 Here, we describe a novel mechanism of metabolic co-regulation in which an i

189 These results identify a novel mechanism of micro-tubule-dependent actin scaling

190 es, opening the possibility of a general and novel mechanism of modulating Notch signalling activity.

191 Subsequently, a novel mechanism of MPR action was elucidated, with the d

192 Our findings reveal a novel mechanism of MSC effects on malignant cells throug

193 hese results reveal, in conscious animals, a novel mechanism of neuromodulation mediated by the carot

194 This lipid mediator switch represents a novel mechanism of OxPAPC-assisted recovery of inflamed

195 ion of babesiosis requires CD4 T cells and a novel mechanism of parasite killing within infected eryt

196 Our data form the basis for a novel mechanism of physiological deficiency that is rele

197 Not only does this study reveal a novel mechanism of picornaviral dissemination, but also

198 These results presented a novel mechanism of PKA and IkappaB pathway, which may be

199 In summary, we have identified a novel mechanism of PLN-induced tumor growth through macr

200 In conclusion, we provide here a novel mechanism of post-translational regulation of dysb

201 These data reveal a novel mechanism of poxvirus inhibition of human innate i

202 O'Brien et al proposed a novel mechanism of primase function based on redox activ

203 These findings demonstrate a novel mechanism of receptor endosomal signaling required

204 Taken together, these results suggest a novel mechanism of regulated viral entry in animal cells

205 Furthermore, we propose a novel mechanism of SAg-associated immunosuppression in h

206 of beta-arrestin activation may represent a novel mechanism of signal transduction and receptor cros

207 gnaling.SIGNIFICANCE STATEMENT We describe a novel mechanism of signal transduction enriched in mediu

208 Our study uncovers a novel mechanism of somatic cell differentiation during g

209 n T-cell-mediated pathogenesis and reveals a novel mechanism of T cell homeostasis and signal-depende

210 anscription and, more importantly, uncover a novel mechanism of TFIID recruitment and gene activation

211 We explored a novel mechanism of TLR3 up-regulation that is induced by

212 to discover new anti-tubercular agents with novel mechanisms of action in order to tackle the scourg

213 raditional PAC-related toxicity pathways and novel mechanisms of action were identified in two avian

214 molecule, enabling more specific targeting, novel mechanisms of action, and higher clinical efficaci

215 New drugs with novel mechanisms of action, such as cardiac myosin activ

216 for more effective antiangiogenic drugs with novel mechanisms of action.

217 ed through the development of new drugs with novel mechanisms of action.

218 and demonstrate therapeutic promise based on novel mechanisms of action.

219 ally inactive phosphatase might have adopted novel mechanisms of action.

220 efforts to identify and validate agents with novel mechanisms of action.

221 diate need for new antibiotic backbones with novel mechanisms of action.

222 search for smoking cessation medication with novel mechanisms of actions that differ from those of cu

223 Recent advancements illustrate novel mechanisms of AMPK regulation, including changes i

224 powerful gene editing tool that can uncover novel mechanisms of clustered miRNA regulation and funct

225 transcriptome holds potential for revealing novel mechanisms of dysfunction that underlie the onset

226 RBM3-induced neuroprotection, controlled by novel mechanisms of escape from translational inhibition

227 to achieve deeper understandings or discover novel mechanisms of eukaryotic transcriptional regulatio

228 mmune responses that ultimately could reveal novel mechanisms of host control.IMPORTANCE Epstein-Barr

229 hancers are suggested in principal to reveal novel mechanisms of how CEBPA is deregulated at the tran

230 We demonstrate novel mechanisms of how granulocytes are recruited to th

231 These findings reveal novel mechanisms of incisor renewal and illustrate how g

232 This study establishes novel mechanisms of innate IL-17A/IL-22 production via P

233 Our results also point to potential novel mechanisms of integrating multiple aspects of deci

234 This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation a

235 eractions and activities of vIL-6, revealing novel mechanisms of vIL-6 function within the ER compart

236 ive screen to identify actinonin as having a novel mechanism-of-action inhibiting apicoplast biogenes

237 Taken together, our findings revealed a novel mechanism on EZH2 ubiquitination and an important

238 effects of schizophrenia alleles to identify novel mechanisms protecting against more rapid cognitive

239 We propose that selective targeting of this novel mechanism provides new treatment opportunities for

240 Our studies unravel a novel mechanism regulating platelet activation that invo

241 Our results suggest a novel mechanism(s) by which HNK exerts its anti-tumor ac

242 In this novel mechanism, slow intracellular Na(+) dynamics endow

243 Diffuse myocardial fibrosis is a novel mechanism that appears to underlie diastolic dysfu

244 -induced stabilization of c-MYC protein as a novel mechanism that can increase total c-MYC levels in

245 tive reward processing and thus identifies a novel mechanism that can support psychopathology, includ

246 This study elucidates a novel mechanism that enables pathway-specific plasticity

247 mportant role in EV71 release and revealed a novel mechanism that EV71 utilizes to induce apoptosis.

248 These results uncover a novel mechanism that implicates Aurora A in the mitotic

249 cal processing of laughter could represent a novel mechanism that impoverishes social relationships a

250 egulation of their expression, we describe a novel mechanism that limits ZEB2 protein synthesis.

251 inability of Hda to interact with DnaA is a novel mechanism that may regulate Hda function.

252 nt EGFR/MAPK promotes gut regeneration via a novel mechanism that operates independently of Insulin/P

253 In this study, we report on a novel mechanism that promotes the proinflammatory functi

254 Our data further reveal a novel mechanism that reduced histone methyltransferase E

255 in human cardiomyocytes and demonstrating a novel mechanism that regulates excitability.

256 junction as a model synapse, we uncovered a novel mechanism that regulates the distribution of acety

257 regulation of Ca(2+) by NCKX4 in cones is a novel mechanism that supports their ability to function

258 s, monocyte IL-1beta production represents a novel mechanism that underlies behavioral complications

259 sible chemoattractant for CAs, but suggest a novel mechanism that VZ-derived Ntn1 directs CAs to the

260 We reveal a novel mechanism that, through modulation of the cytoskel

261 in IL-18 and IL-1beta regulation and uncover novel mechanisms that are relevant to the inflammatory s

262 tem has greatly facilitated the discovery of novel mechanisms that establish precise synaptic connect

263 clock function to alter memory, highlighting novel mechanisms that may contribute to the positive eff

264 of gB may regulate fusion of PILRalpha via a novel mechanism through gH/gL and the gD PFD.

265 eding and sleep are integrated and suggest a novel mechanism through which diet-induced obesity durin

266 Together, these data uncover a novel mechanism through which endodermal-myocardial comm

267 In this study, we identified a novel mechanism through which Gp1 mGluR mediates protein

268 th time-dependent antigen presentation and a novel mechanism through which IL-12 and IL-7 synergistic

269 ination in the bone marrow and they reveal a novel mechanism through which LOX-driven IL6 production

270 Our results reveal a novel mechanism through which symbionts can benefit thei

271 In summary, we have identified a novel mechanism through which the PRMT5/WDR77 complex ma

272 These data provide a novel mechanism through which VS information processing

273 This novel mechanism thus adjusts dynamic processing of visua

274 kemic cells, which has been established as a novel mechanism to escape CD19-specific immunotherapies.

275 This novel mechanism to limit Beclin1 activity has important

276 ize the essential circadian protein BMAL1, a novel mechanism to oppose its proteasome-mediated degrad

277 icroglia act as HIV reservoirs and utilize a novel mechanism to prevent HIV-induced apoptosis.

278 n proteins by AAA proteases may constitute a novel mechanism to produce partially degraded products w

279 Agreements and commitments have provided a novel mechanism to promote cooperation in social dilemma

280 itochondrial metabolism and participate in a novel mechanism to stabilize the decameric form of 2-Cys

281 ry disease-associated EV-D68, have developed novel mechanisms to subvert host innate immune responses

282 s that ciliary dysfunction might represent a novel mechanism underlying atopy.

283 Our results thus identify a novel mechanism underlying calvarial development in cran

284 These data demonstrate a novel mechanism underlying inhibitory synaptogenesis and

285 , the piRNA-rich nict-1 locus could define a novel mechanism underlying phoretic interactions.Nematod

286 Discovery of novel mechanisms underlying addiction may present a solu

287 Our findings provide novel mechanisms underlying EBV-mediated oncogenesis and

288 d host cell plasma membrane perforation as a novel mechanism used by diverse pathogens (Trypanosoma c

289 -452 loss and Slug upregulation, providing a novel mechanism whereby cancer stem cells acquire metast

290 myogenesis and muscle disease, and uncover a novel mechanism whereby disruption of the LINC complex m

291 This study defines a novel mechanism whereby elevated [Ca(2+)] induced by NMD

292 Together, these findings highlight a novel mechanism whereby interactions between Cat-1 and i

293 tions lacking nuclear localization uncover a novel mechanism whereby lipid phosphatase activity in th

294 Taken together, these findings suggest a novel mechanism whereby MCs may contribute to HRV-induce

295 This article describes a novel mechanism whereby membrane-derived microparticles

296 N autoimmune arthritis model, we elucidate a novel mechanism whereby oral AM80 administration suppres

297 ken together, results of our study support a novel mechanism whereby sumoylation of La promotes cell

298 g iterative rounds of screening, we reveal a novel mechanism whereby target engagement by Argonaute 2

299 Taken together, we elucidate a novel mechanism whereby the linker histone H1 prevents S

300 Thus our study revealed a novel mechanism, whereby filopodium formation and cell m