ライフサイエンスコーパス: novel protein

1 id sequence ATTQWKTSAA and confirmed HM-3A a novel protein.

2 structure-function relationships and create novel proteins.

3 f Syn5 includes a number of genes coding for novel proteins.

4 plex morphologies without the acquisition of novel proteins.

5 tive enzymes, and other effectors, including novel proteins.

6 ned thus far, lin-8 and lin-15A, both encode novel proteins.

7 , corresponding to 29 known allergens and 61 novel proteins.

8 n function correlates with immunogenicity of novel proteins.

9 SPR measurements with use of a novel, protein A-based sandwich system for the immobiliz

10 generating samples suitable for detection of novel protein adducts (e.g. by mass spectroscopy).

11 nable the efficient preparation of large and novel protein analogues.

12 i defective genes rde-10 and rde-11 encode a novel protein and a RING-type zinc finger domain protein

13 to infer their biological consequence (i.e. novel protein and increased gene expression).

14 proteins, as well as the potential roles of novel proteins and MAPKs in the polarity establishment r

15 Using antisera against several of the novel proteins and membrane-trafficking components that

16 ucts encoding rcdBB, mmsdh, RMD1, actin, one novel protein, and a 14-3-3 hairpin.

17 bind to host RNA polymerase (RNAP): gp79, a novel protein, and gp36, a distant homolog of sigma(70)

18 Among these novel proteins are three mammalian rRNA methyltransferas

19 Our results show that TsaP is a novel protein associated with T4P function and suggest t

20 To search for novel proteins associated with aortic wall thickening, w

21 We identified 332 known and 114 novel proteins associated with these histone-marked geno

22 alysis, fluorescent protein fusions revealed novel proteins at organelle interfaces such as plastid s

23 Novel protein-based antifibrotic drugs show high specifi

24 for expression of TLT35 in E. coli make this novel protein-based fusion inhibitor a promising candida

25 highly conserved OLF domain, and suggests a novel protein-based hypothesis for glaucoma pathogenesis

26 for inducible expression of LPG, applying a novel protein-based system that allows controlled degrad

27 This novel, protein-based electrochemical sensing architectur

28 Novel protein biomarker models improve identification of

29 Identification of novel protein biomarkers has been limited due to the mas

30 To identify novel protein biomarkers in stool that outperform or com

31 result in a +1-bp frameshift and generate a novel protein C terminus.

32 imental optimization were used to generate a novel protein called BINDI that binds BHRF1 with picomol

33 We report a novel protein, Callipygian (CynA), which localizes to th

34 uence of the amino acid substitutions in the novel protein candidates for direct input into epitope e

35 Previously, we described a novel protein, catabolite control protein E (CcpE) that

36 o assist in drug discovery and the design of novel protein catalysts.

37 nding of enzyme mechanisms and for design of novel protein catalysts.

38 In this work, we identify a small novel protein, CCS4, as a third component in this pathwa

39 Here, we show the novel protein Centrocortin (CEN), which associates with

40 discovery and intracellular location of six novel proteins (cingulins) that are integral components

41 t the association of this network with three novel protein clusters involved in cell wall biogenesis,

42 enome contains a rich resource of shared and novel protein coding genes, a significantly higher amoun

43 ing annotation errors and identify potential novel protein coding regions and sRNA.

44 olution map enabled the identification of 14 novel protein coding regions as well as 44 potential nov

45 of transcripts from RNA-sequencing revealed novel protein-coding and long noncoding RNAs (lncRNAs).

46 We also report a novel protein-coding gene evolution-D6Ertd527e-in which

47 Evidence has been found supporting 16 novel protein-coding genes being added to GENCODE.

48 Novel protein-coding genes can arise either through re-o

49 Altogether, we identified 635 novel protein-coding genes, 508 novel transcribed region

50 prised 28,294 expressed, annotated genes, 78 novel protein-coding genes, and 567 putative long interg

51 analysis enabled us to discover a number of novel protein-coding regions, which includes translated

52 er rigorous data filtering, 51 (presumptive) novel protein-coding transcripts, 5326 long and 679 smal

53 We developed a novel protein complementation assay allowing quantificat

54 We identified a novel protein complex containing the spine regulator Rac

55 Here we report identification of a novel protein complex containing ULK1 and two additional

56 Here we show that WTAP forms a novel protein complex including Hakai, Virilizer homolog

57 the yeast PKM2 homolog, Pyk1, is a part of a novel protein complex named SESAME (Serine-responsive SA

58 ere, we demonstrate that RAD51C is part of a novel protein complex that contains PALB2 and BRCA2.

59 ite stages of Plasmodium and it is part of a novel protein complex with an overall composition overla

60 lear mRNPs and DBC1 (ZIRD)) as subunits of a novel protein complex--named DBIRD--that binds directly

61 lts presented here identify and validate two novel protein components of the putative tRNA translocon

62 Vapyrin is a novel protein composed of two domains that mediate prote

63 Statin therapy downregulated novel proteins concerned with the modulation of pancreat

64 eating therapeutic conjugates and generating novel protein constructs.

65 , we have now identified and characterized a novel protein contact between the Y-family DNA polymeras

66 hila, is regulated in somatic cells by Yb, a novel protein containing an RNA helicase-like motif and

67 Novel protein crystallographic structures of the prototy

68 Here, we describe a novel protein, DAR1, from A. californica that can conver

69 In this study, we demonstrate a novel protein delivery method via encapsulating therapeu

70 A novel protein delivery platform has been created by comb

71 y unknown RNA segment (segment 7) encoding a novel protein designated VP7 was discovered in WFBV.

72 disA-1 abolishes the localization of the novel protein DisAp to T. thermophila striated fibers (k

73 uss a comprehensive overview on Nischarin, a novel protein discovered by our laboratory.

74 These novel proteins distinguish Lh from Lb VLPs; notably, som

75 tor inhibitor-1 (PAI-1) gene that recruits a novel protein-DNA complex responsible for TCDD-inducible

76 m GM12878 and K562 cells and identified many novel protein-DNA interactions in segmental duplication

77 We present a novel protein docking algorithm that utilizes imperfect

78 Thus, Tg appears to be a novel protein elaborated as a single event at the base o

79 The novel proteins elucidated in this work may provide new i

80 PA-X is a novel protein encoded by PA mRNA and is found to decreas

81 Among over 100 novel proteins enriched at a DSB were the phosphatase Si

82 Importantly, we also identified novel proteins enriched in COMC.

83 Moreover, a complex containing the two novel proteins Ere1 and Ere2 mediates cargo-specific rec

84 The novel proteins exhibit significant selective constraint

85 or chemotherapy or vaccination, the need for novel protein expression platforms has become a pressing

86 Here, we developed a novel protein extraction method that does not use demine

87 er take place between 8-10 h of IVF, and the novel protein failed to inhibit G9a activity in time, re

88 us proteins help in functional annotation of novel protein families and in improving annotations of w

89 and draft genomes reveal a 10.5% increase in novel protein families as a function of phylogenetic div

90 al complexity enables us to rapidly identify novel protein families found in new genomes and to perfo

91 The structure shows a novel protein fold and it is clearly not a DNA structura

92 rminal domain of wild-type TnsE identified a novel protein fold including a central V-shaped loop tha

93 The first C-terminal domain D5 forms a novel protein fold of a four-stranded antiparallel beta-

94 It exhibits a novel protein fold, and in contrast to other 2Fe-2S prot

95 73-NTD at 1.02 A resolution, which reveals a novel protein fold.

96 nique biophysical traits, such as exhibiting novel protein folds and unusually high carbohydrate affi

97 The ability to engineer novel protein folds, conformations, and enzymatic activi

98 o determine the mechanistic function of this novel protein for vaccine or inhibitor development.

99 randomly selected and deleted, revealing two novel proteins, FTL_1548 and FTL_1709, which are require

100 ajectories during the ancient evolution of a novel protein function.

101 y be a common mechanism for the evolution of novel protein function.

102 t LNA and GNA in the application of learning novel protein functional knowledge, the two produce very

103 First, it computes our novel protein functional similarity scores by fusing inf

104 proteins can be helpful in understanding how novel protein functional sites evolved on an ancient pro

105 roteolysis by calpains potentially generates novel protein functions, it is important to understand h

106 Casp8p41, a novel protein generated when HIV-1 protease cleaves casp

107 ession of the cell-cycle inhibitor p16 and a novel protein homologous to Scp3, a synaptonemal complex

108 e Electrophile Response Element (EpRE) and a novel protein, human homolog of Xenopus gene which Preve

109 Depletion of three of these novel proteins, i.e. TbTim47, TbTim54, and TbTim62, sign

110 We report a novel protein immobilization matrix for fully integrated

111 Recently in our laboratory, we identified a novel protein in C. elegans involved in dietary choleste

112 This approach allowed the identification of novel proteins in E. oleoabundans, including two photopr

113 resent in a unique TIM complex consisting of novel proteins in T. brucei and is critical for mitochon

114 ially, we demonstrated for a subset of these novel proteins (including cullin1, ephexin, potassium ch

115 dition to Ago2 and PCBP2, identified several novel proteins, including IGF2BP1, hnRNP L, DHX9, ADAR1,

116 works present at the glial-leading edge, and novel proteins, including members of the Prohibitin fami

117 nd in authentic LBs in PD as well as several novel proteins, including the microtubule affinity-regul

118 Using this module, we developed a novel protein interaction assay, Light-Induced Co-cluste

119 roxyanilino)methylidene]naphthalen-2-one), a novel protein interaction inhibitor of replication prote

120 A new study has revealed a novel protein interaction linking microtubule plus-ends

121 ss of complex formation, thus validating the novel protein interaction mode in the 14-3-3beta.ChREBP

122 These results identify a novel protein interaction that links matrix degradation

123 Together these data reveal novel protein interactions and suggest potential pathway

124 These findings identify novel protein interactions involving CLEC14A, CD93 and C

125 -tune binding specificities or change/create novel protein interactions is a common task in structure

126 Novel protein interactions suggest a highly complicated

127 ion plays in promoting signal amplification, novel protein interactions, and protein turnover has pro

128 or genome-wide PPI studies and has uncovered novel protein interactions, providing new insight into p

129 proteins we identified Matrin 3 (MATR3) as a novel protein interactor of PABPN1.

130 ating Wnt signalling and identify Axin1 as a novel protein interactor of the widely-expressed gamma-P

131 identify RV proteins in sIBM that included a novel protein involved in sIBM pathogenesis.

132 2A), through a yeast two-hybrid system, as a novel protein involved in the stabilization of VEGFR-2 b

133 Here we sought to identify novel proteins involved in IL-1beta secretion and intrac

134 forms of anemia has led to the discovery of novel proteins involved in iron homeostasis.

135 To identify novel proteins involved in PD progression, we prepared s

136 Determining the structure and function of a novel protein is a cornerstone of many aspects of modern

137 Here we show that TbTim62, a novel protein, is localized in the mitochondrial inner m

138 generated from human SMN genes and reveals a novel protein isoform predicted to be stably expressed d

139 The identification of novel protein isoforms derived from alternatively splice

140 H2Av are anchored to lipid droplets via the novel protein Jabba [3].

141 ication, and mass spectrometry to identify a novel protein, KHARON1 (KH1), which is important for the

142 uced Mcl-1 degradation was attenuated by the novel protein kinase C (PKC) inhibitor rottlerin.

143 Previous studies suggest that the novel protein kinase C (PKC) isoforms initiate a mitogen

144 Conventional and novel protein kinase C (PKC) isozymes transduce the abun

145 cerol (DAG) content leading to activation of novel protein kinase C (PKC) resulting in decreased insu

146 hodology allows the development of potential novel protein kinase C delta (PKCdelta) analogues for be

147 Here we report that PKCtheta, a novel protein kinase C, down-regulates GIV's GEF functio

148 Therefore, to identify novel protein kinase G substrates in vascular cells, a l

149 on detection for the rapid identification of novel protein kinase inhibitors.

150 n two steps, with the second step defining a novel protein kinase regulatory mechanism.

151 amely, diacylglycerol-triggers activation of novel protein kinases C with subsequent impairments in i

152 onal RNA interference-based screen linked 30 novel protein kinases with ciliogenesis.

153 ated 'rpL22-like short') that would encode a novel protein lacking the C-terminal ribosomal protein s

154 ning 160,000 compounds is a useful source of novel protein ligands by identifying a non-covalent synt

155 nsional structures, and ultimately to design novel protein-like architectures with properties unprece

156 generated by these cells identified multiple novel proteins linked to metastasis.

157 in orb spiders, coupled with the origin of a novel protein (MaSp2).

158 microbiota antigens was assessed by using a novel protein microarray.

159 This study presents a novel protein model of NOR and provides insights into a

160 Discovery of this novel protein modifier raised the possibility that the 4

161 n's C-terminal domain binds lipids through a novel protein motif, permitting complexin to inhibit spo

162 degP strain of Escherichia coli identified a novel protein MzrA and pleiotropic envZ mutations.

163 sembly of large symmetrical structures and a novel protein nanoparticle for encapsulation and cargo d

164 e show that root gravitropism depends on the novel protein, NEGATIVE GRAVITROPIC RESPONSE OF ROOTS (N

165 texture were elucidated and quantified by a novel protein network analysis.

166 Collectively, these data reveal a novel protein network operating in the neural crest-deri

167 In this study, we identify a novel protein, NOP-1, that functions in parallel with CY

168 as IP-10, LBP, FCG3B, and TSP4, and for many novel proteins not previously associated with TB.

169 ew Clr6 HDAC complex, I'', delineated by the novel proteins Nts1, Mug165, and Png3.

170 POT1 in Arabidopsis fueled the evolution of novel protein-nucleic acid interactions and the migratio

171 This cDNA encodes a novel protein of 483 amino acids that displays significa

172 In this study, we demonstrate that Tda2 is a novel protein of the endocytic machinery necessary for n

173 ve reported previously the identification of novel proteins of Mycobacterium tuberculosis by the immu

174 ated only by proteomic data, and 55 putative novel proteins of peroxisomes.

175 draft H. bacteriophora genome sequence were novel proteins of unknown function lacking homologs in C

176 amina analogue NUP-1, represents a cohort of novel proteins operating at the nuclear periphery of try

177 rograming is often accomplished by designing novel protein or RNA parts that respond to specific smal

178 gulated in spinal cords of ALS patients, the novel protein oxidative resistance 1 (Oxr1) protects neu

179 A novel protein, OZONE-RESPONSIVE APOPLASTIC PROTEIN1 (OsO

180 A novel protein, p18, anchors to the endosome membrane and

181 We have identified a novel protein partner called Hp0100 as a component of a

182 Gfi1 and neutrophil elastase and detected a novel protein, PFAAP5 (also known as N4BP2L2), interacti

183 We have recently determined that a novel protein phosphatase, Wip1 (or PPM1D), contributes

184 F159W-Leuko-PNP provides a novel protein platform to investigate the protein confor

185 We identified a novel protein, POLAR, and demonstrate through time-lapse

186 The aim of this study was to test a novel protein polymer-based platform consisting of diblo

187 might exhibit phase behaviour and to design novel protein polymers consisting of biologically active

188 This work provides new insights into the novel protein-primed mechanism of calicivirus VPg-depend

189 ion and characterization of a 628-amino acid novel protein, printor, that interacts with torsinA.

190 In this study, we describe a novel protein production platform that provides both act

191 potential resistance traits that involve no novel protein production.

192 abeled antibodies, we show that two of these novel proteins, products of genes 53 and 54, are part of

193 We identify a novel protein-protein interaction between Sam68 and AR-V

194 TLC1 and -2 subunits, and here we describe a novel protein-protein interaction between SPTLC1 and the

195 Our observations demonstrate a novel protein-protein interaction network between GEP, A

196 es of the PRL-1.Peptide 1 complex revealed a novel protein-protein interaction whereby a sequence mot

197 ding domain of p53; and (iv) it stimulates a novel protein-protein interaction with the E2-ubiquitin

198 The EMP2-FAK association represents a novel protein-protein interaction, not previously report

199 also to bioinformaticans seeking to predict novel protein-protein interactions based on the DDIs.

200 ic binding partners for PRRG4 and identified novel protein-protein interactions for the protein.

201 The ability to rationally design the site of novel protein-protein interactions is an important step

202 These results provide new evidence for novel protein-protein interactions on ECs that may contr

203 nelle and its surface as the active site for novel protein-protein interactions.

204 Computation-based design of novel protein-protein interfaces can serve as a bottom-u

205 Computational design of novel protein-protein interfaces is a test of our unders

206 Here we demonstrate that a novel protein/protein interaction between blood vessel e

207 Thus, this study characterizes a novel protein/protein interaction domain disrupted in a

208 Here we report the design of a novel protein, PS1, that binds a highly electron-deficie

209 nvelope membrane where it possibly confers a novel protein quality control mechanism for chloroplast

210 s nuclear ribonucleoprotein C (hnRNP C) as a novel protein recruited to higher molecular mass fractio

211 A recently discovered novel protein, referred as neuroendocrine marker (NEM),

212 Overall, our studies reveal a novel protein-regulated PTR event in a vertebrate system

213 Taken together, these data reveal novel proteins regulating the platelet response.

214 Here, we identify a novel protein required for paramutation at the maize pur

215 To discover novel proteins required for these processes, we used bio

216 The novel proteins rKR95 and rTR18 possessed the greatest po

217 hat they copurify with each other and with a novel protein, RNA-DIRECTED DNA METHYLATION 1 (RDM1), fo

218 CLAM provides a useful tool to discover novel protein-RNA interactions and RNA modification site

219 ction of the Rho-GAP Rga7 are regulated by a novel protein, Rng10, during cytokinesis in fission yeas

220 ition of G9a activity depends on yet unknown novel protein(s) synthesis.

221 (18)F-FBEM-Cys-Z(EGFR:1907) is a novel protein scaffold-based PET probe for imaging EGFR

222 design-free methods can be used to generate novel protein scaffolds that are tailor-made for catalys

223 A novel protein secretion apparatus called the Por secreti

224 Recently, a novel protein secretion system, the Por secretion system

225 A novel protein secretion system, the type IX secretion sy

226 A novel protein secretion system, the type IX secretion sy

227 r crystal structure determination to explore novel protein sequence space and structure-based functio

228 n for structure-based function annotation of novel protein sequence space.

229 ments have contributed to the acquisition of novel protein sequences during primate and human evoluti

230 n sequence annotation pipeline for analysing novel protein sequences.

231 We have identified a novel protein, SHORT-ROOT INTERACTING EMBRYONIC LETHAL (

232 We describe a novel protein, sisters on the loose (SOLO), which is ess

233 hat Skb1 forms nodes by interacting with the novel protein Slf1, which is a limiting factor for node

234 ed sugar specificity in contemporary BCoV or novel protein specificity in contemporary MHV.

235 these newly identified conserved residues, a novel protein splicing mechanism that includes a second

236 of this CHIP-SirT6 interaction represents a novel protein-stabilizing mechanism and defines an inter

237 protein extensions, 231 exon extensions, 192 novel protein start sites, 19 novel translational frames

238 Rosetta has been used to accurately design a novel protein structure, predict the structure of protei

239 effective tool for engineering and design of novel protein structures (including naturally knotted pr

240 Here, we build novel protein structures by extending naturally occurrin

241 demonstrates the feasibility of determining novel protein structures using FELs.

242 Our studies identify a novel protein substrate for PTEN that couples PTEN to re

243 entified several previously known as well as novel protein substrates.

244 ses, defense against radiation injuries, and novel proteins such as ZBP-89.

245 In this study, a novel protein tagging technology was used to localize th

246 These findings identify APE1 as a novel protein target of SIRT1, and suggest that SIRT1 pl

247 of drug-dependent plasticity and uncovering novel protein targets in the reward circuit may lead to

248 lso investigated the possible mechanisms and novel protein targets involved in rapamycin-induced pres

249 ion of the 6K gene, yielding production of a novel protein, termed transframe (TF), comprised of a C-

250 The sao-1 gene encodes a novel protein that contains a GYF protein-protein intera

251 vides fundamental structural insights into a novel protein that has undergone multiple biochemical an

252 Here, we describe Tks4, a novel protein that is closely related to Tks5.

253 RDM4 encodes a novel protein that is conserved from yeast to humans and

254 Collectively, this work identifies a novel protein that plays a role in the assembly of the m

255 continuous alpha-helical linker to design a novel protein that self assembles into a 750 kDa, 225 A

256 synMuv gene lin-56 and found it to encode a novel protein that shares a THAP-like C(2)CH motif with

257 Mass spectrometry revealed a novel protein that we call suppressor of glucose by auto

258 slation from antisense CCG repeats generates novel proteins that accumulate in ubiquitinated inclusio

259 e, we used a systematic approach to identify novel proteins that are involved in cancerous EGFR signa

260 Designing and producing novel proteins that fold into stable structures and prov

261 biochemical insights into IRES function and novel proteins that function as alternate met-tRNA(i)(me

262 e RNA interference (RNAi) screen to discover novel proteins that function in the replication stress r

263 nity purification and LC-MS/MS to search for novel proteins that interact with R7-RGS heterotrimers i

264 retrieval, included the GET complex and two novel proteins that likely function similarly in membran

265 Characterizing novel proteins that offer crucial insights into the proc

266 We found known and novel proteins that warrant further studies for developi

267 r 70% of the tested compounds and elucidated novel proteins that were experimentally validated.

268 Among the 608 splice variants were 68 novel proteins that were not completely matched to any k

269 We demonstrate that CG42630 encodes a novel protein, the coiled coil domain-containing protein

270 One novel protein, the milk fat globule protein epidermal gr

271 A third novel protein, the product of gene 58, is assembled onto

272 A novel protein, Themis, is important in crossing the posi

273 ved growth factor fragment (LEDGF1-326) as a novel protein therapeutic.

274 This is critical for designing and screening novel protein therapeutics and for understanding their p

275 Novel protein therapeutics have become increasingly impo

276 gh understanding of the biotransformation of novel protein therapeutics.

277 e finishing of large genomes and analysis of novel proteins they encode typically require cloning of

278 We present a novel protein threading method, CNFpred, which achieves

279 The present study delineates a number of novel proteins, TLR3-related pathways, and cellular phen

280 powerful ChIP-MS technique and discovered a novel protein, TRIM24, enriched on OCT4-, SOX2-, and NAN

281 in two affected individuals we identified a novel protein-truncating mutation in the C12orf65 gene,

282 UNC80 protein that bridges NALCN to a large novel protein UNC79 in the same complex, and the last am

283 Deep sequencing of CMG0 and CMG28 revealed novel protein variants in the hypothetical genes TC0237

284 SnoN (Ski-novel protein) was discovered as a nuclear proto-oncogen

285 ased on these novel transcripts, at least 36 novel proteins were detected from shotgun proteomics dat

286 GABA receptor subunits and gephyrin, several novel proteins were isolated in association with NL2.

287 ediated transcription, suggesting that these novel proteins were putative SBP-AR-interacting proteins

288 T cell targets for both known allergens and novel proteins, which may inform future diagnostics and

289 The novel protein will address the insufficient release of n

290 oducts: ribosomal component RpL22-like and a novel protein with a role distinct from RpL22-like.

291 We identify PPIA as a novel protein with levels that are decreased in clinical

292 NdmD itself is a novel protein with one Rieske [2Fe-2S] cluster, one plan

293 ntly differ from their yeast homologues, and novel proteins with high homology to CORVET/HOPS subunit

294 fold proteins is a promising way to engineer novel proteins with pre-specified functionalities.

295 aled the existence of several genes encoding novel proteins with unknown functions, one of which is t

296 ry glands produce a small number of abundant novel proteins with yet unknown functions, in addition t

297 Als2cr4 is a novel protein, with a probable tetraspanin-like membrane

298 e and frequency was comparable for known and novel proteins, with 15 antigens (nine of which were nov

299 that facilitate the de novo generation of a novel protein within an ancestral ORF have remained poor

300 homologous region in IL-22, we engineered a novel protein (Z13-IL22-2) that contains the MPER epitop