ライフサイエンスコーパス: now

1 counterions to compensate charges) are known now.

2 lation in cellulo has remained elusive until now.

3 Until now 2D FTICR MS afforded only a moderate resolution for

4 most entirely on crystalline structures, yet now a clear trend is emerging, shifting the emphasis ont

5 There are now a host of studies demonstrating that metabolic and e

6 affordable sequencing of pathogen genomes - now a staple of the public health microbiology laborator

7 Now a superior hydrogen-free 5/6/5 fused ring energetic

8 However, there is now a wide variety of methods that look for nonrandom di

9 orefathers settled in Burma before 1823, and now account for one in seven of the global population of

10 m leads to a continuum-level expression that now accounts for the underlying energy distributions and

11 Evidence has now accumulated to show that the Hb encodes both rewardi

12 Now, advances in bioreactor technology, metabolic engine

13 Auism spectrum disorder (ASD) now affects one in 68 births in the United States and is

14 te the canopy of central African forests are now aging.

15 We now aim to evaluate RETREAT in the United Network for Or

16 We now aimed to evaluate the potential of positron lymphogr

17 te membrane insertion and channel formation, now aligning ion channel formation with the differential

18 ld have selected for the precise traits that now allow pathogenic enterococci to survive desiccation,

19 High-throughput methods now allow us to interrogate the human immune system for

20 we demonstrate how the XCMS/METLIN platform now allows for the readout of the biological effect of a

21 Learning density models now allows the construction of accurate density function

22 Now, almost 90 years after its first use in breast cance

23 There is now an evolving body of evidence suggesting that these a

24 There is now an opportunity to apply knowledge from NM toxicology

25 We now analysed the mechanisms underlying this "silent surv

26 cell genomics offers over metagenomics, both now and in the near future.

27 es at the molecular and cellular levels were now applied to assess their functional quality: (i) size

28 We now assess HSCT in patients enrolled in the ASTIC trial

29 Up to now, AT macrophages (ATM) accumulation was considered to

30 iscuss harvesting of triplet excitons, which now attracts substantial interest when used in conjuncti

31 ve treatments for perianal Crohn disease are now available and have the promise to better control sep

32 The data now available demonstrate a significant impact of radiat

33 and the PD-1/PD-L1 inhibitory pathways, are now available for clinical use in cancer patients, with

34 These selective probes and inhibitors are now available to the plant science community, and can be

35 ers of structures and functional annotations now available, we have investigated how proteins that as

36 ms with near-human levels of performance are now available, which provide a computationally explicit

37 iments on a high-valent chromium species, is now available.

38 his population, originally termed "Ly-1" and now "B-1," has received renewed interest as an innate-li

39 g accuracy is unknown at this stage, but can now be addressed in future developmental studies.

40 nes; (ii) genes in the phylogenetic tree can now be also grouped according to KOG (The annotation of

41 IRT should now be considered a suitable method for measuring BAT ac

42 Type I interferons (IFN-Is) can now be considered as the wedge that balances clinical pr

43 , the properties of adipocyte precursors can now be defined, and the regulation and function of adipo

44 ocess, knowledge-driven materials design can now be enabled by the rational combination of Machine Le

45 These diverse amyloid templates can now be extended as dynamic self-propagating templates fo

46 These findings can now be extended to models and measures of audiomotor int

47 Our first clinical results should now be prospectively evaluated in a larger patient cohor

48 s of the eddy-covariance systems, which must now be questioned for their accuracy in desert ecosystem

49 nd their corresponding genetic mutations can now be readily detected.

50 ffords the first reported [8]AGNR, which can now be synthesized on a large scale via two operationall

51 The functional consequence of this diet will now be tested in a clinical trial.

52 odone in particular, a licensed drug, should now be tested in clinical trials in patients.

53 tment algorithms for neuropathic pain should now be used in the management of these patients.

54 of intraplate faults has been limited until now, because intraplate earthquake recurrence intervals

55 mathematical techniques, this technology has now been applied to a variety of diseases; however, appl

56 nks to new technologies, such hospitals have now been built downtown, next to the most highly perform

57 This has now been corrected in both the PDF and HTML versions of

58 This has now been corrected in both the PDF and HTML versions of

59 Several computer programs have now been designed to predict RNA modules.

60 2-Methylquinoline has now been identified as a feasible ligand that can coordi

61 Depth boundaries for the mesopelagic have now been shown on a global scale using the distribution

62 Hematopoietic cell transplantation (HCT) has now been shown to be safe and effective for selected HIV

63 Today, several modifiers have now been studied in enough detail to allow a glimpse of

64 re, protein-based epigenetic inheritance has now been uncovered in all domains of life.

65 ed with poor quality of life, a view that is now being challenged.

66 lex genetic and epigenetic methodologies are now being considered.

67 multiple oligonucleotide-based compounds are now being developed for treatment of human brain disorde

68 tive HDL-cholesteryl ester uptake pathway is now being evaluated as a gateway for the delivery of the

69 IPM programs are now being fine-tuned to meet regulatory and market stand

70 ween subgenomes in several model species are now being identified, providing an explanation for bias

71 surgery sealants, tissue adhesives, and are now being investigated as a vitreous humor substitute.

72 engue live-attenuated tetravalent vaccine is now being marketed.

73 e steady advances in the development of LRAs now being paired with emerging immunotherapeutics to cle

74 e form or another for the last 20 years, are now being reviewed to reflect these new wide-ranging cli

75 scle activation, but the mechanisms are only now being uncovered.

76 a substantial suite of experimental studies, now bridging to the wild through field experiments.

77 on the value of this program for its cost is now called for.

78 merging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on mul

79 These and other derivatives are now chemically synthesized and remain the mainstay of th

80 It is now clear that the capacity of cells to maintain proteos

81 The evidence is now clear that the environment is the single largest sou

82 That there is a high-affinity interaction is now clear, and its molecular basis is being unraveled, w

83 This possibility is now close to reality due to a recent discovery of the ad

84 lled Trial registry (ISRCTN07742377), and is now closed to patient entry.

85 sociated with the mid-19th century Gold Rush now coincide with early-20th century industrial emission

86 Perry and colleagues now combine NMR spectroscopy and electrophysiological ex

87 noma in the last few years, with these drugs now commonly used in clinic.

88 ar iMMUnolabelled cell Subsets) approach, we now compare protein abundance and phosphorylation change

89 ng NO x emission reductions, autoxidation is now competing with bimolecular chemistry even in the mos

90 Whereas postzygotic isolation is now complete because of sterility of F1 hybrid progeny,

91 We now confirm that PERVs infect human cells, and we observ

92 While Abraxane(R) is now considered a gold standard in chemotherapy, its 21%

93 of the dendritic cell (DC) lineage, they are now considered to be a specialized subset of tissue-resi

94 PaVE also now contains an image library containing gross clinical

95 We now demonstrate that hypomorphic Foxc1 mutant mice have

96 We now demonstrate that obesity and aging precipitate alter

97 Using the same models, we now demonstrate that repeated exposures to malaria paras

98 We now demonstrate that the vaccinia virus protein F11, whi

99 Numerous animal and cellular models have now demonstrated that mitochondrial reactive oxygen spec

100 a panel of mutant proteins with which we can now describe the complete energetic landscape of the Cdc

101 We now describe the results of the MS-STAT cognitive substu

102 We have now detected a likely intermediate during the conversion

103 We have now devised a new scaling technique to overcome these di

104 Until now, diagnosis has been mainly based on the presence of

105 JBrowse now displays BAM, VCF and other annotation tracks, the a

106 the Middle Triassic, and that diversity was now dominated by reptiles.

107 Yet people are now driving the sixth mass extinction event in Earth's h

108 evelopmental systems, cellular plasticity is now emerging as a general theme in the biology of multip

109 Our methods now enable even novice researchers to successfully desig

110 The term 'cerebral amyloid angiopathy' now encompasses not only a specific cerebrovascular path

111 Most species are now endemic to a single region, but one widely distribut

112 It is now evident that many orphan regulators that lack cognat

113 is goal and articulate both the promise that now exists and what is still needed to bring dramatic an

114 As a consequence, a significant body of work now exists on the architecture, function, and developmen

115 ytic alterations of complex natural products now exists such that expansion of scope seems inevitable

116 on decay, initially seen as a detriment, has now expanded the scope of plasmonic applications to expl

117 We have now expanded this study to evaluate the efficacy of PD-1

118 This is because readthrough transcripts now extend into downstream genes and are subjected to ba

119 We have now extended this method so that out-of-plane orientatio

120 We now find that the ER chaperone Grp170 participates in th

121 With these structures we are now firmly within the "atomic age" of electron cryomicro

122 ence of Fano interference was reported up to now for purely nanomechanical resonators, even if classi

123 Now, fossils and stone tools from a cave in Morocco chal

124 Most sequencing technologies now generate ROIs distributed across the whole genome.

125 Rotavirus vaccines are now globally recommended by the World Health Organizatio

126 ly, RT017 initially was reported in Asia but now has been reported worldwide.

127 however, is extremely challenging and up to now has only been achieved through indirect (14)C determ

128 ies of domain walls under illumination until now have been accessible only to macroscopic studies and

129 We now have developed a hypothesis regarding the mechanisms

130 Methods to augment heart regeneration now have potential to counteract the high morbidity and

131 ts with a CICU stay across the United States now have primary noncardiac diagnoses at discharge.

132 We now highlight the potential of this model for testing di

133 nt combination antiretroviral therapy (ART), now highly effective, safe, and simple.

134 Until now, however, the substantial electrostatic disorder of

135 We have now identified a highly conserved glutamate residue in t

136 field, including the DWH Oceanospirillales (now identified as a Bermanella species), multiple specie

137 n, de-conjugation, and recognition machinery now identified as key factors in DSB repair.

138 s an additional energy source, which we have now identified as thermal undulations.

139 We have now identified that HSV-1 pUL7 and pUL51 form a stable a

140 Glycan Reader has been improved and now identifies most sugar types and chemical modificatio

141 Xu and McPherson now identify a novel mechanism of DENND3 intramolecular

142 Using new reference models, we now identify sites of CENP-A and histone H3.1 binding wi

143 Now in an unexpected twist, King and colleagues have exp

144 ion with over 700 000 chemical structures to now include more than 950 000 unique small molecules.

145 s; (iii) information on intronless genes are now included in the database; (iv) a statistical summary

146 group of non-neosauropod eusauropods, which now includes five genera (Losillasaurus, Turiasaurus, Mi

147 In addition, glia are now increasingly appreciated as active regulators of num

148 However, it is now increasingly recognized that neutrophils are a heter

149 It is also now integrated with built-in 3D visualization which inte

150 The challenge now is to identify the mechanistic integrations of these

151 BldO now joins pleiotropic repressor BldD to exert a multi-la

152 ed as a hormonal and starvation response, we now know that autophagy has a much broader role in biolo

153 thanolaminephosphotransferase 1 (EPT1) gene (now known as SELENOI), responsible for the final step in

154 It is now known that AF genesis requires a vulnerable atrial s

155 by mixed-lineage leukemia (MLL) proteins, is now known to be critical in the regulation of gene expre

156 er the role of non-neuronal cells, which are now known to play an important role in chronic pain proc

157 Of the thousands of extrasolar planets now known, only six have been found that transit hot, A-

158 produce a panoply of antimicrobial peptides now known.

159 Now marking its 40th anniversary, percutaneous coronary

160 n medical and surgical management, there are now more adults living with congenital heart disease (CH

161 and nonspecific therapies to those that are now more targeted and rationally selected.

162 sk of HIV acquisition, but these reviews are now more than a decade old.

163 w challenges expectedly arise, and our focus now must shift to determining the best strategy by which

164 frequent updating and open dissemination are now needed both for appraisal of the evidence about Zika

165 Watson and Puelles now newly propose that the mammalian ventral pallium giv

166 or anomalous radar data on Europa, but until now no penitentes have been identified conclusively on p

167 Until now, no framework has been available to bridge this gap

168 Until now, no perfect reaction route has been proposed for thi

169 Until now, no technology compatible with use in unrestrained a

170 ality and comparability assessment has until now not been demonstrated.

171 full characterisation of this beam has up to now not been performed.

172 es, such as proteomics and metabolomics, are now often incorporated into the everyday methodology of

173 ed beyond the age of 5 years, 18 of whom are now older than 10 years.

174 iscovered some 25 years ago and are produced now on a commercial scale for various applications.

175 The focus of the field is now on pinpointing which molecular effects in specific n

176 t has fascinated scientists for decades, and now one of its visual-target-detecting neurons has been

177 ta obtained at different institutions and is now open for further validation in gliomas and other cer

178 those who apply emicizumab in their practice now or in the future, particularly in view of the thromb

179 The evidence is now overwhelming that partially assembled nucleosome sta

180 We argue that the evidence now overwhelmingly favours an approach that takes fixati

181 DsbA-like mycoredoxin cluster reported here now paves the way for correctly classifying similar enzy

182 al genomics, gene editing, and model systems now permit deconstruction of the complex interplay betwe

183 8 Recent advances in sequencing technologies now permit the analyses of plant DNA from fossil samples

184 High-speed high-resolution data acquisition now permits rapid measurement of the width of a peak (Wh

185 the subsequently elected administration has now placed it under review for potential revision or res

186 l a rare disease, adolescent type 2 diabetes now poses major challenges to paediatric and adult diabe

187 It is now possible to accelerate the discovery of materials wi

188 (hydrogen peroxide, H2O2) content in vivo is now possible using the MitoB probe.

189 ean that human genome sequencing at scale is now possible.

190 Qiu et al. (2017) now present data suggesting that the difficulty of detec

191 in-house screening, Novartis scientists have now produced a compound that shows durable tumor regress

192 Instead of killing cells, caspases now promote the generation of intra- and extracellular r

193 We now provide a general solution to this problem.

194 We now provide additional recommendations regarding four sp

195 Several studies now provide evidence of ketamine hydrochloride's ability

196 n and orphan G protein-coupled receptors and now provide evidence that C4a is a ligand for protease-a

197 Until now, qubits have been assessed primarily by randomized b

198 Moreover, structural priming has now reached sufficient methodological maturity to provid

199 blic health laboratories and researchers can now readily isolate C. auris from complex microbial comm

200 s because of safety concerns, metallic Li is now ready for a revival, thanks to the development of in

201 ing HCV infection with an oral medication is now reality.

202 e development of a whole-organism vaccine is now receiving much scrutiny.

203 We also now recognize ACS that occur without apparent epicardial

204 k of myocardial infarction, and psoriasis is now recognized as an independent risk factor for coronar

205 Yet each is now recognized as having intricate, though not fully elu

206 ypes, including ALECT2 amyloidosis, which is now recognized as one of the most common causes of syste

207 In our institute, we now recommend US as the investigation of choice for diag

208 toring of tropane alkaloids (TA) in foods is now recommended by the European Commission, following a

209 Rescue therapy alone is now recommended for low-emetic-risk radiation therapy.

210 DOF artifacts in standard reconstruction are now recovered.

211 miniaturization in insect brains have until now relied on information based on data collected in two

212 We now report 3-year overall survival outcomes in this tria

213 We now report a new Hmox1 reporter line that makes it possi

214 Jing and colleagues (2) now report comprehensive analyses of transcriptome dynam

215 We now report that activation of mGlu3 induces long-term de

216 We now report that ImmunoCloak interrupts antigen presentat

217 We now report that ShcD binds to active Ret, TrkA, and TrkB

218 s analysis of the CD16A receptor complex and now report that the association of receptor with the sig

219 teric modulators along with knockout mice we now report that the effects of mGlu2/3 agonists on betaA

220 We now report that the recovery of both recipient MDSCs (P

221 We now report that the same conformational TR-FRET based im

222 To explore the utility of SFM4-3, we now report the characterization of its recognition of su

223 We now report the development and technical validation of a

224 We now report the development of a sporadic tauopathy model

225 on scans in a linear quadrupole ion trap, we now report the development of single analyzer neutral lo

226 To close this gap, we now report transient kinetics and product analysis of th

227 hase 3 trials for chronic heart failure, are now reported.

228 ace-to-delay update session, the amygdala is now required for extinction of the updated memory but th

229 ork aimed at generating adequate samples are now required.

230 cies, and in Northern Ireland the species is now restricted to a single population in Peatlands Park,

231 We now reveal that mature domains harbor their own independ

232 alize at an unprecedented pace, the field is now ripe for systematic and functionally relevant studie

233 Although detecting local, cis-eQTLs is now routine, trans-eQTLs, which are distant from the gen

234 s because of their recent common ancestry is now routinely estimated from marker genotype data in mol

235 of HEs becomes crucial and hence clinicians now seek to measure the area of HEs in the digital colou

236 sigma* model applies, any octet expansion is now seen as largely formal, however, because the central

237 Artifacts such as expression tags are now separated into their own class, in order to distingu

238 molecular discoveries and metabolic modeling now serve as a foundation for future examination and dev

239 We now show tetramer- and substrate-dependent filament asse

240 We now show that a number of enzymatically active mitochond

241 We now show that ANI-7 is up to 263-fold more potent at inh

242 We now show that CRMP-1 is a major contributor to actin ass

243 We now show that HCMV induces the enhanced expression and a

244 lectrophysiology, and imaging techniques, we now show that NMDARs have a key role in mediating the ef

245 Ge et al. now show that skin tumors exhibit merged chromatin profi

246 We now show that the differences in myosin monomer concentr

247 plate-based structural homology modeling, we now show that the ectodomain of HAP2 orthologs from Tetr

248 We now show that the homeodomain-containing transcription f

249 We now show that the loss of S100A4 produces two mechanisti

250 However, we now show that the metabolic rate of CTB is much greater

251 ic pathways are required for latency, and we now show that these metabolic pathways are required for

252 We now show that TIM-4 is expressed by a subset of B cells

253 rescence, and superresolution microscopy, we now show that, after granule fusion, actin recovers at t

254 We now show that, in addition to this direct effect on viru

255 We now show that, within hours, a single dose of several an

256 Until now, six different leukocidins have been described, some

257 lenges must be characterized and planned for now so that clinical trials can progress expediently and

258 RNA sequencing (RNA-seq) experiments now span hundreds to thousands of samples.

259 as other platforms to generate trimers that now span multiple subtypes.

260 cantly from lightweight organic electronics, now spanning from displays to logics, because of the vit

261 INTERPRETATION: On average older men now spend 2.4 years and women 3.0 years with substantial

262 Moriarty et al. now suggest that the pH switching that occurs between di

263 EcoCyc now supports running and modifying E. coli metabolic mod

264 In addition, MPA Portable now supports state-of-the-art database search engines an

265 d have triggered the atmospheric escape that now sustains its giant exosphere.

266 As recently published, Canver et al. have now taken the first steps towards addressing these issue

267 "convergent" at long time where its response now tends toward that of a hemicylinder of equal radius.

268 Now that a substantial body of research has established

269 This happens so frequently now, that a name for it has emerged: fake news.

270 Hopkins School of Hygiene and Public Health (now the Bloomberg School of Public Health).

271 o major American oak clades arose in what is now the boreal zone and radiated, in parallel, from east

272 FHA), a surface-displayed adhesin, and until now, the consequences of this interaction were unknown.

273 Until now, the identity of the main structural protein compone

274 Until now, the mechanisms governing soil concentrations have b

275 on in atmospheric particle measurements, but now, the NTA can give us the possibility of applying the

276 Up until now, thermal events have been considered as the only sou

277 Now they are ubiquitous.

278 f the polar organic solvents, and thus until now, they were not considered suitable for electrochemic

279 Building on this foundation, the goal is now to drive malaria towards elimination.

280 vaccine candidates entered clinical trials, now totaling 7 products with an additional 40-plus candi

281 tive care integration for cancer patients is now touted as the optimal care model, yet significant ba

282 Now, two papers in Cell (Pawluk et al. and Rauch et al.)

283 species that make up the oral microbiome are now understood to play a key role in establishment and m

284 Efforts are now underway to develop DOACs that inhibit components of

285 l-cycle therapeutics and intense efforts are now underway to expand the reach of this paradigm.

286 unt to drain the fluid into a body cavity is now universally used, but failure is all too common.

287 hiladelphia College of Pharmacy and Science (now University of the Sciences) (BS), then University of

288 We now use this model, in conjunction with samples from pat

289 specific physiomarker was identified that is now used to investigate adaptive closed-loop stimulation

290 behavioral shifts in the salience of cocaine now vs money later, we found that ketamine, as compared

291 Now we have a clue to the mechanism, as many of these im

292 t outcome of this work is the knowledge that now we have demonstrated that these devices can be succe

293 Pase and the Mad2-binding protein p31(comet) Now we have isolated from extracts of HeLa cells an ATP-

294 damage (WPND) has continued to spread and is now well established in all New England states.

295 It is now well established that data from FFQs and other self-

296 Although it is now well established that the hippocampus supports memor

297 The technique is now widely employed in basic and translational research,

298 rinary medicine, resistance to ivermectin is now widespread, but the mechanisms underlying resistance

299 Now, with the selection of Dr.

300 ely 43 superfamilies, with unsolved problems now yielding to much larger data sets from high-throughp