ライフサイエンスコーパス: nuclear Overhauser effect

1 of polarization between these nuclei via the nuclear Overhauser effect.

2 en determined using the exchange-transferred nuclear Overhauser effect.

3 ner similar to the spin-polarization induced nuclear Overhauser effect.

4 GCG) has been determined using time-averaged nuclear Overhauser effects.

5 shift dispersion, and negative heteronuclear nuclear Overhauser effects.

6 rsion, and negative (1)H-(15)N heteronuclear nuclear Overhauser effects.

7 eristic sequential and mid-range transferred nuclear Overhauser effects.

8 e relaxation rates and amide nitrogen-proton nuclear Overhauser effects.

9 shifts and were confirmed by measurements of nuclear Overhauser effects.

10 pocket was defined through 37 intermolecular nuclear Overhauser effects.

11 relaxation times, T1 and T2, and the 1H-15N nuclear Overhauser effect (1H-15N NOE) indicates that mo

12 ls, was determined utilizing two-dimensional nuclear Overhauser effect (2D NOE) and double-quantum-fi

13 duplex have been made using two-dimensional nuclear Overhauser effect (2D NOE) spectra, at three dif

14 nothiazine and detection of isotope-filtered nuclear Overhauser effects allowed identification of dru

15 Nuclear Overhauser effect analysis, fluorescence spectro

16 resonance techniques using 1290 experimental nuclear Overhauser effect and dipolar coupling constrain

17 spectroscopy in D2O (NOESY (two-dimensional nuclear Overhauser effect and exchange spectroscopy) at

18 nd proton cross-peaks were well dispersed in nuclear Overhauser effect and heteronuclear single quant

19 A structure calculated by using nuclear Overhauser effect and other NMR constraints reve

20 The structure was refined using nuclear Overhauser effect and residual dipolar coupling

21 Solution NMR-based nuclear Overhauser effect and scalar J-coupling constant

22 nstraints based on the observed magnitude of nuclear Overhauser effects and 58 torsion angle restrain

23 Sequential Nuclear Overhauser Effects and double-quantum-filtered c

24 e conformations responsible for the observed nuclear Overhauser effects and inter-nuclear coupling.

25 ined structure as indicated by the number of nuclear Overhauser effects and is shown to play a critic

26 tion structure of recombinant FH1-3 based on nuclear Overhauser effects and RDCs.

27 ular modeling and NMR spectroscopy including nuclear Overhauser effects and residual dipolar coupling

28 ith aliphatic resonances in [Ca(2+)](4)-CaM (nuclear Overhauser effect) and increases the Ca(2+) affi

29 h-affinity complexes using (15)N R(1), R(2), nuclear Overhauser effect, and chemical-shift anisotropy

30 d D-LDH, such as the chemical shift changes, nuclear Overhauser effect, and solvent-induced isotopic

31 Sequential NMR assignments, intramonomer nuclear Overhauser effects, and circular dichroism spect

32 ts has been obtained using NMR spectrometry, nuclear Overhauser effects, and density functional theor

33 ents using (15)N-(13)C-labeled protein, (1)H nuclear Overhauser effects, and longitudinal relaxation

34 First, short-range nuclear Overhauser effects are detected between the arom

35 of a native-like partial core; no non-native nuclear Overhauser effects are observed.

36 Chemical shifts and nuclear Overhauser effects are similar to those of nativ

37 Nuclear Overhauser effects arising from the interactions

38 relaxation measurements as well as [1H]-15N nuclear Overhauser effects at 500 and 600 MHz.

39 inal and transverse 13C relaxation rates and nuclear Overhauser effects at both 500 and 600 MHz (prot

40 The method is based on the nuclear Overhauser effect between bound anesthetic proto

41 n firmly assigned through (a) measurement of nuclear Overhauser effect connectivities, (b) prediction

42 dence of these H3(+) resonance; and observed nuclear Overhauser effects consistent with Hoogsteen and

43 ogram CYANA to build a network of interchain nuclear Overhauser effect constraints that can be used t

44 acetylated peptide and by weak medium-range nuclear Overhauser effect contacts indicative of alpha-h

45 ymmetric dimer interface, 172 intermolecular nuclear Overhauser effect correlations (NOEs) define the

46 the membrane, as supported by intermolecular nuclear Overhauser effect cross-peaks between the peptid

47 Nuclear Overhauser effect crosspeak intensity provided i

48 Using 1H NMR spectroscopy, we observe nuclear Overhauser effect crosspeaks consistent with pro

49 were modeled using experimental transferred nuclear Overhauser effect data derived upon binding R*.

50 he conformational ensemble obtained by using nuclear Overhauser effect data in structure calculations

51 r proteins in solution from experimental NMR nuclear Overhauser effect data only and with minimal ass

52 Chemical shift index analysis and nuclear Overhauser effect data show that PrP(29-231) con

53 Heteronuclear (15)N-(1)H nuclear Overhauser effect data showed that the non-helic

54 In addition, the chemical shift and nuclear Overhauser effect data suggest that amino acids

55 cture was solved based on homonuclear proton nuclear Overhauser effect data using complete relaxation

56 ion of the two domains is not defined by the nuclear Overhauser effect data.

57 sidual dipolar coupling and inter-domain NOE nuclear Overhauser effect data.

58 Analysis of inter-residue nuclear Overhauser effects demonstrates that a native-li

59 In total, 3354 nuclear Overhauser effect-derived distance constraints,

60 a-helical membrane proteins >15 kDa in size, Nuclear-Overhauser effect-derived distance restraints ar

61 of the resulting alkenes were established by nuclear Overhauser effect difference NMR spectroscopy.

62 Furthermore, (13)C-edited nuclear Overhauser effects establish transient formation

63 Heteronuclear nuclear Overhauser effect experiments show that the new

64 ted average of the two is detected in NMR by nuclear Overhauser effect experiments.

65 NMR chemical shift trends and proton-proton nuclear Overhauser effect experiments.

66 in quantitative information from transferred nuclear Overhauser effect experiments.

67 Large variations in the (15)N-(1)H nuclear Overhauser effects for individual amino acids co

68 d question mark1H inverted question mark-15N nuclear Overhauser effects for the 15N nuclear spins usi

69 Intermolecular nuclear Overhauser effects have been used to investigate

70 in conformation as determined by transferred nuclear Overhauser effects in NMR spectra.

71 ies done by using the heteronuclear [1H]-15N nuclear Overhauser effect indicate that almost half of P

72 Steady-state {(1)H}-(15)N heteronuclear nuclear Overhauser effects indicate that the protein's c

73 Distances derived from nuclear Overhauser effects indicate that the three Ser r

74 agnetic resonance spectroscopy, based on 905 nuclear Overhauser effect inter-proton distance restrain

75 to facilitate assignment of the intersubunit nuclear Overhauser effect interactions.

76 The pattern of observed peptide-lipid nuclear Overhauser effects is consistent with a parallel

77 contact zone derived from the intermolecular nuclear Overhauser effects is in agreement with recent b

78 Nuclear Overhauser effect measurements and computational

79 R2) and steady state heteronuclear 15N [1H] nuclear Overhauser effect measurements at 500 and 600 MH

80 ic resonance line-broadening and transferred nuclear Overhauser effect measurements to identify the m

81 Furthermore, based on exchange-transferred nuclear Overhauser effect measurements, we established t

82 unds were verified by NMR spectroscopy using nuclear Overhauser effect methodology.

83 hermal titration calorimetry, intermolecular nuclear Overhauser effects, mutagenesis, and protection

84 ts derived from a combination of transferred nuclear Overhauser effect NMR experiments and molecular

85 Two-dimensional nuclear Overhauser effect NMR spectra demonstrate that t

86 en determined by two-dimensional transferred nuclear Overhauser effect NMR spectroscopy at 600 MHz.

87 have been studied in aqueous solutions using nuclear Overhauser effect (NOE) and transferred NOE NMR

88 ore region as evidenced by an intermolecular nuclear Overhauser effect (NOE) between each metallopept

89 Analyses of NMR chemical shifts and backbone nuclear Overhauser effect (NOE) connectivities showed th

90 ent was based on 2778 unambiguously assigned nuclear Overhauser effect (NOE) connectivities, 297 ambi

91 hemical shifts and 78 unambiguous long-range nuclear Overhauser effect (NOE) constraints.

92 Strong and positive intermolecular nuclear Overhauser effect (NOE) cross-peaks define a spe

93 Long-range nuclear Overhauser effect (NOE) cross-peaks showed the t

94 Distance bounds, calculated from the nuclear Overhauser effect (NOE) crosspeak intensities vi

95 xperimental NMR chemical shifts, plus sparse nuclear Overhauser effect (NOE) data if available.

96 ted protein from unassigned experimental NMR nuclear Overhauser effect (NOE) data only.

97 ts, and distance restraints derived from the nuclear Overhauser effect (NOE) data were used to calcul

98 We also calculated the nuclear Overhauser effect (NOE) distances from the molec

99 l and transverse relaxation rates and 15N-1H nuclear Overhauser effect (NOE) enhancements were measur

100 The nuclear Overhauser effect (NOE) has long been used as a

101 in relaxation rate (R(2)), and heteronuclear nuclear Overhauser effect (NOE) have been carried out at

102 we support these assignments with sequential nuclear Overhauser effect (NOE) information obtained fro

103 between different (1)H environments via the nuclear Overhauser effect (NOE) is included in the NMR p

104 relaxation times made it impractical to use nuclear Overhauser effect (NOE) measurements for assignm

105 cytochrome b5 were quantified using {1H}-15N nuclear Overhauser effect (nOe) measurements, which char

106 he 13C relaxation data, T1, and steady-state nuclear Overhauser effect (NOE) obtained at two differen

107 NMR chemical shifts and nuclear Overhauser effect (NOE) patterns of Ca(2+)-bound

108 Similar chemical shifts and (15)N nuclear Overhauser effect (NOE) patterns of the peptide

109 tative distance restraints, analogous to the nuclear Overhauser effect (NOE) routinely used in soluti

110 emical shift, T1 values, and one-dimensional nuclear Overhauser effect (nOe) saturation transfer expe

111 omplete relaxation matrix methods to analyze nuclear Overhauser effect (NOE) spectroscopic cross-peak

112 ermining resonance assignments, interpreting nuclear Overhauser effect (NOE) spectroscopy (NOESY) spe

113 Nuclear Overhauser effect (NOE) spectroscopy experiments

114 C-(13)C-(1)H correlation and (15)N-separated nuclear Overhauser effect (NOE) spectroscopy experiments

115 Nuclear Overhauser effect (NOE) spectroscopy revealed a

116 A total of 1159 useful nuclear Overhauser effect (NOE) upper distance constrain

117 rted question mark-HN inverted question mark nuclear Overhauser effect (NOE) values of vMIP-II, deter

118 The resulting process is equal to the nuclear Overhauser effect (NOE) where typically continuo

119 the steep inverse distance dependence of the nuclear Overhauser effect (NOE), from which the distance

120 ng a novel combination of chemical shift and nuclear Overhauser effect (NOE)-based methods.

121 (r.m.s.d.) = 1.2 A] was determined from 475 nuclear Overhauser effect (NOE)-derived distance restrai

122 On the basis of 951 nuclear Overhauser effect (NOE)-derived distance restrai

123 angstrom2 were generated with a total of 500 nuclear Overhauser effect (NOE)-derived distance restrai

124 m the human RBCC protein, MID1) based on 670 nuclear Overhauser effect (NOE)-derived distance restrai

125 ed interactions and violated very few of the nuclear Overhauser effect (NOE)-derived distances used i

126 neralized tissue is enhanced by a (1)H-(31)P nuclear Overhauser effect (NOE).

127 erse relaxation rate (R2), and heteronuclear nuclear Overhauser effect (NOE)] measured at two tempera

128 Nuclear Overhauser effects (nOe's) observed by two-dimen

129 876 upper distance constraints derived from nuclear Overhauser effects (NOE) and 173 dihedral angle

130 1878 upper distance constraints derived from nuclear Overhauser effects (NOE) and 314 dihedral angle

131 pendent on the observation of intermolecular nuclear Overhauser effects (NOE) and their assignments,

132 Chemical shift indices and nuclear Overhauser effects (NOE) confirmed helices in th

133 on rate constants (RN(Nx,y)=1/T2) and 1H-15N nuclear Overhauser effects (NOE) were obtained for 143 o

134 Chemical shift indices (CSI) and nuclear Overhauser effects (NOE) with 600 MHz NMR and CD

135 Long-range nuclear Overhauser effects (NOE) within this subdomain a

136 chemical shifts and the pattern of midrange nuclear Overhauser effects (NOE).

137 (T(2)) measurements as well as [(1)H]-(15)N nuclear Overhauser effects (NOE).

138 The PBEs, in combination with HN-HN nuclear Overhauser effects (NOEs) and chemical shift ind

139 domain without an inhibitor is based on 2813 nuclear Overhauser effects (NOEs) and has an average RMS

140 ossibly differences in homonuclear (1)H-(1)H nuclear Overhauser effects (NOEs) and heteronuclear (1)H

141 structure was determined on the basis of the nuclear Overhauser effects (NOEs) and the hydrogen bond

142 intensity of both sequential and long-range nuclear Overhauser effects (NOEs) between backbone amide

143 19F nuclear Overhauser effects (NOEs) between fluorine label

144 Intermolecular nuclear Overhauser effects (NOEs) between protein and wa

145 Observation of several interbase nuclear Overhauser effects (NOEs) clearly indicates a st

146 easure (13)C T(1), T(1rho) and heteronuclear nuclear Overhauser effects (NOEs) for sugar and base nuc

147 ns and nitrogens, and (1)H-(1)H interresidue nuclear Overhauser effects (NOEs) for the two mutants wi

148 to DNA chemical shifts and 24 intermolecular nuclear Overhauser effects (NOEs) identify the 5'-ApG an

149 g, chemical shift mapping and intermolecular nuclear Overhauser effects (NOEs) indicate the presence

150 It retains most of its solution nuclear Overhauser effects (NOEs) upon binding to either

151 stance and angular restraints based on 1H-1H nuclear Overhauser effects (NOEs), hydrogen-bonding netw

152 Based on 1H intermolecular nuclear Overhauser effects (NOEs), the THF rings of all

153 Using paramagnetic probes and protein-DPC nuclear Overhauser effects (NOEs), we define portions of

154 he backbone resonances and measure H(N)-H(N) nuclear Overhauser effects (NOEs).

155 t be defined because there are no long-range nuclear Overhauser effects (NOEs).

156 n distances were estimated from the observed nuclear Overhauser effects (NOEs).

157 rom assigned intra-ligand and protein-ligand nuclear Overhauser effects (NOEs).

158 arameters [chemical shifts, J couplings, and nuclear Overhauser effects (NOEs)] are expected.

159 ifts (CSs), intensities of NOESY crosspeaks [nuclear Overhauser effects (NOEs)], and residual dipolar

160 of r-K2 (1)H-NMR signals and two-dimensional nuclear Overhauser effect (NOESY) experiments in the pre

161 peaks with minor conformation in (19)F-(19)F nuclear Overhauser effect (NOESY) spectra.

162 A combination of FT-IR, (1)H NMR, nuclear Overhauser effect (NOESY), and diffusion-ordered

163 degrees), the set of medium- and short-range nuclear Overhauser effects observed for the active N-ter

164 The simulated nuclear Overhauser effect pair distances are in excellen

165 usion rates, the NH chemical shifts, and the nuclear Overhauser effect patterns provided a coherent p

166 ntribution of conformational exchange to the nuclear Overhauser effect peak intensity, we applied inf

167 sonance assignments and detailed analysis of nuclear Overhauser effects permit the direct comparison

168 ts, coupling constants, relaxation rates and nuclear Overhauser effect prediction applied to the thre

169 Using a nuclear Overhauser effect ratio strategy to define the a

170 pecific (15)N-T(1), (15)N-T(2), (15)N-{(1)H} nuclear Overhauser effect, reduced spectral density, and

171 Spin-lattice, spin-spin, and heteronuclear nuclear Overhauser effect relaxation data for backbone a

172 ust and has a high tolerance for misassigned nuclear Overhauser effect restraints, greatly simplifyin

173 conformational analysis from rotating angle nuclear Overhauser effect (ROESY) data.

174 ion matrix simulation of the two-dimensional nuclear Overhauser effect spectra at various mixing time

175 Multidimensional nuclear Overhauser effect spectra, X-filtered spectra an

176 hanges upon Zn(2+) binding were supported by nuclear Overhauser effect spectrometry (NOESY) studies.

177 centers was assigned through two-dimensional nuclear Overhauser effect spectroscopic analysis coupled

178 evertheless, structure calculations based on nuclear Overhauser effect spectroscopic data combined wi

179 The two distinct structures are derived from nuclear Overhauser effect spectroscopic distance restrai

180 Two-dimensional rotating-frame nuclear Overhauser effect spectroscopy (2D ROESY) (1)H N

181 cal shift measurements, two-dimensional (2D) nuclear Overhauser effect spectroscopy (2D-NOESY) 1H MAS

182 Heteronuclear (1)H-(15)N nuclear Overhauser effect spectroscopy (NOESY) and heter

183 This is accomplished by utilizing nuclear Overhauser effect spectroscopy (NOESY) at subzer

184 Nuclear Overhauser effect spectroscopy (NOESY) experimen

185 ance (NMR) experiments, and (5) NMR transfer nuclear Overhauser effect spectroscopy (NOESY) experimen

186 This, in combination with two-dimensional nuclear Overhauser effect spectroscopy (NOESY) results,

187 cts versus their free components, whereas 2D nuclear Overhauser effect spectroscopy (NOESY) spectra s

188 molecule tend to correlate together in a 2D nuclear Overhauser effect spectroscopy (NOESY) spectrum,

189 g (RFDR) and (1)H magic angle spinning (MAS) nuclear Overhauser effect spectroscopy (NOESY) technique

190 MAS-assisted two-dimensional nuclear Overhauser effect spectroscopy (NOESY) was condu

191 combination of (1)H NMR and two-dimensional Nuclear Overhauser Effect Spectroscopy (NOESY) which rev

192 SY), total correlation spectroscopy (TOCSY), nuclear Overhauser effect spectroscopy (NOESY), and rota

193 To this end, we have used nuclear Overhauser effect spectroscopy (NOESY)-based dis

194 )C relaxation parameters, and rotating-frame nuclear Overhauser effect spectroscopy (ROESY) crosspeak

195 ect spectroscopy (NOESY), and rotating frame nuclear Overhauser effect spectroscopy (ROESY) data were

196 re determined by transferred two-dimensional nuclear Overhauser effect spectroscopy (TRNOESY) measure

197 n the present work, we have used transferred nuclear Overhauser effect spectroscopy (TRNOESY) to dete

198 The NMR method of transferred nuclear Overhauser effect spectroscopy (TRNOESY) was use

199 We used transferred nuclear Overhauser effect spectroscopy (TrNOESY), which

200 Nuclear Overhauser effect spectroscopy allowed for the d

201 Homonuclear two-dimensional nuclear Overhauser effect spectroscopy and double quantu

202 ion-ordered spectroscopy, and rotating-frame nuclear Overhauser effect spectroscopy and high-resoluti

203 Nuclear Overhauser effect spectroscopy and molecular mod

204 Transferred nuclear Overhauser effect spectroscopy and rotating fram

205 VSD-phospholipid micelle interactions using nuclear Overhauser effect spectroscopy and showed that t

206 Intraresidue nuclear Overhauser effect spectroscopy cross peaks were

207 site as reflected in optical spectra and NMR nuclear Overhauser effect spectroscopy cross-peak and hy

208 tion matrix analysis of sets of experimental nuclear Overhauser effect spectroscopy crosspeaks.

209 Nuclear Overhauser effect spectroscopy experiments of th

210 Quantum mechanics calculations and nuclear Overhauser effect spectroscopy NMR studies sugge

211 Analysis by two-dimensional transfer nuclear Overhauser effect spectroscopy of the induced so

212 This method includes the acquisition of nuclear Overhauser effect spectroscopy one-dimensional a

213 Nuclear Overhauser effect spectroscopy revealed a number

214 Detailed analysis of the nuclear Overhauser effect spectroscopy spectra of the pr

215 trad-bound guanine can be extracted from the nuclear Overhauser effect spectroscopy spectrum based on

216 Two-dimensional transferred nuclear Overhauser effect spectroscopy studies of bound

217 Two-dimensional nuclear Overhauser effect spectroscopy suggests that the

218 ct, we have used two-dimensional transferred nuclear Overhauser effect spectroscopy to determine the

219 version recovery method, and the transferred nuclear Overhauser effect spectroscopy was used to study

220 0) IKENLKDCGLF was determined by transferred nuclear Overhauser effect spectroscopy while it was boun

221 d annealing using structural restraints from nuclear Overhauser effect spectroscopy, and scalar and r

222 R spectra, total correlated spectroscopy and nuclear Overhauser effect spectroscopy, show that the mo

223 (K(a) up to 19,000 M(-1)), and is shown--by nuclear Overhauser effect spectroscopy--to adopt the thr

224 upon binding, as demonstrated by transferred nuclear Overhauser effect spectroscopy.

225 ronic acid group at position 4', as shown by nuclear Overhauser effect spectroscopy.

226 und to the recombinant ECD using transferred nuclear Overhauser effect spectroscopy.

227 to Galpha(s), was determined by transferred nuclear Overhauser effect spectroscopy.

228 as measured by NMR experiments of (1)H-(15)N nuclear Overhauser effect, spin-lattice relaxation, and

229 NMR-filtered nuclear Overhauser effect studies confirmed these observ

230 internally inconsistent group of long range nuclear Overhauser effects suggest a close proximity of

231 axation-dispersion experiments, and filtered nuclear Overhauser effects suggest that CCL27 does not a

232 R1) or heteronuclear cross relaxation rates (nuclear Overhauser effect), suggesting that the 14-38 di

233 exhibits fewer helix-related and long range nuclear Overhauser effects than does the d-Ser(B8) analo

234 As monitored by two-dimensional (19)F-(19)F nuclear Overhauser effect, the distance between two phen

235 Contributions of the nuclear Overhauser effect to exchange rates measured wit

236 d, and their relaxation, dipolar shifts, and nuclear Overhauser effects to adjacent residues used to

237 an NMR experiment that allows one to exploit nuclear Overhauser effects to determine internuclear dis

238 gion of the talin rod and use intermolecular nuclear Overhauser effects to determine the structure of

239 Here, we used transferred nuclear Overhauser effects to study the interaction in s

240 ositioned in the heme cavity on the basis of nuclear Overhauser effects to the heme and each other, d

241 l shift perturbation and the inter-molecular nuclear Overhauser effects to the RNA.

242 Nuclear Overhauser effects to urea for these segments ar

243 In previous work, we found using transferred nuclear Overhauser effect (trNOE) analysis that two 13 a

244 ectroscopy experiments, inducing transferred nuclear Overhauser effect (trNOE) and saturation transfe

245 This transferred nuclear Overhauser effect (trNOE) disrupts the observed

246 residues of G(t)alpha derived by transferred nuclear Overhauser effect (TrNOE) NMR.

247 Previous transferred nuclear Overhauser effect (trNOE) studies with peptides

248 d nucleotide was determined from transferred nuclear Overhauser effects (trnOe) experiments to determ

249 contact surfaces are studied by transferred nuclear Overhauser effects (trNOEs) and saturation trans

250 Traditionally, transferred nuclear Overhauser effects (trNOEs), measured from NMR s

251 e geometry calculations based on transferred nuclear Overhauser effects (TRNOEs).

252 re determined by two-dimensional transferred nuclear Overhauser effect (TRNOESY) measurements combine

253 re determined by two-dimensional transferred nuclear Overhauser effect (TRNOESY) measurements combine

254 T(1), T(2), and (1)H/(15)N nuclear Overhauser effect values measured for the amide

255 turation, and reduced heteronuclear (1H-15N) nuclear Overhauser effect values.

256 The transferred nuclear Overhauser effect was used to characterize confo

257 relaxation data and steady-state (1)H- (15)N nuclear Overhauser effects were analyzed using model-fre

258 frame relaxation rates and the heteronuclear nuclear Overhauser effects were carried out on a uniform

259 T(1), T(2), T(1)(rho), and steady-state nuclear Overhauser effects were measured at 500 and 600

260 d question mark1H inverted question mark-15N nuclear Overhauser effects were measured for the backbon

261 Intermolecular (1)H(19)F and (1)H(1)H nuclear Overhauser effects were used to explore interact

262 y arising from changes in creatine level and nuclear overhauser effects, which were not found using c

263 The distance relation of nuclear Overhauser effects with a factor of r(-6) is emp

264 striking enhancement of multiple native-like nuclear Overhauser effects within the tethered protein.