ライフサイエンスコーパス: nuclear RNA

1 ated by changes in short lived heterogeneous nuclear RNA.

2 esis of the complete Ighm/Ighd heterogeneous nuclear RNA.

3 ts association with the inhibitory 7SK small nuclear RNA.

4 en-induced expression of CYP1A heterogeneous nuclear RNA.

5 on at cap 1 on substrate SL RNA and U1 small nuclear RNA.

6 ng, we demonstrate the shuttling of U1 small nuclear RNA.

7 nical mechanisms of base pairing to U1 small nuclear RNA.

8 ynamic deposition on mRNA and other types of nuclear RNA.

9 and H/ACA small nucleolar RNAs and U4 small nuclear RNA.

10 plex required for 3'-end processing of small nuclear RNAs.

11 ylguanosine (TMG) caps on spliceosomal small nuclear RNAs.

12 s, which share some of the features of small nuclear RNAs.

13 ctural features with cellular Sm-class small nuclear RNAs.

14 H/ACA guide RNA, modify ribosomal and small nuclear RNAs.

15 NAs have not been optimized for the study of nuclear RNAs.

16 28S rRNAs and levels of the U-class of small nuclear RNAs.

17 vely regulated by association with the small nuclear RNA 7SK and the HEXIM1 protein.

18 of the large inactive P-TEFb:7SK RNP (small nuclear RNA 7SK ribonucleoprotein) complex and the relea

19 , which prevented the destabilization of the nuclear RNA 7SK, a process normally associated with adul

20 bited by the coordinate actions of 7SK small nuclear RNA (7SK snRNA) and hexamethylene bisacetamide (

21 t LARP7, BCDIN3, and the noncoding 7SK small nuclear RNA (7SK) are vital for the formation and stabil

22 thyl phosphate capping enzyme, and 7SK small nuclear RNA (7SK).

23 cRNAs implicated in RNA processing: U1 small nuclear RNA, a component of the spliceosome, and Malat1,

24 talysis by unwinding base-paired U4/U6 small nuclear RNAs, a step that must be precisely timed.

25 e of changes in nascent transcript and total nuclear RNA abundance for the transcription factors STAT

26 of cytoplasmic ORF59 RNA, ORF57 offsets the nuclear RNA accumulation mediated by RBM15 by preventing

27 r, both types of promoters utilize the small nuclear RNA activating protein complex (SNAP(c)) and the

28 he Myb-like DNA-binding subunit of the small nuclear RNA activating protein complex, binds piRNA clus

29 We identified a zebrafish snapc4 (small nuclear RNA-activating complex polypeptide 4) mutant in

30 ion factors, a partially characterized small nuclear RNA-activating protein complex (SNAP(c)) and the

31 lates the general transcription factor small nuclear RNA-activating protein complex (SNAP(C)) that is

32 ique transcription factor known as the small nuclear RNA-activating protein complex (SNAPc).

33 The small nuclear RNA-activating protein complex SNAP(c) is requir

34 IB, and TFIIH which, together with the small nuclear RNA-activating protein complex, form a transcrip

35 a, K8.1, or a higher level of polyadenylated nuclear RNA after butyrate induction and could not be in

36 t-long RNAs, including spliceosomal U6 small nuclear RNA and a cyclic-di-AMP binding riboswitch RNA.

37 The SL RNA is a small nuclear RNA and a trans splicing substrate for the matur

38 The splicing factor SC35/SRSF2 binds to nuclear RNA and facilitates the incorporation of exon 10

39 ntalization by fluorophore-labeling U1 small nuclear RNA and observing its distribution in the nucleu

40 or, proper 3'-end processing of the U4 small nuclear RNA and some small nucleolar RNAs, and degradati

41 articles (snRNPs), which consist of U1 small nuclear RNA and ten proteins, recognize the 5' splice si

42 the machinery that coordinates the export of nuclear RNA and the import of nuclear proteins.

43 ases the levels of spliceosomal and U7 small-nuclear RNAs and corrects RNA processing defects induced

44 thin snatched fragments and found that small nuclear RNAs and small nucleolar RNAs contributed the mo

45 s in the misexpression of a variety of small nuclear RNAs and small nucleolar RNAs, an effect that is

46 rge complex is composed of P-TEFb, 7SK small nuclear RNA, and hexamethylene bisacetamide-inducible pr

47 lar RNA, natural antisense transcript, small nuclear RNA, and small RNA using published datasets and

48 ricate network formed by U5, U2 and U6 small nuclear RNAs, and a pre-messenger-RNA substrate.

49 We further found that nuclear RNAs are critical to its oligomerization.

50 rcoma-associated herpes virus polyadenylated nuclear RNA) are not efficiently processed to precursor

51 liceosome, a macromolecule composed of small nuclear RNAs associated with proteins.

52 es between the large subunit of the U2 small nuclear RNA auxiliary factor (U2AF65) with the splicing

53 r neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic ag

54 Enteroviruses are dependent upon host nuclear RNA binding proteins for efficient replication.

55 Finally, we determined the nuclear RNA-binding profile of Ago-2, found it bound to

56 Cytosolic aggregation of the nuclear RNA-binding protein (RBP) TDP-43 (43 kDa TAR DNA

57 nderlie ribonucleoprotein (RNP) granules and nuclear RNA-binding protein assemblies that may nucleate

58 Reinduction of a nuclear RNA-binding protein CELF1 (CUGBP Elav-like famil

59 f-function cytoplasmic aggregates or loss of nuclear RNA-binding protein function.

60 we investigated the role of the Arabidopsis nuclear RNA-binding protein HYL1 and the nuclear RNase I

61 Heterogeneous nuclear RNA-binding protein LL (hnRNPLL) is specifically

62 ar ribonucleoprotein C (HNRNPC), an abundant nuclear RNA-binding protein responsible for pre-mRNA pro

63 Cytosolic aggregation of the nuclear RNA-binding protein TDP-43 is a histopathologic

64 TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies

65 A predominantly nuclear RNA-binding protein, HuR translocates to the cyt

66 with the survival factor p54nrb/Nono (54-kDa nuclear RNA-binding protein, non-POU-domain-containing o

67 FUS, a nuclear RNA-binding protein, plays multiple roles in RNA

68 Within this pathway FCA is a plant-specific, nuclear RNA-binding protein, which interacts with FY, a

69 ation initiation factor 2alpha, shuttling of nuclear RNA-binding proteins such as TIA-1 to the cytopl

70 that the three UBA2 genes encode hnRNP-type nuclear RNA-binding proteins that function in a novel wo

71 We identify two, primarily nuclear RNA-binding proteins, hnRNP L and NF90, with pre

72 otide noncoding, polyadenylated, exclusively nuclear RNA called PAN that is highly expressed in lytic

73 Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is imp

74 sistant protein 2 (ARS2), a component of the nuclear RNA CAP-binding complex that is crucial for biog

75 ular spliceosome components, including small nuclear RNAs, cause reproducible uniquely distributed ph

76 and a 'U1 domain' that binds to the U1 small nuclear RNA component of the U1 small nuclear ribonucleo

77 arcoma-associated herpesvirus polyadenylated nuclear RNA contains a 79-nt cis-acting element, the ENE

78 ladenosine (m(6)A) methylation of eukaryotic nuclear RNA controls post-transcriptional gene expressio

79 n factor SNAP(C), which binds to human small nuclear RNA core promoter elements and nucleates pre-ini

80 he 3UTR of nuclear-retained Cat2 transcribed nuclear RNA (Ctn RNA).

81 Nudt16p is a nuclear RNA decapping protein initially identified in Xe

82 While vertebrate Nudt16p is a nuclear RNA decapping protein, Syndesmos is associated w

83 (RNase) that contributes to cytoplasmic and nuclear RNA decay and quality control.

84 BP2 is synthetic lethal with deletion of the nuclear RNA decay factor, RRP6, pointing to a global rol

85 hether RNA cleavage is sufficient to trigger nuclear RNA degradation and transcription termination or

86 merase component of TRAMP4, which stimulates nuclear RNA degradation by the exosome.

87 s of different cofactors associated with the nuclear RNA degradation machinery.

88 uggesting the existence and maintenance of a nuclear RNA degradation pathway in metazoans.

89 e to obtain useful sequencing libraries from nuclear RNA derived from cultured human cells after cros

90 post-transcriptional modification and small nuclear RNA duplexes for splicing.

91 is known about the mechanisms that regulate nuclear RNA editing activity.

92 clear import of specific ADARs and, in turn, nuclear RNA editing.

93 cterized 247 liver lincRNAs, with many being nuclear RNA enriched and regulated by growth hormone.

94 The viral polymerase complex co-opts the nuclear RNA exosome complex and cellular RNAs en route t

95 DIS3 encodes a catalytic subunit of the nuclear RNA exosome complex that mediates RNA processing

96 Mechanistically, the nuclear RNA exosome coordinates the initial steps of vir

97 The nuclear RNA exosome includes a 9-subunit non-catalytic c

98 The nuclear RNA exosome is an essential multi-subunit comple

99 Rrp6 is a key catalytic subunit of the nuclear RNA exosome that plays a pivotal role in the pro

100 hysically interacts with the ribonucleolytic nuclear RNA exosome.

101 Nuclear RNA exosomes catalyze a range of RNA processing

102 get mRNAs with access to REF, which mediates nuclear RNA export by binding to TAP/NXF1.

103 directly with the Tap protein (also known as nuclear RNA export factor 1, encoded by NXF1), which is

104 Spt6), and found that it associates with the nuclear RNA export factor, REF1/Aly.

105 ted from nucleus to cytoplasm by a family of nuclear RNA export factors (NXF).

106 ng RNA polymerase II with RNA processing and nuclear RNA export factors to facilitate regulated gene

107 loss compromises transcriptional elongation, nuclear RNA export, and genome stability.

108 include chromatin remodeling, RNA splicing, nuclear RNA export, mRNA stabilization, and translationa

109 -1 and EBER-2, are highly abundant noncoding nuclear RNAs expressed during all forms of EBV latency.

110 presence of m(6)A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates p

111 of muscleblindlike 1 (MBNL1) protein within nuclear RNA foci and increased CUGBP, ELAV-like family m

112 Thus, nuclear RNA foci are neutral intermediates or possibly n

113 Here, we identify nuclear RNA foci containing the hexanucleotide expansion

114 By contrast, siRNAs fail to reduce nuclear RNA foci despite marked reduction in overall C9o

115 Brains of 6-month-old mice contained nuclear RNA foci, inclusions of poly(Gly-Pro), poly(Gly-

116 liced C9ORF72 transcript and to formation of nuclear RNA foci, suggesting multiple disease mechanisms

117 tionally acquired oligo(A) tails that target nuclear RNAs for degradation.

118 h to compare APA profiles of cytoplasmic and nuclear RNA fractions from human cell lines.

119 Here, we describe the purification of nuclear RNA from early stage Arabidopsis thaliana embryo

120 Loss of repeat-rich, stable nuclear RNAs from euchromatin corresponds to aberrant ch

121 however, required for displacement of small nuclear RNAs from the Gemin5-containing subunits and the

122 Vectors should be useful in conditions where nuclear RNA function is studied or where export to the c

123 hemical modifications of ribosomal and small nuclear RNAs, functions that are carried out in the nucl

124 Human U6 small nuclear RNA gene transcription by RNA polymerase III req

125 Human small nuclear RNA gene transcription by RNA polymerases II and

126 Unlike most protein-coding genes, small nuclear RNA gene transcription starts predominantly at a

127 tart site determinant for the yeast U4 small nuclear RNA gene, SNR14.

128 AP(c) is required for transcription of small nuclear RNA genes and binds to a proximal sequence eleme

129 tor that is required for expression of small nuclear RNA genes.

130 ted, RNAPII-dependent, uridylate-rich, small nuclear RNA genes.

131 the RNA polymerase III-transcribed U1 small nuclear RNA has the same first four nucleotides as splic

132 structural and RBP interaction landscape of nuclear RNAs has yet to be compiled for any organism.

133 CR revealed no changes in DMT1 heterogeneous nuclear RNA (hnRNA) levels following Mn exposure.

134 examined the induction of CRH heterogeneous nuclear RNA (hnRNA), AVP hnRNA and c-fos as a measure of

135 We demonstrate the canonical nuclear RNA [human telomerase RNA (hTR)] is not present

136 RNA, small Cajal body RNA (scaRNA) and small nuclear RNA in human and mouse cells by conventional tra

137 n a biological function to a large noncoding nuclear RNA in the regulation of mRNA export.

138 However, functionalizing these nuclear RNAs in mammalian cells remains challenging, due

139 ed nucleotide of spliced leader and U1 small nuclear RNAs in the kinetoplastid protozoan Trypanosoma

140 ovalent modifications of ribosomal and small nuclear RNAs in the nucleus.

141 hat a base-paired complex of U6 and U2 small nuclear RNAs, in the absence of the approximately 200 ot

142 at the Gemin5-containing subunits bind small nuclear RNA independently of the SMN complex and without

143 hese studies show that REF/Aly can stabilize nuclear RNAs independently of their export and support a

144 sters the 5'ss residues involved in U1 small nuclear RNA interactions, thereby inhibiting excision of

145 e U6 ACAGAGA stem-pre-mRNA and Brr2-U4 small nuclear RNA interactions.

146 Nuclear RNA interference (RNAi) is mediated by the canon

147 The Caenorhabditis elegans nuclear RNA interference defective (Nrde) mutants were i

148 leoprotein (U1-snRNP) that includes U1-small nuclear RNA is a highly conserved intranuclear molecular

149 The 7SK small nuclear RNA is a highly conserved non-coding RNA that re

150 ften signals nuclear import for U-rich small nuclear RNAs, it is unclear how this Sm binding site rem

151 protein La recognizes UUU-3'OH on its small nuclear RNA ligands and stabilizes them against 3'-end-m

152 induction of MMP-1 and MMP-13 heterogeneous nuclear RNA, messenger RNA, and protein.

153 an Ago/Piwi protein and 3' tRNA fragments in nuclear RNA metabolism.

154 the SLA1 snoRNP but does not affect U1 small nuclear RNA methylation.

155 increased by 2- to 10-fold the heterogeneous nuclear RNA, mRNA, protein, and activity levels of GLUT5

156 Seven small nuclear RNAs of the Sm class are encoded by Herpesvirus

157 owed that several viral RNAs (polyadenylated nuclear RNA, open reading frame 58 [ORF58], ORF59, T0.7,

158 Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA).

159 ing transcript referred to as polyadenylated nuclear RNA (PAN RNA).

160 erpesvirus (KSHV) expresses a polyadenylated nuclear RNA (PAN RNA).

161 ions in chromatin transcription by all three nuclear RNA Pols.

162 d by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV).

163 RNA (dicer-like2 dicer-like3 dicer-like4 and nuclear RNA polymerase d2a nuclear RNA polymerase d2b) d

164 3 dicer-like4 and nuclear RNA polymerase d2a nuclear RNA polymerase d2b) do not exhibit inherited res

165 on is thus very similar to that described in nuclear RNA polymerase II-dependent transcription, in wh

166 24 nt siRNA biogenesis requires nuclear RNA polymerase IV (Pol IV), RNA-dependent RNA po

167 repeats in a pathway involving two forms of nuclear RNA polymerase IV (Pol IVa and Pol IVb), RNA-DEP

168 Nuclear RNA polymerase V (Pol V) is an RNA silencing enz

169 olved in transcription by all three types of nuclear RNA polymerase.

170 ukaryotes express three or more multisubunit nuclear RNA polymerases (Pols) referred to as Pols I, II

171 Since their discovery in Metazoa, the three nuclear RNA polymerases (RNAPs) have been found in fungi

172 transcription factor, is broadly required by nuclear RNA polymerases for the initiation of transcript

173 and transcriptional silencing involves three nuclear RNA polymerases that are biochemically undefined

174 n all eukaryotes, plants have two additional nuclear RNA polymerases, abbreviated as Pol IV and Pol V

175 on of eukaryotic genes is performed by three nuclear RNA polymerases, of which RNA polymerase II is t

176 oadly promotes transcription mediated by all nuclear RNA polymerases, thereby acting as a positive mo

177 ) is critical for transcription by all three nuclear RNA polymerases.

178 otor neuron (SMN) complex delivers pre-small nuclear RNAs (pre-snRNAs) to the heptameric Sm ring for

179 oan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA t

180 (LsmAD), found in proteins that function in nuclear RNA processing and mRNA decay, and a PAM2 motif,

181 creasing alleles, and could therefore affect nuclear RNA processing and/or decay.

182 strates its potential function in regulating nuclear RNA processing, as well as a novel gain-of-funct

183 Many steps in nuclear RNA processing, surveillance, and degradation re

184 Strains with mutations in nuclear RNA-processing exosome components, including Rrp

185 We describe a nuclear RNA-processing network in fission yeast with a c

186 nthesis, the 7SK snRNP is a key regulator of nuclear RNA production by RNAPII.

187 luorescent protein 1 (mRFP1), polyadenylated nuclear RNA promoter (pPAN)-enhanced green fluorescent p

188 The human U6 small nuclear RNA promoter, located 5' of the transcription st

189 uide RNAs that are expressed from a U6 small nuclear RNA promoter.

190 rr2 RNA helicase disrupts the U4/U6 di-small nuclear RNA-protein complex (di-snRNP) during spliceosom

191 ains two Sm motifs found in the common small nuclear RNA proteins and the LSm (like-Sm) family of pro

192 the primary PWS region genes appear to have nuclear RNA regulatory functions, suggesting that multip

193 leotides in ribosomal and spliceosomal small nuclear RNAs, respectively.

194 Deep sequencing of nuclear RNA revealed a major fraction of nascent, unspli

195 Differential expression analysis following nuclear RNA-seq of neutrophil active transcriptomes reve

196 apping of transcriptional readthrough, using nuclear RNA-Seq, comparing heat shock, osmotic stress, a

197 nic ncRNAs, small cytoplasmic RNAs and small nuclear RNAs show less consistent patterns.

198 ns and the small RNAs, including tRNA, small nuclear RNA, small nucleolar RNA, and microRNA.

199 ndant small, noncoding RNAs, including small nuclear RNAs, small nucleolar RNAs (snoRNAs), cryptic un

200 the RNA polymerase III-transcribed U6 small nuclear RNA (SNR6) gene.

201 The small nuclear RNA (snRNA) activating protein complex (SNAPc) i

202 by the coordinated actions of the 7SK small nuclear RNA (snRNA) and hexamethylene bisacetamide (HMBA

203 nelles that nonrandomly associate with small nuclear RNA (snRNA) and histone gene loci in human cells

204 plicing requires multiple spliceosomal small nuclear RNA (snRNA) and pre-mRNA rearrangements.

205 The human small nuclear RNA (snRNA) and small cytoplasmic RNA (scRNA) ge

206 ng with the Pol IV subunit NRPD1b; the small nuclear RNA (snRNA) binding protein SmD3; and two marker

207 U1 and U2 gene loci, which produce the small nuclear RNA (snRNA) component of the respective snRNP.

208 The small nuclear RNA (snRNA) components of the spliceosome underg

209 Yeast U2 small nuclear RNA (snRNA) contains three pseudouridines (Psi35

210 lymerase III transcription of human U6 small nuclear RNA (snRNA) genes both negatively and positively

211 Promoters for vertebrate small nuclear RNA (snRNA) genes contain a relatively simple ar

212 The small nuclear RNA (snRNA) genes have been widely used as a mod

213 RNA polymerase (pol) II and III human small nuclear RNA (snRNA) genes have very similar promoters an

214 hly enriched at RNA Pol II-transcribed small nuclear RNA (snRNA) genes, and the loss of LEC results i

215 the transcription of Pol II-dependent small nuclear RNA (snRNA) genes.

216 obe the structure of low-abundance U12 small nuclear RNA (snRNA) in Arabidopsis thaliana and provide

217 ng in mitochondria of trypanosomes and small nuclear RNA (snRNA) maturation in humans.

218 it of a protein complex that regulates small nuclear RNA (snRNA) transcription.

219 he endonucleolytic cleavage of primary small nuclear RNA (snRNA) transcripts within the nucleus.

220 the catalytic Mg(2+) site in the U2/U6 small nuclear RNA (snRNA) triplex, and the 5'-phosphate of the

221 association between coilin and rRNA, U small nuclear RNA (snRNA), and human telomerase RNA, which is

222 des from the 3' end of spliceosomal U6 small nuclear RNA (snRNA), directly catalyzing terminal 2', 3'

223 led spliceosomal complex comprising U5 small nuclear RNA (snRNA), extensively base-paired U4/U6 snRNA

224 clear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, regulates the mRN

225 I-transcribed cellular RNAs, including small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), and t

226 ch sequence called the Sm site in each small nuclear RNA (snRNA), to form the core domain of the resp

227 urvival motor neuron (SMN) protein, U2 small nuclear RNA (snRNA), U5 snRNA, and the small CB-specific

228 ribosomal RNA (rRNA) and spliceosomal small nuclear RNA (snRNA), uridines at specific sites are conv

229 uires 5' splice site recognition by U1 small nuclear RNA (snRNA), which is replaced by U5 and U6 snRN

230 The small nuclear RNA (snRNA)-activating protein complex (SNAPc) i

231 The small nuclear RNA (snRNA)-activating protein complex (SNAPc) i

232 ein is essential for the biogenesis of small nuclear RNA (snRNA)-ribonucleoproteins (snRNPs), the maj

233 nical base-pairing to the 5' end of U1 small nuclear RNA (snRNA).

234 hyltransferase for the U6 spliceosomal small nuclear RNA (snRNA).

235 at a single catalytic metal site in U6 small nuclear RNA (snRNA).

236 to bind RNA stemloops in U1 and/or U2 small nuclear RNA (snRNA).

237 Expression of modified U1 small nuclear RNAs (snRNA) complementary to the splice donor s

238 pins immediately downstream from viral small nuclear RNAs (snRNA).

239 ly dependent on a functional U2 snRNP (small nuclear RNA [snRNA] plus associated proteins), as H2A.Z

240 gonucleotide [MO] and an engineered U7 small nuclear RNA [snRNA]) to correct this splicing defect.

241 Most of the major spliceosomal small nuclear RNAs (snRNAs) (i.e. U1, U2, U4 and U5) are synth

242 itional production of 3'-extensions of small nuclear RNAs (snRNAs) and biogenesis of novel transcript

243 It assembles from five U-rich small nuclear RNAs (snRNAs) and over 200 proteins in a highly

244 bles the heptameric Sm protein core on small nuclear RNAs (snRNAs) and plays a critical role in the b

245 Small nuclear RNAs (snRNAs) are essential factors in messenger

246 In animals, most small nuclear RNAs (snRNAs) are synthesized by RNA polymerase

247 Uridine-rich small nuclear RNAs (snRNAs) are the basal components of the sp

248 Because spliceosomal small nuclear RNAs (snRNAs) bind the substrate, snRNA structur

249 es requiring RNAPII for transcription, small nuclear RNAs (snRNAs) display a further requirement for

250 ly, we found that TOE1 associated with small nuclear RNAs (snRNAs) incompletely processed spliceosoma

251 Transcription of genes coding for the small nuclear RNAs (snRNAs) is dependent upon a unique transcr

252 ross-links identified in the U4 and U6 small nuclear RNAs (snRNAs) suggest U4/U6 stem I as a Brr2p su

253 f ubiquitously expressed, uridine-rich small nuclear RNAs (snRNAs) transcribed by RNA polymerase II (

254 olves effects of SmD3 on the levels of small nuclear RNAs (snRNAs) U4 and U5.

255 During their biogenesis small nuclear RNAs (snRNAs) undergo multiple covalent modifica

256 toplasm, precursors to specific tRNAs, small nuclear RNAs (snRNAs), and small nucleolar RNAs (snoRNAs

257 ons, we previously proposed the use of small nuclear RNAs (snRNAs), especially U7snRNA to shuttle the

258 RNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs), piwi-associated RNAs (piRNAs) and

259 of fluorescently labeled spliceosomal small nuclear RNAs (snRNAs), target the nascent transcripts of

260 mbly of heptameric Sm protein rings on small nuclear RNAs (snRNAs), which are essential for snRNP fun

261 s)-subnuclear compartments enriched in small nuclear RNAs (snRNAs)-and promotes efficient spliceosoma

262 machine composed of both proteins and small nuclear RNAs (snRNAs).

263 nes that encode proteins and noncoding small nuclear RNAs (snRNAs).

264 mprising 30 proteins plus U4/U6 and U5 small nuclear RNAs (snRNAs).

265 e 27-nt repeats could be the source of small nuclear RNA specifically regulating eNOS expression.

266 ssential spliceosome factors including small nuclear RNAs, splicing proteins, and endogenous pre-mRNA

267 suggested to play roles in transcription and nuclear RNA stability in addition to its more broadly ch

268 of PAN RNA, suggesting that REF/Aly promotes nuclear RNA stability.

269 for precursor mRNA splicing through U6 small nuclear RNA stabilization.

270 target sequences within different classes of nuclear RNA substrates.

271 an one copy per cell, even in the absence of nuclear RNA surveillance and during late meiosis.

272 activates exosome-mediated 3'-5' turnover in nuclear RNA surveillance and processing pathways.

273 Unexpectedly, the TRAMP and exosome nuclear RNA surveillance complexes are also implicated i

274 his, we identified in vivo binding sites for nuclear RNA surveillance factors, Nrd1, Nab3 and the Trf

275 A key question in nuclear RNA surveillance is how target RNAs are recogniz

276 roducts of SMD are primarily degraded by the nuclear RNA surveillance machinery.

277 In budding yeast, the nuclear RNA surveillance system is active on all pre-mRN

278 3' oligo(A) tails that are characteristic of nuclear RNA surveillance targets.

279 Rrp6-mediated nuclear RNA surveillance tunes eukaryotic transcriptomes

280 Most lncRNAs are targeted for nuclear RNA surveillance, but a subset with 3' cleavage

281 ous reports linking poly(A) tail length with nuclear RNA surveillance.

282 splicing errors that are actively removed by nuclear RNA surveillance.

283 berrant splicing events that are targeted by nuclear RNA surveillance.

284 Levels of heterogeneous nuclear RNA synthesis demonstrated that edn1 mRNA stimul

285 The shift from cytoplasmic to nuclear RNA targets was accompanied by a dramatic transl

286 ly any RNA (e.g., mRNA, ribosomal RNA, small nuclear RNA, telomerase RNA and so on).

287 s and a revised model for CTD-mediated small nuclear RNA termination.

288 method, we generated CLIP-Seq libraries from nuclear RNA that had been UV-crosslinked and immunopreci

289 without the association of 7SK RNA, a small nuclear RNA that is bound to approximately 50% of total

290 U85 small CB-specific RNA, U2 small nuclear RNA, the survival of motor neurons protein, and

291 cellular factor PA28gamma in the control of nuclear RNA trafficking and HTLV-1-induced latency.

292 cription factor SNAP(c), which directs small nuclear RNA transcription.

293 rmally encode IgM and IgD from heterogeneous nuclear RNA transcripts via alternative splicing, lack i

294 Although uridine-rich small nuclear RNAs (U-snRNAs) are essential for pre-mRNA splic

295 The auxiliary factor of U2 small nuclear RNA (U2AF) is a heterodimer consisting of 65- an

296 n HEXIM1 immunoprecipitates, while the small nuclear RNAs, U6 and U2, were not.

297 oding RNAs, including the uridine-rich small nuclear RNA (UsnRNA) and enhancer RNA (eRNA), and in the

298 of the mutants on the synthesis of U5 small nuclear RNA were analyzed.

299 suppression of 3' end formation by U1 small nuclear RNA, which is known to bind pre-mRNA at the earl

300 with RNA-Seq is more predictable than PolyA+ nuclear RNA, while the opposite is true for PolyA- RNA.