ライフサイエンスコーパス: nuclear family

1 COME from 35 hospitals in the UK, and their nuclear family.

2 l for the number of ASPs contributed by each nuclear family.

3 orithm-namely, genotype elimination within a nuclear family.

4 t residue 1126 of the mature receptor in one nuclear family.

5 ultiple parent-offspring pairs from the same nuclear family.

6 on the basis of data from arbitrary types of nuclear families.

7 t cases included 2,107 Pima Indians from 715 nuclear families.

8 xtended pedigrees were no more powerful than nuclear families.

9 grees and are not restricted to sib pairs or nuclear families.

10 nvolving 186 affected sibling pairs from 160 nuclear families.

11 relapsing individuals and 11 controls from 5 nuclear families.

12 ated in our previous linkage analysis of 428 nuclear families.

13 ng of quantitative trait loci (QTL) based on nuclear families.

14 ix SNP and fed these into Transmit using 148 nuclear families.

15 d 29 SNP throughout this region in psoriatic nuclear families.

16 for quantitative traits and extended here to nuclear families.

17 aximum detection rate is 34% for four-person nuclear families.

18 hree of 18 unrelated BBS probands from small nuclear families.

19 ian population-based sample of 232 Caucasian nuclear families.

20 Findings were confirmed in 52 nuclear families (132 members with clinical phenotypes,

21 rs2299620), in 7,351 Pima Indians from 4,549 nuclear families; 34% of participants had diabetes.

22 A cohort of 49 nuclear families, 40 with familial DCM and 9 with sporad

23 In the 52 nuclear families, 86 individuals (65.2%) were male and t

24 ase and automated pedigree software, that 23 nuclear families affected with MCPHA are connected to a

25 A total of 234 Finnish JIA nuclear families and 639 elderly Finnish controls withou

26 tric" linkage analysis of X-linked traits in nuclear families and extended pedigrees.

27 trios, and quartets of biallelic markers in nuclear families and in independent sib pairs.

28 Most families are nuclear families and the average household has 7 persons

29 antitative trait loci have been developed on nuclear-family and extended-pedigree data.

30 merican family-based study population (n=219 nuclear families) and two case-control populations--one

31 tions for a set of tightly linked markers in nuclear families, and the objective is to identify famil

32 ave implemented the basic model for use with nuclear families, and we illustrate its application thro

33 esting, counseling, and risk calculation for nuclear families, as well as extended family members at

34 the MHC region on chromosome 6p21-22 in 225 nuclear families ascertained by African American proband

35 an based on 354 markers in 513 members of 92 nuclear families ascertained through extreme obesity and

36 Sixteen variants were genotyped in 580 nuclear families ascertained through offspring with asth

37 sease associations for both case-control and nuclear family-based data-including application of corre

38 ide some guidance to investigators designing nuclear family-based linkage disequilibrium studies for

39 sian population, with both case-control- and nuclear-family-based approaches.

40 Analysis of the Nuclear-Family-based cohort revealed that the rate of Eo

41 lso found in 12 Caucasian Amish kindreds (24 nuclear families) by both sib-pair and transmission dise

42 e phenotyping and genomic analysis utilizing nuclear families can provide a diagnosis in some cases a

43 st three carefully selected individuals in a nuclear family can recover >90% of the information avail

44 In the Nuclear-Family cohort, combined gene and common environm

45 udy, we examined genome screen data from 148 nuclear families, collected without reference to phenoty

46 es in different family structures, including nuclear families commonly used in complex disease gene m

47 l clones (TCC) directed against MOG in three nuclear families, comprised of four individuals affected

48 e performed a genomewide linkage scan in 204 nuclear families comprising 853 individuals and 270 affe

49 A total of 296 nuclear families consisting of a schizophrenia proband,

50 Using a sample of 201 nuclear families consisting of a total of 694 individual

51 The three kindreds, one extended and two nuclear families, contained 13 affected individuals, 11

52 -23 and 20p12 in a cohort of 115 multiethnic nuclear families containing 145 SLE-affected sibpairs.

53 Among 264 nuclear families containing 966 siblings, 516 autosomal

54 inkage disequilibrium typically are based on nuclear-family data including affected individuals and t

55 The methods are illustrated using nuclear-family data to evaluate the contribution of loci

56 mutation as an inheritance inconsistency in nuclear-family data, as a function of both the number of

57 packages for model-free linkage analysis of nuclear-family data, by applying them to single-marker d

58 d an extensive simulation study on simulated nuclear-family data, varying the number of trait loci, f

59 oach is applicable to either case/control or nuclear-family data, with case/control data modeled via

60 applicable, as a test for linkage, only for nuclear-family data.

61 I (Heath 1997) in our simulation study using nuclear-family data.

62 named XQTL, which uses X-linked markers in a nuclear family design.

63 tism Symptom Scale (BPASS), were measured in nuclear families, each ascertained through two probands

64 were conducted in 3,369 individuals from 906 nuclear families enrolled, without selection, in a longi

65 of complex disease we have regenotyped five nuclear families first studied in the 1996 UK multiple s

66 analysis to obesity, and 236 sib pairs in 82 nuclear families, for linkage analysis to energy metabol

67 These comprised 451 sib pairs in 127 nuclear families, for linkage analysis to obesity, and 2

68 ned 92 affected individuals, representing 82 nuclear families, for mutations, using single-strand con

69 In this study, 413 subjects in 88 nuclear families from a general population sample were e

70 blood assay in 392 children belonging to 135 nuclear families from an area hyperendemic for tuberculo

71 The PDT can use data from related nuclear families from extended pedigrees and is valid ev

72 tests of association when data from related nuclear families from larger pedigrees are used.

73 Our previous research involving 167 nuclear families from the Autism Genetic Resource Exchan

74 Analyzing 726 meiotic events in 95 nuclear families from the CEPH panel pedigrees, we find

75 Here, we use 489 nuclear families from the mainland USA, Puerto Rico and

76 andard methods require selection of a single nuclear family from any extended pedigrees when testing

77 segregates with a disease phenotype in small nuclear families, from genome-wide oligonucleotide micro

78 Our previous genomewide linkage scan of 428 nuclear families (GeneQuest) identified a significant ge

79 This statistic, when applied to nuclear families, generalizes the transmission/disequili

80 In this study, 80 nuclear families have been examined for linkage of total

81 me-wide linkage scans with hundreds of small nuclear families have identified new susceptibility gene

82 Nuclear-Family heritability appeared to be high (72.0%).

83 of the peasant economy is based on autarkic nuclear family households.

84 is of data on multigenerational extended and nuclear families identified the features of structural a

85 asthma index families and randomly selected nuclear families in a rural community in China.

86 The sample included 155 siblings from 42 nuclear families in Brazil.

87 The kindred consists of several related nuclear families in which all parent unions of affected

88 rt comprised 1,037 predominantly white (82%) nuclear families in which at least 1 member had SLE.

89 Nuclear families in which at least one sibling was born

90 transmission of memory disorders differs in nuclear families in which the AD-affected proband did ca

91 We recruited a sample of 393 small nuclear families (including 250 full-sib and 46 half-sib

92 Analysis of 150 nuclear families indicated statistically significant lin

93 ies in 1465 American white subjects from 218 nuclear families indicated that allelic variation at, or

94 At the same time, inferring phase from nuclear families may be hampered by missing family membe

95 adjusted for age, sex, percent body fat, and nuclear family membership).

96 e storage rate after adjusting for age, sex, nuclear family membership, and percentage of body fat (P

97 investigated blood pressure in 1,183 Chinese nuclear families (mother, father, and first two children

98 In a second sample of 298 nuclear families (n=1283 individuals), the Arg16Gly poly

99 In our previous genome-wide scan of Finnish nuclear families, obesity was linked to chromosome Xq24.

100 d nonsmokers, representing approximately 404 nuclear families of African American (AA) or European Am

101 tal of 2037 smokers and non-smokers from 602 nuclear families of African- or European-American (AA or

102 mple consisting of 2037 individuals from 602 nuclear families of African-American (AA) or European-Am

103 ruct a general approach that can accommodate nuclear families of any size, with or without parental i

104 ed out a complex segregation analysis in 636 nuclear families of consecutively ascertained and rigoro

105 found to be associated with total IgE in 420 nuclear families of Costa Rican children with asthma.

106 Participants were 2037 subjects from 602 nuclear families of either African-American (AA) or Euro

107 ch controls the functional activity of NFAT (nuclear family of activated T cell) proteins.

108 scan of 1,261 individuals, representing 402 nuclear families, of African American (AA) origin.

109 The 2,527 offspring came from 1,303 nuclear families, of which 77.6% had two or more sibling

110 tinct units, which will usually be sibships, nuclear families, or small pedigrees.

111 d to include only one affected offspring per nuclear family per extended pedigree; multiple three-mar

112 obese (BMI >or=35 kg/m(2)), and 84.8% of the nuclear families possessed >or=1 morbidly obese sibling

113 of 914 EoE probands (n = 2192 first-degree "Nuclear-Family" relatives) and an international registry

114 tart site by sequencing, and analysis of 562 nuclear families revealed 6 haplotypes.

115 ample (187 families, 564 subjects), a German nuclear family sample (211 families, 751 subjects) and a

116 211 families, 751 subjects) and a Pittsburgh nuclear family sample (247 families, 729 subjects).

117 ilies (n=1240 individuals) were added to the nuclear family sample, and the Gln27Glu polymorphism in

118 only to triads, whereas some are amenable to nuclear families (sibships).

119 gregation and heritability based on twin and nuclear family study designs is summarized.

120 region in a sample of 181 sib pairs from 82 nuclear families that were selected on the basis of a dy

121 de meals especially for working parents in a nuclear family therefore it is imperative to determine t

122 icate this finding; combined analysis of 194 nuclear families through use of the transmission/disequi

123 ificate data dating back to 1967 and allowed nuclear families to be reconstructed by linking children

124 ssue and then perform simulation studies for nuclear families to compare the methods in terms of powe

125 wo approaches to segregation analysis in 102 nuclear families to estimate genetic models for componen

126 We collected 70 families, ranging from small nuclear families to extended multigenerational pedigrees

127 le-nucleotide polymorphism data collected in nuclear families to localize crossovers with high spatia

128 one heterozygous for DRD4*7R), including 12 nuclear family trios and 52 trios from four large TS kin

129 Canadian replication cohort consisted of 364 nuclear family trios with one type 1 diabetes-affected o

130 We analyzed intermarker LD in 62 nuclear families using microsatellite markers covering e

131 ng the number of affected individuals in the nuclear family was included.

132 iduals of Chinese and Japanese descent, from nuclear families, was genotyped for two polymorphisms, r

133 ed data from 716 Pima Indians comprising 217 nuclear families, we have tested a number of polymorphic

134 g all possible affected sib pairs (ASPs) per nuclear family, we obtained a peak maximum LOD score bet

135 the hoarding phenotype in a data set with 53 nuclear families, which were collected by the Tourette S

136 of data simulated for 956 siblings from 263 nuclear families who had participated in a linkage study

137 re generated using 9,291 subjects from 2,900 nuclear families who participated in the National Heart,

138 In a sample of 729 nuclear families with 1089 affected and 1165 unaffected

139 A total of 337 nuclear families with 2 parents and at least 1 biologic

140 enotyping these in an independent set of 636 nuclear families with 974 affected offspring revealed 75

141 Fifty-five nuclear families with at least two asthmatic siblings (2

142 sis of HLA class II alleles in 180 Caucasian nuclear families with at least two children with insulin

143 ng technology in finding causal mutations in nuclear families with dominantly inherited traits otherw

144 an also produce multimegabase haplotypes for nuclear families with just two children and can handle f

145 However, for nuclear families with more than one child, error detecti

146 If the sample contains independent nuclear families with multiple affected children, then o

147 data on a polymorphism of the SDR5A2 gene in nuclear families with multiple cases of prostate cancer.

148 jects (815 siblings and 86 parents) from 222 nuclear families with multiple nicotine-addicted sibling

149 h rs2227476 (P = 0.01) was replicated in 240 nuclear families with one affected child from Mali.

150 Here we present a GWAS in 212 nuclear families with pediatric VTE followed by targeted

151 Analysis of a nuclear family with three affected offspring identified

152 es can be performed by genetic analysis of a nuclear family with three or more children.

153 It is applicable to any size of nuclear family, with or without ambiguous phase informat

154 Six hundred fifteen nuclear families yielded 870 sib pairs for linkage, with