ライフサイエンスコーパス: nuclear import

1 itotic NPC disassembly-reassembly or general nuclear import.

2 interaction with Importin-beta for efficient nuclear import.

3 ges that modulate its catalytic activity and nuclear import.

4 nse to apoptotic stimuli by facilitating its nuclear import.

5 onship between the phosphorylation event and nuclear import.

6 Progerin did not cause global inhibition of nuclear import.

7 reverse transcription, are not required for nuclear import.

8 of the precursor and cleavage, resulting in nuclear import.

9 lear dependence upon hsc70 for CaM-dependent nuclear import.

10 and importin-alpha7 are required for the XPA nuclear import.

11 1 transport-receptor and cargoes destined to nuclear import.

12 that is important for HIV-1 infection after nuclear import.

13 CR/CD3-mediated enhancement of HIV infection/nuclear import.

14 d TLR2-mediated enhancement of HIV infection/nuclear import.

15 ng importin-alpha3, a regulator of NF-kappaB nuclear import.

16 erse transcription, confounding the study of nuclear import.

17 s on sRNA binding, which is required for its nuclear import.

18 d the mechanism by which mTOR controls STAT1 nuclear import.

19 pha/beta-dependent and transportin-dependent nuclear import.

20 s rate of nuclear export exceeds its rate of nuclear import.

21 p153-Nup50 interface decreases efficiency of nuclear import.

22 60 and both importins are essential for Hxk2 nuclear import.

23 lates HDAC6 tubulin deacetylase activity and nuclear import.

24 omote cytoplasmic localization by inhibiting nuclear import.

25 cked TLR2- and TCR/CD3-induced HIV infection/nuclear import.

26 ce to molecular transport, and increases YAP nuclear import.

27 ction of resting CD4 T cells at the level of nuclear import.

28 postentry steps of reverse transcription and nuclear import.

29 e and is facilitated by both DNA binding and nuclear import.

30 ular trafficking of proteins including their nuclear import.

31 rane, making it accessible for importins and nuclear import.

32 the MRTF-A regulatory RPEL domain, promoting nuclear import.

33 e nuclear membrane, and an overall defect in nuclear import.

34 omain and central region that regulates MDMX nuclear import.

35 cytoplasm to the nucleus via retrograde tRNA nuclear import, a process that is conserved from yeast t

36 ort the hypothesis that viral antagonists of nuclear import actively manipulate host responses in spe

37 t of a STAT1 mutant incapable of binding its nuclear import adaptor karyopherin-alpha1 (KPNA1).

38 The prolyl-3,4-dihydroxylase Ofd1 and nuclear import adaptor Nro1 regulate the hypoxic respons

39 but not Rrp47, is found associated with the nuclear import adaptor protein Srp1.

40 Consistent with this, leptomycin B-induced nuclear import and adrenocorticotropic hormone (ACTH) tr

41 and H4, modifications that are important for nuclear import and chromatin assembly.

42 We find that HERC3 restricts NF-kappaB nuclear import and DNA binding without affecting IkappaB

43 Nuclear import and export are often considered inverse p

44 rs to originate from dual regulation of both nuclear import and export by phosphorylation, as mutants

45 ecreased in hypoxia, and the use of specific nuclear import and export inhibitors clearly showed that

46 s are dynamically connected and identify the nuclear import and export mechanisms of actin.

47 Cofilin and Profilin, which regulate the nuclear import and export of actin, also localize to the

48 Both nuclear import and export of DEX-induced RFP-GRalpha wer

49 lear pore complex is the primary conduit for nuclear import and export of molecules.

50 The fine balance between nuclear import and export of TR has emerged as a critica

51 ytosol and nucleus is controlled by specific nuclear import and export signals and that oxidative str

52 f the substrate is used to directly modulate nuclear import and export, thereby regulating the report

53 and sufficient for glucose-responsive ChREBP nuclear import and export.

54 found in Alzheimer's disease brains, delayed nuclear import and furthermore blocked the ability of nu

55 These data provide a mechanism for MeCP2 nuclear import and have implications for the design of t

56 Eukaryotic ribosome biogenesis requires nuclear import and hierarchical incorporation of approxi

57 tion by phosphorylating Ser 67, which drives nuclear import and inhibits nuclear export.

58 Our data support a model in which HIV nuclear import and integration are concerted steps, and

59 anscription activity but displays a block in nuclear import and integration, as measured by quantitat

60 ted in later steps of replication, including nuclear import and integration.

61 dark reversion attenuates red light-induced nuclear import and interaction of phyB(Ser86Asp)-YFP Pfr

62 It is also demonstrated that Hxk2 nuclear import and its binding to Kap95 and Kap60 depend

63 nuclear localization signal to Ala abolished nuclear import and Oxtr-induced gene expression.

64 lation of a cellular factor necessary for L1 nuclear import and retrotransposition.

65 s, Acl4 serves a dual function to facilitate nuclear import and simultaneously protect unassembled Rp

66 hese modifications are important for histone nuclear import and subsequent chromatin assembly.

67 PI3K inhibitor blocked HIV infection/nuclear import and T cell activation and exerted a moder

68 We also show that the Hxk2 nuclear import and the binding of Hxk2 with Kap60 are gl

69 stem into the cytoplasm, allowing subsequent nuclear import and the initiation of gene expression, re

70 as the most important karyopherins for Rrp6 nuclear import and the nuclear localization signals reco

71 How environmental factors influence histone nuclear import and the nucleosome assembly pathway, lead

72 TRN-SR2 protein-protein interaction for HIV nuclear import and validate the IN/TRN-SR2 interaction i

73 (another HIV-1 cofactor implicated in viral nuclear import) and LEDGF/p75 in the targeting of the vi

74 phosphatase activity, nuclear factor-kappaB nuclear import, and general cell signaling.

75 ral events, including reverse transcription, nuclear import, and integration, and enhances viral prod

76 ics and efficiency of reverse transcription, nuclear import, and integration.

77 n infected cells during cytoplasmic transit, nuclear import, and mRNA synthesis.IMPORTANCE The fates

78 anine expansions on the homeodomain-mediated nuclear import, and our data clearly show that the expan

79 lexes (vRNPs), thereby resulting in impaired nuclear import, and that the additional acquired mutatio

80 ology approaches, we evaluated the impact of nuclear import antagonism on host expression networks by

81 Viral nuclear import antagonists, expressed by several highly

82 Using a reconstituted nuclear import assay, we show that antibodies to hsc70 s

83 By using in vitro nuclear import assays and immuno-cytofluorescence, we di

84 Mutagenesis and nuclear import assays showed that NLS acetylations promo

85 R3-8 of beta-catenin were highly active for nuclear import but displayed a comparatively weak export

86 etion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration.

87 ly has the primary role of regulating Dorsal nuclear import, but also has a secondary role in shuttli

88 activities of Ddx19 are dispensable for MKL1 nuclear import, but RNA binding is required.

89 nly composed of Tpr, is not required for HIV nuclear import, but that Nup153 is essential.

90 dditional antiviral blocks exist upstream of nuclear import, but the ISGs that suppress infection, e.

91 y, we provide evidence that targeting S100A4 nuclear import by low-dose paclitaxel, a microtubule-sta

92 f truncated AR variants, this basal level of nuclear import can be augmented by unique COOH-terminal

93 Consistent with the behavior of normal nuclear import cargoes, HIV-1 IN is released from the co

94 As for most nuclear import cargoes, the driving force behind HIV-1 p

95 e-assembled on endosome to synchronize their nuclear import, could coordinate genome-wide transcripti

96 mutants, srp1-31 displays the characteristic nuclear import defect of importin-alpha mutants, whereas

97 ed binding of PKCdelta to importin-alpha and nuclear import, demonstrating that tyrosine kinase inhib

98 p1 overexpression increased the rate of Pten nuclear import detected by photobleaching experiments, w

99 Its C-terminal zinc finger domain mediates nuclear import, DNA binding, and recruitment of the core

100 ure-based assays of proteosomal degradation, nuclear import, enhancer DNA occupancy, and SRY-dependen

101 The strongest nuclear import/export activity was mapped to Arm repeats

102 ogenous Nup358 and Nup62 impeded the rate of nuclear import/export of beta-catenin to a greater exten

103 ding affinity of the mutant photoreceptor to nuclear import facilitators FHY1 (for FAR-RED ELONGATED

104 eukaryotic translation initiation factor 4E nuclear import factor 1 (Eif4enif1), which encodes an eu

105 Importantly, we identified importin 9 as the nuclear import factor for actin.

106 s as a gp130-sensitive transactivator of the nuclear import factor importin-alpha5 (Impalpha5), and i

107 stable and stoichiometric complex with host nuclear import factor RanBP5 that can be modelled using

108 Here we report that the nuclear import factor Srp1 (also known as importin alpha

109 We found that miR-128 targets the 3' UTR of nuclear import factor transportin 1 (TNPO1) mRNA.

110 We show that Ddx19 is not a general nuclear import factor, and that its specific effect on M

111 and depletion of either Formin-2 or actin's nuclear import factor, importin-9, increases the number

112 ytes, ribosomal proteins that did not engage nuclear import factors were targets for UBE2O.

113 tubule dynamics and 2) postsynaptic Frizzled nuclear import (FNI).

114 TLR2 but not IL-2 signals promoted HIV nuclear import; however, both signals were required for

115 tion of TDP-43 C-terminal fragments and of a nuclear import-impaired mutant.

116 ough etoposide treatment similarly inhibited nuclear import in a mouse embryonic fibroblast model.

117 sc70 is required for the maximal rate of SRY nuclear import in living cells but has no impact upon SR

118 that TLR2 activation enhances HIV infection/nuclear import in resting CD4(+) T cells through both T

119 everse transcription products, but increased nuclear import in the presence of Vpr independent of the

120 Increased nuclear import in turn drives the expression of a cohere

121 ein and cellular factors implicated in viral nuclear import, including transportin 3 (TNPO3) and nucl

122 suppressed TLR2-mediated enhancement of HIV nuclear import/infection.

123 first reported series of constrained peptide nuclear import inhibitors.

124 it model of heart failure, where ISO-induced nuclear import is ablated, but G(q)-agonist mediated exp

125 Here, we show that A3B nuclear import is an active process requiring at least o

126 Nuclear import is an essential step in small nuclear rib

127 The process of nuclear import is considered to be the bottleneck of the

128 Regulation of nuclear import is fundamental to eukaryotic biology.

129 Calcium-activated CCTalpha nuclear import is mediated by binding of its C-terminus

130 The biological significance of this tRNA nuclear import is not entirely clear.

131 factor, and that its specific effect on MKL1 nuclear import is separate from its role in mRNA export.

132 y of developmental phenotypes increases, but nuclear import is unaffected.

133 ups, ooc-5-mutant embryos displayed impaired nuclear import kinetics, although the nuclear pore-size

134 lasm of infected cells and exploits the host nuclear import machinery to gain access to the nucleus,

135 ermed here escortins-to securely connect the nuclear import machinery with pathways that deposit r-pr

136 ospora arabidopsidis co-opts the host cell's nuclear import machinery.

137 that the present-day A3B enzyme retained the nuclear import mechanism of an ancestral AID protein dur

138 Therefore, the nuclear import mechanism of NRF-2 is unique among Ets fa

139 990, involved heat-shock protein 70-mediated nuclear importing mechanism.

140 We hypothesized that retrograde tRNA nuclear import might function in proofreading tRNAs to e

141 ness in a fashion that is independent of the nuclear import/nuclear retention of COP1.

142 ed the activation of importin beta-dependent nuclear import of 53BP1, a large NCT cargo.

143 n ELISA-based assay and in cells, to inhibit nuclear import of a binary PB1-PA complex as well as tra

144 transcription factor-dependent mechanism for nuclear import of a cognate transcriptional repressor JA

145 participates in mRNA export, translation and nuclear import of a key transcriptional regulator.

146 The design in principle should coordinate nuclear import of a tRNA synthetase with the demands of

147 n of TNPO1 affects L1 retrotransposition and nuclear import of an L1-ribonucleoprotein complex (using

148 a code that determines importin-independent nuclear import of ankyrin repeats (ARs), a structural mo

149 -) cells with a vector encoding APP restored nuclear import of anMan-containing HS.

150 Eukaryotic ribosome biogenesis requires the nuclear import of approximately 80 nascent ribosomal pro

151 ain and are critical for the recognition and nuclear import of ASF/SF2.

152 Four compounds were found to inhibit nuclear import of C in transfected cells, with one able

153 nal-regulated kinases activity and prevented nuclear import of calcineurin, independent of NFAT activ

154 ive in primary human macrophages, indicating nuclear import of capsids or capsid-like structures.

155 n essential cofactor for importin-7-mediated nuclear import of cargo proteins.

156 n nuclear pore formation and is required for nuclear import of CRABP2 and for transcriptional activat

157 This export occurs after the nuclear import of cyclin B-Cdk1 complexes, requires the

158 In contrast, Hsp40 overexpression increased nuclear import of D3 and minimized thyroid hormone effec

159 Here we show that hypoxia leads to nuclear import of D3 in neurons, without which thyroid h

160 Nuclear import of ErbB3 occurs via importin beta1, which

161 Nap1 is a histone chaperone involved in the nuclear import of H2A-H2B and nucleosome assembly.

162 cAMP signaling stimulates nuclear import of HDAC4 and HDAC5, but the underlying me

163 The nuclear import of HDAC4 and its association with chromat

164 We show that cAMP-stimulated nuclear import of HDAC5 requires a signaling mechanism t

165 o reversed Abeta oligomer- and ApoE4-induced nuclear import of HDACs, preventing the loss in BDNF.

166 Whether this interaction mediates the nuclear import of HIV remains controversial.

167 ind that NLRX1 depletion results in impaired nuclear import of HIV-1 DNA in human monocytic cells.

168 PO3) is a cellular karyopherin implicated in nuclear import of HIV-1.

169 replication that has been implicated in the nuclear import of HIV.

170 rRS) distributes to the nucleus and that the nuclear import of human TyrRS is regulated by its cognat

171 The nuclear import of IAV genome is an indispensable step in

172 ated inhibition of Hsp40 resulted in reduced nuclear import of IAV RNPs, diminished viral polymerase

173 ck protein 40 (Hsp40/DnaJB1) facilitates the nuclear import of incoming IAV viral ribonucleoproteins

174 ortin-alpha5), which is known to mediate the nuclear import of ISGF3.

175 ts, we propose that actin assembly regulates nuclear import of JMY in response to DNA damage.

176 es both cytoplasmic actin polymerization and nuclear import of JMY, and we find that damage-induced n

177 binding of importins to the NLS and prevent nuclear import of JMY.

178 entity is not associated with defects in the nuclear import of key pluripotency factors.

179 CXCL12-dependent nuclear import of LASP-1 could be blocked by CXCR4 antag

180 se 2A catalytically control the constitutive nuclear import of latent STAT1 by KPNA1, which are key m

181 interaction with STAT1, was required for the nuclear import of latent STAT1, transcriptional inductio

182 In this role, FHY3 indirectly mediates the nuclear import of light-activated phyA, which triggers d

183 ole for the mRNA export factor Ddx19/Dbp5 in nuclear import of MKL1, the signal-responsive transcript

184 pendently inhibiting SRF gene expression and nuclear import of MRTF-A.

185 calization signal mutant version and induced nuclear import of NEMO in digitonin-permeabilized cells.

186 ifically blocked the importin alpha-mediated nuclear import of NF-kappaB and prevented lipopolysaccha

187 ion significantly increased the CN-dependent nuclear import of NFATc3 in the mDA neurons of transgeni

188 (mTOR) kinases had no significant effect on nuclear import of NFATc4.

189 leoprotein (vRNP) complex without disrupting nuclear import of NP alone.

190 NRF-2alpha and NRF-2beta form a complex, the nuclear import of NRF-2alphabeta becomes strictly depend

191 It is known that nuclear import of nuclear factor-kappaB (NF-kappaB) play

192 ne transfer and enhance understanding of the nuclear import of other viral DNA genomes, such as those

193 lasmic translocation of kaiso depends on the nuclear import of p120ctn in complex with MUC1-CT and th

194 data show that KPNB1 is required for timely nuclear import of PER/CRY in the negative feedback regul

195 Although nuclear import of phyA is regulated by the transport fac

196 We also demonstrate that impaired nuclear import of phyA-5 is brought about by weakened bi

197 phenotype of the mutant is caused by reduced nuclear import of phyA-5 under low fluences of far-red l

198 x, whereby it plays a role in regulating the nuclear import of phyA.

199 phyB fragments in vitro and showed that the nuclear import of phyB can be facilitated by phytochrome

200 We recently showed that nuclear import of phytochromes can be analyzed in a cell

201 at reverse transcription is not required for nuclear import of PICs, indicating that a viral core unc

202 ility dramatically reduce NE association and nuclear import of PICs.

203 TCS mutations, in POLR1C impair assembly and nuclear import of POLR3, but not POLR1, leading to decre

204 pathway of nuclear holo-TFIID, regulated by nuclear import of preformed cytoplasmic submodules.

205 tored the binding of hexon at the NE and the nuclear import of protein VII (pVII), indicating that th

206 t with PS-ASOs in the cytoplasm and that the nuclear import of PS-ASOs is at least partially through

207 ate NCAM ligands leads to the generation and nuclear import of PSA-lacking and -carrying NCAM fragmen

208 determined that specifically preventing the nuclear import of pSMAD3 using the TAT-SNX9 peptide inhi

209 Active nuclear import of Ran exchange factor RCC1 is mediated b

210 Dif1 protein inhibits RNR by promoting nuclear import of Rnr2-Rnr4.

211 omolog of yeast and human proteins linked to nuclear import of selective cargo.

212 3 (Tnpo3, Transportin-SR2) is implicated in nuclear import of splicing factors and HIV-1 replication

213 r results elucidate the structural bases for nuclear import of splicing factors and the Tnpo3-CPSF6 n

214 gs strongly implicate hsc70 in CaM-dependent nuclear import of SRY.

215 tein hsc70 plays a key role in CaM-dependent nuclear import of SRY.

216 V-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes.

217 TDP2 UBA-Ub binding interface do not affect nuclear import of TDP2, but severely compromise its abil

218 Nuclear import of the 70-kDa fragment may activate cellu

219 (1147) abolished L1-stimulated generation or nuclear import of the 70-kDa fragment, respectively.

220 Both in vitro hexon binding and in vivo nuclear import of the AdV genome were strongly reduced i

221 that uncoating is tightly regulated to allow nuclear import of the genome while minimizing the exposu

222 When nuclear import of the HIV-1 reverse transcription comple

223 We show that Nup116 mediates nuclear import of the karyopherin Kap121, and each prote

224 description of a protein factor involved in nuclear import of the L1 element and demonstrates that m

225 interacted directly with KPNA1 and regulated nuclear import of the mTOR-KPNA1 complex.

226 We speculate that nuclear import of the PIC may proceed concurrently with

227 ey role in HIV infection by facilitating the nuclear import of the pre-integration complex (PIC) that

228 PARP-1 did not impair reverse transcription, nuclear import of the preintegration complex, or viral D

229 n form of lamin A, causing a major defect in nuclear import of the protein, translocated promoter reg

230 Here, we show that the nuclear import of the PSA-carrying NCAM fragment is medi

231 Conversely, nuclear import of the S14A mutant of Hxk2 was significan

232 s of Hxk2 with Kap60 and Xpo1 indicated that nuclear import of the S14D mutant of Hxk2 is severely de

233 odon recognition domain that is critical for nuclear import of the synthetase.

234 id core disassembles to allow the subsequent nuclear import of the viral genome.

235 Both prevent nuclear import of the viral ribonucleoprotein (vRNP) com

236 Generation and nuclear import of this fragment in cultured cerebellar n

237 nstance, gene expression entails coordinated nuclear import of transcriptional regulators to activate

238 by different mechanisms, with eVP24 blocking nuclear import of tyrosine-phosphorylated STAT1 and mVP4

239 bioinformatics analysis showed that to have nuclear import of TyrRS directly controlled by tRNA(Tyr)

240 of tRNA(Tyr) expression, which led to robust nuclear import of TyrRS.

241 V nucleoprotein (NP) is known to mediate the nuclear import of viral genome via its nuclear localizat

242 DNA production by competitively blocking the nuclear import of viral nucleocapsids.

243 Antiviral VHHs prevented nuclear import of viral ribonucleoproteins or mRNA trans

244 mmalian nucleotide excision repair (NER) and nuclear import of XPA from the cytoplasm for NER is regu

245 XPA nuclear import, showed no effect on the nuclear import of XPA in our siRNA knockdown analysis.

246 responsible for the UV (ultraviolet)-induced nuclear import of XPA.

247 Only depletion of ZO-2 reduced the nuclear import of YAP.

248 ous report of a dependence of UV-induced XPA nuclear import on ataxia telangiectasia and Rad3-related

249 ypically ascribed to roles in either histone nuclear import or deposition.

250 that Hat1 is not required for either histone nuclear import or deposition.

251 variety of proteins, in some cases affecting nuclear import or export.

252 e, Ssa1p, has been thought to facilitate the nuclear import or to maintain the solubility of most Cyt

253 abundant, suggesting that MX2 inhibits HIV-1 nuclear import, or destabilizes nuclear HIV-1 DNA.

254 ay represents a general importin-independent nuclear import pathway and is frequently used by AR-cont

255 assical NLS and importin alpha/beta mediated nuclear import pathway has already been described for be

256 asis of the unique features of the classical nuclear import pathway in plants.

257 Thus, the IPO3 nuclear import pathway is an early and crucial determina

258 Here we show that a nonclassical nuclear import pathway via IPO3 (importin 3, transportin

259 d found that rAAV2 can utilize the classical nuclear import pathway, involving the nuclear pore compl

260 tification of a general importin-independent nuclear import pathway.

261 ancer through silencing of components of the nuclear import pathway.

262 review the structural basis of the principal nuclear import pathways and the molecular basis of their

263 The majority of nuclear import pathways are mediated by importin-cargo i

264 and immuno-cytofluorescence, we dissect the nuclear import pathways of NRF-2.

265 n that are known, or suspected, to alter the nuclear import pathways used by HIV-1 confer resistance

266 Several nuclear import pathways, by contrast, were not affected

267 templates for evaluating virus antagonism of nuclear import processes but also can reveal candidate c

268 only enhanced the reverse transcription and nuclear import processes in single-cycle HIV-1 infected

269 n signaling by blocking karyopherin-mediated nuclear import processes.

270 toplasm by blocking the interaction with the nuclear import protein importin-alpha.

271 ts nuclear accumulation, by accelerating its nuclear import rate and reducing its nuclear export rate

272 ER-CRY repressive complex by controlling the nuclear import rate, whereas FBXL3 separately regulates

273 velopmental program does not correspond with nuclear import rates, but provide evidence that PKC acti

274 hat the Ub-conjugating enzyme UBE2E3 and its nuclear import receptor importin 11 (Imp-11) regulate Nr

275 tal structure of the FUS PY-NLS bound to its nuclear import receptor Karyopherinbeta2 (Kapbeta2; also

276 This dsRBD-NLS is recognized by the nuclear import receptor transportin 1 (Trn1; also called

277 The nuclear import receptors importin beta and transportin p

278 iruses to regulate the kinetics of terminase nuclear import, reflecting a mechanism of virus:host ada

279 l GTPase Ran, which is a master regulator of nuclear import required for nuclear localization of TDP-

280 These data resolve independent nuclear import routes for Rrp6 and Rrp47, reveal a struc

281 ed to imply the absence of a need for active nuclear import, sequence and structural analysis suggest

282 and IMPalpha2 to impede their normal role in nuclear import, shedding new light on the cellular funct

283 , previously proposed to be required for XPA nuclear import, showed no effect on the nuclear import o

284 nters the nucleus remains unclear because no nuclear import signal has been identified in the beta-ar

285 es also highlight the likelihood that, after nuclear import, specialized mechanisms exist to guide th

286 we demonstrated that the rate of HIF-1alpha nuclear import substantially influences its stabilizatio

287 signal (PY-NLS)/karyopherinbeta2 (Kapbeta2) nuclear import system regulates Gli ciliary localization

288 e in CRPC cells utilize distinct pathways of nuclear import that affect the antitumor efficacy of tax

289 Among the known pathways of protein nuclear import, the karyopherin beta2/transportin pathwa

290 A has well-defined domains necessary for its nuclear import, the region responsible for the transloca

291 uit cytoplasmic proteins destined for active nuclear import to the nuclear transport machinery.

292 s and proteins involved in lipid metabolism, nuclear import, translation, and RNA processing.

293 nucleocytoplasmic shuttling due to impaired nuclear import (V60L; mediated by Exportin-4) or export

294 uorescence-based import assay, the defect in nuclear import was corroborated.

295 mph nodes and tumors to show that while NFAT nuclear import was fast (t(1/2 max) approximately 1 min)

296 To clarify the mechanism of MeCP2 nuclear import, we isolated proteins that interact with

297 Specifically, GSK3beta activity and nuclear import were increased by imatinib mesylate (IM),

298 lpha mutants that impair interactions during nuclear import were used together with cytoplasmic Ran G

299 e immunity by selectively targeting PY-STAT1 nuclear import while leaving the transport of other carg

300 erivatives thereof that retain CaM-dependent nuclear import, with an increased rate of nuclear accumu